{"title":"Severe multivessel coronary heart disease in a young woman with familial hypercholesterolemia and congenital heart disease: A case report","authors":"","doi":"10.1016/j.crwh.2024.e00641","DOIUrl":"10.1016/j.crwh.2024.e00641","url":null,"abstract":"<div><p>The prevalence of premature atherosclerotic cardiovascular disease (ASCVD) ranges from 7% to 30%, but the incidence in young patients is increasing. Traditional risk factors, such as hypertension, hyperlipidemia, obesity, and diabetes, have an increasing prevalence in young patients and especially in young women. A 32-year-old woman presented with dyspnea and exertional chest pain. She had a history of familial hypercholesterolemia and unidentified aortic valve disease status after a pulmonary autograft at the age of 20. Due to insurance changes with the onset of the COVID-19 pandemic, she lost access to specialty care. She was not on any cholesterol-lowering agents prior to admission. An electrocardiogram demonstrated no ST changes with elevated high-sensitivity troponin-I concerning for non-ST elevation myocardial infarction. Laboratory data also revealed elevated LDL-C greater than 400. Due to concern for multivessel disease and complex anatomy, she underwent coronary computerized tomography angiography, which verified her multivessel coronary artery disease. An echocardiogram demonstrated a preserved ejection fraction and moderate aortic regurgitation. Her coronary artery bypass graft was deferred due to possible future valvular surgery. She underwent percutaneous coronary intervention with drug-eluting stents to left circumflex and left anterior descending arteries. Familial hypercholesterolemia is a prevalent but under-recognized and under-treated risk factor for premature ASCVD, which can be adequately identified through improved risk assessment and managed with aggressive combination anti-hyperlipidemia therapy.</p></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214911224000626/pdfft?md5=5a69bbc63a562ac15936dd6e6eb17556&pid=1-s2.0-S2214911224000626-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141841817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ewing sarcoma of the uterus: A case report","authors":"","doi":"10.1016/j.crwh.2024.e00640","DOIUrl":"10.1016/j.crwh.2024.e00640","url":null,"abstract":"<div><p>A case is described of Ewing sarcoma of the uterus, an atypical presentation of an already rare cancer.</p><p>A 55-year-old woman presented with abdominal pain, abnormal uterine bleeding and a uterine mass that measured 11 × 10 × 14.5 cm and demonstrated heterogeneous enhancement with possible areas of central necrosis, concerning for sarcoma. She had a complete surgical resection with total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy, bilateral pelvic lymph node dissection, and excision of mesenteric tumor implants. Her final pathology showed primary Ewing sarcoma-primitive neuroectodermal tumor of the uterus with metastatic spread to the peritoneal cavity. She finished 14 cycles of vincristine-doxyrubicin-cyclophosphamide–ifosfamide, etoposide chemotherapy with no evidence of recurrent metastatic disease at 6-month follow-up.</p><p>Ewing sarcoma is a rare cancer, predominantly seen in adolescents, that typically are of the bone, although in rare instances it can arise from soft tissue; even rarer are presentations in the female genital tract. Even with typical presentations of Ewing sarcoma of the bone, metastatic disease has an overall poor prognosis. The scarcity of cases of metastatic Ewing sarcoma–peripheral neuroendocrine tumors of the uterus makes the condition especially difficult to study. This report describes a case of Ewing sarcoma of the uterus treated by complete surgical resection and aggressive multimodal chemotherapy.</p></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214911224000614/pdfft?md5=03c8ef9cc292ce76540c022ba3ca18a6&pid=1-s2.0-S2214911224000614-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ovarian lymphangioma resected during abdominal hysterectomy: A case report","authors":"","doi":"10.1016/j.crwh.2024.e00639","DOIUrl":"10.1016/j.crwh.2024.e00639","url":null,"abstract":"<div><p>Ovarian lymphangioma, a rare pathologic finding, is an ovarian mass characterized by lymphatic tissue lined with endothelial cells. It is normally asymptomatic and may be found incidentally during abdominal surgery for other pathologies.</p><p>This report describes a case of a 49-year-old woman presenting to her primary care physician for three months of abdominal bloating and irregular menses. Magnetic resonance imaging revealed a 31 × 23 × 20 cm uterine mass suspected to be the cause of her symptoms. Total abdominal hysterectomy and bilateral salpingectomy were performed. During surgery, the right ovary was flattened and densely adhered to the body of the uterus, necessitating right oophorectomy. Pathology of the right ovary revealed flattened endothelial cells lining cystic spaces, consistent with the diagnosis of ovarian lymphangioma. Taken together, this case and the literature suggest that ovarian lymphangioma should be considered in the differential of ovarian masses, and their management shared more widely to help encourage the development of standard practice guidelines. There are no clear guidelines for when, and how often, to monitor these lesions after resection. In this case, the patient was seen at two-week and six-week follow-up visits with no new symptoms. Given that some case reports describe malignant transformation, patients should be followed this closely in the post-surgical period, and the best cadence for follow-up should be determined to improve outcomes.</p></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214911224000602/pdfft?md5=6467fd668bf402e293ba09c973f37050&pid=1-s2.0-S2214911224000602-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141852215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Laparoscopic bilateral salpingo-oophorectomy for recurrent ovarian endometriotic cysts in a woman taking adjuvant tamoxifen for breast cancer: A case report","authors":"","doi":"10.1016/j.crwh.2024.e00637","DOIUrl":"10.1016/j.crwh.2024.e00637","url":null,"abstract":"<div><p>The case report describes the management of endometriotic cysts in a woman taking adjuvant tamoxifen. A diagnosis of endometriosis was made at the age of 38, and the condition was initially managed with a low-dose estrogen-progestogen combination; the patient then switched to dienogest at the age of 45. Following a diagnosis of breast cancer at the age of 46, dienogest was stopped and adjuvant tamoxifen treatment started. After 4 months the patient was diagnosed with bilateral ovarian cysts and underwent laparoscopic bilateral salpingo-oophorectomy. Endometriosis was diagnosed in both ovaries on histopathological examination. This case report describes progression of endometriosis in a tamoxifen user.</p></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214911224000584/pdfft?md5=2546a5e728740a9e8502e664fe90e505&pid=1-s2.0-S2214911224000584-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141731875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Early recognition and mobilization of resources in managing amniotic fluid embolism for a high-risk obstetric patient: A case report","authors":"","doi":"10.1016/j.crwh.2024.e00634","DOIUrl":"10.1016/j.crwh.2024.e00634","url":null,"abstract":"<div><p>A 33-year-old woman, gravida 3 para 2, at 39 weeks of gestation, undergoing induction of labor, had a seizure. She was transferred to the operating room and underwent a cesarean delivery for non-reassuring fetal status. An amniotic fluid embolism (AFE) was suspected given her cardiovascular collapse, disseminated intravascular coagulation, and early right heart failure. Early mobilization of resources (e.g., blood bank, gynecology oncology, extracorporeal membrane oxygenation) was necessary as the hospital was in a stand-alone building. Biomarkers were sent during the acute event. The creation of an AFE order set is discussed.</p></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214911224000559/pdfft?md5=c11e9197559e4a662eb5b2532a2a8d42&pid=1-s2.0-S2214911224000559-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141698700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Management of gastrointestinal stromal tumor and acute appendicitis during pregnancy: A case report","authors":"","doi":"10.1016/j.crwh.2024.e00635","DOIUrl":"10.1016/j.crwh.2024.e00635","url":null,"abstract":"<div><p>Gastrointestinal stromal tumors (GISTs) are neoplasms of neural cells in the gastrointestinal tract; they typically develop in older adults, with less than 10% of cases presenting among patients under the age of 40. This report describes the clinical course and management of a 28-year-old woman with a history of irritable bowel syndrome (IBS) who presented with acute upper abdominal pain. Surgical pathology confirmed a diagnosis of metastatic GIST. The patient underwent imatinib therapy and subsequent surgical tumor debulking. Postoperatively, she presented with acute appendicitis, for which she eventually required appendectomy, and she became pregnant approximately 1 year after the initial diagnosis. This case highlights several treatment challenges that may be encountered in young patients presenting with GIST.</p></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214911224000560/pdfft?md5=94657d7ca351722d6ece6dbf9514ce1a&pid=1-s2.0-S2214911224000560-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141623634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kelly Devlin , Alexander Gross , Melina Flanagan , Krista Pfaendler
{"title":"Elevated lactate dehydrogenase – A red herring in the diagnosis of a sclerosing stromal tumor: A case report","authors":"Kelly Devlin , Alexander Gross , Melina Flanagan , Krista Pfaendler","doi":"10.1016/j.crwh.2024.e00633","DOIUrl":"https://doi.org/10.1016/j.crwh.2024.e00633","url":null,"abstract":"<div><p>Sclerosing stromal tumors are a rare type of ovarian tumor in the category of sex cord stromal tumors, which arise from the ovarian connective tissue. This report concerns a case of a sclerosing stromal tumor in a 19-year-old nulliparous woman who presented with the chief complaints of menstrual irregularities and dyspareunia. Preoperative imaging revealed a complex right adnexal mass with blood flow and without associated ascites. Tumor markers were all normal except lactate dehydrogenase, which was elevated. The elevated lactate dehydrogenase, in combination with patient age and menstrual irregularities, initially misdirected the clinicians toward suspicion for dysgerminoma or other malignant germ cell tumor of the ovary. Clinicians should beware of excluding the diagnosis of sex cord stromal tumor on the differential in a young person with an adnexal mass and elevated lactate dehydrogenase.</p></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214911224000547/pdfft?md5=c6cb1f77bae21d40a979e00153de0623&pid=1-s2.0-S2214911224000547-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141607564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Spontaneous conception in a 40-year-old woman after allogeneic stem cell transplant with active graft-versus-host disease: A case report","authors":"","doi":"10.1016/j.crwh.2024.e00636","DOIUrl":"10.1016/j.crwh.2024.e00636","url":null,"abstract":"<div><p>This article presents a case of spontaneous conception and live birth in a 40-year-old woman who had undergone gonadotoxic chemotherapy and allogenic stem cell transplant for relapsed acute myelogenous leukemia complicated by treatment-refractory graft-versus-host disease. The patient's follicle stimulating hormone level was 44.4 mIU/mL at age 38 and then decreased to 4.1 mIU/mL at age 41, suggesting ovarian recovery. Her graft-versus-host disease subjectively improved during pregnancy. She ultimately delivered a healthy neonate. This case demonstrates the potential for ovarian recovery after stem allogenic cell transplant in a patient of advanced reproductive age and provides insight into the limited knowledge about graft-versus-host disease in pregnancy. As survival after stem cell transplant continues to improve, understanding the downstream consequences of the treatment, including for fertility and pregnancy, is of growing importance.</p></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214911224000572/pdfft?md5=52ddfad11e645a12b519405c99fb579c&pid=1-s2.0-S2214911224000572-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141623641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christine Herforth , Laura Stevens , Philippe E. Zimmern
{"title":"Corona mortis injury during anterior vaginal wall suspension: A case report","authors":"Christine Herforth , Laura Stevens , Philippe E. Zimmern","doi":"10.1016/j.crwh.2024.e00632","DOIUrl":"https://doi.org/10.1016/j.crwh.2024.e00632","url":null,"abstract":"<div><p>The corona mortis is a variant vascular anastomosis that crosses behind the superior pubic ramus connecting the external and internal iliac vessels. Its location with respect to key landmarks in the retropubic space varies. This case demonstrates a life-threatening hemorrhage following an anterior vaginal wall suspension due to needle passer injury of the corona mortis successfully managed with endovascular embolization. Surgeons operating in the retropubic space need to be cognizant of this vascular variant and potential for significant bleeding when injured. Prompt vascular control either endovascularly or with open exploration is critical in preventing patient mortality.</p></div>","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214911224000535/pdfft?md5=7c4e972c483befe2d56081a206280f49&pid=1-s2.0-S2214911224000535-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Health after childbirth","authors":"","doi":"10.1016/j.crwh.2024.e00629","DOIUrl":"10.1016/j.crwh.2024.e00629","url":null,"abstract":"","PeriodicalId":9657,"journal":{"name":"Case Reports in Women's Health","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221491122400050X/pdfft?md5=44f874787e6b69ccec615aeb8e996056&pid=1-s2.0-S221491122400050X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142242675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}