New T-lymphocyte subpopulations and their characteristics: Challenges to the classical division of lymphocyte function.

IF 1.5 4区 医学 Q4 IMMUNOLOGY
Central European Journal of Immunology Pub Date : 2024-01-01 Epub Date: 2024-11-09 DOI:10.5114/ceji.2024.144071
Filip Lewandowski, Paulina Niedźwiedzka-Rystwej
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引用次数: 0

Abstract

Recent advances in immunology have challenged the conventional division of T-lymphocyte function by uncovering novel subpopulations with diverse roles and characteristics. This article reviews these discoveries and their implications for understanding immune regulation and disease pathogenesis. Innovative techniques have enabled the identification of previously unrecognized T-lymphocyte subsets, disrupting the classical classification system. Helper lymphocytes, including Tfh1, Tfh2, Tfh17, GC-Tfh, and circulating Tfh cells, exhibit distinct functions in immune responses and disease states. Additionally, newly identified cytotoxic T-cell subsets, such as CD8+CD39+ and CD8+CD28+ cells, demonstrate unique effector properties with potential therapeutic applications in cancer immunothe- rapy. Furthermore, the discovery of CD20+ T cells challenges traditional views, offering new avenues for immunotherapy in cancer, autoimmune disorders, and infectious diseases. These findings expand our understanding of T-lymphocyte biology and suggest targets for more effective therapeutic interventions. Further research is essential to fully elucidate the clinical relevance and therapeutic potential of these T-lymphocyte subpopulations, paving the way for personalized and targeted immune-based treatments.

新的t淋巴细胞亚群及其特征:对传统淋巴细胞功能分裂的挑战。
免疫学的最新进展通过揭示具有不同作用和特征的新亚群,挑战了t淋巴细胞功能的传统分裂。本文综述了这些发现及其对理解免疫调节和疾病发病机制的意义。创新技术已经能够识别以前未被识别的t淋巴细胞亚群,破坏了经典的分类系统。辅助淋巴细胞,包括Tfh1、Tfh2、Tfh17、GC-Tfh和循环Tfh细胞,在免疫应答和疾病状态中表现出不同的功能。此外,新发现的细胞毒性t细胞亚群,如CD8+CD39+和CD8+CD28+细胞,显示出独特的效应特性,在癌症免疫治疗中具有潜在的治疗应用。此外,CD20+ T细胞的发现挑战了传统观点,为癌症、自身免疫性疾病和传染病的免疫治疗提供了新的途径。这些发现扩大了我们对t淋巴细胞生物学的理解,并为更有效的治疗干预提供了靶点。进一步的研究是必要的,以充分阐明这些t淋巴细胞亚群的临床相关性和治疗潜力,为个性化和靶向免疫治疗铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.00
自引率
0.00%
发文量
17
审稿时长
6-12 weeks
期刊介绍: Central European Journal of Immunology is a English-language quarterly aimed mainly at immunologists.
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