Chronic inflammatory demyelinating polyneuropathy complicated by pre-eclampsia progressing to HELLP syndrome and pulmonary embolism: A case report

IF 0.6 Q4 OBSTETRICS & GYNECOLOGY

Case Reports in Women's Health Pub Date : 2025-07-26 DOI:10.1016/j.crwh.2025.e00737

Michael Herman , Alexandra Herman , Shruti Karanth , Jacquelyn Blackstone

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Abstract

Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune mediated peripheral neurologic disease characterized by symmetric, ascending progressive limb weakness and paresthesia. It is a rare and diagnostically challenging condition. Pregnancy-induced CIDP is especially rare, with few case series describing treatment courses, pregnancy outcomes and complications.

This report concerns a case of a 20-year-old primigravida with CIDP who was initially misdiagnosed with bilateral Bell's palsy. Symptoms progressively worsened to include ascending limb weakness, allodynia, urinary retention and fecal incontinence; she later met criteria for CIDP. Her pregnancy went on to be complicated by prolonged hospitalization and pre-eclampsia; after induction of intravenous immunoglobulin therapy, she developed acute pulmonary embolism and HELLP syndrome, and required emergent C-section delivery. The diagnosis, treatment and management of severe pregnancy complications associated with CIDP are described.

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慢性炎症性脱髓鞘多神经病变并发先兆子痫进展为HELLP综合征和肺栓塞1例报告

慢性炎症性脱髓鞘性多神经病变（CIDP）是一种自身免疫介导的周围神经疾病，其特征是对称的、上升的进行性肢体无力和感觉异常。这是一种罕见且具有诊断挑战性的疾病。妊娠引起的CIDP尤其罕见，很少有病例系列描述治疗过程，妊娠结局和并发症。本报告涉及一位20岁的初产妇，他最初被误诊为双侧贝尔氏麻痹。症状逐渐恶化，包括上升肢体无力、异常性疼痛、尿潴留和大便失禁；她后来达到了CIDP的标准。由于长期住院治疗和先兆子痫，她的怀孕变得更加复杂；经诱导静脉免疫球蛋白治疗后，患者出现急性肺栓塞和HELLP综合征，需要紧急剖腹产。诊断，治疗和管理的严重妊娠并发症与CIDP描述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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