Cellular Oncology最新文献

{"title":"Precision oncology in gastric cancer: navigating molecular subtypes, therapeutic targets, and future horizons.","authors":"Yanyun Hong, Xiaodong Wang, Hang Yu, Xiaosun Liu, Chao Tang","doi":"10.1007/s13402-026-01218-1","DOIUrl":"https://doi.org/10.1007/s13402-026-01218-1","url":null,"abstract":"<p><p>Gastric cancer (GC) remains a leading cause of cancer-related mortality globally and is characterized by significant inter- and intra-tumoral heterogeneity, which poses major challenges to effective treatment. Although traditional \"one-size-fits-all\" chemotherapy regimens have improved outcomes, the prognosis for advanced disease remains poor, necessitating a paradigm shift towards personalized medicine. This review provides a comprehensive synthesis of the current landscape of precision oncology in GC. We systematically analyze the clinical implications of major molecular classification systems, particularly The Cancer Genome Atlas (TCGA) subtypes (EBV-positive, MSI-H, GS, and CIN), and their role in guiding therapeutic stratification. The integration of molecular profiling has revolutionized the management of GC. We discuss the evolution of targeted therapies, ranging from established standards, like HER2 inhibition, to emerging targets, including Claudin18.2 and FGFR2, highlighting their potential of overcoming resistance mechanisms. Furthermore, we evaluate the efficacy of immune checkpoint inhibitors (PD-1/PD-L1 blockade), specifically in the context of high microsatellite instability (MSI-H) and EBV-positive subtypes, where these have demonstrated robust antitumor activity. Beyond tissue-based markers, this article also explores the expanding role of liquid biopsies, including circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA), as non-invasive tools for real-time monitoring of disease progression and therapeutic response. Precision oncology represents a transformative approach in GC, moving beyond histology to a molecularly driven treatment framework. However, realizing its full potential requires addressing challenges related to tumor heterogeneity and drug resistance. Future research must focus on validating novel biomarkers and developing synergistic combination strategies to further improve patient survival.</p>","PeriodicalId":9690,"journal":{"name":"Cellular Oncology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative analysis and functional validation identified palmitoylated PHGDH as a therapeutic target for colon adenocarcinoma.","authors":"Yixian Song, Lingling Lin, Dejian Liu, Mengqing Zhu, Pei Wang, Ke Li, Aimin Li, Kequan Chen, Zhanhui Ye","doi":"10.1007/s13402-026-01207-4","DOIUrl":"10.1007/s13402-026-01207-4","url":null,"abstract":"","PeriodicalId":9690,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13079263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BCAA catabolism mediates POU2AF1 propionylation to enhance T-ALL development.","authors":"Sijia Dan, Yilu Xu, Li Xie, Xiaoxiao He, Haotian Liu, Lu Zhao, Liyuan Cao, Bo Qu, Yan Lu, Chiqi Chen, Zhuo Yu, Jiangbo Wan, Pu Chen, Junke Zheng","doi":"10.1007/s13402-026-01201-w","DOIUrl":"10.1007/s13402-026-01201-w","url":null,"abstract":"","PeriodicalId":9690,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial taxa associated with lung cancer cases in Southeast Asians: a pilot case-control study.","authors":"Adrian Low, Yah Ru Juang, Fransiskus X Ivan, Lina Ang, Luke Hao Shuan Ooi, Sean Wei Jun Chan, Micheal Mac Aogain, Tavleen Kaur Jaggi, Sanjay H Chotirmall, Yann Felix Boucher, Anthony Chau Ang Yii, Mariko Siyue Koh, Darren Wan Teck Lim, Jonathan Wei Jie Lee, Wei Jie Seow","doi":"10.1007/s13402-026-01193-7","DOIUrl":"10.1007/s13402-026-01193-7","url":null,"abstract":"","PeriodicalId":9690,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13069060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A habitat radiomics model based on contrast-enhanced MRI for predicting early treatment response to hepatic arterial infusion chemotherapy in patients with unresectable hepatocellular carcinoma.","authors":"Guanhui Li, Xuefei Zhao, Jie Long, Yi Li, Zhexuan Ye, Lili Rao, Yuqin He, Shujie Lai, Yuxin Tang, Hao Zhong, Chao Li, Jie Li, Changxu Cai, Hao Wu, Xiang Lan, Nan You, Jun Wang, Liangzhi Wen","doi":"10.1007/s13402-026-01196-4","DOIUrl":"10.1007/s13402-026-01196-4","url":null,"abstract":"","PeriodicalId":9690,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting sialic acid metabolism: a therapeutic strategy against gastric cancer driven by WZ35.","authors":"Boxiang Hong, Ying Wang, Xinran Feng, Lihan Wei, Yichen Huang, Xiawei Zhang, Longyuchen Xu, Pinyan Jin, Liyuan Huang, Rui Li, Xinyu Wu, Zhi Li, Hangyu Ye, Tongke Chen, Xiaoyan Wang, Hao Zhang","doi":"10.1007/s13402-026-01194-6","DOIUrl":"10.1007/s13402-026-01194-6","url":null,"abstract":"","PeriodicalId":9690,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CX3CL1-CX3CR1 signaling orchestrates malignant progression of prostate cancer through luminal progenitor-macrophage crosstalk.","authors":"Yu Jiang, Yuchen Guo, Lizhuang Han, Shiwei Wang, Fang Wang, Yongliang Zhao, Jiajia Wang, Junyan Han, Miaomiao Liu, Zhihua Liu, Qin Zhang","doi":"10.1007/s13402-026-01179-5","DOIUrl":"10.1007/s13402-026-01179-5","url":null,"abstract":"<p><strong>Purpose: </strong>Progression to castration-resistant prostate cancer (CRPC) is shaped by dynamic interactions within the tumor microenvironment (TME). However, the specific cellular crosstalk driving therapeutic resistance and metastasis remains incompletely defined. This study aims to identify key signaling axes between therapy-resistant luminal progenitor (luminal-2) cells and immune components in the TME, particularly tumor-associated macrophages (TAMs), and to determine how these interactions promote immunosuppression and cancer stem-like cell expansion during disease progression.</p><p><strong>Methods: </strong>We employed an integrative phenomics approach combining single-cell transcriptomics with genetically engineered mouse models (GEMMs) and orthotopic allograft models of prostate cancer. Spatiotemporal changes in cell populations were profiled across disease stages. The functional contribution of the CX3CL1-CX3CR1 axis was evaluated through genetic ablation of Cx3cr1 in host mice, followed by assessment of TAM infiltration, luminal progenitor cell dynamics, tumor growth, and immunosuppression signature score.</p><p><strong>Results: </strong>Single-cell profiling revealed a distinct luminal-2 progenitor population with high CX3CL1 expression that recruits CX3CR1⁺ TAMs and supports a pro-tumoral program. These CX3CL1^hi luminal-2 cells and CX3CR1^hi TAMs expand in a stage-specific manner and co-evolve during CRPC progression, forming an immunosuppressive and pro-metastatic niche. Host Cx3cr1 deletion disrupted this signaling axis, leading to reduced TAM infiltration, suppression of luminal progenitor cells expansion, and significant inhibition of tumor growth and progression.</p><p><strong>Conclusion: </strong>The CX3CL1-CX3CR1 axis functions as a critical mediator of reciprocal signaling between luminal-2 progenitors and TAMs that promotes immune evasion, stemness maintenance, and therapeutic resistance in prostate cancer. Disrupting this pathway impairs the pro-tumoral niche and may represent a promising therapeutic approach for advanced prostate cancer.</p>","PeriodicalId":9690,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting senescence-like tumor-associated macrophages sensitizes chemotherapy in triple-negative breast cancer.","authors":"Hongxu Zhou, Chengzhao Xu, Jiabeini Zhang, Yangxuzhu Liu, Xiaochuan Gao, Ziqi He, Yuheng Wu, Qian Zhao, Baoling Liang, Dong Song","doi":"10.1007/s13402-026-01197-3","DOIUrl":"10.1007/s13402-026-01197-3","url":null,"abstract":"","PeriodicalId":9690,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CircBARD1 suppresses tumor progression driven by H3K18 lactylation-CCNA2 axis in human bladder cancer.","authors":"Zhenghui Hu, Nan Jiang, Bo Xie, Jiatong Zhou, Juntao Lin, Xianwu Chen, Xuejian Zhou, Yan Zhang, Mengjing Fan, Ning He, Xiaodong Jin, Feifan Wang","doi":"10.1007/s13402-026-01180-y","DOIUrl":"10.1007/s13402-026-01180-y","url":null,"abstract":"","PeriodicalId":9690,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13003086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NUAK1 silencing enhances radiotherapy-induced ferroptosis in locally advanced rectal cancer by impairing Nrf2-driven transcription of GPX4.","authors":"Zhicheng Zhuang, Bingjie Guan, Ye Wang, Xinru Lin, Huajun Cai, Bin Chen, Shoufeng Li, Xing Liu, Jinfu Zhuang, Guoxian Guan","doi":"10.1007/s13402-026-01187-5","DOIUrl":"10.1007/s13402-026-01187-5","url":null,"abstract":"","PeriodicalId":9690,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13000069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147479644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}