{"title":"大同地区结核分枝杆菌耐药性及基因型分析","authors":"C. Wei, Yueping Wang, Shuping Li","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.05.012","DOIUrl":null,"url":null,"abstract":"Objective \nTo analyze the drug resistance and genotypes of Mycobacterium tuberculosis in Datong area. \n \n \nMethods \nA total of 120 strains of Mycobacterium tuberculosis isolated in the Fourth People’s Hospital of Datong from January 2018 to January 2019 were collected. Drug sensitivity tests were carried out by proportional method. The genotypes of 120 strains of Mycobacterium tuberculosis were analyzed by polymerase chain reaction (PCR) and spacer oligonucleotide typing (spoligotyping). \n \n \nResults \nOf the 120 strains of Mycobacterium tuberculosis, 78 strains were sensitive to isoniazid, rifampicin, ethambutol and streptomycin, and 42 strains were resistant to these drugs, with the drug resistance rate of 35.00%. Eighty-three strains (69.17%) were Beijing genotype, 37 strains (30.83%) were non-Beijing genotype. Gender, age, affected lung, history of tuberculosis treatment, strain source, genotyping had no significant effect on drug resistance or genotype of tuberculosis strains (P>0.05). \n \n \nConclusions \nBeijing genotype Mycobacterium tuberculosis is a major epidemic strain in Datong region, and no significant correlation is found between drug resistance and genotype of Mycobacterium tuberculosis in Datong area. \n \n \nKey words: \nMycobacterium tuberculosis; Drug resistance; Genotype; Analysis","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"11 1","pages":"41-43"},"PeriodicalIF":0.0000,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Drug resistance and genotypes of Mycobacterium tuberculosis in Datong area\",\"authors\":\"C. Wei, Yueping Wang, Shuping Li\",\"doi\":\"10.3760/CMA.J.ISSN.1674-4756.2020.05.012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective \\nTo analyze the drug resistance and genotypes of Mycobacterium tuberculosis in Datong area. \\n \\n \\nMethods \\nA total of 120 strains of Mycobacterium tuberculosis isolated in the Fourth People’s Hospital of Datong from January 2018 to January 2019 were collected. Drug sensitivity tests were carried out by proportional method. The genotypes of 120 strains of Mycobacterium tuberculosis were analyzed by polymerase chain reaction (PCR) and spacer oligonucleotide typing (spoligotyping). \\n \\n \\nResults \\nOf the 120 strains of Mycobacterium tuberculosis, 78 strains were sensitive to isoniazid, rifampicin, ethambutol and streptomycin, and 42 strains were resistant to these drugs, with the drug resistance rate of 35.00%. Eighty-three strains (69.17%) were Beijing genotype, 37 strains (30.83%) were non-Beijing genotype. Gender, age, affected lung, history of tuberculosis treatment, strain source, genotyping had no significant effect on drug resistance or genotype of tuberculosis strains (P>0.05). \\n \\n \\nConclusions \\nBeijing genotype Mycobacterium tuberculosis is a major epidemic strain in Datong region, and no significant correlation is found between drug resistance and genotype of Mycobacterium tuberculosis in Datong area. \\n \\n \\nKey words: \\nMycobacterium tuberculosis; Drug resistance; Genotype; Analysis\",\"PeriodicalId\":9667,\"journal\":{\"name\":\"Central Plains Medical Journal\",\"volume\":\"11 1\",\"pages\":\"41-43\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-03-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Central Plains Medical Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.05.012\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Central Plains Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.05.012","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Drug resistance and genotypes of Mycobacterium tuberculosis in Datong area
Objective
To analyze the drug resistance and genotypes of Mycobacterium tuberculosis in Datong area.
Methods
A total of 120 strains of Mycobacterium tuberculosis isolated in the Fourth People’s Hospital of Datong from January 2018 to January 2019 were collected. Drug sensitivity tests were carried out by proportional method. The genotypes of 120 strains of Mycobacterium tuberculosis were analyzed by polymerase chain reaction (PCR) and spacer oligonucleotide typing (spoligotyping).
Results
Of the 120 strains of Mycobacterium tuberculosis, 78 strains were sensitive to isoniazid, rifampicin, ethambutol and streptomycin, and 42 strains were resistant to these drugs, with the drug resistance rate of 35.00%. Eighty-three strains (69.17%) were Beijing genotype, 37 strains (30.83%) were non-Beijing genotype. Gender, age, affected lung, history of tuberculosis treatment, strain source, genotyping had no significant effect on drug resistance or genotype of tuberculosis strains (P>0.05).
Conclusions
Beijing genotype Mycobacterium tuberculosis is a major epidemic strain in Datong region, and no significant correlation is found between drug resistance and genotype of Mycobacterium tuberculosis in Datong area.
Key words:
Mycobacterium tuberculosis; Drug resistance; Genotype; Analysis
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