Central Plains Medical Journal最新文献

{"title":"Comparison of effects of hysterectomy at two different timings in patients with high-grade squamous intraepithelial lesion","authors":"R. Guo, Mengling Zhao, Yun Feng, Fen-Fen Chu, Miaomiao Zhang, Qian Wang","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.05.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.05.003","url":null,"abstract":"Objective \u0000To compare the curative effects on high-grade squamous intraepithelial lesion (HSIL) by performing total hysterectomy (LTH) immediately after fast frozen section examination (FSE) and performing total hysterectomy after fast FSE frozen section examination and conventional pathological determination. \u0000 \u0000 \u0000Methods \u0000Eighty-four patients with HSIL diagnosed in Pathology Department of the First Affiliated Hospital of Zhengzhou University from January 2016 to April 2017 who were going to have total hysterectomy operation were divided into two groups by their own willingness on operation. Patients in one-step operation group were given cervical cold knife conization (CKC) for FSE; if patients were diagnosed as non-cancer by FSE, patients underwent total hysterectomy immediately. Patients in two-step group underwent CKC for FSE first; if patients were diagnosed as non-cancer by FSE, clinicians ended the surgery; then, patients experienced routine pathological examination; if the results of pathological examination proved not to be cancer, patients underwent total hysterectomy; if the FSE showed a cancer result, patients underwent the radical operation of cervical cancer. The hospital stay, treatment coast, intraoperative bleeding volume, postoperative complication, anxiety degree and inappropriate rate of operation were compared between the two groups. \u0000 \u0000 \u0000Results \u0000Compared to two-step group, one-step group had shorter hospital stay, less hospital coast, lower anxiety degree and shorter time for the first anal exhaust (P 0.05). \u0000 \u0000 \u0000Conclusions \u0000Performing CKC and total hysterectomy at the same time has more advantages, however, it also has limited accuracy. Therefore, clinicians should attach importance to prevention of inappropriate hysterectomy, and investigation on high-risk of exacerbation of HSIL to guide the formulation of treatment protocol. \u0000 \u0000 \u0000Key words: \u0000Hysterectomy; High-grade intraepithelial lesion; Treatment; Fast frozen section examination; Conventional paraffin pathology","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"1 1","pages":"8-11"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77771084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curative effects of emergency cervical cerclage on cervical incompetence and related factors influencing prognosis","authors":"Li Peng, Guiping Zhang, Xinyi Dan","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.05.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.05.011","url":null,"abstract":"Objective \u0000To investigate the curative effects of emergency cervical cerclage (ECC) on cervical incompetence (CIC), and to analyze the related factors influencing prognosis. \u0000 \u0000 \u0000Methods \u0000The clinical and pathological data from 36 CIC patients treated by ECC in Nanyang First People’s Hospital from June 2016 to June 2018 were retrospectively collected. The curative effects were analyzed. The pregnancy outcomes were compared among patients with different cervical dilatation degrees, and the related factors influencing prognosis were analyzed. \u0000 \u0000 \u0000Results \u0000After ECC, gestational weeks of 36 CIC patients were prolonged by (8.55±4.86)weeks, and the neonatal survival rate was 83.33%(30/36). Compared to cervical dilatation degree>6.0 cm group, cervical dilatation degree≤6.0 cm group had longer prolongation time of gestational week, less abortion cases and better neonatal weight, and the difference between the two groups was significant (P 2.5 cm group had longer prolongation time of gestational week, less abortion cases, better neonatal weight, and the difference between the two groups was significant (P 6.0 cm were independent risk factors influencing pregnancy outcomes (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000The perinatal outcomes are relatively better in CIC patients with cervical dilatation degree ≤6.0 cm and cervical length >2.5 cm. The cervical length ≤2.5 cm and cervical dilatation degree >6.0 cm are independent risk factors of pregnancy outcomes. \u0000 \u0000 \u0000Key words: \u0000Cerclage, cervical; Cervical incompetence; Prognosis; Influencing factor","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"06 1","pages":"37-40"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85945992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of triple therapy of chemoradiotherapy, intracavitary brachytherapy and hyperthermia on advanced cervical cancer","authors":"Jia Li, F. Ma","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.05.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.05.015","url":null,"abstract":"Objective \u0000To investigate the effects of triple therapy of chemoradiotherapy, intracavitary brachytherapy and hyperthermia in the treatment of advanced cervical cancer. \u0000 \u0000 \u0000Methods \u0000A total of 400 patients with advanced cervical cancer admitted to Shanxi Cancer Hospital from July 2011 to June 2016 were selected as the research subjects. They were divided into study group and control group according to the random number table method. Patients in the control group were treated by conventional chemoradiotherapy and intracavitary brachytherapy, and patients in the study group were treated by hyperthermia on the basis of treatment for control group. The curative effects and the changes of leptin and insulin like growth factor 2 (IGF2) in cervical cancer cells before and after treatment were compared between the two groups. After treatment, patients in the two groups were followed up for 3 years, and the tumor-free survival and death of the two groups were recorded. \u0000 \u0000 \u0000Results \u0000The short-term total effective rate of the study group was 74.00% (148/200), higher than the 53.00% (106/200) of the control group (P 0.05). After treatment, the levels of IGF2 and leptin in the study group were lower than those in the control group (P<0.05). During the 3-year follow-up period, the tumor-free survival rate (62.00%, 124/200) and case fatality rate (5.00%, 10/200) in the study group were significantly lower than the 30.50% (61/200) and 17.00%(34/200) in the control group(P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Triple therapy of chemoradiotherapy, intracavitary brachytherapy and hyperthermia is effective in the treatment of advanced cervical cancer, which is beneficial to the short-term and long-term clinical effect. \u0000 \u0000 \u0000Key words: \u0000Chemoradiotherapy; Advanced cervical cancer; Intraluminal brachytherapy; Hyperthermia","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"9 1","pages":"50-53"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87204015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Danzhi Xiaoyao powder on late-onset post-pubertal acne caused by disharmony of Conception and Thoroughfare Vessels","authors":"Xinfen Xu","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.05.029","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.05.029","url":null,"abstract":"Objective \u0000To investigate the clinical effects of Danzhi Xiaoyao powder in the treatment of late-onset post-pubertal acne caused by disharmony of Conception and Thoroughfare Vessels. \u0000 \u0000 \u0000Methods \u0000A retrospective analysis was performed on the clinical data of 72 patients with late-onset post-pubertal acne caused by disharmony of Conception and Thoroughfare Vessels admitted to Heze Hospital of Traditional Chinese Medicine from March 2016 to September 2018. All patients were divided into two groups according to treatment methods, with 36 cases in each group. Patients in the control group were treated with conventional western medicine, and patients in the observation group were treated with Danzhi Xiaoyao powder. The levels of serum sex hormone, improvement of skin rash and clinical therapeutic effect were compared between the two groups. \u0000 \u0000 \u0000Results \u0000Compared with the preoperative indexes, the serum sex hormone levels and global acne grading system (GAGS) scores in the two groups were lower after treatment, and the indexes in observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). The total effective rate of the observation group was 94.44% (34/36), higher than the 72.22% (26/36) of the control group, and the difference was statistically significant (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Danzhi Xiaoyao powder can effectively reduce the serum sex hormone level and improve the skin rash in the patients with late-onset post-pubertal acne caused by disharmony of Conception and Thoroughfare Vessels. \u0000 \u0000 \u0000Key words: \u0000Delayed acne after puberty caused by disharmony of Conception and Thoroughfare Vessels; Danzhi Xiaoyao powder; Serum sex hormone level; Rash situation","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"82 1","pages":"97-99"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79963784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug resistance and genotypes of Mycobacterium tuberculosis in Datong area","authors":"C. Wei, Yueping Wang, Shuping Li","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.05.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.05.012","url":null,"abstract":"Objective \u0000To analyze the drug resistance and genotypes of Mycobacterium tuberculosis in Datong area. \u0000 \u0000 \u0000Methods \u0000A total of 120 strains of Mycobacterium tuberculosis isolated in the Fourth People’s Hospital of Datong from January 2018 to January 2019 were collected. Drug sensitivity tests were carried out by proportional method. The genotypes of 120 strains of Mycobacterium tuberculosis were analyzed by polymerase chain reaction (PCR) and spacer oligonucleotide typing (spoligotyping). \u0000 \u0000 \u0000Results \u0000Of the 120 strains of Mycobacterium tuberculosis, 78 strains were sensitive to isoniazid, rifampicin, ethambutol and streptomycin, and 42 strains were resistant to these drugs, with the drug resistance rate of 35.00%. Eighty-three strains (69.17%) were Beijing genotype, 37 strains (30.83%) were non-Beijing genotype. Gender, age, affected lung, history of tuberculosis treatment, strain source, genotyping had no significant effect on drug resistance or genotype of tuberculosis strains (P>0.05). \u0000 \u0000 \u0000Conclusions \u0000Beijing genotype Mycobacterium tuberculosis is a major epidemic strain in Datong region, and no significant correlation is found between drug resistance and genotype of Mycobacterium tuberculosis in Datong area. \u0000 \u0000 \u0000Key words: \u0000Mycobacterium tuberculosis; Drug resistance; Genotype; Analysis","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"11 1","pages":"41-43"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84558024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of radiofrequency thermocoagulation of lumbar sympathetic ganglion in the treatment of neuropathic pain of lower limbs","authors":"Baohui Zhang","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.04.026","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.04.026","url":null,"abstract":"Objective \u0000To study the clinical effect of radiofrequency thermocoagulation of lumbar sympathetic ganglion in the treatment of neuropathic pain of lower extremity. \u0000 \u0000 \u0000Methods \u0000A total of 44 cases of patients with neuropathic pain of lower extremity treated in Linfen People’s Hospital from January 2017 to February 2019 were selected as research objects.They were divided into observation group and control group based on single random equalization method, with 22 cases in each group. The control group was treated with conventional chemical mutilation, while the observation group was treated with radiofrequency thermocoagulation of lumbar sympathetic nerve. Preoperative and postoperative pain scores, postoperative quality of life scores and preoperative and postoperative skin temperature changes of lower limbs were compared between the two groups. \u0000 \u0000 \u0000Results \u0000There was no significant difference in skin temperature of lower limbs between the two groups before treatment (P>0.05); at 1, 2 and 3 months after treatment, there was a significant difference in skin temperature of lower limbs (P 0.05). VAS pain scores in the observation group were lower than those in the control group at 1, 2 and 3 months after treatment (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Radiofrequency thermocoagulation of lumbar sympathetic nerve can relieve pain of patients with neuropathic pain of lower extremity, which is safe. \u0000 \u0000 \u0000Key words: \u0000Sympathetic ganglion; Radiofrequency thermocoagulation; Lower limbs; Neuropathic pain","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"70 1","pages":"85-87"},"PeriodicalIF":0.0,"publicationDate":"2020-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79936257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of efficacy and safety of laparoscopic versus retropubic radical prostatectomy in the treatment of localized prostate cancer","authors":"Jun Fang, Xin Jiang, Zhenpu Wang, Hongli Zhang","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.04.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.04.011","url":null,"abstract":"Objective \u0000To compare the efficacy and safety of radical prostatectomy by laparoscopic approach and retropubic approach in patients with localized prostate cancer. \u0000 \u0000 \u0000Methods \u0000Thirty-seven patients with localized prostate cancer treated in Zhengzhou People’s Hospital from January 2013 to June 2018 were divided into two groups according to different surgical approaches. Twenty-two cases in control group were treated by posterior pubic approach, and 15 cases in observation group were treated by laparoscopy. The perioperative indexes such as operation time, indwelling catheter time, hospitalization time, intraoperative bleeding volume and pain score were recorded and compared between the two groups. The incidence of complications such as urinary incontinence, anastomotic stricture, urinary leakage and erectile dysfunction in the two groups were higher than those of the two groups. \u0000 \u0000 \u0000Results \u0000After treatment, the observation group had shorter hospital stay compared with the control group, significantly reduced intraoperative bleeding, lower pain score, but longer operation time (P 0.05). \u0000 \u0000 \u0000Conclusions \u0000In the treatment of radical prostatectomy, laparoscopic approach can achieve the effect similar to that of the retropubic approach, and it has minimally invasive advantage, which is beneficial to the postoperative recovery of the patients. \u0000 \u0000 \u0000Key words: \u0000Prostate cancer; Laparoscopy; Radical resection","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"102 1","pages":"35-37"},"PeriodicalIF":0.0,"publicationDate":"2020-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89153345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of capsule endoscopy in the diagnosis of unexplained gastrointestinal bleeding","authors":"Ji-ye Li","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.04.021","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.04.021","url":null,"abstract":"Objective \u0000To investigute the diagnostic value of capsule endoscopy (CE) for unexplained gastrointestinal bleeding (OGIB). \u0000 \u0000 \u0000Methods \u0000Sixty patients with OGIB in General Hospital of Jinmei Group from January 2014 to February 2018 were divided into group A (n=28) and group B (n=32) according to bleeding stop time. The patients in group A underwent CE examination within 3 day stoping bleeding, while the patients in group B 3 d after stoping bleeding. \u0000 \u0000 \u0000Results \u0000The total positive rate of CE in 60 patients was 90%. The proportion of vascular malformation, multiple ulcers or erosion were higher than other types (P<0.05). The positive detection rate of group A was 100%, the posttive detection of group B rate was 81.25%, the difference was significant (P<0.05); the average hospital stay in group A was shorter than that in group B (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000The positive rate of OGIB diagnosis in CE is higher, and performing examination earlier, can get better diagnosis effect, which can provide guidance for clinical treatment, reduce blood transfusion and shorten hospitalization time. \u0000 \u0000 \u0000Key words: \u0000Gastrointestinal bleeding; Capsule endoscopy; Vascular malformation","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"10 1","pages":"69-71"},"PeriodicalIF":0.0,"publicationDate":"2020-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89306024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of MRI in the diagnosis of shoulder injury","authors":"Guohui Yang, Yuquan Liang, Tao Li, Jinzhao Jiang, Xinping Shen","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.04.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.04.002","url":null,"abstract":"Objective \u0000To explore the value of MRI in the diagnosis of shoulder joint injury. \u0000 \u0000 \u0000Methods \u0000Fifteen patients with shoulder joint injury confirmed by shoulder arthroscopy admitted to Shenzhen Hospital of Hong Kong University from January 2015 to December 2018 were selected, the clinical data of preoperative routine MRI and Mr shoulder arthrography (MRA) were analyzed retrospectively. \u0000 \u0000 \u0000Results \u0000Arthroscopic results showed that in 15 patients with shoulder joint injury, there were 2 full-thickness rotator cuff tears, 10 partial rotator cuff tears and 3 glenoid lip injuries. The results of MRA were 2 cases, 10 cases and 3 cases, which were consistent with arthroscopic results. Routine MRI diagnosis results: 1 case of rotator cuff full-thickness tear (correct diagnosis rate was 93.3%, missed diagnosis rate was 50.0%, misdiagnosis rate was 0), 12 cases of rotator cuff partial tear (correct diagnosis rate was 86.7%, missed diagnosis rate was 0, misdiagnosis rate was 40.0%), 2 cases of rotator cuff tear complicated with glenoid lip injury (positive diagnosis rate was 93.3%, missed diagnosis rate 33.3%, misdiagnosis rate was 0), of which 2 cases were misdiagnosed as rotator cuff partial tear MRA and arthroscopy showed 1 case of full-thickness rotator cuff tear and 1 case of glenoid lip injury caused by rotator cuff tear. \u0000 \u0000 \u0000Conclusions \u0000Compared with conventional MRI, MR arthrography can improve the diagnosis accuracy of shoulder joint injury and has clinical application value. \u0000 \u0000 \u0000Key words: \u0000Shoulder arthrography; Magnetic resonance imaging; Glenoid lip; Rotator cuff; Injury","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"52 1","pages":"4-7"},"PeriodicalIF":0.0,"publicationDate":"2020-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87474085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between gene mutation of epidermal growth factor receptor and clinical characteristics of lung adenocarcinoma","authors":"Y. Miao, Xin-Jian Gao, Ya-Wen Zheng, Zhihong Zhao, Y. Liu","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.04.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.04.003","url":null,"abstract":"Objective \u0000To investigate the relationship between the gene mutation of epidermal growth factor receptor (EGFR) and the clinical characteristics of lung adenocarcinoma. \u0000 \u0000 \u0000Methods \u0000The clinical data of 194 patients with lung adenocarcinoma diagnosed by surgical resection (pulmonary resection, wedge resection, or lobectomy) in the First Affiliated Hospital of Zhengzhou University from January 2017 to January 2019 were collected. The relationship between EGFR gene mutation and clinicopathological characteristics including sex, age, smoking history, tumor markers, adenocarcinoma pathological classification, extent of differentiation in patients with lung adenocarcinoma were analyzed, further searched for factors that predicted the mutations of EGFR. \u0000 \u0000 \u0000Results \u0000In the 194 patients with lung adenocarcinoma, there were 120 cases (61.86%) with EGFR gene mutation, the mutation rate of female was higher than that of male (χ2=10.746, P=0.001), the mutation rate of EGFR gene in patients of age≥60 was higher than that in patients of age 0.05). Among the main pathological types of lung adenocarcinoma, the proportion of acinar type was the highest in EGFR mutation group(63.9%, 124/194), the others were solid type, papillary type, adherent type, mucinous adenocarcinoma, the differences between the main pathological types and EGFR gene mutation, the differentiation degree of each excised lesion were statistically significant (χ2=10.275, 17.131; P=0.001, 0.001). There were more exons 19 and exon 21 in EGFR mutants, further analysis showed that there was significant difference between different pathological sub-types and mutations of exon 19 and exon 21(χ2=18.613, P=0.001). \u0000 \u0000 \u0000Conclusions \u0000EGFR gene mutation is related to sex, age, smoking history, main pathological types and tumor differentiation degrees, but it is not related to tumor marker. Mutations of exon 19 and exon 21 are related to main pathological types. \u0000 \u0000 \u0000Key words: \u0000Lung adenocarcinoma; Epidermal growth factor; Receptor; Pathology","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"40 1","pages":"8-11"},"PeriodicalIF":0.0,"publicationDate":"2020-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74927825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}