Lalani De Silva , Kaumadi Udeshika , Sinha De Silva , Priyani Amarathunga
{"title":"Russell body cervicitis: A case report and literature review highlighting diagnostic pitfalls","authors":"Lalani De Silva , Kaumadi Udeshika , Sinha De Silva , Priyani Amarathunga","doi":"10.1016/j.crwh.2025.e00707","DOIUrl":"10.1016/j.crwh.2025.e00707","url":null,"abstract":"<div><div>Russell bodies have been observed in various inflammatory and neoplastic conditions, although their presence in the female genital tract is rare, with fewer than ten documented cases of Russell body cervicitis. This case report appears to be the first of Russell body cervicitis identified during pregnancy. A 28-year-old woman, at 20 weeks of gestation, underwent a cervical polypectomy after a polyp was detected incidentally during a cervical cerclage procedure. Pathological examination revealed an inflamed endocervical polyp with predominant plasma cell infiltrate. Most of the plasma cells contained intracytoplasmic Russell bodies and there were some Mott cells. Immunohistochemical stains confirmed the polyclonal nature of the plasma cell infiltrate.</div><div>This report highlights the diagnostic challenges associated with Russell body cervicitis, given its rarity and histological resemblance to other inflammatory and neoplastic conditions. A review of the literature reveals that the few reported cases presented as a non-neoplastic process during reproductive age, with an uneventful follow-up. This report contributes to the limited knowledge of Russell body cervicitis, particularly in the context of pregnancy.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"46 ","pages":"Article e00707"},"PeriodicalIF":0.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isabella Charlotte Maréchal-Ross , Sashi Siva , Karen Mizia , Jeremy Nicholas Pulvers , Isabella Turton , Ali Moghimi
{"title":"Hemangioma of the umbilical cord: A case report and proposal for standardised reporting criteria","authors":"Isabella Charlotte Maréchal-Ross , Sashi Siva , Karen Mizia , Jeremy Nicholas Pulvers , Isabella Turton , Ali Moghimi","doi":"10.1016/j.crwh.2025.e00708","DOIUrl":"10.1016/j.crwh.2025.e00708","url":null,"abstract":"<div><div>Umbilical cord hemangiomas are rare benign vascular anomalies with limited documentation in the literature. Given their association with adverse perinatal outcomes, standardised criteria for reporting and monitoring are needed. This case report presents an instance of umbilical cord hemangioma and proposes a structured framework for future documentation.</div><div>A comprehensive literature review using OVID Medline and Embase identified cases of umbilical cord hemangiomas, their clinical presentations, and maternal and neonatal outcomes. A case diagnosed in the third trimester is presented, detailing antenatal surveillance, histopathological findings, and perinatal outcomes. Key parameters were analysed in the context of the literature to inform standardised reporting criteria.</div><div>A 36-year-old woman (G3P2) was diagnosed with an umbilical cord hemangioma at 29 + 3 weeks gestation following a routine growth scan. Serial ultrasound scans demonstrated lesion stability until 35 + 4 weeks, prompting increased fetal surveillance. Multidisciplinary consensus favoured expectant management, leading to an uncomplicated spontaneous vaginal delivery at 39 weeks. Histopathology confirmed a cord hemangioma composed of dilated, ectatic vascular channels lined by endothelial cells.</div><div>This case contributes to the growing body of evidence on umbilical cord hemangiomas by providing detailed clinical, ultrasound, and histopathological findings. Successful expectant management and favourable perinatal outcomes highlight the role of serial ultrasound surveillance. Given the rarity and potential risks of these lesions, standardised reporting is essential to improve understanding and to guide management. By proposing a set of standardised reporting criteria, this case report serves as a step toward enhancing data consistency and informing management strategies.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"46 ","pages":"Article e00708"},"PeriodicalIF":0.7,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Infliximab treatment for Cronkhite-Canada syndrome in pregnancy: A case report","authors":"Ayano Rosemary Nakamura , Shuji Yamamoto , Yoshitsugu Chigusa , Masaki Mandai , Haruta Mogami","doi":"10.1016/j.crwh.2025.e00706","DOIUrl":"10.1016/j.crwh.2025.e00706","url":null,"abstract":"<div><div>Cronkhite-Canada syndrome (CCS) is a rare nonhereditary disorder characterized by gastrointestinal polyps and protein-losing enteropathy. While an increasing number of CCS cases have been reported worldwide, no documented cases involving pregnant patients could be found. Consequently, optimal management strategies for CCS during the preconception period and pregnancy remain unclear., The present report concerns the case of a 36-year-old woman with steroid-refractory CCS stabilized with gastrointestinal surgeries and infliximab, an anti-tumor necrosis factor-α (TNF-α) agent, who became pregnant. Infliximab was continued throughout pregnancy and postpartum. Despite persistent hypoalbuminemia, sh delivered a healthy infant weighing 2518 g vaginally at 38 weeks and 2 days without CCS exacerbation. Both the patient and her infant experienced an uneventful postpartum course. This case suggests that maintaining disease control with anti-TNF-α therapy in pregnant patients with CCS may contribute to optimizing maternal and neonatal outcomes.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"46 ","pages":"Article e00706"},"PeriodicalIF":0.7,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Uterine rupture in labor after prior ultrasound-guided percutaneous microwave ablation of uterine fibroids: A case report","authors":"Yucui Zeng, Yanlan Wang, Xiaoyan Guang","doi":"10.1016/j.crwh.2025.e00702","DOIUrl":"10.1016/j.crwh.2025.e00702","url":null,"abstract":"<div><div>Ultrasound-guided percutaneous microwave ablation for the treatment of uterine fibroids has gained widespread clinical application due to its efficacy. However, reports on fertility outcomes and pregnancy complications following this treatment remain scarce. This report presents the case of a 31-year-old woman who underwent ultrasound-guided percutaneous microwave ablation for uterine fibroids. Regular postoperative follow-up revealed a significant reduction in the size of the uterine fibroids. Six months later, the patient successfully achieved natural conception, and her pregnancy progressed without any abnormalities. Given her strong preference for vaginal delivery, she was admitted to hospital at 40 weeks of gestation for monitoring when she began to exhibit signs of labor. However, uterine rupture occurred without any apparent warning during the labor. Following emergency surgical intervention, the neonate and the patient had a favorable outcome. This case underscores the efficacy of percutaneous microwave ablation for uterine fibroids but also emphasizes the need for postoperative follow-up to promptly identify any complications during the third trimester of pregnancy.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"46 ","pages":"Article e00702"},"PeriodicalIF":0.7,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Marginal resection preferred over radical resection for a large abdominal wall desmoid tumor during pregnancy: A case report","authors":"Riku Watanabe , Hiroki Shinmura , Yasuyuki Yokoyama , Takashi Matsushima","doi":"10.1016/j.crwh.2025.e00701","DOIUrl":"10.1016/j.crwh.2025.e00701","url":null,"abstract":"<div><div>Desmoid tumors are locally aggressive soft-tissue tumors known for their lack of metastatic potential but high recurrence rate after resection. Few cases of desmoid tumors during pregnancy have been reported, making treatment decisions more challenging.</div><div>This report presents the case of a woman with an abdominal wall desmoid tumor resected at 17 weeks of gestation. The large mass (13.4 cm × 7.4 cm) was compressing the uterus, which necessitated surgical intervention. Marginal resection of the tumor was performed with microscopically positive margins. The patient's postoperative course was uneventful, and she had a normal vaginal delivery at 38 weeks. No recurrence of the tumor was observed at 24-month follow-up. This case represents the largest pregnancy-related abdominal desmoid tumor (22 cm × 12 cm) resected marginally during pregnancy. The procedure allowed for a vaginal delivery rather than a cesarean section.</div><div>Surgical management of desmoid tumors in pregnancy should aim to remove the tumor while preserving function and anatomical integrity. While this approach is feasible for smaller tumors, larger tumors, as in this case, may result in loss of function and anatomical structure. This raises the question of whether marginal resection should be considered when preservation of function and structure is not feasible with radical resection. This case reinforces the fundamental surgical principle that when clear surgical margins cannot be achieved without compromising function and structure, marginal resection should be considered.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"46 ","pages":"Article e00701"},"PeriodicalIF":0.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Glanzmann's thrombasthenia in a twin pregnancy: A case report","authors":"Vicky X. Xu , Shaun P. Brennecke","doi":"10.1016/j.crwh.2025.e00697","DOIUrl":"10.1016/j.crwh.2025.e00697","url":null,"abstract":"<div><div>Glanzmann's thrombasthenia (GT) is a rare autosomal recessive bleeding disorder caused by deficient or defective integrin αIIbβ3 on platelets, leading to impaired platelet aggregation. Pregnancy in women with GT poses significant challenges due to the increased risk of bleeding antenatally, intrapartum, and postpartum, as well as potential complications for the neonate, such as neonatal alloimmune thrombocytopenia (NAIT). This case report details the contemporary, multidisciplinary management of a 35-year-old primigravid woman with a dichorionic, diamniotic twin pregnancy and GT which included an elective caesarean section under general anaesthesia performed at 36 + 5 weeks of gestation, with recombinant factor VIIa (NovoSeven) and tranexamic acid (TXA) treatment preoperatively and pre-emptive uterotonic administration intraoperatively to minimise haemorrhage. Postpartum management included a seven-week course of TXA. This case highlights the importance of a proactive, multidisciplinary care plan to optimize pregnancy outcomes in women with GT, with a focus on minimizing the risk of severe haemorrhage.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"46 ","pages":"Article e00697"},"PeriodicalIF":0.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vaginocutaneous fistula caused by recurrent labial abscess: A case report","authors":"Komkrit Aimjirakul, Teerapan Seehanantawong, Apisith Saraluck","doi":"10.1016/j.crwh.2025.e00698","DOIUrl":"10.1016/j.crwh.2025.e00698","url":null,"abstract":"<div><div>Urogenital fistulas are characterized by communication tracts that connect two surfaces or distinct organ systems. A vaginocutaneous fistula is a rare type of urogenital fistula that is characterized by persistent perineal discharge. This case report describes a female patient who suffered from recurrent labial abscesses and a fistula that connected the lower vagina to the inner thigh. There were symptoms of persistent perineal discharge, and the patient had an offensive odor. The patient had a history of six recurrent right labial abscesses over a period of two years prior to the formation of two fistulous openings. The right medial aspect of the inner thigh, adjacent to the labia majora, was found to have a 0.7 cm opening, which was confirmed by magnetic resonance imaging. Intraoperatively, the fistulous tract was readily delineated using dye. Complete fistulectomy was performed. This report highlights an unusual presentation of a urogenital fistula, the diagnostic challenges, and the management strategies. It emphasizes the need for timely identification and intervention in such cases.</div></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"46 ","pages":"Article e00698"},"PeriodicalIF":0.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Towards a greater understanding of uterine sarcomas","authors":"Raji Ganesan","doi":"10.1016/j.crwh.2025.e00683","DOIUrl":"10.1016/j.crwh.2025.e00683","url":null,"abstract":"","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":"45 ","pages":"Article e00683"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}