Cancers最新文献

{"title":"Outcomes of Robotic Pancreatectomy in the Octogenarian: A Multicenter Retrospective Cohort Study.","authors":"Kosei Takagi, Yuichiro Uchida, Tomokazu Fuji, Takeshi Takahara, Kazuya Yasui, Takeyoshi Nishiyama, Ichiro Uyama, Koichi Suda, Toshiyoshi Fujiwara","doi":"10.3390/cancers17183038","DOIUrl":"10.3390/cancers17183038","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Due to the increasing incidence of pancreatic and periampullary cancers with advancing age, coupled with the growing evidence supporting minimally invasive pancreatectomy, the demand for such procedures is rising. However, data on the feasibility of robotic pancreatectomy in octogenarian patients remain scant. This study aimed to investigate overall outcomes of robotic pancreatectomy and evaluate its safety and feasibility in octogenarian patients. <b>Methods</b>: A multicenter, retrospective study was conducted, including 380 patients who underwent robotic pancreatectomy at two high-volume centers in Japan from April 2020 to December 2024. Using prospectively collected data, we compared outcomes between younger patients (<80 years) and octogenarian patients (≥80 years). Multivariable logistic regression analyses were performed to assess the impact of age on postoperative outcomes. <b>Results</b>: Among the 380 patients, with a median age of 72 (interquartile range: 61-77) years, 213 underwent robotic pancreatoduodenectomy (RPD), and 167 underwent robotic distal pancreatectomy (RDP). Octogenarian patients were found to have more comorbidities and a higher incidence of malignant diseases. Octogenarians experienced significantly longer hospital stays post-RPD (22 [octogenarian; n = 36] vs. 14 [younger; n = 177] days, <i>p</i> < 0.001) and post-RDP (14 [n = 23] vs. 10.5 [n = 144] days, <i>p</i> = 0.02), yet their perioperative outcomes were comparable. Multivariable analyses indicated that age (≥80 years) was not a significant risk factor for major complications following robotic pancreatectomy (odds ratio, 1.33; 95% confidence interval, 0.59-2.84; <i>p</i> = 0.479). <b>Conclusions</b>: This multicenter study conducted at high-volume centers suggests that robotic pancreatectomy can be safely performed in carefully selected octogenarian patients.</p>","PeriodicalId":9681,"journal":{"name":"Cancers","volume":"17 18","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Use of Integrin Signaling in Melanoma Cells: Physical Link with the Extracellular Matrix (ECM).","authors":"Katarzyna Adamiak-Nikolouzou, Andrzej T Słomiński, Zofia Skalska, Iwona Inkielewicz-Stępniak","doi":"10.3390/cancers17183037","DOIUrl":"10.3390/cancers17183037","url":null,"abstract":"<p><p>Extracellular matrix (ECM) macromolecules play a vital role in the regulation of cellular phenotype. Ongoing interactions of the extracellular matrix and cells via surface receptors can affect the cellular behavior selectively or non-selectively. Under physiological conditions, the ECM-cell interactions are essential for ensuring balance, whereas the dysregulation of these interactions can lead to the onset of diseases. Extensive knowledge of the integrins with two non-covalently linked α and β subunits plays a vital role in cell-cell adhesion and ECM interactions. The identification of a key adhesion signaling pathway may lead to new therapeutic strategies targeting melanoma cells. This review highlights the potential role of integrins as a selective target in melanoma therapy, which would reduce side effects and increase the effects of the treatment.</p>","PeriodicalId":9681,"journal":{"name":"Cancers","volume":"17 18","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Centralized Surgical Care Improves Survival in Non-Functional Well-Differentiated Pancreatic Neuroendocrine Tumors.","authors":"Ahmed Alnajar, Amber Collier, Mehmet Akcin, John I Lew, Tanaz M Vaghaiwalla","doi":"10.3390/cancers17183030","DOIUrl":"10.3390/cancers17183030","url":null,"abstract":"<p><p><b>Background:</b> Non-functional well-differentiated pancreatic neuroendocrine tumors (WD-PanNETs) are complex, heterogeneous malignancies with variable prognosis. Despite guideline recommendations, disparities in access to specialized care may impact survival. This study examines whether treatment facility type, geographic travel distance, and treatment modalities are associated with survival outcomes in patients diagnosed with WD-PanNETs. <b>Results:</b> Among 20,174 patients with WD-PanNETs, the median age was 62 years (IQR: 52-70), and 54% were men. The majority were treated at non-academic hospitals (76%), with 2.9% traveling >250 miles for care. Patients treated at non-academic hospitals (24%) had 50% lower 15-year survival rates compared to those treated at academic hospitals (58%) and integrated hospitals (56%) (<i>p</i> < 0.001). Patients traveling >250 miles had a 72% 15-year survival rate, compared to 43% for those traveling <12.5 miles (<i>p</i> < 0.001). In the context of facility-type and geographic distance, treatment at non-academic hospitals <250 miles was associated with a 21% higher mortality risk (HR 1.21, 95% CI 1.12-1.31, <i>p</i> < 0.001), and treatment at low-volume hospitals increased mortality risk by 25% (HR 1.25, 95% CI 1.14-1.37, <i>p</i> < 0.001). In contrast, primary tumor resection was associated with a 64% reduction in mortality risk (HR 0.36, 95% CI 0.33-0.38, <i>p</i> < 0.001), which remained significant at all disease stages. <b>Conclusion:</b> Treatment at academic or high-volume centers and longer travel distances were associated with improved OS in patients with WD-PanNETs. Primary tumor resection remains critical, while systemic therapies were primarily used in later-stage disease. These findings support policies that improve access to centralized, multidisciplinary care.</p>","PeriodicalId":9681,"journal":{"name":"Cancers","volume":"17 18","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CAR-T Cell Therapies in B-Cell Acute Lymphoblastic Leukemia: Emerging Data and Open Issues.","authors":"Caterina Alati, Martina Pitea, Matteo Molica, Luca Scalise, Gaetana Porto, Erica Bilardi, Giuseppe Lazzaro, Maria Caterina Micò, Marta Pugliese, Filippo Antonio Canale, Barbara Loteta, Virginia Naso, Giorgia Policastro, Giovanna Utano, Andrea Rizzuto, Violetta Marafioti, Marco Rossi, Massimo Martino","doi":"10.3390/cancers17183027","DOIUrl":"10.3390/cancers17183027","url":null,"abstract":"<p><p>CAR-T therapy has transformed the treatment of relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL), particularly in pediatric and young adult patients. Many studies report one-year overall survival rates of between 60% and 80% following therapy. Event-free survival rates at one year are around 50-70%, with 40-50% of patients in remission after two years. Despite these impressive results, disease relapse remains a problem. Future CAR-T cell platforms should target multiple antigens, and the optimal design of such constructs must be determined. Modern trials should explore the role of CAR-T cell therapy as a consolidation treatment for patients with high-risk ALL, including those with persistent minimal residual disease at the end of induction/consolidation therapy, an IKZF1-positive gene expression profile, or a TP53 mutation or Ph-like gene expression profile. Improving the efficiency of gene-editing methods could lead to higher success rates in creating CAR-T cells, as well as reducing manufacturing time and costs. Producing universal CAR-T cells from healthy donors could significantly reduce production time and costs. These issues underscore the dynamic and evolving nature of B-ALL research. Ongoing studies and clinical trials are addressing many of these challenges in order to improve outcomes for B-ALL patients and expand the applications of CAR-T cell therapy.</p>","PeriodicalId":9681,"journal":{"name":"Cancers","volume":"17 18","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Psychological Burden in Individuals with Hereditary Risk of Pancreatic Cancer Under Surveillance: Evaluation of Distress 3 Years After Enrollment.","authors":"Veronica Marinelli, Maria Angela Mazzi, Olga Maggioni, Elisa Venturini, Michela Rimondini, Michele Milella, Salvatore Paiella, Roberto Salvia","doi":"10.3390/cancers17183014","DOIUrl":"10.3390/cancers17183014","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Background:&lt;/b&gt; Pancreatic cancer (PC) remains one of the deadliest malignancies, with long-term survival often reliant on early detection through surgery and chemotherapy. Unfortunately, the late-stage presentation of the disease contributes to its poor prognosis, leading to an increased focus on surveillance for high-risk individuals (HRIs) to facilitate earlier diagnosis. Despite the growing implementation of such programmes globally, there is a lack of longitudinal studies examining the benefits of PC surveillance, particularly regarding the well-being of participants. The study aimed to evaluate the distress experienced by HRIs 3-years after engaging in PC screening at Verona Pancreas Institute and to describe which participant characteristics contributed to the increase in stress. &lt;b&gt;Methods:&lt;/b&gt; This is a longitudinal follow-up (FU) of a previously published cohort. HRIs with heredo-familial predisposition undergoing PC surveillance with MRCP and a clinical visit were re-evaluated from 2019 to 2023 in the same psychological assessment using Perceived Stress Scale (PSS), General Self-Efficacy Scale (GSES), Coping Orientation to Problems Experienced (COPE) and The Scale of Perceived Social Support (MSPSS) 3 years after the baseline assessment. The FU assessments were conducted by a clinical psychologist via telephone after the radiological and clinical evaluations were made. &lt;b&gt;Results:&lt;/b&gt; Of the 54 HRIs initially evaluated, ten did not respond to phone contacts. The remaining 44 HRIs, of whom 29 (65.9%) were female, with a mean age of 56.1 years (SD = 10.2), agreed to participate in a FU psychological assessment. After 3 years, the participant exhibited an increase in stress levels (PSS-T0 mean 14.8; T1 mean 16.9), a decrease in problem-solving abilities (GSES-from 32.02 to 28.09, &lt;i&gt;p&lt;/i&gt; &lt; 0.01), a deterioration in adaptive capacity to the situation (COPE total score from 64.0 to 61.39, &lt;i&gt;p&lt;/i&gt; = 0.05), and a reduction in perceived social support (MSPSS-T0: 4.59; T1: 4.27, &lt;i&gt;p&lt;/i&gt; = 0.02). A significant decrease was also observed in the use of denial (from 2.84 to 2.32; &lt;i&gt;p&lt;/i&gt; = 0.02). Based on the psychological characteristics of the 44 HRIs, stratified according to PSS reassessed at FU, 3 distinct clusters were identified: (a) Normal Stress (32% of the sample): HRIs with a PSS score &lt; 14; (b) Stable Clinical Stress (46% of the sample): HRIs with PSS at FU &gt; 14 and PSS at baseline &gt; 14; (c) New Clinical Stress (22% of the sample): HRIs with PSS at FU &gt; 14 and PSS at baseline &lt; 14. After 3 years of surveillance for PC, 67% of the total study sample (Stable Clinical Stress group and New Clinical Stress group) exhibited high perceived stress. Over the course of the 3 years, 7 HRIs (15.9%) lost a family member due to PC. &lt;b&gt;Conclusions:&lt;/b&gt; The data suggest the need to include psychological care pathways within the surveillance programmes. These insights can enhance existing literature and aid in creating comprehensive surveill","PeriodicalId":9681,"journal":{"name":"Cancers","volume":"17 18","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12469056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally Invasive Distal Pancreatectomy as the Standard of Care in the US: Are We There Yet?","authors":"Laleh Foroutani, Andrew Gonzalez, Jaeyun Jane Wang, Bahaa I Aburayya, Amir Ashraf Ganjouei, Jean Feng, Lucas Willian Thornblade, Kenzo Hirose, Ajay V Maker, Eric Nakakura, Carlos Uriel Corvera, Adnan Alseidi, Mohamed A Adam","doi":"10.3390/cancers17183015","DOIUrl":"10.3390/cancers17183015","url":null,"abstract":"<p><strong>Introduction: </strong>While there is an increasing shift towards minimally invasive distal pancreatectomy (MIDP), little is known about how utilization of MIDP vs. open distal pancreatectomy (ODP) has evolved over time. We aimed to determine competing temporal trends in use and outcomes of MIDP (laparoscopic and robotic) over time and to determine if a threshold of effectiveness has been reached.</p><p><strong>Methods: </strong>Adults undergoing MIDP and ODP were identified from the National Cancer Database (2010-2021) and the National Surgical Quality Improvement Program database (2014-2022). Propensity score matching (PSM) was performed to address baseline differences between groups before comparing outcomes. Joinpoint regression analysis (JRA) was employed to assess adjusted trends in adoption and outcomes. We calculated Annual Percentage Change (APC) and Average Annual Percentage Change (AAPC) to quantify yearly adoption rates and their trends, respectively.</p><p><strong>Results: </strong>Among 21,966 patients in the NCDB cohort, 49.5% underwent MIDP, including 33.7% laparoscopic distal pancreatectomy (LDP) and 15.8% robotic distal pancreatectomy (RDP), while 50.5% underwent ODP. ODP declined from 74.1% of cases (2010) to 41.1% (2021), with an AAPC of -4.9%. MIDP increased significantly throughout the study from 25.9% of cases (2010) to 58.9% (2021), with an AAPC of 6.3%. Among MIDP subgroups, there was an initial increase in LDP until 2016, after which its rate of utilization stagnated with an AAPC of 0.7% (<i>p</i> > 0.05). In contrast, RDP demonstrated steady growth with an AAPC of about 15% (<i>p</i> < 0.05). A consistent and significant decline in clinically relevant postoperative pancreatic fistula rates occurred across all surgical approaches, with the most pronounced improvement observed in the robotic approach. MIDP approaches had significantly shorter hospital stays and lower mortality rates; however, RDP cases were associated with longer operative times compared to LDP and ODP.</p><p><strong>Conclusions: </strong>Over the past decade, the use of MIDP increased while ODP decreased. This increase was initially driven by greater use of LDP, which plateaued after 2016, and was further driven by the increased use of the robotic approach. Specifically, RDP demonstrated consistent growth, while LDP showed a decline around 2016. These findings highlight changing practice patterns, accompanied by improvements across all surgical approaches. This may provide insights for clinical training and resource allocation.</p>","PeriodicalId":9681,"journal":{"name":"Cancers","volume":"17 18","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Shoushtari et al. A Phase Ib Study of Sotrastaurin, a PKC Inhibitor, and Alpelisib, a PI3Kα Inhibitor, in Patients with Metastatic Uveal Melanoma. <i>Cancers</i> 2021, <i>13</i>, 5504.","authors":"Alexander N Shoushtari, Shaheer Khan, Kimberly Komatsubara, Lynn Feun, Nicolas Acquavella, Shahnaz Singh-Kandah, Tiffany Negri, Alexandra Nesson, Kelly Abbate, Serge Cremers, Elgilda Musi, Grazia Ambrosini, Shing Lee, Gary K Schwartz, Richard D Carvajal","doi":"10.3390/cancers17183018","DOIUrl":"10.3390/cancers17183018","url":null,"abstract":"<p><p><b>Figure</b> [...].</p>","PeriodicalId":9681,"journal":{"name":"Cancers","volume":"17 18","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of Ex Vivo Confocal Microscopy for Surgical Margin Assessment of High-Risk Nodular Basal Cell Carcinoma.","authors":"William Stramke, Luca Tonellotto, Emmanuella Guenova, François Kuonen","doi":"10.3390/cancers17183019","DOIUrl":"10.3390/cancers17183019","url":null,"abstract":"<p><p><b>Background:</b> Accurate margin assessment during surgical treatment is essential to prevent recurrences of BCC. Mohs surgery or alternative peripheral and deep en-face margin assessment (PDEMA) based on conventional histopathology are considered the gold standard for excising high-risk BCC, as it allows stepwise and complete examination of peripheral and deep margins. However, it is labor-intensive and time-consuming. EVCM has emerged as a promising alternative, allowing rapid intraoperative evaluation of fresh excised tissue. <b>Objective:</b> To assess the diagnostic accuracy of EVCM in a PDEMA workflow of high-risk nodular BCCs. <b>Methods:</b> A retrospective monocentric study was conducted at the Lausanne University Hospital (CHUV) between March 2024 and May 2025. A total of 51 patients with histologically confirmed nodular BCCs considered as high-risk and thus addressed for EVCM-assisted excision were included, yielding 171 surgical margin samples. EVCM and conventional histology-based PDEMA analyses were compared. <b>Results:</b> EVCM achieved an overall sensitivity of 93.8% (95% CI: 71.7-98.9%) and specificity of 98.7% (95% CI: 95.2-99.7%) compared to conventional histology. The positive and negative predictive values were 88.2% (95% CI: 63.6-97.4%) and 99.4% (95% CI: 96.4-99.9%), respectively. <b>Conclusion:</b> EVCM demonstrates high diagnostic accuracy for the intraoperative PDEMA of high-risk, nodular BCC. Its integration in PDEMA surgical workflows may improve efficiency, although confirmatory studies are needed in broader clinical settings.</p>","PeriodicalId":9681,"journal":{"name":"Cancers","volume":"17 18","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poor Oral Health and Risk of Respiratory Tract Cancer: A Prospective Cohort Study from the UK Biobank.","authors":"Danting Yang, Hyung-Suk Yoon, Tara Hashemian, Young-Rock Hong, Shama D Karanth, Sai Zhang, Heba El-Ahmad, Shannon M Wallet, Qiuyin Cai, Xiao-Ou Shu, Ji-Hyun Lee, Jae Jeong Yang","doi":"10.3390/cancers17183028","DOIUrl":"10.3390/cancers17183028","url":null,"abstract":"<p><strong>Background/objectives: </strong>The individual and combined effects of diverse dental problems on site-specific respiratory tract cancer remain insufficiently addressed. This study investigated the associations between six oral conditions-dentures, loose teeth, painful gums, bleeding gums, toothache, and mouth ulcers-and the risk of developing cancers of the lung, bronchus, larynx, and trachea, both individually and collectively.</p><p><strong>Methods: </strong>This prospective cohort study, utilizing baseline data from the UK Biobank, analyzed 438,762 participants aged 40-69 years. Multivariable Cox proportional hazards models were employed to estimate hazard ratios (HRs) and 95% CIs for incident respiratory tract cancer associated with individual oral conditions and their cumulative impact. Effect modification by sociodemographics, lifestyle, and underlying medical conditions was further assessed.</p><p><strong>Results: </strong>During the follow-up (median = 11.0 years), 3568 participants developed respiratory tract cancer. After adjusting for confounders, including smoking history, individuals with any oral issues exhibited a 35-76% higher risk of respiratory tract cancer (HR [95% CI]: 1.35 [1.25-1.46] for the total risk, 1.34 [1.24-1.45] for bronchus/lung cancer, and 1.76 [1.23-2.52] for laryngeal cancer). Dentures (1.48 [1.36-1.60]), loose teeth (1.36 [1.20-1.54]), and painful gums (1.25 [1.04-1.50]) had a strong association with respiratory tract cancer. The overall risk escalated progressively with the number of concurrent problems (HR [95% CI] of 1.32 [1.22-1.43] for one, 1.42 [1.25-1.62] for two, 1.57 [1.23-1.98] for three, and 1.71 [1.16-2.50] for ≥four). Associations were pronounced among smokers (<i>p</i>-interaction = 0.002).</p><p><strong>Conclusions: </strong>Poor oral health is linked to a heightened risk of respiratory tract cancer, especially when coupled with smoking, underscoring the importance of oral health promotion in cancer prevention strategies.</p>","PeriodicalId":9681,"journal":{"name":"Cancers","volume":"17 18","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological Features and Prognosis of Lung Adenocarcinoma Presenting as Ground-Glass Opacity: A Single-Center Experience.","authors":"Monica Casiraghi, Lara Girelli, Attilio Elettore, Luca Bertolaccini, Antonio Mazzella, Claudia Bardoni, Mariano Lombardi, Valeria Midolo, Giuseppe Petralia, Patrick Maisonneuve, Juliana Guarize, Lorenzo Spaggiari","doi":"10.3390/cancers17183016","DOIUrl":"10.3390/cancers17183016","url":null,"abstract":"<p><p><b>Objectives</b>: Adenocarcinoma presenting as ground-glass opacities (GGOs) often corresponds to lepidic growth tumor and is associated with less invasive behavior and a good prognosis. The aim of this study is to investigate the correlation between radiological and pathological findings of GGO and their relationship with lung cancer-specific survival (LCSS) and incidence of relapses to better define their surgical management. <b>Methods</b>: One hundred seventy-two patients underwent lung resection for adenocarcinoma presenting as pure GGO or partial solid GGO at CT scan. Based on consolidation-to-tumor ratio (CTR) at CT scan, patients were categorized into two groups: pure GGO (CTR 0) and partial solid GGO (CTR ≤ 0.5, 0.5 < CTR ≤ 0.75, and 0.75 < CTR ≤ 1.0). Histological analysis confirmed diagnosis, invasiveness, and grading. <b>Results</b>: Comparing the group with pure GGO (n = 90; 52.3%) and the groups with partial solid GGO (n = 82; 47.7%), invasive adenocarcinoma was significantly more frequent in the last one (<i>p</i> = 0.0006). In the partial solid GGO group, the majority of tumors were G2, and the percentage of G3 tumors increased with the CTR increasing (<i>p</i> < 0.0001). Twenty-one (12.2%) patients experienced disease recurrence: 16 (9.3%) were invasive adenocarcinoma (IA), and 5 (2.9%) were minimally invasive adenocarcinomas (MIA); radiologically, 13 (7.5%) were pure GGO, and 8 (4.6%) had a solid component. At multivariate analysis, relapse was associated with age > 60 (<i>p</i> = 0.037), clinical stage ≥ cIB (<i>p</i> = 0.002), and sublobar resection (<i>p</i> = 0.005). <b>Conclusions:</b> Pure GGO was associated with minor invasiveness, with prognosis dependent on age, clinical stage, and type of surgery (sublobar vs. lobar resection). Sublobar resections had a higher recurrence risk.</p>","PeriodicalId":9681,"journal":{"name":"Cancers","volume":"17 18","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}