{"title":"Vaginal polypoid endometriosis in a woman in her 30s with advanced pelvic endometriosis: A case report and literature review","authors":"Vishal Bahall, Lance De Barry","doi":"10.1016/j.crwh.2025.e00768","DOIUrl":"10.1016/j.crwh.2025.e00768","url":null,"abstract":"<div><div>Polypoid endometriosis is a remarkably rare variant of endometriosis that may clinically and morphologically mimic benign or malignant neoplasms. Vaginal involvement is particularly uncommon and can pose diagnostic challenges due to its atypical presentation. Recognition of this clinical entity is crucial, especially in women with advanced pelvic endometriosis and a history of abnormal vaginal bleeding.</div><div>This report concerns the case of a 36-year-old woman with a known history of stage IV endometriosis who presented with intermenstrual bleeding, postcoital bleeding, secondary infertility and chronic abdominal pain. Clinical assessment revealed a left-sided mass arising from pelvis and multiple polypoid masses that was just visible posterior to cervix. Pelvic ultrasonography revealed bilateral endometriomas and an endometrial polyp. She was scheduled for laparoscopic cystectomy, hysteroscopic polypectomy and removal of polypoid vaginal polyp. Excisional biopsy of the lesion demonstrated endometrial glands and stroma within fibrotic tissue consistent with vaginal polypoid endometriosis.</div><div>This case adds to the limited body of literature describing polypoid endometriosis of the vagina. It underscores the importance of careful, individualized decision-making for treatment, particularly for young women desirous of fertility preservation.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"48 ","pages":"Article e00768"},"PeriodicalIF":0.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145620405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Salmonella-induced ovarian abscess developing in bilateral ovarian endometriomas: A case report","authors":"Eriko Iito, Lifa Lee, Tomohito Kobiyama, Naho Tokunaga, Koki Yagi, Mao Sekimata, Naoki Abe, Sachino Kira, Sotaro Hayashi, Masamitsu Kurakazu, Satoshi Nishiyama, Hiroshi Tsujioka","doi":"10.1016/j.crwh.2025.e00758","DOIUrl":"10.1016/j.crwh.2025.e00758","url":null,"abstract":"<div><div><em>Salmonella</em> species are common causes of foodborne illnesses, typically resulting in self-limiting gastroenteritis. In rare cases, however, they can cause extraintestinal infections, including pelvic infections. This report concerns a rare case of <em>Salmonella</em> infection of bilateral ovarian endometriomas. A 29-year-old nulligravid woman with known bilateral ovarian endometriomas presented with persistent fever and lower abdominal pain, following symptoms of diarrhea. Computed tomography on admission showed moderate ascites and increased density of mesenteric fat, suggestive of peritonitis. Her symptoms and inflammatory markers persisted, despite 5 days of empirical antibiotic therapy for pelvic inflammatory disease (intravenous ceftriaxone 1 g/day, clindamycin 2400 mg/day, and oral doxycycline 200 mg/day). Repeat computed tomography showed worsening peritonitis and a new right-sided pleural effusion, prompting surgical intervention. Laparotomy revealed purulent material within both endometriomas and cultures confirmed <em>Salmonella</em> infection. Detailed history-taking indicated that the patient had ingested raw eggs before symptom onset. The patient made a full recovery after surgery and tailored antibiotic therapy adjusted according to the susceptibility. This case highlights the importance of considering <em>Salmonella</em> as a rare cause of tubo-ovarian abscess, especially in patients with a history of dietary exposure and pre-existing endometriomas. Prompt surgical drainage and appropriate antibiotic therapy are key to preventing complications and preserving fertility.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"48 ","pages":"Article e00758"},"PeriodicalIF":0.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145424595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rachel Watkin , Kalen Hubbs , Michael Clark , Shannon Wood
{"title":"Female genital tuberculosis in an infertility patient resulting in destruction of ovarian tissue: A case report","authors":"Rachel Watkin , Kalen Hubbs , Michael Clark , Shannon Wood","doi":"10.1016/j.crwh.2025.e00749","DOIUrl":"10.1016/j.crwh.2025.e00749","url":null,"abstract":"<div><div>Female genital tuberculosis is an important cause of infertility in endemic regions; it most often affects the fallopian tubes and uterine endometrium, though involvement of the ovaries, cervix, and vagina/vulva have also been reported.</div><div>This report concerns the case of a 30-year-old nulligravid woman who presented for evaluation following discovery of a right adnexal mass in the setting of right-sided abdominal pain. On initial evaluation, the patient also reported a history of secondary amenorrhea and the inability to conceive for six months. Laparoscopic and hysteroscopic findings were concerning for extensive adhesive disease resulting in loss of normal fallopian tube and uterine architecture, as well as complete obliteration of the right ovary. Ultimately, the patient's history and surgical findings were highly suggestive of female genital tuberculosis with sequelae resulting in diffuse pelvic organ disease. An endometrial biopsy confirmed the diagnosis with a positive tuberculosis PCR and acid-fast bacillus culture.</div><div>This case highlights the importance in considering female genital tuberculosis in the workup of infertility, the obstacles to definitive diagnosis, and the detrimental impact longstanding disease can have on pelvic organ function. Additionally, the loss of normal ovarian tissue in this patient may provide a pathophysiologic basis for the previously established association between diminished ovarian reserve and female genital tuberculosis.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"48 ","pages":"Article e00749"},"PeriodicalIF":0.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Peritoneal inclusion cyst presenting as a rectocele after sacrohysteropexy: A case report","authors":"Kasra Akbari , Mansooreh Yaraghi","doi":"10.1016/j.crwh.2025.e00756","DOIUrl":"10.1016/j.crwh.2025.e00756","url":null,"abstract":"<div><div>Peritoneal inclusion cysts (PICs) are mesothelial-lined cystic lesions that usually arise in reproductive-aged women after prior pelvic or abdominal surgery. Their diagnosis is often difficult, as they can mimic ovarian tumors or malignant pelvic masses. There are very few reports of PICs following pelvic reconstructive surgery. This report concerns the case of a 40-year-old nulliparous woman with a history of open sacrohysteropexy for stage IV pelvic organ prolapse who presented with progressive left lower quadrant pain and a vaginal bulge. Imaging revealed a large multilocular retroperitoneal cyst enveloping the left ovary and extending into the rectovaginal septum. Tumor markers were within normal limits. Due to the cyst's proximity to the bowel, ureter, and major vessels, and to avoid mesh erosion, a vaginal surgical approach was selected. Approximately 300 mL of serous fluid was drained, the cyst wall was excised under rectal guidance, and marsupialization was performed to the vaginal mucosa. Histopathology confirmed a benign mesothelial-lined cyst. At one-year follow-up, the patient remained asymptomatic with no recurrence evident on imaging. This is seemingly the first reported case of a retroperitoneal PIC following sacrohysteropexy. The case underscores the diagnostic challenges posed by PICs and highlights the role of individualized, minimally invasive management. Clinicians should maintain a high index of suspicion for PICs when evaluating postoperative pelvic or vaginal masses, particularly when imaging suggests a cystic lesion.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"48 ","pages":"Article e00756"},"PeriodicalIF":0.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145333856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ultrasound-guided caesarean section as a safer intraoperative strategy for vasa previa type III: A case report","authors":"Stefania Carlucci , Guglielmo Stabile , Teresa Silvestris , Letizia Iagnemma , Davide Maizzi , Antongiulio Del Bianco , Stefano Bettocchi","doi":"10.1016/j.crwh.2025.e00755","DOIUrl":"10.1016/j.crwh.2025.e00755","url":null,"abstract":"<div><div>Vasa previa refers to the presence of chorionic vessels (arterial or venous) unprotected by Wharton's jelly, traversing the membranes over or near the internal cervical orifice. If diagnosed prenatally, the condition has a survival rate of up to 97 %. Ultrasound has proven to be a useful diagnostic tool, although its use for general population screening remains a topic of debate. In addition to its diagnostic applications, ultrasound may serve as a valuable intraoperative aid during complex caesarean sections, particularly in high-risk cases such as pregnancies complicated by vasa previa, by contributing to safer and more precise surgical management. The present report concerns a case of type III vasa previa in a patient with three previous caesarean sections, where mapping of the fetal vessels was challenging due to the cephalic presentation during labor. During the caesarean section, ultrasound evaluation of the anterior uterine wall allowed the surgeon to select the best approach for the hysterotomy. Standardizing the intraoperative transuterine ultrasound approach could provide valuable guidance in selecting the most appropriate uterine incision, thereby enhancing surgical safety and promoting both maternal and fetal well-being.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"48 ","pages":"Article e00755"},"PeriodicalIF":0.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Maternal collapse in pregnancy: evolving aetiology and healthcare system response","authors":"Danny Tucker , Melissa Freestun","doi":"10.1016/j.crwh.2025.e00750","DOIUrl":"10.1016/j.crwh.2025.e00750","url":null,"abstract":"","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"48 ","pages":"Article e00750"},"PeriodicalIF":0.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145796994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Idiopathic ovarian vein thrombosis in a nonpregnant premenopausal woman in her 40s: A case report","authors":"Ibrahim Hersi, Lubabah Al-Ani, Mehtab Shah, Mohamed Elmezaien, Rehmani Jawad, Olumide Ofinran","doi":"10.1016/j.crwh.2025.e00769","DOIUrl":"10.1016/j.crwh.2025.e00769","url":null,"abstract":"<div><div>Ovarian vein thrombosis (OVT) is a rare and often underdiagnosed condition, most frequently associated with pregnancy, infection, malignancy, or recent surgery. Idiopathic OVT (i.e. that occurring in the absence of identifiable risk factors) is exceedingly uncommon and can easily be overlooked due to its non-specific presentation. This article reports the case of a 40-year-old multiparous woman who presented with a 6-day history of severe left-sided lower abdominal pain associated with fever and nausea. Clinical examination demonstrated left iliac fossa tenderness without palpable adnexal masses. Contrast-enhanced computed tomography (CT) showed a bulky left ovary and left ovarian vein, initially reported as suggestive of left adnexal torsion. Given the presumed diagnosis, diagnostic laparoscopy was undertaken and revealed a thrombosed left ovarian ligament without torsion, leading to left partial salpingectomy. Postoperatively, the final CT report concluded that the appearances were highly suggestive of left ovarian vein thrombosis. The patient was commenced on anticoagulation following haematology consultation. This case demonstrates that OVT may arise in the absence of known risk factors and highlights the diagnostic challenges when it mimics more common acute pelvic pathologies. Careful radiological review, multidisciplinary involvement, and a high index of suspicion are essential to avoid unnecessary surgical intervention and ensure timely anticoagulation in stable patients.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"48 ","pages":"Article e00769"},"PeriodicalIF":0.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145690802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Post-colpocleisis pyocolpos: Three case reports","authors":"Kasra Akbari , Mansooreh Yaraghi","doi":"10.1016/j.crwh.2025.e00761","DOIUrl":"10.1016/j.crwh.2025.e00761","url":null,"abstract":"<div><div>Colpocleisis is a procedure to safely manage advanced pelvic organ prolapse, particularly in older individuals and those who are medically compromised. An exceptionally uncommon and underreported infection-related complication following colpocleisis is postoperative pelvic abscess. This case series describes the clinical presentation and diagnostic challenges, along with the management approaches of this unusual complication. Three women in their early 70s, with prior comorbidities, developed pelvic abscesses 10–15 days after colpocleisis. All three presented with systemic inflammatory signs, including fever, leukocytosis, and elevated inflammatory markers. One of the women also developed a concurrent urinary tract infection. Diagnosis was confirmed by transperineal ultrasonography and contrast-enhanced computed tomography. Management involved surgical drainage through colpotomy with reopening of the obliterated vaginal canal. Purulent material was thoroughly evacuated. Cultures of abscesses revealed polymicrobial infections in all cases. One patient with septic shock had an additional positive bloodstream culture.</div><div>Pyocolpos is an uncommon yet serious infectious complication following colpocleisis that is more commonly observed as a consequence of post-hysterectomy vaginal cuff hematoma. Clinicians should be extremely cautious when examining postoperative febrile patients, even when common illnesses such as urinary tract infections are present. In this case series, surgical drainage and tailored antibiotic therapy resulted in full remission of all three patients without compromising prolapse repair or triggering recurrence. Future studies are required to guide the best course of management.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"48 ","pages":"Article e00761"},"PeriodicalIF":0.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Caterina Iaquinta, Ginevra Guarrera, Caterina De Luca, Carmela Votino, Alessandro Svelato, Fulvio Zullo, Roberta Venturella
{"title":"Interstitial pregnancy after frozen embryo transfer in a woman with prior bilateral salpingectomy: A case report and literature review","authors":"Caterina Iaquinta, Ginevra Guarrera, Caterina De Luca, Carmela Votino, Alessandro Svelato, Fulvio Zullo, Roberta Venturella","doi":"10.1016/j.crwh.2025.e00753","DOIUrl":"10.1016/j.crwh.2025.e00753","url":null,"abstract":"<div><div>We describe a rare case of interstitial pregnancy following frozen embryo transfer in a woman with previous bilateral salpingectomy. The 33-year-old patient with a history of recurrent early pregnancy loss conceived after in vitro fertilization. Transvaginal ultrasound revealed a gestational sac with cardiac activity implanted in the interstitial portion of the left uterine cornua, surrounded by a thin myometrial mantle. Medical management with methotrexate was unsuccessful, and serum human chorionic gonadotropin levels continued to rise. The patient underwent laparoscopic cornual wedge resection using local infiltration, monopolar resection, and double-layer closure. The procedure was completed with minimal blood loss, an uneventful postoperative course, and preservation of uterine integrity and future fertility potential. The patient was discharged on the second postoperative day, and follow-up confirmed a steady decline in human chorionic gonadotropin levels. This case highlights that interstitial pregnancy may occur even after bilateral salpingectomy, underlining the importance of early ultrasound surveillance, timely surgical management, and preventive strategies such as complete cornual excision at salpingectomy and single embryo transfer to reduce risks and optimize reproductive outcomes.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"48 ","pages":"Article e00753"},"PeriodicalIF":0.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Heterotopic pregnancy following ovulation induction with clomiphene citrate therapy: A case report","authors":"Amanda Almeida , Adrianna Zambrano , Elizette Rodriguez , Vidhi Raval , Judith Vinod , Laura Molina , Heather Gabai Hernandez , Adrian Abreu","doi":"10.1016/j.crwh.2025.e00757","DOIUrl":"10.1016/j.crwh.2025.e00757","url":null,"abstract":"<div><div>A heterotopic pregnancy is a rare, life-threatening condition in which an intrauterine and ectopic pregnancy occur simultaneously. The incidence of these pregnancies is increasing as the use of assisted reproductive technology and ovulation-inducing agents becomes more common and accessible. A 31-year-old woman with polycystic ovarian syndrome conceived following clomiphene citrate-induced ovulation and was later diagnosed with a heterotopic pregnancy at 10 weeks 2 days of intrauterine gestation and 9 weeks 2 days of ectopic gestation by transvaginal ultrasound following painless vaginal bleeding and rectal pain. The ectopic pregnancy was managed surgically, and the intrauterine pregnancy progressed to a full-term vaginal delivery. This case calls attention to the importance of physicians maintaining a high index of suspicion for heterotopic pregnancy in patients undergoing ovulation induction, despite reassuring imaging and nonspecific symptoms.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"48 ","pages":"Article e00757"},"PeriodicalIF":0.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145333855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}