Central Plains Medical Journal最新文献

{"title":"Significanee of ginsenoside Rg1 in laryngeal cancer Hep2 cells proliferation and eNOS/iNOS pathways","authors":"Jiantao Li, T. Kong, Yu-han Sun, Guangxi Mi","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.03.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.03.003","url":null,"abstract":"Objective \u0000To investigate the significance of ginsenoside Rg1 in laryngeal cancer Hep2 cells proliferation and endothelial nitric oxide/inducible nitric-oxide synthse (eNOS/iNOS) pathways. \u0000 \u0000 \u0000Methods \u0000In the study, laryngeal cancer Hep2 cells were calculated by ginsenoside Rg1, with drug concentrations as 40 μmol/L, 60 μmol/L, 80 μmol/L , respectively, and cells in different concentrations were all cultured for 24, 48, 72 h as ginsenoside Rg1 group; and a normal training was set as the control group. Methyl thiazolyl tetrazolium method was used to test cell proliferation activity of every group. Flowcytometry analysis was used to analyze the proportion of each cell cycle in each phase. Transcription-polymerase chain reaction method was used to detect cell eNOS and iNOS expression level. \u0000 \u0000 \u0000Results \u0000Rg1 had inhibitory effects on Hep2 cells proliferation, showing time and dose dependent, with 80 μmol/L concentration for the optimum effect. Compared with control group, after been calculated by 80 μmol/L Rg1 for 24, 48, 72 h, Hep2 cells apoptosis rate increased gradually (P<0.01); S phase and G2/M phase cells proportion gradually declined, while G0/G1 phase cell proportion increased (P<0.01). Compared with control group, iNOS levels of ginsenoside Rg1 group decreased, but the content of NO and eNOS was higher. Compared with control group, ginsenoside Rg1 group had higher expression of iNOS mRNA in Hep2 cell lines, and lower eNOS mRNA expression, which was in line with results of spectrophotometric determination. \u0000 \u0000 \u0000Conclusions \u0000Ginsenoside Rg1 can inhibit human laryngeal cancer cells Hep2 cells proliferation, and its mechanism may be related to antioxidant effect of ginsenoside Rg1, by which the eNOS expression is promoted, iNOS expression is inhabited, and the NO activity is improved. \u0000 \u0000 \u0000Key words: \u0000Ginsenoside Rg1; Laryngeal cancer Hep2 cells; Nitric oxide synthase; Nitric oxide","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"25 1","pages":"10-13"},"PeriodicalIF":0.0,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84264504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of tripterygium wilfordii tablets combined with benazepril on patients with chronic nephritis","authors":"Yudong Liu","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.03.031","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.03.031","url":null,"abstract":"Objective \u0000To investigate the clinical efficacy of tripterygium wilfordii tablets and benazepril combination therapy in the treatment of patients with chronic nephritis. \u0000 \u0000 \u0000Methods \u0000Eighty patients who underwent diagnosis and treatment for chronic nephritis in Fourth People’s Hospital of Shangqiu from January 2015 to December 2018 were selected and divided into control group and observation group by random number table method. Patients in the control group were treated with benazepril therapy, and patients in the observation group were treated with tripterygium wilfordii tablets and benazepril combination therapy. The clinical diagnosis and treatment outcomes of the two groups were compared. \u0000 \u0000 \u0000Results \u0000After treatment, the clinical cure rate of the observation group was 87.50% (35/40), significantly higher than the 72.50% (29/40) in the control group (P 0.05). The levels of renal function indexes, such as creatinine, blood urea nitrogen, red blood cell count, glomerular filtration rate, 24 h urine protein quantitation, urine β2-microglobulin, and urinary red blood cell count, were improved in both groups after treatment, and the improvement in the observation group was greater than the control group (P 0.05). \u0000 \u0000 \u0000Conclusions \u0000Tripterygium wilfordii tablets and benazepril combination therapy can get good diagnostic and therapeutic outcomes in the treatment of chronic nephritis, which has positive significance for the improvement of clinical manifestation, and can effectively improve the renal function of patients, with higher safety. \u0000 \u0000 \u0000Key words: \u0000Chronic nephritis; Tripterygium wilfordii tablet; Benazepril; Clinical efficacy","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"107 1","pages":"116-118"},"PeriodicalIF":0.0,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78363148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical analysis on 33 cases of eosinophilic pulmonary disease","authors":"B. Tu","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.03.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.03.004","url":null,"abstract":"Objective \u0000To summarize the experience of diagnosis and treatment of eosinophilic lung disease (ELD), and to improve the diagnosis and treatment of such diseases. \u0000 \u0000 \u0000Methods \u0000Retrospective analysis was performed on clinical data from 33 patients with ELD diagnosed and hospitalized in the First Affiliated Hospital of Zhengzhou University from January 2016 to January 2019, including medical history, course of disease, clinical manifestations, laboratory examination, imaging examination, and pathological results, diagnosis and treatment and prognosis. \u0000 \u0000 \u0000Results \u0000Among the 33 patients with ELD, 19 patients were males and 14 patients were females, with an average age of (41.30±14.26)years. There were 20 cases of allergic bronchopulmonary aspergillosis (ABPA), 8 cases of chronic eosinophilic pneumonia (CEP), and 5 cases of eosinophilic granulomatous polyangiitis (EGPA) among the 33 ELD patients. Thirty-three patients all underwent peripheral blood determination, and peripheral blood eosinophils (EOS) increased in 27 patients. Twenty-eight patients underwent serum total immunoglobulin E(IgE) determination, and 25 patients of them had elevated serum total IgE. Twenty-six patients underwent pulmonary function tests, and 18 of them had pulmonary dysfunction, and 8 patients had diffuse dysfunction. Thoracic computed tomography showed mainly infiltration in the lungs, with patchy, strip-like, clump-like, and ground-glass-like high-density shadows in the lungs. Pathological examination of lung tissue showed eosinophil infiltration. Glucocorticoid alone or in combination with other drugs is effective in the treatment of ELD. \u0000 \u0000 \u0000Conclusions \u0000ELD has a variety of clinical manifestations, for which resaon the disease could be misdiagnosed easily. Its diagnosis mainly depends on clinical manifestations, laboratory tests, imaging examinations. And lung histopathology should be performed for diagnosis if necessary. Glucocorticoid is the basic drug for ELD treatment. \u0000 \u0000 \u0000Key words: \u0000Eosinophilic lung disease; Eosinophil; Lung tissue biopsy; Glucocorticoid","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"129 1","pages":"14-18"},"PeriodicalIF":0.0,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86888072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curative effects of Sextant minimally invasive percutaneous pedicle screw fixation and open pedicle screw fixation on thoracolumbar multiple spine fractures","authors":"Tongle Yuan, Xiao-ming Zhang","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.03.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.03.014","url":null,"abstract":"Objective \u0000To compare the curative effects of Sextant minimally invasive percutaneous pedicle screw fixation and open pedicle screw fixation on thoracolumbar multiple spine fractures. \u0000 \u0000 \u0000Methods \u0000A retrospective analysis was performed on clinical data from 50 patients with thoracolumbar multiple spine fractures who were admitted to Zhengzhou Cardiovascular Hospital from January 2016 to December 2018. They were divided into minimally invasive group (28 cases) and open group (22 cases) according to surgical methods. The minimally invasive group was given Sextant minimally invasive percutaneous pedicle screw fixation, while the open group was given open pedicle screw fixation. The related indexes of surgery (operating time, intraoperative blood loss, incision length, postoperative drainage volume, hospital stay), pain status evaluated by visual analogue scale (VAS) score, vertebral function assessed by Oswestry disability index (ODI), height of vertebral anterior margin, Cobbs angle, and activity of serum creatine kinase were compared between the two groups. All patients were followed up for 6 months, and the complications were compared between the two groups. \u0000 \u0000 \u0000Results \u0000The intraoperative blood loss, incision length, postoperative drainage volume and hospital stay in minimally invasive group were significantly less than those in open group (all P 0.05. \u0000 \u0000 \u0000Conclusions \u0000Compared with open surgery, the trauma of Sextant minimally invasive percutaneous pedicle screw fixation is less for patients with thoracolumbar multiple spine fractures, which can reduce blood loss and shorten hospital stay. And it is conducive to recovery of injured vertebrae height. \u0000 \u0000 \u0000Key words: \u0000Thoracolumbar multiple spine fracture; Sextant minimally invasive percutaneous pedicle screw fixation; Open pedicle screw fixation","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"4 1","pages":"52-56"},"PeriodicalIF":0.0,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85402380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of brachial-ankle artery pulse wave velocity in assessing progress of blood pressure in young adults","authors":"Chun-rong Jin","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.03.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.03.011","url":null,"abstract":"Objective \u0000To investigate the predictive value of brachial-ankle artery pulse wave velocity (baPWV) in assessing blood pressure progress in young adults. \u0000 \u0000 \u0000Methods \u0000A total of 100 patients who met inclusion criteria were selected from First Hospital of Shanxi Medical University. The 100 patients underwent physical examination and baPWV monitoring during October 2014 to October 2016 for the first time, and finished the second physical examination and baPWV monitoring between December 2017 to December 2018. The first physical examination data and baPWV data were set as baseline indicators, and the clinical data of the second time as observation indicators. The correlation between baPWV and progress of blood pressure in young adults was studied and analyzed. \u0000 \u0000 \u0000Results \u0000In comparison between observation indicators and baseline indicators, there were statistical differences in age, systolic blood pressure, diastolic blood pressure, fasting blood glucose, baPWV, diabetes mellitus and arteriosclerosis (P 0.05). The baPWV was linearly correlated with baseline blood pressure, blood pressure in observation indicators and blood pressure progress. For every 1 m/s increase of baPWV, the baseline systolic and diastolic blood pressures increased by 2.970 mmHg (1 mmHg=0.133 kPa) and 0.881 mmHg (1 mmHg=0.133 kPa), the systolic and diastolic blood pressures in observation indicators increased by 2.640 mmHg and 0.597 mmHg, respectively, and the changes of systolic and diastolic blood pressures of baseline indicators and observation indicators increased by 1.542 mmHg and 0.433 mmHg, respectively. \u0000 \u0000 \u0000Conclusions \u0000Dynamic monitoring of baPWV can predict the progression of arteriosclerosis and the change of blood pressure. \u0000 \u0000 \u0000Key words: \u0000Brachial-ankle artery pulse wave velocity; Young adults; Blood pressure","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"2 1","pages":"42-45"},"PeriodicalIF":0.0,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87121089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influencing factors of recurrence in patients with spinal bone tumor within 1 year after surgery","authors":"Huanyu Qi, Peng Zhang","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.03.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.03.009","url":null,"abstract":"Objective \u0000To analyze the influencing factors of recurrence in patients with spinal bone tumor within 1 year after surgery. \u0000 \u0000 \u0000Methods \u0000The clinical data from 94 patients with spinal bone tumors treated by surgery in Shanxi Cancer Hospital from March 2016 to March 2018 were retrospectively analyzed. All patients were reexamined every three months after discharge. The recurrence rate was recorded during the one-year follow-up. Then the influencing factors of recurrence within 1 year after treatment were analyzed in terms of patient’s gender, age, tumor major diameter, Tomita typing, Enneking stage, surgical approach, morbidity segment, bisphosphonate dosage, surgical method, postoperative radiotherapy, insulin-like growth factor 2 (IGF2) expression, insulin-like growth factor Ⅱ mRNA binding protein 3 (IMP3) expression and invasion range. \u0000 \u0000 \u0000Results \u0000During 1-year follow-up after discharge, 38 of 94 patients with spinal bone tumor had recurrence, with a recurrence rate of 40.43%. Advanced Tomita typing, positive IMP3 expression, non-use of bisphosphonates, invasion to ventricular septum, and non-postoperative radiotherapy were the single influencing factors of the recurrence of spinal bone tumor (P<0.05). Advanced Tomita typing, positive IMP3 expression, non-use of bisphosphonates, invasion to ventricular septum, and non-postoperative radiotherapy were independent influencing factors of recurrence of spinal bone tumors within 1 year after surgery (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Advanced Tomita typing, positive IMP3 expression, non-use of bisphosphonates, invasion to ventricular septum, and non-postoperative radiotherapy are independent influencing factors of recurrence of spinal bone tumors within 1 year after surgery. \u0000 \u0000 \u0000Key words: \u0000Spinal bone tumors; Surgery; Recurrence; Influencing factors","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"5 1","pages":"34-37"},"PeriodicalIF":0.0,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86848791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of injection of botulinum toxin combined with Vojta training on fine motor function of children with spastic cerebral palsy","authors":"F. Chen, Ni Liu","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.03.023","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.03.023","url":null,"abstract":"Objective \u0000To investigate the effects of injection of botulinum toxin (BTX) combined with Vojta training on fine motor function of children with spastic cerebral palsy. \u0000 \u0000 \u0000Methods \u0000Sixty children with spastic cerebral palsy who were admitted to Nanyang Central Hospital from January 2014 to January 2019 were selected as the research objects. They were divided into control group and observation group by drawing method, with 30 cases in each group. The control group was given Vojta training only, while the observation group was given injection of BTX and Vojta training. The gross motor function scale (GMFM-88) score, modified Asworth spasticity scale (MAS), fine motor function measure scale (FMFM) score and Peabody developmental motor scale-fine motor (PDMS-FM) score were compared between the two groups. \u0000 \u0000 \u0000Results \u0000After treatment, the adductor angle and popliteal fossa angle of the thigh in the observation group were (119.30±14.81)° and (136.07±14.45)°, respectively, larger than the (109.63±13.43)° and (127.85±13.04)° in the control group (P 0.05). \u0000 \u0000 \u0000Conclusions \u0000Injection of BTX combined with Vojta training can effectively regulate the lower limb joint range of motion, improve the fine motor function of children with spastic cerebral palsy, and improve their quality of life. \u0000 \u0000 \u0000Key words: \u0000Botulinum toxin; Vojta training; Spastic cerebral palsy; Fine motor function","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"26 1","pages":"86-89"},"PeriodicalIF":0.0,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90133376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of delayed umbilical cord clamping on hemoglobin level of preterm infants after birth","authors":"Zhulian Nie, Chuande Liao","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.03.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.03.005","url":null,"abstract":"Objective \u0000To investigate the influence of delayed umbilical cord clamping on hemoglobin levels of preterm infants after birth. \u0000 \u0000 \u0000Methods \u0000Sixty preterm infants born in Wuzhou People’s Hospital during December, 2017 to April 2019 were selected and divided into two groups by umbilical cord cutting time. In the 30 preterm infants of observation group, umbilical cords were cut 2 min after birth or after umbilical cord stopped pulsing; while the umbilical cord of control group were cut immediately within 10 s after birth. The hemoglobin level, hematocrit (HCT) were compared between the two groups. \u0000 \u0000 \u0000Results \u0000There was no statistical difference in HCT or hemoglobin level between the two groups (P>0.05). On 3 days after birth, the HCT and hemoglobin levels were higher than the levels prior to birth in the two groups (P 0.05). The transcutaneous bilirubin levels on the fifth day after birth were higher than those on the first day after birth in both groups (P 0.05). The rate of blood transfusion was 30.00% (2/30) in the observation group, lower than the 86.67% (11/30) in the control group (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Delayed umbilical cord clamping can improve hemoglobin level, without increasing incidence of hyperbilirubinemia. It is an effective and safe method to prevent anemia. \u0000 \u0000 \u0000Key words: \u0000Preterm infants; Delayed umbilical cord clamping; Hemoglobin","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"10 1","pages":"19-21"},"PeriodicalIF":0.0,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82465791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of rosuvastatin in different doses on myocardial indexes, serum lipid level and adverse cardiovascular events in patients with coronary heart disease after percutaneous coronary intervention","authors":"Shi-zun Guo, Man K. Du","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.03.028","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.03.028","url":null,"abstract":"Objective \u0000To observe the effects of rosuvastatin in different doses on myocardial indexes, serum lipid level and adverse cardiovascular events in patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI). \u0000 \u0000 \u0000Methods \u0000Eighty-six patients with CHD treated by PCI in Nanyang First People’s Hospital from March 2018 to March 2019 were selected. According to random number table method, they were divided into control group and observation group, with 43 cases in each group. The control group was treated with rosuvastatin calcium, 5 mg/time, 1 time/day; while the observation group was treated with rosuvastatin calcium, 10 mg/time, 1 time/day. The serum lipid levels, such as total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C), inflammatory factors, such as interleukin-6 (IL-6), C-reactive protein (CRP), myocardial indicators, such as troponin-I (cTn-I), creatine kinase (CK), creatine kinase isoenzyme (CK-MB), incidence of adverse cardiovascular events and drug adverse reactions were compared between the two groups. \u0000 \u0000 \u0000Results \u0000After treatment, the levels of TC, TG, LDL-C, IL-6, CRP, cTn-I, CK and CK-MB in the two groups were lower than those before treatment, and the above indexes in the observation group were lower than those in the control group (P 0.05). \u0000 \u0000 \u0000Conclusions \u0000The advantages of high-dose rosuvastatin in treatment of CHD patients after PCI is more significant than low-dose rosuvastatin in adjusting their serum lipid level, reducing inflammatory response, protecting cardiomyocytes and reducing adverse cardiovascular events. \u0000 \u0000 \u0000Key words: \u0000Coronary disease; Intervention surgery; Rosuvastatin; Myocardial index; Serum lipid level","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"148 1","pages":"105-108"},"PeriodicalIF":0.0,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77848940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and adverse reactions of minocycline combined with halometasone cream for external use in the treatment of bullous pemphigoid","authors":"Hui-Yen Chang","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.03.029","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.03.029","url":null,"abstract":"Objective \u0000To investigate the clinical efficacy and adverse reactions of minocycline combined with halometasone cream in the treatment of bullous pemphigoid. \u0000 \u0000 \u0000Methods \u0000Forty patients with bullous pemphigoid treated in Shanxi Bethune Hospital from April 2016 to April 2019 were selected and divided into control group and observation group according to the admission order, with 20 cases in each group. Patients in the control group were treated with halometasone cream externally, while patients in the observation group were treated with minocycline combined with halometasone cream externally. The number of new blisters, clinical efficacy, eosinophil (EOS) count in peripheral blood and adverse reactions were observed and compared between the two groups. \u0000 \u0000 \u0000Results \u0000There was no statistical difference in the number of new blisters between the two groups before treatment (P>0.05). After treatment, the number of new blisters was less in the observation group, compared to the control group (P 0.05); while, EOS count was lower in the observation group than that in the control group after treatment (P 0.05). \u0000 \u0000 \u0000Conclusions \u0000Minocycline combined with halometasone cream in the treatment of bullous pemphigoid can effectively and safely improve the clinical symptoms of patients, reduce the number of new blisters, and decrease peripheral blood EOS count, without increasing the incidence of adverse reactions, which is of great clinical significance. \u0000 \u0000 \u0000Key words: \u0000Minocycline; Halometasone cream; Bullous pemphigoid; Clinical efficacy; Adverse reactions","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"70 1","pages":"109-111"},"PeriodicalIF":0.0,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72734127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}