Casopis lekaru ceskych最新文献_第5页

Lékové interakce - rizika u pacientů s polypragmazií. 药物相互作用--多发性瘫痪患者的风险。

Casopis lekaru ceskych Pub Date : 2024-01-01

Karolína Russ, Tereza Vaňková

{"title":"Lékové interakce - rizika u pacientů s polypragmazií.","authors":"Karolína Russ, Tereza Vaňková","doi":"","DOIUrl":"","url":null,"abstract":"Polypharmacy, a phenomenon of today's medicine, brings a great risk of drug interactions. Some of them can lead to serious side effects or treatment failure, knowledge in this field is dramatically developing. Pharmacokinetic drug interactions can occur not only when drugs are metabolized by the cytochrome P450 isoenzyme system, but also at the level of transporters, a number of which have already been described. In order to assess their clinical significance, it is necessary to orient oneself in the pharmacodynamics and pharmacokinetics of drugs, but also to consider other factors that will influence the impact of drug interactions. The physician should be familiar with commonly prescribed drugs with a high interaction potential, be aware of strong inducers and inhibitors of CYP450, as well as the possible influence of genetic polymorphism of some of its isoforms. However, one should not rely on the interpretation of drug interactions only using available interaction databases. No software is yet capable of evaluating interactions comprehensively and in the context of a specific patient, their health status and comorbidities. Also, the information available from clinical studies and observations needs to be properly understood and translated into real practice. Nowadays, it is a great advantage a doctor can consult with a clinical pharmacist or pharmacologist on the issue of drug interactions in a specific patient. This article summarizes the issue of drug interactions, focusing on the less intuitive ones, with examples from practice.","PeriodicalId":9645,"journal":{"name":"Casopis lekaru ceskych","volume":"163 1","pages":"9-17"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ancient sanctuary of Asclepius, god of medicine, on the island of Paros (Greece). 古代医神阿斯克勒庇俄斯的圣地，位于帕罗斯岛（希腊）。

Casopis lekaru ceskych Pub Date : 2024-01-01

Tomáš Alušík, Pavla Alušíková Dostalíková

{"title":"Ancient sanctuary of Asclepius, god of medicine, on the island of Paros (Greece).","authors":"Tomáš Alušík, Pavla Alušíková Dostalíková","doi":"","DOIUrl":"","url":null,"abstract":"Asclepius was the main healing deity of the Classical Antiquity. After his gradual establishment, his cult expanded throughout the Greek world, especially in the 5th and 4th centuries BC. Asclepius was worshipped in sacred precincts labelled asklepieia (singular asklepieion), which served both as religious sites and as medical facilities where the sick came for healing. One of the smaller asklepieia is located on the island of Paros in the Cyclades, on two terraces about 3 km southwest of the centre of Parikia. The site was partially excavated in 1898-1899 by the German archaeologist Otto Rubensohn (1867-1964) and incompletely published in 1902. Over the last few years, the authors have been working on a project to (re)identify all surviving finds based on original descriptions and original excavation documentation, and to better understand the healing practices at the site. From the 6th century BC at the latest, the cult of Apollo, a deity with certain healing powers, is attested here, who was succeeded by his mythological son Asclepius sometime between the end of the 5th and the beginning of the 4th centuries BC. During the 4th and probably also in the 3rd century BC, a large complex is built on both terraces, with a temple, retaining and enclosure walls, a specific circular structure, a building for pilgrims and the performance of healing sleep, an altar and 2 sacred healing springs. The site's greatest bloom occurred in the 4th to 2nd century BC and especially in the Roman period, in the 1st to 3rd centuries.","PeriodicalId":9645,"journal":{"name":"Casopis lekaru ceskych","volume":"163 6","pages":"250-258"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Searching for ways to survive cardiac arrest and extracorporeal oxygen therapy - ECPR. 寻找心脏骤停和体外氧疗（ECPR）存活的方法。

Casopis lekaru ceskych Pub Date : 2024-01-01

Jiří Knor

引用次数: 0

Questions and questionnaires about acute climacteric syndrome. 有关急性更年期综合征的问题和问卷。

Casopis lekaru ceskych Pub Date : 2024-01-01

Tomáš Fait, Vlasta Dvořáková

引用次数: 0

Zogala D. Artificial intelligence in medical imaging. Zogala D. 医学影像中的人工智能。

Casopis lekaru ceskych Pub Date : 2024-01-01

David Zogala

引用次数: 0

Changes in contraceptive behavior in Czechia. 捷克避孕行为的变化。

Casopis lekaru ceskych Pub Date : 2024-01-01

Jiřina Kocourková, Jitka Slabá, Bára Idlbeková

{"title":"Changes in contraceptive behavior in Czechia.","authors":"Jiřina Kocourková, Jitka Slabá, Bára Idlbeková","doi":"","DOIUrl":"","url":null,"abstract":"The rapid increase in the proportion of women using hormonal contraception in the 1990s was positively reflected in a rapid decline in the number of abortions. Czechia was unique not only among Eastern European countries, but also worldwide. At the same time the decline in the prevalence of hormonal contraception from a peak of almost 50 % in 2007 to 30 % in 2021 meant a slowing and gradual halt in the further decline in abortions. The results of the GGP 2020-2022 survey in Czechia showed that the lower use of hormonal contraception among women was only partly offset by the increased use of other reliable methods of protection against unintended pregnancy (e.g. condom use). The largest decline in the use of hormonal contraceptives in the form of the pill occurred among the youngest women aged 18-27 years, from 76 to 37 %, which was partly reflected in the more intensive use of condoms (an increase from 21 to 35% in the 18-27 age group), but is worrying, that this age group saw the largest increase in the use of less reliable methods (withdrawal from 11 to 22 % and an increase in the use of the barren days method from 1 to 6 %) and also the largest increase in the proportion of women using neither method (from 7 to 17 %). The lowest proportion of female hormonal pill users was found among female with higher education. However an important finding is that when less reliable methods are used, there is an effort to combine at least two methods. Women have a more important role in determining how to protect themselves from unintended pregnancy.","PeriodicalId":9645,"journal":{"name":"Casopis lekaru ceskych","volume":"162 7-8","pages":"307-313"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141562756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infertility problems in the context of reproductive ageing. 生殖老龄化背景下的不孕不育问题。

Casopis lekaru ceskych Pub Date : 2024-01-01

Anna Šťastná, Adéla Volejníková

引用次数: 0

Surgical and pharmacological treatment of childhood obesity. 儿童肥胖症的手术和药物治疗。

Casopis lekaru ceskych Pub Date : 2024-01-01

Jan Boženský, Bohuslav Procházka

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Intenzivní léčba závislosti na tabáku v Česku v letech 2010-2022. 2010-2022 年捷克共和国的烟草依赖强化治疗。

Casopis lekaru ceskych Pub Date : 2024-01-01

Kamila Zvolská, Miroslav Zvolský, Jolana Čady, Eva Králíková

{"title":"Intenzivní léčba závislosti na tabáku v Česku v letech 2010-2022.","authors":"Kamila Zvolská, Miroslav Zvolský, Jolana Čady, Eva Králíková","doi":"","DOIUrl":"","url":null,"abstract":"In the 10th version of the World Health Organization's International Classification of Diseases, tobacco dependence is a separate diagnostic unit, F17. As with other diseases, there are effective treatments - psychobehavioral interventions and pharmacotherapy to suppress withdrawal symptoms. The aim of this analysis was to evaluate the development of reporting of selected intensive tobacco dependence treatment interventions in the Czech Republic. Data provided by the National Register of Covered Health Services of the Institute of Health Information and Statistics of the Czech Republic for the period 2010-2022, with a distinction per county and anonymized per centers for tobacco dependence and trained physicians. Between 2010 and 2022, an average of 1094 initial intervention procedures were reported annually in the country, indicating the number of smokers treated, and 2584 control visits. The Centre for Tobacco Dependence of the General University Hospital in Prague had the largest share in the total reporting of 25501 procedures (average 35.5 %). Intensive treatment for tobacco dependence should be offered and available as treatment for other diseases. However, of the approximately two million smokers in the Czech Republic, only about 0.5 ‰ undergo it annually.","PeriodicalId":9645,"journal":{"name":"Casopis lekaru ceskych","volume":"163 1","pages":"44-48"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adipose tissue in the treatment of androgenic alopecia. 脂肪组织在雄激素性脱发治疗中的应用。

Casopis lekaru ceskych Pub Date : 2023-01-01

Athanasios J Stefanis

引用次数: 0