Central European Journal of Immunology最新文献_第5页

Abnormal expression of CXCL13, MIF and IL-35 in patients with primary Sjögren's syndrome and its relationship with disease severity. 原发性Sjögren综合征患者CXCL13、MIF和IL-35的异常表达及其与病情严重程度的关系

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 DOI: 10.5114/ceji.2023.127536

Ronghua Wang, Yushu Yang, Xuying Liu, Lingyan Lei, Xuan Qi

{"title":"Abnormal expression of CXCL13, MIF and IL-35 in patients with primary Sjögren's syndrome and its relationship with disease severity.","authors":"Ronghua Wang, Yushu Yang, Xuying Liu, Lingyan Lei, Xuan Qi","doi":"10.5114/ceji.2023.127536","DOIUrl":"https://doi.org/10.5114/ceji.2023.127536","url":null,"abstract":"Introduction: The aim of the study was to detect the saliva chemokine (C-X-C motif) ligand 13 (CXCL13), macrophage migration inhibitory factor (MIF), and interleukin 35 (IL-35) levels in patients with primary Sjögren's syndrome (pSS) and pSS-associated interstitial lung disease (pSS-ILD), and to explore the relationship between CXCL13, MIF, IL-35 levels, and disease severity.Material and methods: ESSDAI score was used to evaluate the disease activity of pSS patients, and the levels of CXCL13, MIF and IL-35 in saliva of subjects were detected and analyzed, and the relationship between CXCL13, MIF, IL-35 and the occurrence of pSS was evaluated. Pearson's correlation coefficient was used to analyze the correlation between CXCL13, MIF, IL-35 and ESSDAI score. ROC curve analysis was conducted to assess the diagnostic value of CXCL13, MIF, IL-35 and their combined application in pSS.Results: The levels of CXCL13, MIF, and IL-35 in saliva were positively correlated with ESSDAI score. Saliva CXCL13 and IL-35 are risk factors for the development of pSS into pSS-ILD. The ROC curve shows that the combination of saliva CXCL13, MIF and IL-35 has the highest diagnostic efficiency for pSS-ILD.Conclusions: CXCL13, MIF and IL-35 are related to the activity of pSS, and the combined diagnosis of these three indexes is expected to be an important method to predict the occurrence and development of pSS.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 2","pages":"144-149"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/41/06/CEJI-48-50697.PMC10485687.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10587668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A biomarker and molecular mechanism investigation for thyroid cancer. 甲状腺癌症的生物标志物和分子机制研究。

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 Epub Date: 2023-09-29 DOI: 10.5114/ceji.2023.132163

Keju Xie

{"title":"A biomarker and molecular mechanism investigation for thyroid cancer.","authors":"Keju Xie","doi":"10.5114/ceji.2023.132163","DOIUrl":"https://doi.org/10.5114/ceji.2023.132163","url":null,"abstract":"Introduction: This study aimed to reveal the potential molecular mechanism associated with thyroid cancer (THCA) prognosis, and investigate promising biomarkers for THCA.Material and methods: Differentially expressed genes (DEGs) were compared between THCA samples (THCA group) and normal samples (N group). Then, enrichment analysis and protein-protein interaction (PPI) network analysis were performed, followed by prognostic hub gene exploration from the PPI network. Furthermore, the prognostic and mutation analysis was performed on these hub genes. Finally, the associations of the hub gene with immune cells were investigated.Results: A total of 802 DEGs were obtained between the THCA group and the N group. These DEGs were mainly enriched in pathways such as lysine degradation. From the PPI network, 20 hub genes, including CD44, CCND1, SNAI1, and KIT, were investigated. The survival analysis showed that the up-regulation of CD44 and down-regulation of SNAI1 contributed to the favorable and unfavorable outcomes of patients with THCA, respectively. Meanwhile, the diagnostic analysis showed that the AUC of KIT in THCA was larger than 0.9. Furthermore, the gene mutation analysis showed that the alternated CCND1 participated in the cell cycle pathway. Finally, the correlation analysis showed that prognostic genes such as CD44 were positively correlated with immune cells such as M1 macrophages.Conclusions: A total of 20 hub genes including CCND1, CD44, SNAI1, and KIT were revealed as potential biomarkers for the differential diagnosis, prognosis, and development of drug targets of THCA. The lysine degradation pathway and cell cycle pathway might take part in the progression of THCA.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 3","pages":"203-218"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anticitrullinated antibodies recognize rheumatoid arthritis associated T-cell epitopes modified by bacterial L-asparaginase. 抗瓜氨酸抗体识别细菌L-天冬酰胺酶修饰的类风湿性关节炎相关T细胞表位。

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 Epub Date: 2023-09-21 DOI: 10.5114/ceji.2023.131455

Tsvetelina Batsalova, Ivanka Teneva, Krum Bardarov, Dzhemal Moten, Balik Dzhambazov

{"title":"Anticitrullinated antibodies recognize rheumatoid arthritis associated T-cell epitopes modified by bacterial L-asparaginase.","authors":"Tsvetelina Batsalova, Ivanka Teneva, Krum Bardarov, Dzhemal Moten, Balik Dzhambazov","doi":"10.5114/ceji.2023.131455","DOIUrl":"https://doi.org/10.5114/ceji.2023.131455","url":null,"abstract":"Citrullinated proteins and anti-citrullinated protein antibodies (ACPAs) play an important role in the pathogenesis of rheumatoid arthritis (RA). It has been suggested that during inflammation or dysbiosis, bacteria could initiate production of ACPAs. Most patients with RA are seropositive for ACPAs, but these antibodies have overlapping reactivity to different posttranslational modifications (PTMs). For initiation and development of RA, T lymphocytes and T cell epitopes are still required. In this study, we evaluated the ability of bacterial L-asparaginase to modify RA-related T cell epitopes within type II collagen (CII259-273 and CII311-325), as well as whether these modified epitopes are recognized by ACPAs from RA patients. We included 12 patients with early RA and 11 healthy subjects selected according to predefined specific criteria. LC-MS/MS analyses revealed that the bacterial L-asparaginase can modify investigated T cell epitopes. ELISA tests showed cross-reactivity of ACPA positive sera from early RA patients towards the enzymatically modified immunodominant T cell epitopes within type II collagen (CII), but not to the modified irrelevant peptides. These data suggest that the cross-reactive ACPAs recognize the \"carbonyl-Gly-Pro\" motif in CII. Moreover, the T cell recognition of the modified major immunodominant T cell epitope Gal264-CII259-273 was not affected. This epitope was still able to activate autoreactive T cells from early RA patients. It is likely that such modifications are the missing link between the T cell priming and the development of anti-modified protein antibodies (AMPAs). Our results provide additional information on the etiology and pathogenesis of RA.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 3","pages":"174-188"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel inflammatory markers in patients with severe COVID-19 and a pulmonary thrombotic event. 严重新冠肺炎和肺血栓事件患者的新炎症标志物。

IF 1.5 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 Epub Date: 2023-09-21 DOI: 10.5114/ceji.2023.131382

Jarosław Bakiera, Karolina Strzelec-Pawełczak, Katarzyna Czarnek, Ida Osuchowska-Grochowska, Jacek Bogucki, Agnieszka Markiewicz-Gospodarek, Aleksandra Górska, Zuzanna Chilimoniuk, Sebastian Radej, Mateusz Szymański, Piero Portincasa, Cezary Grochowski

{"title":"Novel inflammatory markers in patients with severe COVID-19 and a pulmonary thrombotic event.","authors":"Jarosław Bakiera, Karolina Strzelec-Pawełczak, Katarzyna Czarnek, Ida Osuchowska-Grochowska, Jacek Bogucki, Agnieszka Markiewicz-Gospodarek, Aleksandra Górska, Zuzanna Chilimoniuk, Sebastian Radej, Mateusz Szymański, Piero Portincasa, Cezary Grochowski","doi":"10.5114/ceji.2023.131382","DOIUrl":"10.5114/ceji.2023.131382","url":null,"abstract":"Venous thromboembolism (VTE), clinically manifested as deep vein thrombosis (DVT) or acute pulmonary embolism (PE), is the third most common acute cardiovascular syndrome following myocardial infarction and stroke. The annual incidence of PE is between 39 and 115 per 100,000 inhabitants. The incidence of VTE is almost eight times higher in people aged 80 and older than in the fifth decade of life. We performed a retrospective study of 226 COVID-19 patients and selected group of patients who experienced a pulmonary thrombotic event. The incidence of PE in hospitalized COVID-19 patients was approximately 1.9-8.9%. The retrospective nature of the analyzed cohorts and relatively short observation periods could have led to underestimation of the actual incidence of PE. This study underlines the role of novel inflammatory biomarkers such as neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with a pulmonary thrombotic event in COVID-19. We suggest that these biomarkers may have high assessment value and complement routinely used biomarkers.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 3","pages":"167-173"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value and immunological role of PTPN21 in pan-cancer analysis. PTPN21在泛癌分析中的预后价值及免疫学作用。

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 DOI: 10.5114/ceji.2023.129970

YanE Yang, WenChao Yang, Xingxing Su, CaiXia Cheng

{"title":"Prognostic value and immunological role of PTPN21 in pan-cancer analysis.","authors":"YanE Yang, WenChao Yang, Xingxing Su, CaiXia Cheng","doi":"10.5114/ceji.2023.129970","DOIUrl":"https://doi.org/10.5114/ceji.2023.129970","url":null,"abstract":"Introduction: At present, cancer remains a persistent public health challenge facing the whole world. Studies have found that PTPN21 is associated with the development of cancer. However, the prognostic potential of PTPN21 in pan-cancer remains unclear. In this work, we aimed to analyze the expression and prognostic value of PTPN21 in pan-cancer and to further study the relationship between PTPN21 and immune infiltration.Material and methods: TCGA and GEO data were used for expression and survival analysis. Genetic alterations in PTPN21 from TCGA cancer were studied in cBioPortal. TIMER2 was used to evaluate the correlation between PTPN21 expression and immune infiltration. The R packages \"ggplot2\" and \"clusterProfiler\" were used for GO and KEGG analysis.Results: PTPN21 was found to be a valuable diagnostic biomarker in multiple cancers, including bladder urothelial carcinoma (BLCA), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), and lung squamous cell carcinoma (LUSC). In addition, we observed that PTPN21 expression was associated with a variety of tumor mutations. Our results indicated a correlation between PTPN21 expression and immune infiltration. Enrichment analysis showed that PTPN21 was mainly involved in the regulation of neuroactive ligand-receptor interaction.Conclusions: Our study showed that PTPN21 expression is associated with clinical prognosis, mutation, and immune infiltration of tumors. PTPN21 may be a potential biomarker for many cancers, especially in KIRC.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 2","pages":"111-125"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/53/d0/CEJI-48-51128.PMC10485688.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10569893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HMBOX1, a member of the homeobox family: current research progress. homeobox家族成员HMBOX1:研究进展。

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 DOI: 10.5114/ceji.2023.126615

Yu Jiang, Hongli Mu, Hengli Zhao

{"title":"HMBOX1, a member of the homeobox family: current research progress.","authors":"Yu Jiang, Hongli Mu, Hengli Zhao","doi":"10.5114/ceji.2023.126615","DOIUrl":"https://doi.org/10.5114/ceji.2023.126615","url":null,"abstract":"Homeobox containing 1 (HMBOX1) is a transcription factor that was identified in 2006 from a cDNA library of the human pancreas. It belongs to the HNF gene class of the homeobox family. HMBOX1 is widely expressed in normal human tissues; however, its expression level is rather uneven. Homeobox members have been widely reported to participate in embryonic development and differentiation as well as in pathological and physiological processes. Although research on the role of HMBOX1 is still in its infancy, many reports have revealed its regulatory role in cell differentiation, immune regulation, inflammation, and tumor progression. HMBOX1 plays an important role in promoting the differentiation of bone marrow stromal stem cells (BMSCs) into endothelial cells and contributes to their physiological functions. As an immunoregulatory factor, HMBOX1 can significantly inhibit the inflammatory response in hepatocytes and NK cells and impede the infiltration of peripheral immune cells to the liver. In tumor development, HMBOX1 exerts diametrically opposite biological functions, inhibiting or promoting the process. HMBOX1 possesses complex and diverse biological functions. In this review, we provide a brief overview of the research on HMBOX1.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 1","pages":"63-69"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8c/9b/CEJI-48-50543.PMC10189581.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9758302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The immunology of corneal limbal stem cells: the up-to-date approach to stem cell transplantation. 角膜缘干细胞免疫学：干细胞移植的最新方法。

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 Epub Date: 2023-09-29 DOI: 10.5114/ceji.2023.132033

Katarzyna Samelska, Magdalena Kupis, Katarzyna Szymanek, Justyna Izdebska, Anna Zaleska-Żmijewska, Piotr Skopiński

{"title":"The immunology of corneal limbal stem cells: the up-to-date approach to stem cell transplantation.","authors":"Katarzyna Samelska, Magdalena Kupis, Katarzyna Szymanek, Justyna Izdebska, Anna Zaleska-Żmijewska, Piotr Skopiński","doi":"10.5114/ceji.2023.132033","DOIUrl":"https://doi.org/10.5114/ceji.2023.132033","url":null,"abstract":"Limbal epithelial stem cells (LSC, LESC) are multipotent cells used as regenerative treatment of the cornea in patients with limbal epithelial stem cell deficiency (LSCD, LESCD). There are different types of stem cell grafting including cultivated limbal epithelial transplantation (CET) and simple limbal epithelial transplantation (SLET). The outcomes of the techniques have been assessed as similar, with differences in the sample size required during the procedures. The most important culture components for stem cell cultivation include 3T3 murine fibroblasts, human amniotic membrane (HAM), fibrin gel, and culture medium. The culture medium may be enriched with serum or not; however, xenobiotic-free materials are preferred because of the low risk of pathogen transmission. Multiple studies have defined molecules important for maintaining the function of LSC including C/EBP δ, Bmi-1, p63 α, interleukins (IL-6), epithelial structural proteins - keratins, and antibodies against epidermal growth factor receptor (EGFR). The cell phenotype of LSC has been described with factors of transplantation success rate such as a high percentage of p63 positive cells. The article emphasizes the role of recipient tissue preparation, modern cultivation techniques and pathophysiological processes in LSC transplantation effectiveness.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 3","pages":"245-250"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The persistence of SARS-CoV-2 neutralizing antibodies after COVID-19: A one-year observation. Is a SARS-CoV-2 vaccination booster dose necessary? COVID-19后SARS-CoV-2中和抗体的持久性:一年观察是否有必要接种SARS-CoV-2强化疫苗?

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 DOI: 10.5114/ceji.2023.126206

Adam Tworek, Krzysztof Jaroń, Małgorzata Cicha, Andrzej Rydzewski, Waldemar Wierzba, Artur Zaczyński, Zbigniew Król, Grażyna Rydzewska

{"title":"The persistence of SARS-CoV-2 neutralizing antibodies after COVID-19: A one-year observation. Is a SARS-CoV-2 vaccination booster dose necessary?","authors":"Adam Tworek, Krzysztof Jaroń, Małgorzata Cicha, Andrzej Rydzewski, Waldemar Wierzba, Artur Zaczyński, Zbigniew Król, Grażyna Rydzewska","doi":"10.5114/ceji.2023.126206","DOIUrl":"https://doi.org/10.5114/ceji.2023.126206","url":null,"abstract":"Introduction: The aim of this study was to investigate the persistence of SARS-CoV-2 neutralizing antibodies (NAbs) one year after contracting COVID-19.Material and methods: The study included 38 patients - 34 men and 4 women - suffering from COVID-19 between March 15 and May 26, 2020. The median age in the group was 31 years, ranging from 22 to 67 years. The levels of neutralizing antibodies were measured at three time-points - baseline, 6 months, and 12 months. The primary endpoint was a post-infection positive result for NAbs (> 15 AU/ml; Liaison SARS-CoV-2 S1/S2 IgG quantitative test) 12 months after infection.Results: The median level of NAbs after 12 months was 26.5 AU/ml. At the end of observation (12 months), 21 of the 38 patients had a NAb level of >15 AU/ml (positive). The median antibody half-life was 5.8 months.Conclusions: A high percentage of the patients maintained positive levels of antibodies 6 and 12 months after COVID-19 infection. The dynamics of the antibody level decline suggests the need for booster vaccination at least once a year.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 2","pages":"92-96"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/16/7d/CEJI-48-50430.PMC10485689.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10587674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunological mechanisms of arterial damage in pediatric patients with primary hypertension. 原发性高血压患儿动脉损伤的免疫学机制。

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 DOI: 10.5114/ceji.2023.127542

Adam Bujanowicz, Piotr Skrzypczyk

{"title":"Immunological mechanisms of arterial damage in pediatric patients with primary hypertension.","authors":"Adam Bujanowicz, Piotr Skrzypczyk","doi":"10.5114/ceji.2023.127542","DOIUrl":"https://doi.org/10.5114/ceji.2023.127542","url":null,"abstract":"Primary hypertension is a disease that is being diagnosed with increasing frequency in pediatric patients, and many of them are found to have hypertension-mediated organ damage (HMOD), including arterial damage. The pathophysiology of primary hypertension and the formation of HMOD is multifactorial. One mechanism studied in recent years is the subclinical inflammation accompanying the elevation of blood pressure. Experimental studies, studies in adults and children, revealed the involvement of immune mechanisms in the formation of vascular lesions in the course of primary hypertension. The paper summarizes the current knowledge on this subject and points to possible therapeutic targets. Particular emphasis is placed on data from pediatric patients with primary hypertension, as a relation between arterial damage (early vascular aging) and immune system activation had already been found in children. The correct identification of immunological mechanisms may not only broaden our understanding of primary hypertension as a disease but also, more importantly, lead to the most effective methods of its treatment.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 2","pages":"150-157"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/09/49/CEJI-48-50699.PMC10485694.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10587665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Downregulation of HMGB1 in thymoma cells affects T cell differentiation. 胸腺瘤细胞中HMGB1的下调影响T细胞的分化。

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 Epub Date: 2023-09-29 DOI: 10.5114/ceji.2023.132198

Jian Li, Zeyang Zhang, Yuan Chen, Yuanguo Wang, Yuxin Liu, Peng Zhang

{"title":"Downregulation of HMGB1 in thymoma cells affects T cell differentiation.","authors":"Jian Li, Zeyang Zhang, Yuan Chen, Yuanguo Wang, Yuxin Liu, Peng Zhang","doi":"10.5114/ceji.2023.132198","DOIUrl":"https://doi.org/10.5114/ceji.2023.132198","url":null,"abstract":"Introduction: Thymoma is the most common anterior mediastinal tumor and is closely associated with myasthenia gravis (MG). Our previous study showed that the expression of Th17 cells increased and the expression of Treg decreased in MG-associated thymoma tissues and peripheral blood. High mobility group box 1 (HMGB1) is an inflammatory mediator and participates in the pathogenesis of various autoimmune diseases. However, its function in thymoma is still unclear. Material and methods: We first analyzed immune indices in peripheral blood of patients with MG-associated thymoma and patients with thymoma alone. Next, we explored the expression of HMGB1 in MG-associated thymoma and thymoma alone tissues. Furthermore, we transfected si-HMGB1 in thymoma cell line Thy0517 and co-cultured Thy0517 with peripheral blood mononuclear cells (PBMC).Results: In this study, the levels of IgG, C3, C4, CRP and globulins in peripheral blood of patients with MG-associated thymoma were different from those of patients with thymoma alone (p < 0.05). The expression of HMGB1 in MG-associated thymoma tissues was higher than thymoma alone. Co-culture of Thy0517 and PBMC showed that the percentage of Th17 cells in PBMC was lower than that in the control group, and the percentage of Treg cells was higher than that in the control group.Conclusions: These findings demonstrate that HMGB1 is involved in the mechanism of abnormal Th17/Treg cell differentiation in thymoma and affects the occurrence of immune abnormalities in MG-associated thymoma.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 3","pages":"237-244"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0