Chemical Physics Impact最新文献

{"title":"\"Enhancing structural and optical properties of CuO thin films through gallium doping: A pathway to enhanced photoluminescence and predict for solar cells applications\"","authors":"Sinovuyo Siyalo,&nbsp;Habtamu Fekadu Etefa,&nbsp;Francis Birhanu Dejene","doi":"10.1016/j.chphi.2025.100832","DOIUrl":"10.1016/j.chphi.2025.100832","url":null,"abstract":"<div><div>This study explores the transformative impact of gallium (Ga) doping on the structural and optical properties of copper oxide (CuO) thin films synthesized via chemical bath deposition (CBD) to Enhanced Photoluminescence. Structural analysis using X-ray diffraction (XRD) and scanning electron microscopy (SEM) revealed that moderate Ga doping significantly enhanced crystallinity, improved grain connectivity, and minimized defects. However, excessive doping levels led to phase segregation and structural inconsistencies. The crystalline size (D) was meticulously analyzed using Williamson-Hall (W-H) and Scherrer methods based on XRD data. Optical characterization through UV–Vis spectroscopy demonstrated a remarkable redshift in the absorption edge, attributed to Ga-induced bandgap modifications at the optimal doping concentration of 0.4 M decreased from 2.60 eV to 1.95 eV This modification notably enhanced the material's light-harvesting capabilities, making it more effective for photovoltaic applications. Fourier-transform infrared (FTIR) spectroscopy highlighted distinct Cu-O vibrations and notable changes in hydroxyl and C<img>O bonding, signifying alterations in surface chemistry and bonding structures. These structural and chemical modifications contribute to the material's enhanced performance. Photoluminescence (PL) analysis revealed a pronounced green emission at 530 nm under 0.4 M Ga doping, linked to changes in radiative and non-radiative recombination processes. Indeed, Ga doping enhances the structural and optical properties of CuO thin films, including tailored bandgap energy, improved crystallinity, and superior optical absorption. These improvements make Ga-doped CuO thin films promising to predict solar cells and photocatalytic applications technologies, boosting the efficiency of photovoltaic and photoluminescence systems.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"10 ","pages":"Article 100832"},"PeriodicalIF":3.8,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural tailoring of etoricoxib: A spectrochemical, medicinal and pharmacological study","authors":"Bakul Akter ,&nbsp;Silvia Aishee ,&nbsp;Abdullah Hridoy ,&nbsp;Md. Mehedi Hasan Pulok ,&nbsp;Mohammad Ariful Islam ,&nbsp;Antu Biswas ,&nbsp;Aurna Patwary ,&nbsp;Majedul Hoque ,&nbsp;MD. Sazidul Islam ,&nbsp;Md. Nipatul Hasan Nirob ,&nbsp;Faisal Islam Chowdhury ,&nbsp;Monir Uzzaman","doi":"10.1016/j.chphi.2025.100830","DOIUrl":"10.1016/j.chphi.2025.100830","url":null,"abstract":"<div><div>Etoricoxib (ETC), a selective cyclooxygenase enzyme (COX-2) inhibitor, is widely utilized to manage pain and inflammation. Nevertheless, its therapeutic efficacy is limited by poor aqueous solubility, low bioavailability, and significant cardiovascular risks, including increased blood pressure, thrombosis, and the potential for myocardial infarction. This study aimed to address these limitations through structural modifications of etoricoxib. A total of 21 derivatives were designed by introducing various functioning sets at the R3, R2, and R1 sites of ETC. Quantum chemical calculations were performed to assess alterations in physicochemical properties, such as HOMO–LUMO energy gaps, electrostatic potential, enthalpy, and dipole moments. Notably, most of the derivatives showed improved binding affinities, particularly ETC9 and ETC19, demonstrating the highest binding interactions in molecular docking studies (-10.1 and -10.8 kcal/mol, respectively). Furthermore, molecular dynamics (MD) simulations accomplished by exploiting the YASARA dynamics software program with the AMBER14 energy field throughout 100 ns revealed that the ETC9 and ETC19 derivatives exhibited enhanced stability and flexibility profiles compared to the parent drug, ETC. ADMET and PASS predictions confirmed the drug-like properties of most derivatives, particularly ETC19 and ETC9, which also showed improved absorption, better blood-brain barrier penetration, and reduced toxicity. These outcomes underscore the prospect of the de novo-designed etoricoxib analogues as safer and more effective alternatives, effectively addressing the pharmacological limitations and safety concerns associated with the parent drug.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"10 ","pages":"Article 100830"},"PeriodicalIF":3.8,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in lamb wave high-frequency devices using diamond-like carbon (DLC) coatings","authors":"Jatinder Pal Singh ,&nbsp;Ajay Kumar Sao ,&nbsp;Babita Sharma ,&nbsp;Satyam Garg ,&nbsp;Anjali Sharma ,&nbsp;Reema Gupta ,&nbsp;Lokesh Rana ,&nbsp;Mallika Verma ,&nbsp;Akhilesh Pandey ,&nbsp;Archibald Theodore Nimal ,&nbsp;Upendra Mittal ,&nbsp;Amit Kumar Vishwakarma ,&nbsp;Monika Tomar ,&nbsp;Arijit Chowdhuri","doi":"10.1016/j.chphi.2025.100833","DOIUrl":"10.1016/j.chphi.2025.100833","url":null,"abstract":"<div><div>Diamond-like carbon (DLC) stands as a material of profound scientific and technological importance, owing to its exceptional blend of mechanical, tribological, and chemical properties. Lamb wave devices, vital in sensing, communication, and structural health monitoring, require efficient surface acoustic wave (SAW) propagation for their diverse applications. Theoretical studies suggest that DLC coatings can accelerate SAWs due to their high elastic constant and low mass density, making them highly desirable for enhancing SAW device performance. In the present work, a process for reliable deposition of DLC films on the SiO₂/Si membrane has been investigated, aiming to optimize their functionality. MEMS (micro-electromechanical system) technology was adopted for the development of SiO₂/Si membrane-based Lamb wave devices utilising piezoelectric ZnO thin film and high-velocity DLC coating. The DLC films were coated on the SiO₂/Si membrane using the Hot Filament Chemical Vapor Deposition (HFCVD) method followed by deposition of a piezoelectric layer of ZnO film through RF magnetron sputtering. The patterning of aluminium electrodes for the fabrication of Lamb wave devices was carried out using lithography. The frequency response of the Lamb wave devices prepared without and with DLC coatings was studied and it was found that the Lamb wave devices without DLC coatings showed a return loss of -27.97 dB at a frequency of 286 MHz. However, with the incorporation of DLC coating, the frequency increased to 345 MHz with a lower return loss of -19.46 dB. The outcomes of this research underscore the potential of DLC coatings to optimize the Lamb wave device functionalities, promising enhanced performance and broader applications. Continued exploration and refinement in this field hold promise for further enhancing DLC coatings and broadening the scope of Lamb wave device applications.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"10 ","pages":"Article 100833"},"PeriodicalIF":3.8,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, synthesis, structural characterization, in vitro anticancer activity, and in silico studies of some new hydroxylated and fluorinated-substituted hydrazone derivatives","authors":"Reşit Çakmak ,&nbsp;Eyüp Başaran ,&nbsp;Ömer Erdoğan ,&nbsp;Suraj N. Mali ,&nbsp;Semiha Köprü ,&nbsp;Haya Yasin ,&nbsp;Shailesh S. Gurav ,&nbsp;Giray Topal","doi":"10.1016/j.chphi.2025.100829","DOIUrl":"10.1016/j.chphi.2025.100829","url":null,"abstract":"<div><div>Today, due to improved lifestyles and increased survival, the number of new cancer cases and cancer-related deaths continues to increase. In this study, novel hydroxylated and fluorinated-substituted hydrazone derivatives bearing an aromatic nitro moiety (<strong>2a</strong>-<strong>d</strong> and <strong>3a</strong>-<strong>d</strong>) were designed as potential anticancer drug candidates, synthesized for the first time, and evaluated for their anticancer activity against chondrosarcoma (SW1353), a common primary malignant cartilage-forming tumor, neuroblastoma (SH-SY5Y), a type of brain cancer, and healthy (L929) cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method for 24 h. The chemical structures of the target molecules were confirmed by FT-IR, 1D NMR (¹H- and ¹³C- NMR, and APT), 2D NMR (COSY, HETCOR, and HMBC), and elemental analysis. Some of the compounds targeted against these cancer cell lines showed activity greater than 200 μM, whereas others (<strong>2d</strong> and <strong>3a</strong>) demonstrated significant cytotoxic activity. Among them, compound <strong>3a</strong> (IC₅₀ = 9.45 ± 2.14 μM), a fluorinated-substituted hydrazone derivative, showed significant cytotoxic activity against the human SW1353 cell line compared to cisplatin (IC₅₀ = 11.9 ± 0.95 μM). The anti-migratory properties of compounds <strong>2d</strong> and <strong>3a</strong> in SW1353 cells, were investigated. In particular, compound <strong>3a</strong> exhibited anti-migration behavior in SW1353 cells, with a wound closure rate of 22.25 % compared with control cells. Further, scaffolds <strong>2d</strong> and <strong>3a</strong> exhibited the best docking with target receptor proteins 2OH4 (−8.3 and −8.4 kcal/mol) and 3QX3 (−12.2 and 11.0 kcal/mol), thereby supporting our bioactivity studies. Compounds <strong>2a, 3a, 3b</strong>, and <strong>3c</strong> showed high gastrointestinal (GI) absorption, with all except <strong>3a</strong> being non-permeable to the blood-brain barrier (BBB). Most compounds, except <strong>3d</strong>, are non-substrates of P-glycoprotein (P-gp). In conclusion, the <em>in vitro</em> and <em>in silico</em> results of some of the tested compounds indicate that they could be promising molecular frameworks for further studies.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"10 ","pages":"Article 100829"},"PeriodicalIF":3.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of uniaxial compressive and tensile strains on the structural, dynamical, electronic, and optical properties of ZrCl2 monolayer: Ab-initio calculations","authors":"Hind Alqurashi ,&nbsp;Bothina Hamad ,&nbsp;M.O. Manasreh","doi":"10.1016/j.chphi.2025.100828","DOIUrl":"10.1016/j.chphi.2025.100828","url":null,"abstract":"<div><div>Recently, the two-dimensional material zirconium dihalide (ZrCl₂) has received a significant attention for prospective device applications due to its unique electronic, mechanical, magnetic, and topological properties. This work reports theoretical predictions for the structural, dynamical, electronic, and optical properties of ZrCl₂ under uniaxial compressive and tensile strains using density functional theory (DFT). The band gap structures were found to be highly sensitive to the uniaxial compressive and tensile strains of ZrCl₂ monolayer (ML). The unstrained ZrCl₂ ML has a semiconducting behavior with an indirect band gap of 1.19 eV. Under the uniaxial compressive tensile stress (ε_x) of <span><math><mo>−</mo></math></span>6%, <span><math><mo>−</mo></math></span>4%, <span><math><mo>−</mo></math></span>2%, the ZrCl₂ ML retains the semiconducting behavior with indirect band gaps of 0.00, 0.30, 0.73, respectively. However, the ZrCl₂ ML has a semiconductor behavior with direct band gaps of 0.91, 0.56, and 0.41 eV for applied tensile strains of 2%, 4%, and 6%, respectively. In addition, the optical properties of ZrCl₂ ML are calculated, and the optical absorption is found to exhibit a significant anisotropy in the photon energy range of 0 - 13 eV. Based on the result of the optical properties, a ZrCl₂ ML is expected to potentially be a candidate for optoelectronic applications, such as an infrared photodetector.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"10 ","pages":"Article 100828"},"PeriodicalIF":3.8,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-efficiency borohydride oxidation and oxygen reduction on titanium-supported Au(NiMo) catalysts for Alkaline fuel cells","authors":"Sukomol Barua,&nbsp;Aldona Balčiūnaitė,&nbsp;Jūratė Vaičiūnienė,&nbsp;Loreta Tamašauskaitė-Tamašiūnaitė,&nbsp;Eugenijus Norkus","doi":"10.1016/j.chphi.2025.100827","DOIUrl":"10.1016/j.chphi.2025.100827","url":null,"abstract":"<div><div>In this research, we used a straightforward and cost-effective methodology to fabricate a three-dimensional nickel-molybdenum (NiMo) thin-layer coating, sparsely decorated with gold crystallites, on a titanium substrate (denoted as Au(NiMo)/Ti). The catalysts were prepared by depositing NiMo onto a Ti surface through a simple electrochemical deposition technique involving a dynamic hydrogen bubble template, followed by gold crystallite decoration via galvanic displacement. The prepared NiMo/Ti and Au(NiMo)/Ti catalysts were investigated as promising potential materials for alkaline fuel cells. The Au(NiMo)/Ti-3 catalyst with an Au:Ni:Mo molar ratio of 1:52.5:2.4 exhibited significantly higher electrocatalytic activity toward the oxidation of sodium borohydride and the reduction of oxygen compared to the NiMo/Ti with a Mo:Ni molar ratio of 1:7.8 to 1:24.3, and Au(NiMo)/Ti-2 and Au(NiMo)/Ti-1 catalysts with Au:Ni:Mo molar ratios of 1:50.1:5.5 and 1:51.2:7.5, respectively. Direct alkaline NaBH₄-H₂O₂ single fuel cell tests were conducted using the prepared NiMo/Ti-3 with Mo:Ni molar ratio of 1:24.3 and Au(NiMo)/Ti-3 catalysts as the anode materials. The investigation revealed that the peak power density of up to 162 mW cm⁻² was attained at 25°C with a current density of 202 mA cm⁻² and a cell voltage of 0.8 V, when Au(NiMo)/Ti-3 was employed as the anode catalyst. The highest Au mass-specific peak power density of 42.9 kW g⁻¹ was obtained at 55°C. The Au(NiMo)/Ti-3 catalyst demonstrated significantly higher activity and greater stability than the NiMo/Ti-3 catalyst. Overall, the NiMo/Ti and Au(NiMo)/Ti catalysts are promising materials for use as anodes in direct sodium borohydride fuel cells.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"10 ","pages":"Article 100827"},"PeriodicalIF":3.8,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacophore-based approach for the identification of prospective UDP-2,3-diacylglucosamine hydrolase (LpxH) inhibitor from natural product database against Salmonella Typhi","authors":"Divyapriya Karthikeyan ,&nbsp;Sanjit Kumar ,&nbsp;NS Jayaprakash","doi":"10.1016/j.chphi.2025.100824","DOIUrl":"10.1016/j.chphi.2025.100824","url":null,"abstract":"<div><div>Antibiotics are essential for the treatment of typhoid fever, which is caused by <em>Salmonella</em> Typhi. The global increase of antibiotic resistance in <em>S</em>. Typhi is a significant public health threat. The traditional approach to discovering new drugs is a lengthy process. To address this, ligand-based pharmacophore modeling was used to identify potential inhibitors of the <em>S.</em> typhi LpxH protein, a crucial enzyme in the lipid A biosynthesis pathway. A natural compound library of 852,445 molecules was screened against a pharmacophore model developed from known LpxH inhibitors. Further, virtual screening, molecular docking, and MD simulation (100 ns) studies identified two lead compounds, 1615 and 1553. A comparative analysis of both molecules showed that compound 1615 exhibited the highest stability, with the lowest potential energy, minimal fluctuations, and stable hydrogen bonding, indicating strong binding at the active site. Compound 1553 also demonstrated good stability, though with slightly higher fluctuations. Both compounds underwent toxicity prediction and ADMET analysis, showing favorable drug-like properties, with compound 1615 emerging as the most promising inhibitor due to its optimal electronic energy and minimal chemical potential. The study concluded that compounds 1615 and 1553 hold significant potential as lead molecules for developing new treatments against drug-resistant <em>S.</em> Typhi infections. This study illustrates how computational techniques, such as MD simulations and pharmacophore modeling, can speed up drug discovery, especially in the fight against antibiotic resistance.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"10 ","pages":"Article 100824"},"PeriodicalIF":3.8,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adsorption of Mo and O at S-vacancy on ReS2 surface of ReS2/MoTe2 vdW heterointerface","authors":"Puneet Kumar Shaw ,&nbsp;Jehan Taraporewalla ,&nbsp;Sohaib Raza ,&nbsp;Akash Kumar ,&nbsp;Rimisha Duttagupta ,&nbsp;Hafizur Rahaman ,&nbsp;Dipankar Saha","doi":"10.1016/j.chphi.2025.100817","DOIUrl":"10.1016/j.chphi.2025.100817","url":null,"abstract":"<div><div>Applications like high density information storage, neuromorphic computing, nanophotonics, etc. require ultra-thin electronic devices which can be controlled with applied electric field. Of late, atomically thin two-dimensional (2D) materials based van der Waals (vdW) heterointerfaces have emerged as suitable candidates for ultra-low power nanoelectric devices. In this work, employing density functional theory (DFT), the monolayer ReS₂/monolayer MoTe₂ vdW heterostructure with Sulfur vacancy is studied to examine various ground state electronic properties. Here, we emphasize the changes in effective band gap owing to defect-induced states as well as modulation of the energy gap value with Molybdenum (Mo) and Oxygen (O) adsorption at the defect site. Nanoscaled devices based on atom-thin 2D layered materials, exhibit promising switching between non-conducting and conducting states. Therefore, determining the role of defect-induced states and the adsorption of atoms/molecules on surfaces is crucial. Moreover, a detailed theoretical study to determine surface properties and relative energetic stability of the vdW heterostructures is carried out. The charge re-distribution between the constituent layers is also analyzed by obtaining Electron Difference Density (EDD) for different heterointerfaces. Nonetheless, the efficacy of switching between non-conducting and conducting states is assessed based on the adsorption energy of adatoms binding at the defect site.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"10 ","pages":"Article 100817"},"PeriodicalIF":3.8,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microwave-assisted synthesis and swelling behavior of poly lactic acid (PLA) grafted Cordia dichotoma gum-based hydrogels","authors":"Jyoti Sinha ,&nbsp;Abubakar Hamisu Mijinyawa ,&nbsp;Faisal Islam Chowdhury ,&nbsp;Muhd Zu Azhan Yahya ,&nbsp;Pramod Kumar Singh ,&nbsp;Geeta Durga","doi":"10.1016/j.chphi.2025.100825","DOIUrl":"10.1016/j.chphi.2025.100825","url":null,"abstract":"<div><div>GBHs, or gum-based hydrogels, or superabsorbents, are derived from natural gums. In their unmodified form, these natural polysaccharides may be limited in their application due to physical matrix erosion caused by intensive swelling. Therefore, tailoring their structure to achieve desired swelling properties is crucial. In this study, a biodegradable gum (<em>CDG</em>) was extracted from <em>Cordia dichotoma</em> fruits using ethanol, and its corresponding grafted copolymer <em>aka CDG-g-PLA</em> was synthesized <strong>for the first time</strong> by graft copolymerization of poly (lactic acid) (PLA) onto the backbone of <em>CDG</em> by exposure to microwave irradiation. The synthesized <em>CDG-g-PLA</em> copolymer was characterized by FTIR, SEM, XRD, TGA, DSC, and DLS measurements <strong>to study its physico-chemical properties</strong>. The FTIR analysis proved the grafting of PLA at the –OH group on the backbone of <em>CDG</em> biopolymer which was supported by all other characterizations. The XRD patterns showed a broad peak at 2θ = 26.4 for <em>CDG-g-PLA</em> confirming its amorphous nature. DLS measurements exhibited that particles in the <em>CDG</em> and <em>CDG-g-PLA</em> copolymer formed a coarse suspension in water with particle sizes &gt; 1 µm. The negative value of zeta potential results confirmed the hydrogels to be anionic. The swelling of <em>CDG-g-PLA</em> in water was measured and found to be significantly lower than <em>CDG</em>, making them <strong>novel</strong> candidates for <strong>drug-delivery</strong> and <strong>sustainable</strong> food packaging applications.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"10 ","pages":"Article 100825"},"PeriodicalIF":3.8,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143179949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mn-doped ZnO thin films as a platform for reagentless uric acid biosensor","authors":"Bilasini Devi Naorem ,&nbsp;Jatinder Pal Singh ,&nbsp;Babita Sharma ,&nbsp;Satyam Garg ,&nbsp;Athira C ,&nbsp;Hashima Sherin ,&nbsp;Mahima Momaliya ,&nbsp;Muskan ,&nbsp;Shubhi Sahu ,&nbsp;Arijit Chowdhuri ,&nbsp;Mallika Verma ,&nbsp;Monika Tomar ,&nbsp;Neha Batra","doi":"10.1016/j.chphi.2025.100823","DOIUrl":"10.1016/j.chphi.2025.100823","url":null,"abstract":"<div><div>In this study, sol gel technique is used to fabricate manganese (Mn) doped ZnO thin films and further utilize them as a platform for uric acid biosensors. The objective was to introduce manganese into the ZnO matrix to enhance its redox properties, capitalizing on the multivalent nature of manganese. The Mn-doped thin films of concentrations varying from 3 %,5 %,7 % and 10 % were prepared and further characterized using UV–vis spectroscopy, X-ray diffraction (XRD) spectroscopy, Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM) and cyclic voltammetry (CV) measurements. The ZnO thin films with 7 % doping of Mn exhibited improved redox behaviour, as evident by the distinct redox peaks. In order to immobilise the uricase enzyme, the 7 % Mn doped composition was used, creating a highly sensitive and focused uric acid detection platform. The fabricated biosensor exhibits excellent performance in terms of sensitivity (40 µAmM^-1cm^-2), selectivity with &lt;5 % deviation found in presence of other known markers present in human sera, and shelf life &gt;12 weeks, enabling precise and sensitive uric acid detection. This study brings to light an alternate approach in developing point of care biosensors using transition metal doped ZnO thin films.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"10 ","pages":"Article 100823"},"PeriodicalIF":3.8,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}