Cell and Tissue Research最新文献_第7页

Comparative study on a unique architecture of the brook lamprey liver and that of the hagfish and banded houndshark liver. 关于溪灯鱼肝脏独特结构与哈吉鱼和带钩鱼肝脏结构的比较研究。

IF 3.2 3区生物学

Cell and Tissue Research Pub Date : 2024-11-01 Epub Date: 2024-10-01 DOI: 10.1007/s00441-024-03917-3

Noriaki Ota, Haruka Hirose, Yuji Yamazaki, Hideaki Kato, Kazuho Ikeo, Junri Sekiguchi, Sachie Matsubara, Hayato Kawakami, Nobuyoshi Shiojiri

{"title":"Comparative study on a unique architecture of the brook lamprey liver and that of the hagfish and banded houndshark liver.","authors":"Noriaki Ota, Haruka Hirose, Yuji Yamazaki, Hideaki Kato, Kazuho Ikeo, Junri Sekiguchi, Sachie Matsubara, Hayato Kawakami, Nobuyoshi Shiojiri","doi":"10.1007/s00441-024-03917-3","DOIUrl":"10.1007/s00441-024-03917-3","url":null,"abstract":"Although the liver of the lamprey, a group of cyclostomes that diverged the earliest among vertebrates, has abundant bile ducts in the larval stage, which degenerate during metamorphosis, there is no comparative study on its architecture with other early diverged vertebrates in terms of the morphological evolution of vertebrate livers. The present study was undertaken to compare the characteristics of the brook lamprey liver with those of the hagfish and banded houndshark, which have the portal triad type liver architecture, and to discuss its evolution. Although the liver of the brook lamprey had two-cell cords of hepatocytes lined by sinusoids in the ammocoetes larval stage, intrahepatic bile ducts around portal veins penetrated into the liver parenchyma with convolution and gradual reduction in diameter. They also faced dilated sinusoids. The epithelial cells had characteristic intercellular spaces. These characteristics were distinct from those of bile ducts in the hagfish and banded houndshark livers. Although the liver architectures of the hagfish and banded houndshark were similar, the latter penetrated the intrahepatic bile ducts more deeply along the portal veins than the former, in which intrahepatic bile ducts were restricted near the hilum. After metamorphosis, bile ducts degenerated in brook lampreys. These data indicate that the liver architecture of the ammocoetes larva is unique in the parenchymal distribution of bile ducts, their sinusoidal facing, and morphology among extant vertebrates. The periportal distribution of intrahepatic biliary structures may have been established prior to the divergence of the cyclostomes and gnathostomes.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":" ","pages":"93-110"},"PeriodicalIF":3.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The complex neurochemistry of the cockroach antennal heart. 蟑螂触角心脏的复杂神经化学。

IF 3.2 3区生物学

Cell and Tissue Research Pub Date : 2024-11-01 Epub Date: 2024-09-06 DOI: 10.1007/s00441-024-03915-5

Hans Agricola, Peter Bräunig

引用次数: 0

A historical perspective of Kupffer cells in the context of infection. 从历史角度看感染背景下的 Kupffer 细胞。

IF 3.2 3区生物学

Cell and Tissue Research Pub Date : 2024-10-11 DOI: 10.1007/s00441-024-03924-4

Carolyn T Graham, Siamon Gordon, Paul Kubes

引用次数: 0

Diabetes compromises tight junction protein claudin 14 in the urinary bladder. 糖尿病会损害膀胱中的紧密连接蛋白 Claudin 14。

IF 3.2 3区生物学

Cell and Tissue Research Pub Date : 2024-10-01 Epub Date: 2024-08-20 DOI: 10.1007/s00441-024-03908-4

Soumitra Mohanty, John Kerr White, Andrea Scheffschick, Berenice Fischer, Anuj Pathak, Jonas Tovi, Claes-Göran Östenson, Pontus Aspenström, Hanna Brauner, Annelie Brauner

{"title":"Diabetes compromises tight junction protein claudin 14 in the urinary bladder.","authors":"Soumitra Mohanty, John Kerr White, Andrea Scheffschick, Berenice Fischer, Anuj Pathak, Jonas Tovi, Claes-Göran Östenson, Pontus Aspenström, Hanna Brauner, Annelie Brauner","doi":"10.1007/s00441-024-03908-4","DOIUrl":"10.1007/s00441-024-03908-4","url":null,"abstract":"Infections are common in patients with diabetes. Moreover, increasing incidence of antibiotic resistance impedes the complete bacterial clearance and calls for alternative treatment strategies. Along with antibacterial resistance, compromised host conditions create a favorable condition for the disease progression. In particular, cell junction proteins are of major importance as they contribute to a tight cell barrier, protecting against invading pathogens. However, the impact of high glucose on cell junction proteins has received little attention in the urinary bladder but merits closer investigation. Here, we report that during diabetes the expression of cell junction protein, claudin 14 is compromised in the human urine exfoliated cells and in the urinary bladder of type 2 diabetic mouse. Further in vitro analysis confirmed a direct correlation of lower intracellular calcium levels with claudin 14 expression in high glucose-treated human uroepithelial cells. Moreover, external calcium supplementation in high glucose-treated cells significantly affected the cell migration and restored the claudin 14 expression through focal adhesion and β-1 integrins. Strengthening the epithelial barrier is essential, especially in individuals with diabetes where basal calcium levels could contribute.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":" ","pages":"27-33"},"PeriodicalIF":3.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Involvement of vimentin- and BLBP-positive glial cells and their MMP expression in axonal regeneration after spinal cord transection in goldfish. 波形蛋白和 BLBP 阳性神经胶质细胞及其 MMP 表达参与金鱼脊髓横断后的轴突再生

IF 3.2 3区生物学

Cell and Tissue Research Pub Date : 2024-10-01 Epub Date: 2024-08-09 DOI: 10.1007/s00441-024-03907-5

Akihito Takeda, Minami Teshima, Kengo Funakoshi

{"title":"Involvement of vimentin- and BLBP-positive glial cells and their MMP expression in axonal regeneration after spinal cord transection in goldfish.","authors":"Akihito Takeda, Minami Teshima, Kengo Funakoshi","doi":"10.1007/s00441-024-03907-5","DOIUrl":"10.1007/s00441-024-03907-5","url":null,"abstract":"In goldfish, spinal cord injury triggers the formation of a fibrous scar at the injury site. Regenerating axons are able to penetrate the scar tissue, resulting in the recovery of motor function. Previous findings suggested that regenerating axons enter the scar through tubular structures surrounded by glial elements with laminin-positive basement membranes and that glial processes expressing glial fibrillary acidic protein (GFAP) are associated with axonal regeneration. How glia contribute to promoting axonal regeneration, however, is unknown. Here, we revealed that glial processes expressing vimentin or brain lipid-binding protein (BLBP) also enter the fibrous scar after spinal cord injury in goldfish. Vimentin-positive glial processes were more numerous than GFAP- or BLBP-positive glial processes in the scar tissue. Regenerating axons in the scar tissue were more closely associated with vimentin-positive glial processes than GFAP-positive glial processes. Vimentin-positive glial processes co-expressed matrix metalloproteinase (MMP)-14. Our findings suggest that vimentin-positive glial processes closely associate with regenerating axons through tubular structures entering the scar after spinal cord injury in goldfish. In intact spinal cord, ependymo-radial glial cell bodies express BLBP and their radial processes express vimentin, suggesting that vimentin-positive glial processes derive from migrating ependymo-radial glial cells. MMP-14 expressed in vimentin-positive glial cells and their processes might provide a beneficial environment for axonal regeneration.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":" ","pages":"15-25"},"PeriodicalIF":3.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autophagy accompanying the developmental process of male germline stem cells. 自噬伴随着男性生殖干细胞的发育过程。

IF 3.2 3区生物学

Cell and Tissue Research Pub Date : 2024-10-01 Epub Date: 2024-08-14 DOI: 10.1007/s00441-024-03910-w

Zhuofei Jiang, Liji Chen, Tao Wang, Jie Zhao, Shuxian Liu, Yating He, Liyun Wang, Hongfu Wu

{"title":"Autophagy accompanying the developmental process of male germline stem cells.","authors":"Zhuofei Jiang, Liji Chen, Tao Wang, Jie Zhao, Shuxian Liu, Yating He, Liyun Wang, Hongfu Wu","doi":"10.1007/s00441-024-03910-w","DOIUrl":"10.1007/s00441-024-03910-w","url":null,"abstract":"Germline stem cells are a crucial type of stem cell that can stably pass on genetic information to the next generation, providing the necessary foundation for the reproduction and survival of organisms. Male mammalian germline stem cells are unique cell types that include primordial germ cells and spermatogonial stem cells. They can differentiate into germ cells, such as sperm and eggs, thereby facilitating offspring reproduction. In addition, they continuously generate stem cells through self-renewal mechanisms to support the normal function of the reproductive system. Autophagy involves the use of lysosomes to degrade proteins and organelles that are regulated by relevant genes. This process plays an important role in maintaining the homeostasis of germline stem cells and the synthesis, degradation, and recycling of germline stem cell products. Recently, the developmental regulatory mechanism of germline stem cells has been further elucidated, and autophagy has been shown to be involved in the regulation of self-renewal and differentiation of germline stem cells. In this review, we introduce autophagy accompanying the development of germline stem cells, focusing on the autophagy process accompanying the development of male spermatogonial stem cells and the roles of related genes and proteins. We also briefly outline the effects of autophagy dysfunction on germline stem cells and reproduction.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":" ","pages":"1-14"},"PeriodicalIF":3.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innexin expression and localization in the Drosophila antenna indicate gap junction or hemichannel involvement in antennal chemosensory sensilla. 果蝇触角中 Innexin 的表达和定位表明缝隙连接或半通道参与了触角化学感觉小体的活动。

IF 3.2 3区生物学

Cell and Tissue Research Pub Date : 2024-10-01 Epub Date: 2024-08-23 DOI: 10.1007/s00441-024-03909-3

Sinisa Prelic, Ian W Keesey, Sofia Lavista-Llanos, Bill S Hansson, Dieter Wicher

{"title":"Innexin expression and localization in the Drosophila antenna indicate gap junction or hemichannel involvement in antennal chemosensory sensilla.","authors":"Sinisa Prelic, Ian W Keesey, Sofia Lavista-Llanos, Bill S Hansson, Dieter Wicher","doi":"10.1007/s00441-024-03909-3","DOIUrl":"10.1007/s00441-024-03909-3","url":null,"abstract":"Odor detection in insects is largely mediated by structures on antennae called sensilla, which feature a strongly conserved architecture and repertoire of olfactory sensory neurons (OSNs) and various support cell types. In Drosophila, OSNs are tightly apposed to supporting cells, whose connection with neurons and functional roles in odor detection remain unclear. Coupling mechanisms between these neuronal and non-neuronal cell types have been suggested based on morphological observations, concomitant physiological activity during odor stimulation, and known interactions that occur in other chemosensory systems. For instance, it is not known whether cell-cell coupling via gap junctions between OSNs and neighboring cells exists, or whether hemichannels interconnect cellular and extracellular sensillum compartments. Here, we show that innexins, which form hemichannels and gap junctions in invertebrates, are abundantly expressed in adult drosophilid antennae. By surveying antennal transcriptomes and performing various immunohistochemical stainings in antennal tissues, we discover innexin-specific patterns of expression and localization, with a majority of innexins strongly localizing to glial and non-neuronal cells, likely support and epithelial cells. Finally, by injecting gap junction-permeable dye into a pre-identified sensillum, we observe no dye coupling between neuronal and non-neuronal cells. Together with evidence of non-neuronal innexin localization, we conclude that innexins likely do not conjoin neurons to support cells, but that junctions and hemichannels may instead couple support cells among each other or to their shared sensillum lymph to achieve synchronous activity. We discuss how coupling of sensillum microenvironments or compartments may potentially contribute to facilitate chemosensory functions of odor sensing and sensillum homeostasis.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":" ","pages":"35-62"},"PeriodicalIF":3.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A century of andrology in Cell & Tissue Research: looking back while moving forward 细胞与组织研究领域的一个世纪：回顾过去，展望未来

IF 3.6 3区生物学

Cell and Tissue Research Pub Date : 2024-09-18 DOI: 10.1007/s00441-024-03916-4

Andreas Meinhardt, Peter Sutovsky

{"title":"A century of andrology in Cell & Tissue Research: looking back while moving forward","authors":"Andreas Meinhardt, Peter Sutovsky","doi":"10.1007/s00441-024-03916-4","DOIUrl":"https://doi.org/10.1007/s00441-024-03916-4","url":null,"abstract":"This article commemorates the 100th anniversary of the first issue of Cell & Tissue Research (CTR), the longest-running active journal dedicated to cell biology. Reflecting the significant contributions of spermatology and embryology to the early days of cell biology, the majority of articles in CTR’s inaugural issue centered on plant and animal sperm cells. A brief synopsis of these articles provides a launching point for revisiting 100 years of research on the male germ cells and fertility in humans and animals and offers a perspective on the current state and future directions of the andrology field. Early technological advances in light and electron microscopy enabled descriptive studies that ushered in the era of mechanistic, biochemistry-based inquiry focused on the understanding of physiological sperm processes such as sperm capacitation, acrosomal exocytosis, and sperm-egg interactions. In the last 20 years, progress in flow cytometry, cell imaging, and omics revealed new information on sperm proteome, transcriptome, metabolome, and overall phenome of fertile and infertile spermatozoa. Going back to the journal’s roots, recent advances in male germ cell isolation, transplantation, modification, and cryopreservation have been discussed on the pages of CTR. Newest trends such as gene editing and artificial intelligence/machine learning are now making inroads into andrological inquiry and assisted reproductive therapy of male infertility.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":"17 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142247299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photoneuroendocrine, circadian and seasonal systems: from photoneuroendocrinology to circadian biology and medicine 光神经内分泌、昼夜节律和季节系统：从光神经内分泌学到昼夜节律生物学和医学

IF 3.6 3区生物学

Cell and Tissue Research Pub Date : 2024-09-12 DOI: 10.1007/s00441-024-03913-7

Horst-Werner Korf

{"title":"Photoneuroendocrine, circadian and seasonal systems: from photoneuroendocrinology to circadian biology and medicine","authors":"Horst-Werner Korf","doi":"10.1007/s00441-024-03913-7","DOIUrl":"https://doi.org/10.1007/s00441-024-03913-7","url":null,"abstract":"This contribution highlights the scientific development of two intertwined disciplines, photoneuroendocrinology and circadian biology. Photoneuroendocrinology has focused on nonvisual photoreceptors that translate light stimuli into neuroendocrine signals and serve rhythm entrainment. Nonvisual photoreceptors first described in the pineal complex and brain of nonmammalian species are luminance detectors. In the pineal, they control the formation of melatonin, the highly conserved hormone of darkness which is synthesized night by night. Pinealocytes endowed with both photoreceptive and neuroendocrine capacities function as “photoneuroendocrine cells.” In adult mammals, nonvisual photoreceptors controlling pineal melatonin biosynthesis and pupillary reflexes are absent from the pineal and brain and occur only in the inner layer of the retina. Encephalic photoreceptors regulate seasonal rhythms, such as the reproductive cycle. They are concentrated in circumventricular organs, the lateral septal organ and the paraventricular organ, and represent cerebrospinal fluid contacting neurons. Nonvisual photoreceptors employ different photopigments such as melanopsin, pinopsin, parapinopsin, neuropsin, and vertebrate ancient opsin. After identification of clock genes and molecular clockwork, circadian biology became cutting-edge research with a focus on rhythm generation. Molecular clockworks tick in every nucleated cell and, as shown in mammals, they drive the expression of more than 3000 genes and are of overall importance for regulation of cell proliferation and metabolism. The mammalian circadian system is hierarchically organized; the central rhythm generator is located in the suprachiasmatic nuclei which entrain peripheral circadian oscillators via multiple neuronal and neuroendocrine pathways. Disrupted molecular clockworks may cause various diseases, and investigations of this interplay will establish a new discipline: circadian medicine.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":"106 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142203196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential of animal-welfare compliant and sustainably sourced serum from pig slaughter blood. 从猪屠宰血液中提取符合动物福利标准且可持续的血清的潜力。

IF 3.2 3区生物学

Cell and Tissue Research Pub Date : 2024-09-01 Epub Date: 2024-07-11 DOI: 10.1007/s00441-024-03904-8

Olga Hahn, Kirsten Peters, Alexander Hartmann, Dirk Dannenberger, Claudia Kalbe

{"title":"Potential of animal-welfare compliant and sustainably sourced serum from pig slaughter blood.","authors":"Olga Hahn, Kirsten Peters, Alexander Hartmann, Dirk Dannenberger, Claudia Kalbe","doi":"10.1007/s00441-024-03904-8","DOIUrl":"10.1007/s00441-024-03904-8","url":null,"abstract":"The animal product most used as a stimulatory additive for cell cultivation is still fetal bovine serum (FBS). Besides the ethical concerns regarding serum collection, the main problems of FBS are batch-to-batch variability and the resulting risk of lower reproducibility, the differences between species, the presence of undefined/unknown components, and the risk of contamination. In contrast, pig blood, which is a by-product of slaughter, is a sufficiently available and sustainable resource with a high degree of standardization in terms of donor age, weight, and genetics. The variations in preparations from pig slaughter blood seem to be comparatively low, and consequently, batch effects might be much smaller, suggesting that the reproducibility of the research data obtained may be increased. Our pilot study aimed to investigate, as a proof of concept, whether adult human and porcine stem cells of different tissue origins proliferate and differentiate adequately when FBS is completely or partially replaced by porcine serum (PS). We could show that the human and porcine stem cells were vital and proliferated under partial and full PS supplementation. Furthermore, using PS, the two cell types studied showed tissue-specific differentiation (i.e., lipid vacuoles as a sign of adipogenic or myotubes as a sign of myogenic differentiation). In conclusion, the pig slaughter blood-derived serum has promising potential to be a replacement for FBS in adult stem cell cultures. Therefore, it could serve as a basis for the development of new cell culture supplements.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":" ","pages":"205-214"},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11371839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141578975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0