Cellular Oncology最新文献

{"title":"B3GNT3 facilitates NFKB2 processing and non-canonical NF-κB activation to drive lung adenocarcinoma progression.","authors":"Ying Lin, Yao Zhang, Bo Yu, Jialei Wang, Zheng Wu, Huijie Wang","doi":"10.1007/s13402-026-01192-8","DOIUrl":"10.1007/s13402-026-01192-8","url":null,"abstract":"","PeriodicalId":9690,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12992861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147467178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct clinical and genomic profiles of braf mutation subtypes in Chinese colorectal cancer: a retrospective cohort study with cross-population validation.","authors":"Wentao Yang, Yi Duan, Xiao Huang, Wang Song, Jingyi Qian, Yiwei Zeng, TianAn Guo, Yunyu Wu, Hong Li, Xuan Zou, Ye Xu","doi":"10.1007/s13402-026-01185-7","DOIUrl":"10.1007/s13402-026-01185-7","url":null,"abstract":"","PeriodicalId":9690,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12992859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147467110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell transcriptomic mapping of patient-derived primary liver cancer organoids reveals molecular subtypes and guides precision drug targeting.","authors":"Shipeng Dai, Jian Wu, Yue Chai, Zhouxiao Li, Yuchen Xie, Hongyu Wang, Ziyuan Liu, Yanshu He, Hengsong Cao, Weiwei Tang, Jintao Xu, Zongkang Zhang, Yongxiang Xia, Xuehao Wang, Li Liu, Xinyi Xia, Yun Gao","doi":"10.1007/s13402-026-01190-w","DOIUrl":"10.1007/s13402-026-01190-w","url":null,"abstract":"","PeriodicalId":9690,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12992744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147467097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NR2F2/AGAP2 axis: regulating lipid synthesis to drive AML progression via AMPKα/ACC pathway.","authors":"Qi Xin, Henan Zhang, Zheng Zhao, Gang Xu, Jihong Zhang","doi":"10.1007/s13402-026-01184-8","DOIUrl":"10.1007/s13402-026-01184-8","url":null,"abstract":"","PeriodicalId":9690,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12992729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147467123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatocellular carcinoma and vitamin D metabolism: novel targets and therapeutic strategies.","authors":"Hanlin Gao, Li He, Zhi Chen, Gang Wang","doi":"10.1007/s13402-026-01183-9","DOIUrl":"10.1007/s13402-026-01183-9","url":null,"abstract":"","PeriodicalId":9690,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12979787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies to target PD-1/PD-L1 in the tumor microenvironment.","authors":"Yulan Kui, Fan Tong, Ruiguang Zhang, Xiaorong Dong, Jian Wang","doi":"10.1007/s13402-026-01181-x","DOIUrl":"10.1007/s13402-026-01181-x","url":null,"abstract":"","PeriodicalId":9690,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12963217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147353674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disconnect between in vitro and in vivo efficacy of the MPS1 inhibitor NTRC 0066-0 against glioblastoma.","authors":"Mark C de Gooijer, Daria M Fedorushkova, Ping Zhang, Levi C M Buil, Ceren H Çitirikkaya, Hilal Çolakoğlu, Ana Rita R Maia, Irena Bočkaj, Margarita Espitia-Ballestas, Laura E Kuil, Jos H Beijnen, Olaf van Tellingen","doi":"10.1007/s13402-026-01175-9","DOIUrl":"10.1007/s13402-026-01175-9","url":null,"abstract":"","PeriodicalId":9690,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":"46"},"PeriodicalIF":4.8,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12909347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146200221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippo signalling pathway mediates oncogenic properties of NAB2::STAT6 in solitary fibrous tumour.","authors":"Carmen Salguero-Aranda, Laura Lobo-Selma, Amparo Beltrán-Povea, Sergio Baute-González, Paula Gilabert-Prieto, Carmen Jordán-Perez, José Alberto Fernández-Juárez, Ana Teresa Amaral, René Rodríguez, Juan Díaz-Martín, Enrique de Álava","doi":"10.1007/s13402-026-01173-x","DOIUrl":"10.1007/s13402-026-01173-x","url":null,"abstract":"","PeriodicalId":9690,"journal":{"name":"Cellular Oncology","volume":"49 1","pages":"43"},"PeriodicalIF":4.8,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12891060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ENY2 transcription and export complex 2 subunit deficiency induces nucleolar stress to inhibit tumor progression through NPM1/MDM2/p53-dependent and -independent responses.","authors":"Shiqi Zuo, Siyuan He, Zhiqin Zhu, Yanjie Hou, Ziqing Wu, Yao Tang, Yujiao Zou","doi":"10.1007/s13402-025-01148-4","DOIUrl":"10.1007/s13402-025-01148-4","url":null,"abstract":"<p><strong>Purpose: </strong>The selective induction of nucleolar stress in cancer cells has become a potential anticancer therapy. However, precisely regulating the key molecules involved in nucleolar stress remains a challenging topic in current research. ENY2 transcription and export complex 2 subunit (ENY2) is a transcription-associated nuclear protein that is upregulated in several cancers. However, its specific function and mechanistic role in oncogenesis remain poorly characterized and require further exploration.</p><p><strong>Methods: </strong>ENY2 was identified by screening ChIP-seq and public databases. Its role in tumor development was confirmed through in vivo and in vitro experiments. RNA sequencing, polysome profiling, agarose gel electrophoresis, and immunofluorescence suggested ENY2's involvement in ribosome biogenesis. Interacting proteins were identified by confocal microscopy, co-IP, and molecular docking, then validated by western blotting and ubiquitination assays. Finally, drug resistance experiments evaluated ENY2's clinical potential.</p><p><strong>Results: </strong>We discovered that the overexpression of ENY2 significantly enhances tumor growth and cell cycle progression both in vitro and in vivo. Conversely, depletion of ENY2 facilitating the release of NPM1 into the nucleoplasm, thereby impeding ribosomal subunit export and inducing nucleolar stress. Additionally, the released NPM1 interacts with MDM2 within the nucleus to stabilize p53 protein levels, consequently inhibiting tumor growth. Notably, knockdown of ENY2 in p53-mutant cancer cell lines exhibits an augmented binding affinity and silencing efficacy of RISC towards target mRNA molecules, ultimately suppressing tumor proliferation through a p53-independent manner.</p><p><strong>Conclusions: </strong>This study elucidated a previously unrecognized role of ENY2 in tumor growth, clarified the NPM1/MDM2/ p53-dependent mechanism of ENY2-mediated tumor cell growth suppression. We also provided a novel p53-independent RISC-IL11 nucleolar stress response pathway, which may provide a new target for the treatment of breast cancer.</p>","PeriodicalId":9690,"journal":{"name":"Cellular Oncology","volume":"49 1","pages":"41"},"PeriodicalIF":4.8,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12876109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding SR protein regulation: kinases, phosphatases, and therapeutic targeting strategies.","authors":"Nasi Liu, Fleur van der Ende, Bob van de Water, Sylvia E Le Dévédec","doi":"10.1007/s13402-026-01168-8","DOIUrl":"10.1007/s13402-026-01168-8","url":null,"abstract":"","PeriodicalId":9690,"journal":{"name":"Cellular Oncology","volume":"49 1","pages":"40"},"PeriodicalIF":4.8,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12872631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}