Central European Journal of Immunology最新文献_第6页

Photodynamic therapy augments oxaliplatin-induced immunogenic cell death in colorectal cancer. 光动力疗法增强奥沙利铂诱导的大肠癌癌症免疫原性细胞死亡。

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 Epub Date: 2023-09-29 DOI: 10.5114/ceji.2023.132053

Xiaobo Wang, Lei Ren, Linhan Ye, Jing Cao

{"title":"Photodynamic therapy augments oxaliplatin-induced immunogenic cell death in colorectal cancer.","authors":"Xiaobo Wang, Lei Ren, Linhan Ye, Jing Cao","doi":"10.5114/ceji.2023.132053","DOIUrl":"https://doi.org/10.5114/ceji.2023.132053","url":null,"abstract":"Colorectal cancer is one of the most frequently diagnosed cancers. Immunotherapy has been proven to be a potential treatment option for colorectal cancer. Colorectal cancer maintains immune escape by expressing low immunogenicity and following the tolerogenic cell death pathway. There is also emerging evidence that oxaliplatin and photodynamic therapy (PDT) can promote anti-tumor immunity. However, the effect of PDT combined with oxaliplatin on colorectal cancer remains elusive. Here, we analyzed the viability of HCT116 and DLD-1 cell lines after treatment with the combination of PDT and oxaliplatin. We found that the viability decreased significantly after the combination treatment. Meanwhile, we also detected that sinoporphyrin sodium (DVDMS)-derived PDT could amplify oxaliplatin-induced immunogenic cell death (ICD) in different colorectal cancer cell lines. More importantly, the combination of DVDMS-derived PDT and oxaliplatin presented strong immunogenic potential in immunocompetent BALB/c mice in the vaccination assay. Taken together, our data demonstrated that the combination of DVDMS-derived PDT and oxaliplatin is a potential novel therapy for colorectal cancer.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 3","pages":"189-202"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An unusual cause of rapidly progressive glomerulonephritis associated with ANCA vasculitis and ovarian malignancy - a relapse 39 years after initial treatment. 与ANCA血管炎和卵巢恶性肿瘤相关的快速进展性肾小球肾炎的不寻常原因-在初始治疗后39年复发。

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 DOI: 10.5114/ceji.2023.127744

Nikola Simovic, Petar Djuric, Jelena Stojsic, Nada Dimkovic, Radomir Naumovic

{"title":"An unusual cause of rapidly progressive glomerulonephritis associated with ANCA vasculitis and ovarian malignancy - a relapse 39 years after initial treatment.","authors":"Nikola Simovic, Petar Djuric, Jelena Stojsic, Nada Dimkovic, Radomir Naumovic","doi":"10.5114/ceji.2023.127744","DOIUrl":"https://doi.org/10.5114/ceji.2023.127744","url":null,"abstract":"A 69-year-old woman presented with severe anemia, proteinuria, microscopic hematuria and rapidly progressive renal failure. She was admitted to the nephrology department due to severe deterioration of renal function with complaints of malaise, fever, dry cough and occasional epistaxis that appeared 2 months prior to admission. Histopathologic examination of a specimen from kidney biopsy and immunologic findings revealed ANCA positive pauci-immune crescentic glomerulonephritis. The patient had a history of ovarian granulosa cell tumor and lung metastases that were treated surgically with postoperative radiotherapy and chemotherapy. Thoracic computed tomography showed tissue neoplasm in the right lung and ultrasound-guided percutaneous transthoracic biopsy confirmed granulosa cell tumor. That was a relapse, thirty-nine years after initial treatment of malignant disease and twenty-four years after surgical resection of metastases from both lungs. Although the association between malignancy and vasculitis has been well known for decades, this is the first described case of ANCA vasculitis associated with any type of gynecological malignancy and glomerulonephritis.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 2","pages":"163-166"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/75/25/CEJI-48-50761.PMC10485690.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10587672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Intraoral and maxillofacial abnormalities in patients with autosomal dominant hyper-IgE syndrome. 常染色体显性高IgE综合征患者口腔颌面部异常。

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 Epub Date: 2023-09-05 DOI: 10.5114/ceji.2023.130874

Ildikó Tar, Márta Szegedi, Ewa Krasuska-Sławińska, Edyta Heropolitańska-Pliszka, Ewa A Bernatowska, Elif Öncü, Sevgi Keles, Sukru N Guner, Ismail Reisli, Nevena Gesheva, Elissaveta Naumova, Lydie Izakovicova-Holla, Jiri Litzman, Igor Savchak, Larysa Kostyuchenko, Melinda Erdõs

{"title":"Intraoral and maxillofacial abnormalities in patients with autosomal dominant hyper-IgE syndrome.","authors":"Ildikó Tar, Márta Szegedi, Ewa Krasuska-Sławińska, Edyta Heropolitańska-Pliszka, Ewa A Bernatowska, Elif Öncü, Sevgi Keles, Sukru N Guner, Ismail Reisli, Nevena Gesheva, Elissaveta Naumova, Lydie Izakovicova-Holla, Jiri Litzman, Igor Savchak, Larysa Kostyuchenko, Melinda Erdõs","doi":"10.5114/ceji.2023.130874","DOIUrl":"10.5114/ceji.2023.130874","url":null,"abstract":"Autosomal dominant hyper-IgE syndrome (AD-HIES) is an inborn error of immunity (IEI) caused by a dominant-negative mutation in the signal transducer and activator of transcription 3 (STAT 3). This disease is characterized by chronic eczematoid dermatitis, recurrent staphylococcal skin abscesses, pneumonia, pneumatoceles, and extremely high serum IgE levels. Loss-of-function STAT3 mutations may also result in distinct non-immunologic features such as dental, facial, skeletal, and vascular abnormalities, central nervous system malformations and an increased risk for bone fractures. Prophylactic treatment of Candida infections and prophylactic antimicrobial therapy for staphylococcal skin infections and sinopulmonary infections are essential. An awareness of the oral and maxillofacial features of HIES may facilitate early diagnosis with genetic counselling and may improve future patient care. This study describes oral, dental, and maxillofacial manifestations in 14 patients with genetically defined AD-HIES. We also review the literature and propose recommendations for the complex care of patients with this rare primary immunodeficiency.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"1 1","pages":"228-236"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71071975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exposure duration of ambient fine particulate matter determines the polarization of macrophages. 环境细颗粒物的暴露时间决定了巨噬细胞的极化。

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 Epub Date: 2023-09-19 DOI: 10.5114/ceji.2023.130978

Xiangru Li, Hongyan Cai, Wei Wu, Shaoyan Si, Minli Zhu

{"title":"Exposure duration of ambient fine particulate matter determines the polarization of macrophages.","authors":"Xiangru Li, Hongyan Cai, Wei Wu, Shaoyan Si, Minli Zhu","doi":"10.5114/ceji.2023.130978","DOIUrl":"https://doi.org/10.5114/ceji.2023.130978","url":null,"abstract":"Ambient fine particulate matter (FPM) promotes airway inflammation and aggravates respiratory and cardiovascular diseases. Macrophage polarization plays an essential role in FPM-induced inflammation and tissue repair. The balance of pro-inflammatory M1-type and anti-inflammatory M2-type macrophages determines the fate of tissues and is involved in the pathogenesis of various FPM-induced diseases. The mechanism of macrophage polarization induced by FPM is still not fully understood. Here, we explored the effect of ambient FPM exposure duration on the polarization of peritoneal macrophages. Mice were exposed to concentrated ambient FPM for different duration. Markers of M1-type macrophage and M2-type macrophage in peritoneal macrophages were detected. We found that macrophage polarization was affected by FPM both in vitro and in vivo. Acute FPM stimulation in vitro and short-term concentrated ambient FPM exposure in vivo promoted the expression of NLRP3 and NOS2 and inhibited the expression of ARG1 and CD206. With the extension of concentrated ambient FPM exposure time, ARG1 was gradually up-regulated, and NLRP3 was gradually down-regulated. These results indicate that FPM exposure duration interferes with macrophage polarization. This may provide new insight into the treatment of patients exposed to FPM.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 3","pages":"219-227"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Presence of tubuloreticular inclusions in ultrastructural studies of renal biopsies in children with lupus nephropathy - one-center preliminary study. 在儿童狼疮肾病肾活检超微结构研究中存在小管网状包裹体-单中心初步研究。

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 DOI: 10.5114/ceji.2023.125237

Tomasz Koszutski, Łukasz Mielańczyk, Grażyna Kucharska, Natalia Matysiak, Agnieszka Wiernik, Grzegorz Kudela, Lidia Hyla-Klekot

{"title":"Presence of tubuloreticular inclusions in ultrastructural studies of renal biopsies in children with lupus nephropathy - one-center preliminary study.","authors":"Tomasz Koszutski, Łukasz Mielańczyk, Grażyna Kucharska, Natalia Matysiak, Agnieszka Wiernik, Grzegorz Kudela, Lidia Hyla-Klekot","doi":"10.5114/ceji.2023.125237","DOIUrl":"https://doi.org/10.5114/ceji.2023.125237","url":null,"abstract":"Introduction: Juvenile systemic lupus erythematosus (jSLE) is an autoimmune disease that develops as a result of multi-level immune dysregulation, including the interferon pathway. Nephropathy develops at an early stage and eventually affects 90% of patients. A renal biopsy allows one to classify lupus nephritis and determine the proper treatment. Biopsy assessment should be done not only in a light microscope but also in a transmission electron microscope (TEM). Its usage may reveal the presence of intracellular tubuloreticular inclusions (TRIs), considered as a morphological marker of interferon hyperactivity.Material and methods: Renal biopsies of 10 children with jSLE and nephropathy were analyzed in TEM. The location, structure, and size of TRIs were assessed. Demographic data, nephropathy manifestation, non-renal symptoms, and serological activity of lupus were analyzed.Results: All the patients were female with an average onset at 12.7 years of age and met SLE criteria. Nephropathy manifested with proteinuria (n = 10) and hematuria (n = 6). Glomerular filtration rate (GFR) was normal in all patients. In three children with early disease onset, it manifested with hematological disorders. TRIs were revealed in 7 biopsies, with the highest expression in the youngest children, with peripheral cytopenia, membranous glomerulonephritis, and lupus nephritis.Conclusions: Demonstration of TRIs in renal biopsies of children with juvenile systemic lupus may confirm the diagnosis of lupus nephritis and is a sign of involvement of the interferon pathway at the early stage of the disease.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 1","pages":"26-34"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/16/5c/CEJI-48-50170.PMC10189577.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9930542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic values of regulatory T cells (Tregs) and Treg-related genes in gastric cancer. 调节性T细胞(treg)及其相关基因在胃癌中的预后价值

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 DOI: 10.5114/ceji.2023.126773

Liang Zheng, Luping Lin, Jintian Song, Sha Huang, Lizhu Chen, Hui Li, Ning Ma, Qingyue Chen, Yigui Chen

{"title":"Prognostic values of regulatory T cells (Tregs) and Treg-related genes in gastric cancer.","authors":"Liang Zheng, Luping Lin, Jintian Song, Sha Huang, Lizhu Chen, Hui Li, Ning Ma, Qingyue Chen, Yigui Chen","doi":"10.5114/ceji.2023.126773","DOIUrl":"https://doi.org/10.5114/ceji.2023.126773","url":null,"abstract":"Introduction: This study attempted to investigate the potential of a risk model constructed for regulatory T cells (Tregs) and their related genes in predicting gastric cancer (GC) prognosis.Material and methods: We used flow cytometry to detect the content of CD4+CD25+ Tregs. After detecting expression of five Treg-related genes by quantitative real-time polymerase chain reaction (qRT-PCR), Pearson analysis was employed to analyze the correlation between Tregs and related gene expression. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), colony formation and transwell assays were used to detect the effects of a disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAMTS12) on cell functions. A prognostic risk model was built after Cox regression analysis. The Kaplan-Meier method was employed to assess how Tregs, 5-gene risk scores and expression of 5 genes were correlated with the survival time.Results: A significantly increased content of Tregs was found in GC tissues (p < 0.05). 5 Treg- related genes were significantly up-regulated in GC with a positive correlation with the content of Tregs (p < 0.05). Overexpression of ADAMTS12 significantly enhanced the viability, proliferation, migration and invasion of tumor cells. Kaplan-Meier analysis demonstrated poor overall survival and disease-free survival in the high-risk group. The results of survival analysis of Treg content and related gene expression were consistent with those of Cox analysis.Conclusions: The risk model constructed based on five Treg-related genes can enable effective prediction in the prognosis of GC patients.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 1","pages":"14-25"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d8/9a/CEJI-48-50567.PMC10189578.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9930539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The comparison of SARS-CoV-2 antibody levels in medical personnel induced by different types of vaccines compared to the natural infection. 不同类型疫苗诱导医务人员SARS-CoV-2抗体水平与自然感染的比较

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 DOI: 10.5114/ceji.2023.125239

Ljiljana Božić, Darija Knežević, Maja Travar, Nataša Miljuš, Miroslav Petković, Jela Aćimović, Jelena Djaković Dević, Miloš P Stojiljković, Dejan Bokonjić, Ranko Škrbić

{"title":"The comparison of SARS-CoV-2 antibody levels in medical personnel induced by different types of vaccines compared to the natural infection.","authors":"Ljiljana Božić, Darija Knežević, Maja Travar, Nataša Miljuš, Miroslav Petković, Jela Aćimović, Jelena Djaković Dević, Miloš P Stojiljković, Dejan Bokonjić, Ranko Škrbić","doi":"10.5114/ceji.2023.125239","DOIUrl":"https://doi.org/10.5114/ceji.2023.125239","url":null,"abstract":"Introduction: During the last two and a half years, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread around the world. Most of the SARS-CoV-2 vaccines are designed to produce anti-SARS-CoV-2 immunoglobulin G (IgG) against the viral S-glycoprotein. The aim of this study was to measure the anti-S antibody titres among the medical personnel who had been fully vaccinated with different types of vaccines, and to compare them with those who were COVID-19 convalescents.Material and methods: In this study serum was collected from 261 healthcare workers, of whom 227 were vaccinated, while 34 were recovered participants who were not immunised. Serum samples were collected 21 days after the first dose and 60 and 180 days after the second dose of the vaccines and tested with a commercial ELISA kit.Results: The highest antibody level (12 AU/ml) was measured in the Pfizer-BioNTech group, followed by Sinopharm (9.3 AU/ml), Sputnik V (5.9 AU/ml), Sinovac (4.6 AU/ml) and Oxford/Astra- Zeneca vaccine (2.5 AU/ml) 60 days after the second dose of the vaccines (90 days after the first dose). The seropositivity rate for mRNA vaccine was 88.5%, for vector vaccines 86.2% and for inactivated vaccines 71.4%. When comparing these antibody levels with COVID-19 convalescents, higher antibody titres were found in vaccinated participants (5.76 AU/ml vs 7.06 AU/ml), but the difference was not significant (p = 0.08).Conclusions: Individuals vaccinated with mRNA and vector vaccines had a higher seroconversion rate compared to the group vaccinated with inactivated vaccines, or convalescents.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 1","pages":"35-42"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0b/12/CEJI-48-50172.PMC10189579.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9930545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Efficacy evaluation of direct antiviral drugs against hepatitis B virus in improving the degree of liver fibrosis. 乙型肝炎病毒直接抗病毒药物在改善肝纤维化程度方面的疗效评估。

IF 1.5 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 Epub Date: 2023-06-01 DOI: 10.5114/ceji.2023.127621

Liang Miao, Lihua Cao, Guiqiang Wang

{"title":"Efficacy evaluation of direct antiviral drugs against hepatitis B virus in improving the degree of liver fibrosis.","authors":"Liang Miao, Lihua Cao, Guiqiang Wang","doi":"10.5114/ceji.2023.127621","DOIUrl":"10.5114/ceji.2023.127621","url":null,"abstract":"Introduction: The aim of the study was to find an ideal index reflecting inflammation and fibrosis for patients after antiviral treatment, and compare it with imaging examination (liver stiffness measurement - LSM) and traditional liver fibrosis models (APRI and FIB-4).Material and methods: A total of 77 chronic hepatitis B (CHB) patients who achieved a sustained virological response (SVR) after entecavir (ETV) treatment were included, and the changes of various clinical indicators before and after treatment were compared.Results: After 78 weeks of ETV treatment, WBC and PLT of 77 patients were significantly increased, while ALT, AST and total bilirubin were significantly decreased (p < 0.05). There was no significant difference in serum creatinine (Cr) or blood urea nitrogen (BUN) compared to the values before treatment (p > 0.05). The three non-invasive liver fibrosis indexes, namely, LSM, APRI and FIB-4, were significantly decreased in 77 patients compared to the values before treatment (p < 0.001).Conclusions: Acoustic radiation force impulse (ARFI), fibrosis-4 (FIB-4), aspartate aminotransferase-to-platelet ratio index (APRI) have a high consistency with the grading of liver fibrosis, and can be used to evaluate the severity of liver fibrosis. Among them, ARFI has good diagnostic value for the classification of different degrees of liver fibrosis and the best diagnostic accuracy.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 2","pages":"126-134"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/56/27/CEJI-48-50708.PMC10485686.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10569889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe complications of nivolumab monotherapy in an adolescent with malignant melanoma. nivolumab单药治疗青少年恶性黑色素瘤的严重并发症。

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 Epub Date: 2023-08-30 DOI: 10.5114/ceji.2023.130864

Aleksandra Grzegorczyk, Zuzanna Marczyńska, Rafał Matkowski, Marcin Ziętek, Wojciech Pietras, Elżbieta Latos-Grażyńska, Krzysztof Kałwak, Iwona Dachowska-Kałwak

{"title":"Severe complications of nivolumab monotherapy in an adolescent with malignant melanoma.","authors":"Aleksandra Grzegorczyk, Zuzanna Marczyńska, Rafał Matkowski, Marcin Ziętek, Wojciech Pietras, Elżbieta Latos-Grażyńska, Krzysztof Kałwak, Iwona Dachowska-Kałwak","doi":"10.5114/ceji.2023.130864","DOIUrl":"10.5114/ceji.2023.130864","url":null,"abstract":"This study presents a case of a 17-year-old female patient who had previously undergone surgical resection of melanoma in the right periscapular area. She was administered adjuvant treatment with the PD-1 inhibitor nivolumab as monotherapy. The mechanism of action of this drug is based on increased stimulation of the immune system. The patient developed a series of complications including capillary leak syndrome and hypothyroidism after the fifth cycle of therapy, as a result of dysregulation of immunity. Nivolumab treatment had to be discontinued and glucocorticosteroids were administered as a salvage therapy. After several months, two relapses developed in the subcutaneous tissue - first in the left and then in the right iliac region, confirmed as distant metastases of malignant melanoma, treated with resections of the lesions and intensity-modulated radiation therapy. Follow-up imaging studies and clinical examinations showed no metastases or pathologically enlarged lymph nodes.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"1 1","pages":"251-256"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71071960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic active Epstein-Barr virus infection as the basis of neoplasm development. Transformation of chronic lymphocytic leukaemia to NK-cell lymphoma/leukaemia was observed by flow cytometry - a diagnostic report. 慢性活动性EB病毒感染是肿瘤发展的基础。流式细胞术（一份诊断报告）观察了慢性淋巴细胞白血病向NK细胞淋巴瘤/白血病的转化。

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 Epub Date: 2023-09-04 DOI: 10.5114/ceji.2023.130865

Katarzyna Karwicka, Olga Jankowska-Łęcka, Marek Hus

{"title":"Chronic active Epstein-Barr virus infection as the basis of neoplasm development. Transformation of chronic lymphocytic leukaemia to NK-cell lymphoma/leukaemia was observed by flow cytometry - a diagnostic report.","authors":"Katarzyna Karwicka, Olga Jankowska-Łęcka, Marek Hus","doi":"10.5114/ceji.2023.130865","DOIUrl":"https://doi.org/10.5114/ceji.2023.130865","url":null,"abstract":"The case report presents a patient with chronic lymphocytic leukaemia that was diagnosed in 2006 in Rotterdam, the Netherlands. In September 2010, the patient was admitted to the Department of Haematology in Poland due to progression of the underlying disease. The clinical problem during treatment was the suspicion of Richter's transformation into another, more aggressive non-Hodgkin lymphoma. The diagnosis was based on the peripheral blood immunophenotype. The patient was diagnosed with an immunoglobulin deficiency. Unfortunately, repeated examinations did not confirm the transformation hypothesis, despite the increasing symptoms. The patient was treated with various therapeutic regimens until May 2021, when an increased number of NK cells was diagnosed in the peripheral blood. NK-cell lymphoproliferative disease was finally diagnosed de novo. Nevertheless, it was found that the patient had active Epstein-Barr virus (EBV) and Cytomegalovirus (CMV) infection. The suspected NK-cell lymphoma/leukaemia was most likely a complication of the active EBV infection and severe immunodeficiency state.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 3","pages":"257-266"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0