Case Reports in Women's Health最新文献_第3页

The management of pregnancy for a woman with bilateral Klippel-Trenaunay syndrome: A case report 双侧Klippel-Trenaunay综合征1例妊娠管理

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Case Reports in Women's Health Pub Date : 2026-03-01 Epub Date: 2026-02-25 DOI: 10.1016/j.crwh.2026.e00795

R. Meenakshi Menon , Richa Sasmita Tirkey , Edwin Stephen , Ahlam Al Hinai , Aaisha Al Balushi , Bashair Al Siyabi , Dina Al Balushi , Khalifa Al Wahaibi , Ibrahim Abdelhady , Bader Al Rawahi , Yarab Al Bulushi , Azza Al Abri , Kusuma Helemani , Nihal Al Riyami

{"title":"The management of pregnancy for a woman with bilateral Klippel-Trenaunay syndrome: A case report","authors":"R. Meenakshi Menon , Richa Sasmita Tirkey , Edwin Stephen , Ahlam Al Hinai , Aaisha Al Balushi , Bashair Al Siyabi , Dina Al Balushi , Khalifa Al Wahaibi , Ibrahim Abdelhady , Bader Al Rawahi , Yarab Al Bulushi , Azza Al Abri , Kusuma Helemani , Nihal Al Riyami","doi":"10.1016/j.crwh.2026.e00795","DOIUrl":"10.1016/j.crwh.2026.e00795","url":null,"abstract":"<div><div>Klippel-Trenaunay syndrome is rare. It is diagnosed in childhood and the gender distribution is almost equal. A challenge arises in pregnancy, as several risks are significantly elevated, such as hemorrhage, bleeding of the varicosities, and life-threatening thromboembolic events. Due to the rarity of the condition, there is limited literature and guidelines regarding management of pregnancy for these patients. This report describes a successful pregnancy outcome in a 34-year-old primigravida with Klippel-Trenaunay syndrome. The aim is to contribute to the limited literature pertaining to this condition and emphasize the role of meticulous planning of antenatal care and birth, to help formulate clinical guidelines in the management of pregnancy in Klippel-Trenaunay syndrome. Multidisciplinary comprehensive clinical evaluation, involving obstetricians, vascular surgeons, a thrombosis team, anesthesiologists, intensivists, radiologists and intervention radiologists, along with the use of ultrasound and magnetic resonance imaging, aids in identifying the extent of disease and to individualize management.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"49 ","pages":"Article e00795"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147395687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent endometrial carcinoma with immune-mediated thrombocytopenia following durvalumab: A case report 杜伐单抗后复发性子宫内膜癌伴免疫介导的血小板减少：1例报告

IF 0.6

Case Reports in Women's Health Pub Date : 2026-03-01 Epub Date: 2025-12-02 DOI: 10.1016/j.crwh.2025.e00773

Ami Sakakibara , Shimpei Nagai , Terumi Shirane , Tomomi Sakai , Yoko Fujioka , Makiko Hino , Yoshihisa Hattori , Takashi Kurahashi

{"title":"Recurrent endometrial carcinoma with immune-mediated thrombocytopenia following durvalumab: A case report","authors":"Ami Sakakibara , Shimpei Nagai , Terumi Shirane , Tomomi Sakai , Yoko Fujioka , Makiko Hino , Yoshihisa Hattori , Takashi Kurahashi","doi":"10.1016/j.crwh.2025.e00773","DOIUrl":"10.1016/j.crwh.2025.e00773","url":null,"abstract":"<div><div>The use of immune checkpoint inhibitors (ICIs) has expanded the therapeutic landscape for advanced or recurrent endometrial carcinoma. Durvalumab—a programmed death-ligand 1 (PD-L1) inhibitor—demonstrated clinical benefit in the 2023 DUO-E trial when combined with carboplatin and paclitaxel. Immune thrombocytopenia (ITP) is an uncommon but potentially life-threatening immune-related adverse event (irAE). A 73-year-old woman with recurrent endometrial carcinoma developed severe ITP after three cycles of paclitaxel, carboplatin, and durvalumab. Fourteen days after cycle 3 she presented with pyelonephritis, bacteremia, and acute disseminated intravascular coagulation (DIC). Despite infection control, her platelet count declined to 1 × 10<sup>3</sup>/μL, with epistaxis, hematuria, and melena. Suspecting ITP as an irAE, intravenous immunoglobulin (IVIG 10 g/day × 5 days) and high-dose intravenous prednisolone (1 mg/kg/day) were administered. Platelet counts improved gradually to 85 × 10<sup>3</sup>/μL by hospital day 32, and she was discharged on a steroid taper. This appears to be the first Japanese report of durvalumab-associated ITP in endometrial carcinoma. Clinicians should maintain a high index of suspicion for ITP when unexpected thrombocytopenia or bleeding occurs during durvalumab therapy and initiate prompt treatment.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"49 ","pages":"Article e00773"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145683994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subdermal contraceptive implant migration to the pulmonary vasculature: A case report 皮下避孕植入物迁移至肺血管：1例报告

IF 0.6

Case Reports in Women's Health Pub Date : 2026-03-01 Epub Date: 2026-01-05 DOI: 10.1016/j.crwh.2026.e00782

Alejandra Tellez Aguilera , Maria Fernanda Zalapa Gómez , Eliana López Zamora , Fernanda Isabel Velázquez Vega , Rogelio A. Lozano Esparza , Victor Sánchez Sotelo , Jorge Aguilar Castillo , José Carlos Alberto Martínez Ramírez

{"title":"Subdermal contraceptive implant migration to the pulmonary vasculature: A case report","authors":"Alejandra Tellez Aguilera , Maria Fernanda Zalapa Gómez , Eliana López Zamora , Fernanda Isabel Velázquez Vega , Rogelio A. Lozano Esparza , Victor Sánchez Sotelo , Jorge Aguilar Castillo , José Carlos Alberto Martínez Ramírez","doi":"10.1016/j.crwh.2026.e00782","DOIUrl":"10.1016/j.crwh.2026.e00782","url":null,"abstract":"<div><div>Subdermal implants are highly effective long-acting reversible contraceptives. Rarely, they may migrate intravascularly. This report concerns the case of a 22-year-old woman who presented for removal of a non-palpable etonogestrel implant. Imaging revealed migration to the pulmonary vasculature. Surgical consultation confirmed intravascular embolization to the basal anterior segmental artery of the left lower lobe. Extraction of the implant was performed without complications. Subdermal contraceptive implant embolization into the pulmonary vasculature is an emerging iatrogenic complication. The clinical relevance of this complication lies not only in its potential for pulmonary damage but also in its diagnostic challenge and management complexity. While endovascular retrieval should be considered the first-line approach, especially in cases detected early, in the present case this was not feasible due to endothelialization; thoracotomy ensured safe removal. Pulmonary migration of contraceptive implants is rare but potentially serious. Delayed diagnosis may preclude endovascular removal.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"49 ","pages":"Article e00782"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145921264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complete hydatidiform mole with coexisting fetus: A case report 完全性葡萄胎伴胎儿1例

IF 0.6

Case Reports in Women's Health Pub Date : 2026-03-01 Epub Date: 2025-11-29 DOI: 10.1016/j.crwh.2025.e00770

Yuanhua Xiang, Wei Zhang, Dongmin Chen, Ting Luo

{"title":"Complete hydatidiform mole with coexisting fetus: A case report","authors":"Yuanhua Xiang, Wei Zhang, Dongmin Chen, Ting Luo","doi":"10.1016/j.crwh.2025.e00770","DOIUrl":"10.1016/j.crwh.2025.e00770","url":null,"abstract":"<div><div>Complete hydatidiform mole with coexisting fetus (CHMCF) is an exceptionally rare and clinically challenging obstetric condition. Its diagnosis and management require a high index of suspicion and a multidisciplinary approach. This report presents the case of a woman in her 30s who presented for a routine prenatal examination at 15 weeks of gestation. Ultrasonography revealed a placenta with a mixed echogenicity area exhibiting a characteristic honeycomb-like appearance, alongside a coexisting viable fetus with normal biometry. Serum β-human chorionic gonadotropin (β-hCG) was markedly elevated at 259,762 mIU/mL. Through serial monitoring and multidisciplinary consultation, a diagnosis of CHMCF was suspected and later confirmed by postnatal genetic analysis. The pregnancy was complicated by persistent vaginal bleeding at 21 weeks, leading to termination following a comprehensive risk-benefit assessment. This case underscores the diagnostic challenges, the critical role of cytogenetic analysis, the importance of patient counseling regarding the significantly elevated risks of obstetric complications and gestational trophoblastic neoplasia (GTN), and the necessity for meticulous post-evacuation surveillance. This report aims to enhance clinical awareness and outline a structured management protocol for this rare entity.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"49 ","pages":"Article e00770"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145658696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in detection and treatment of maternal sepsis 产妇败血症的检测与治疗进展

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Case Reports in Women's Health Pub Date : 2025-12-01 Epub Date: 2025-09-19 DOI: 10.1016/j.crwh.2025.e00751

Michael J. Fassett

引用次数: 0

Malignant uterine/broad-ligament perivascular epithelioid cell tumor (PEComa) coexisting with leiomyoma in a postmenopausal woman: A case report 恶性子宫/宽韧带血管周围上皮样细胞瘤（PEComa）并发平滑肌瘤1例

IF 0.6

Case Reports in Women's Health Pub Date : 2025-12-01 Epub Date: 2025-11-15 DOI: 10.1016/j.crwh.2025.e00767

Derar I.I. Ismerat , Barah K.S. Alsalameh , Majd Oweidat , Karam M. Hmidat , Areen Sulaiman , Yara Atawneh , Baraa Z. Zawahra , Izzeddin A. Bakri , Hani Hour

{"title":"Malignant uterine/broad-ligament perivascular epithelioid cell tumor (PEComa) coexisting with leiomyoma in a postmenopausal woman: A case report","authors":"Derar I.I. Ismerat , Barah K.S. Alsalameh , Majd Oweidat , Karam M. Hmidat , Areen Sulaiman , Yara Atawneh , Baraa Z. Zawahra , Izzeddin A. Bakri , Hani Hour","doi":"10.1016/j.crwh.2025.e00767","DOIUrl":"10.1016/j.crwh.2025.e00767","url":null,"abstract":"<div><div>Perivascular epithelioid cell tumor of the uterus is a rare mesenchymal neoplasm with variable malignant potential and nonspecific clinical and radiologic features, often mistaken preoperatively for leiomyoma. This report describes the case of a postmenopausal woman with seven months of persistent postmenopausal bleeding, pelvic pain, and symptomatic anemia. Pelvic ultrasound and magnetic resonance imaging demonstrated a markedly enlarged, irregular uterus with multiple masses interpreted as fibroids. The patient underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy for refractory bleeding and concern for occult malignancy. Histopathological examination revealed coexisting benign leiomyomas and a malignant perivascular epithelioid cell tumor involving the uterine wall with extension into the broad ligament. The tumor showed epithelioid morphology with brisk mitotic activity, necrosis, and dual myomelanocytic differentiation on immunohistochemistry (HMB-45 and desmin positive). Whole-body positron emission tomography demonstrated no metastatic disease. Complete resection followed by adjuvant radiotherapy was associated with resolution of bleeding and pain. This case highlights that malignant uterine perivascular epithelioid cell tumor can mimic benign leiomyoma, may coexist with a true leiomyoma, and should be considered in women with persistent postmenopausal bleeding and an enlarged fibroid-appearing uterus.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"48 ","pages":"Article e00767"},"PeriodicalIF":0.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145575908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges in managing cervical cancer in pregnancy: Three case reports 妊娠期宫颈癌管理的挑战：三例报告

IF 0.6

Case Reports in Women's Health Pub Date : 2025-12-01 Epub Date: 2025-11-09 DOI: 10.1016/j.crwh.2025.e00765

Katie Crabb , Janet Okwesa , Jason K.W. Yap , Fong Lien Kwong

{"title":"Challenges in managing cervical cancer in pregnancy: Three case reports","authors":"Katie Crabb , Janet Okwesa , Jason K.W. Yap , Fong Lien Kwong","doi":"10.1016/j.crwh.2025.e00765","DOIUrl":"10.1016/j.crwh.2025.e00765","url":null,"abstract":"<div><div>Cervical cancer in pregnancy is a rare but increasingly recognised condition, affecting approximately 0.1–12.0 per 10,000 pregnancies annually. Symptoms such as vaginal bleeding, discharge, dyspareunia, and pelvic pain may overlap with normal pregnancy-related changes, often leading to delayed diagnosis. Speculum and bimanual examination is essential in pregnant women presenting with vaginal bleeding. Urgent colposcopy referral (for example, in the UK through the two-week wait pathway) is essential. Management strategies depend on cancer stage, gestational age, and patient preferences. Options include pregnancy termination with immediate treatment or consideration of neoadjuvant chemotherapy during pregnancy in women who wish to postpone definitive therapies until after delivery. Pelvic lymphadenectomy for staging is considered safe prior to 22 weeks of gestation. Neoadjuvant chemotherapy is contraindicated in the first trimester but may be administered safely later in pregnancy. Serial magnetic resonance imaging is valuable for monitoring tumour progression and informing treatment plans. This case series highlights the clinical and ethical complexities in managing cervical cancer in pregnancy and underscores the importance of specialist, multidisciplinary, and individualised care. Further research is necessary to develop standardised, evidence-based guidelines for this challenging clinical scenario.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"48 ","pages":"Article e00765"},"PeriodicalIF":0.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145690800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal diagnosis and management of high-grade cervical neuroendocrine carcinoma: A case report 高级别宫颈神经内分泌癌的产前诊断和治疗1例

IF 0.6

Case Reports in Women's Health Pub Date : 2025-12-01 Epub Date: 2025-10-25 DOI: 10.1016/j.crwh.2025.e00760

Juan Sebastián Jiménez Rodríguez , Jairo Alonso Hernández , Paula Andrea Gallego , Carlos David Ramos Sarmiento

{"title":"Prenatal diagnosis and management of high-grade cervical neuroendocrine carcinoma: A case report","authors":"Juan Sebastián Jiménez Rodríguez , Jairo Alonso Hernández , Paula Andrea Gallego , Carlos David Ramos Sarmiento","doi":"10.1016/j.crwh.2025.e00760","DOIUrl":"10.1016/j.crwh.2025.e00760","url":null,"abstract":"<div><div>High-grade neuroendocrine carcinoma of the cervix is a rare and aggressive malignancy, accounting for less than 2 % of all cervical cancers. Its occurrence during pregnancy is exceptional, with only 21 cases reported in the literature to date. This report presents the case of a 25-year-old primigravida diagnosed at 29.5 weeks of gestation with a high-grade small cell neuroendocrine carcinoma of the cervix, confirmed by histopathology and immunohistochemistry. The patient was initially managed conservatively, but tumor progression prompted delivery by cesarean section at 31 weeks, followed by immediate modified radical hysterectomy, bilateral pelvic lymphadenectomy, and partial omentectomy. Adjuvant chemotherapy with cisplatin and etoposide was administered. Pathological evaluation confirmed the diagnosis, with no lymph node or omental metastases. A comprehensive review of the literature identified 21 similar cases, highlighting the lack of standardized treatment protocols for this population. Multidisciplinary coordination was essential for balancing maternal oncologic priorities with fetal outcomes. This case contributes to the limited data on neuroendocrine cervical carcinoma in pregnancy and reinforces the importance of individualized, team-based management.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"48 ","pages":"Article e00760"},"PeriodicalIF":0.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute cardiovascular complications of pregnancy 妊娠期急性心血管并发症

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Case Reports in Women's Health Pub Date : 2025-12-01 Epub Date: 2025-09-10 DOI: 10.1016/j.crwh.2025.e00748

Jana Karam , Chrisandra Shufelt

引用次数: 0

Gestational trophoblastic disease-induced thyroid storm: A case report 妊娠滋养层病致甲状腺风暴1例

IF 0.6

Case Reports in Women's Health Pub Date : 2025-12-01 Epub Date: 2025-11-29 DOI: 10.1016/j.crwh.2025.e00771

Abera Wondie Gizaw , Suleiman Ayalew Belay , Abilo Tadesse , Yohannes Kenaw Babu , Girma Damtew Adisu , Yilkal Yehuala , Segenet Bizuneh Mengistu

{"title":"Gestational trophoblastic disease-induced thyroid storm: A case report","authors":"Abera Wondie Gizaw , Suleiman Ayalew Belay , Abilo Tadesse , Yohannes Kenaw Babu , Girma Damtew Adisu , Yilkal Yehuala , Segenet Bizuneh Mengistu","doi":"10.1016/j.crwh.2025.e00771","DOIUrl":"10.1016/j.crwh.2025.e00771","url":null,"abstract":"<div><div>Gestational trophoblastic disease describes tumors caused by abnormal proliferation of trophoblastic tissue. A rare but potentially fatal complication is thyroid storm, which results from excessive thyroid hormone secretion stimulated by high levels of beta-human chorionic gonadotropin.</div><div>A 28-year-old woman (gravida 4, para 1, with two prior miscarriages) presented with vaginal bleeding, abdominal pain, vomiting, palpitations, dyspnea, and an enlarging neck swelling. Examination revealed hypertension, tachycardia, hypoxia, an enlarged thyroid gland, pulmonary crackles, elevated jugular venous pressure, and a holosystolic murmur. The uterus was consistent with a 20-week gestation and was actively bleeding. The patient was confused and agitated without focal neurological deficits. Laboratory evaluation showed anemia, abnormal liver function, suppressed thyroid-stimulating hormone, and markedly elevated beta-human chorionic gonadotropin. Imaging demonstrated the classic “snowstorm” appearance of a molar pregnancy, which was confirmed by histopathology. The Burch-Wartofsky score supported the diagnosis of thyroid storm. She received anti-thyroid treatment and underwent uterine evacuation. Nine weeks after discharge, her hormone levels had normalized and serum beta-human chorionic gonadotropin was undetectable.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"48 ","pages":"Article e00771"},"PeriodicalIF":0.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145690801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0