Case Reports in Psychiatry最新文献

Identification and Treatment of Catatonia Presenting as Agitation and Self Injury in an Adolescent With Rett Syndrome. 青少年Rett综合征中以躁动和自残为表现的紧张症的识别和治疗。

Case Reports in Psychiatry Pub Date : 2025-09-29 eCollection Date: 2025-01-01 DOI: 10.1155/crps/9715900

Asim Al-Omari, Sarah Mohiuddin

{"title":"Identification and Treatment of Catatonia Presenting as Agitation and Self Injury in an Adolescent With Rett Syndrome.","authors":"Asim Al-Omari, Sarah Mohiuddin","doi":"10.1155/crps/9715900","DOIUrl":"https://doi.org/10.1155/crps/9715900","url":null,"abstract":"Catatonia is a complex psychomotor syndrome associated with several psychiatric disorders, including schizophrenia and autism. It is also associated with neurologic conditions such as encephalitis and epilepsy. Catatonia has also been described in genetic syndromes such as Down Syndrome. Catatonia presents with two main subtypes. Retarded catatonia is characterized by stupor, immobility, mutism, rigidity, and withdrawal, as well as negativism, posturing, and echolalia/echopraxia. Excited catatonia is primarily characterized by psychomotor agitation and occasionally self-injurious behaviors. Though the pathophysiology of catatonia remains poorly understood, treatment with benzodiazepines is effective in many cases, with electroconvulsive therapy indicated in cases of poor response. Rett syndrome is an X-linked neurodevelopmental disease associated with mutations in methyl-CpG-binding protein 2 and is characterized by regression of spoken language and purposeful hand skills, gait abnormalities, and stereotyped hand movements. Herein we describe a case of catatonia associated with Rett syndrome in a 17-year-old female. Her presentation was notable for hyperactivity, impulsive behaviors, agitation, self-injurious behaviors, and aggression. The patient had limited response to multiple medication trials. Initially she had a positive response to treatment with lorazepam, with later waning efficacy despite dose escalation. The patient was admitted to the inpatient psychiatry and completed an index course of 13 ECT treatments followed by maintenance ECT, completing 30 treatments in total. Treatment resulted in significant improvements in self-injurious behaviors, agitation, and overall engagement. In conclusion, catatonia should be considered in individuals with Rett syndrome who present with agitation and self-injury to aid in overall symptom improvement and outcome.","PeriodicalId":9631,"journal":{"name":"Case Reports in Psychiatry","volume":"2025 ","pages":"9715900"},"PeriodicalIF":0.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12500369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three Episodes of Neuroleptic Malignant Syndrome With Risperidone: A Case Report and Literature Review. 利培酮致3例抗精神病药恶性综合征1例并文献复习。

Case Reports in Psychiatry Pub Date : 2025-09-11 eCollection Date: 2025-01-01 DOI: 10.1155/crps/6669246

Forouzan Elyasi, Solmaz Alaei, Fatemeh Heydari, Mehran Zarghami

{"title":"Three Episodes of Neuroleptic Malignant Syndrome With Risperidone: A Case Report and Literature Review.","authors":"Forouzan Elyasi, Solmaz Alaei, Fatemeh Heydari, Mehran Zarghami","doi":"10.1155/crps/6669246","DOIUrl":"10.1155/crps/6669246","url":null,"abstract":"Background: Neuroleptic malignant syndrome (NMS) is an idiosyncratic and life-threatening side effect that usually occurs in response to dopamine receptor antagonist medications. Despite increased awareness, the diagnosis of NMS remains challenging due to its wide differential diagnoses, which can lead to delayed treatment and increased mortality or premature reinitiation of the causative agent, culminating in recurrent NMS, a phenomenon with limited reports. This case presents a patient who experienced three episodes of NMS within 1 year, all triggered by risperidone. Case Presentation: A 58-year-old male patient with schizophrenia presented to the emergency department of a university hospital in Northern Iran, due to decreased consciousness, fever, and rigidity. Initial laboratory results showed elevated creatine phosphokinase (CPK) at 14,949 U/L. He had two previous episodes of rhabdomyolysis and hospitalization in the past year. Review of prior hospital records indicated treatment for rhabdomyolysis with symptoms consistent with NMS, without making this diagnosis. Conclusion: In any patient treated with dopaminergic drugs who suffer from mental status changes, muscle stiffness, high fever, and dysautonomia, especially who have complications such as rhabdomyolysis, kidney failure, seizures, leukocytosis, and increased CPK and lactate dehydrogenase (LDH), the possibility of NMS should be considered.","PeriodicalId":9631,"journal":{"name":"Case Reports in Psychiatry","volume":"2025 ","pages":"6669246"},"PeriodicalIF":0.0,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Othello Syndrome Induced by Dopamine Agonists in Parkinson's Disease: A Case Report. 多巴胺激动剂诱发帕金森病奥赛罗综合征1例报告。

Case Reports in Psychiatry Pub Date : 2025-09-05 eCollection Date: 2025-01-01 DOI: 10.1155/crps/8517387

Ghazi Uddin Ahmed, Haadi Uddin Ahmed, Ahmed Asad Raza, Abedin Samadi

{"title":"Othello Syndrome Induced by Dopamine Agonists in Parkinson's Disease: A Case Report.","authors":"Ghazi Uddin Ahmed, Haadi Uddin Ahmed, Ahmed Asad Raza, Abedin Samadi","doi":"10.1155/crps/8517387","DOIUrl":"10.1155/crps/8517387","url":null,"abstract":"Background: Othello syndrome (OS) is a rare psychiatric disorder characterized by delusional jealousy and unfounded suspicions of infidelity. It has been associated with neurological diseases such as Parkinson's disease (PD), particularly in patients receiving dopamine agonists (DAs). Case Presentation: A 69-year-old man with a longstanding diagnosis of PD developed OS after transitioning from levodopa/carbidopa to ropinirole due to intolerance. Six months after initiating ropinirole, the patient began experiencing intense, delusional beliefs regarding his wife's fidelity, despite no cognitive decline or psychiatric history. The delusional symptoms significantly strained his marital relationship. Clinical Findings and Diagnostic Assessment: Neurological examination remained consistent with PD, and no structural brain abnormalities were observed on magnetic resonance imaging (MRI). The temporal association between ropinirole use and symptom onset led to the diagnosis of ropinirole-induced OS. Ropinirole was gradually discontinued over 4 weeks, and quetiapine was introduced. The patient showed substantial improvement in psychiatric symptoms with resolution of delusional beliefs and restoration of spousal rapport. Conclusion: This case highlights the potential for DAs, including ropinirole, to induce OS in PD patients. Clinicians should remain vigilant for psychiatric side effects during PD treatment and consider timely intervention, including medication adjustment and antipsychotic therapy, to prevent severe psychosocial consequences.","PeriodicalId":9631,"journal":{"name":"Case Reports in Psychiatry","volume":"2025 ","pages":"8517387"},"PeriodicalIF":0.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12431818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delayed Posthypoxic Leukoencephalopathy in a Catatonic-Appearing Patient: A Case Report. 出现紧张性症状的迟发性后毒性脑白质病1例报告。

Case Reports in Psychiatry Pub Date : 2025-08-29 eCollection Date: 2025-01-01 DOI: 10.1155/crps/9978149

Meredith Bentley, Jordan Gaal, Janice Hostetter, Suzanne Holroyd, John Pickstone, Kelly Melvin

{"title":"Delayed Posthypoxic Leukoencephalopathy in a Catatonic-Appearing Patient: A Case Report.","authors":"Meredith Bentley, Jordan Gaal, Janice Hostetter, Suzanne Holroyd, John Pickstone, Kelly Melvin","doi":"10.1155/crps/9978149","DOIUrl":"10.1155/crps/9978149","url":null,"abstract":"Delayed posthypoxic leukoencephalopathy (DPHL) is a rare diagnosis that may present similarly to other more common neurological conditions, such as catatonia. While often seen with carbon-monoxide poisoning, it can also be due to anoxia due to other causes, such as drug overdose or cardiac arrest. Due to the delayed nature of its symptoms and overlap with other conditions, it can be initially misdiagnosed. We present a 50-year-old female patient with a history of depression who was found unresponsive, hypoxic, and febrile at her home for an unknown amount of time. The initial concern was for sepsis. Initial computed tomography (CT) of the head and magnetic resonance imaging (MRI) of the brain were normal. The patient had rhabdomyolysis with secondary renal failure, shock liver, and acute pancreatitis. Once medically stabilized, her cognition returned to a normal baseline. However, 10 days into her hospitalization, her mental state deteriorated, displaying symptoms of mutism, stupor, staring, decreased oral intake, and perseveration. Catatonia, secondary to a major depressive episode, was suspected. Lorazepam was titrated upward without result. Lack of response to lorazepam prompted a repeat brain MRI, revealing diffuse white matter changes in the frontal, temporal, parietal, and occipital lobes of both hemispheres. A diagnosis of DPHL was made. She was then started on carbidopa/levodopa 25/100 mg with improvement and was discharged to a rehabilitation facility.","PeriodicalId":9631,"journal":{"name":"Case Reports in Psychiatry","volume":"2025 ","pages":"9978149"},"PeriodicalIF":0.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ICD-11 Diagnosis of Body Integrity Dysphoria: A Case Report. ICD-11诊断身体完整性焦虑1例报告。

Case Reports in Psychiatry Pub Date : 2025-08-27 eCollection Date: 2025-01-01 DOI: 10.1155/crps/6022329

Jonathan Monk-Cunliffe, Jordan Lin, Anish Patel

{"title":"ICD-11 Diagnosis of Body Integrity Dysphoria: A Case Report.","authors":"Jonathan Monk-Cunliffe, Jordan Lin, Anish Patel","doi":"10.1155/crps/6022329","DOIUrl":"10.1155/crps/6022329","url":null,"abstract":"Background: Body integrity dysphoria (BID) is a rare disorder, in which individuals experience a persistent desire to become physically disabled, often through limb amputation. It is now included within the International Classification of Diseases 11th Revision (ICD-11), and this is one of the first case reports to describe the application of these new diagnostic criteria. This also raises the question of treatment pathways for individuals with the disorder, with recognition bringing legitimacy to patients' experience, and responsibility to professionals. Case Presentation: We describe the experience of a 50-year-old man with a long standing desire for his leg to be amputated. He described frustration with the support available, and shame associated with accessing this. After discussions in an online forum he caused dry ice burns to his leg, which resulted in a below-knee amputation. The patient was satisfied with this outcome. All the essential features of ICD-11 diagnostic requirements for BID were met, as well as a number of additional clinical features. Conclusions: New diagnostic criteria appeared both accurate and acceptable to our patient. This formal recognition of the diagnosis presents a new challenge to services about how best to support individuals, and whether there needs to be development of clinical guidance to support clinicians.","PeriodicalId":9631,"journal":{"name":"Case Reports in Psychiatry","volume":"2025 ","pages":"6022329"},"PeriodicalIF":0.0,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12408126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe Anemia From Vitamin B12 Deficiency Presenting With a Craving for Bleach Powder: An Odd Case of Pica. 严重贫血的维生素B12缺乏表现为渴望漂白粉：异食癖的一个奇怪的案例。

Case Reports in Psychiatry Pub Date : 2025-08-22 eCollection Date: 2025-01-01 DOI: 10.1155/crps/8779524

Emmanuel D Meram, Sesilia Kammo, Shea Repins, Gregory C Mahr

{"title":"Severe Anemia From Vitamin B12 Deficiency Presenting With a Craving for Bleach Powder: An Odd Case of Pica.","authors":"Emmanuel D Meram, Sesilia Kammo, Shea Repins, Gregory C Mahr","doi":"10.1155/crps/8779524","DOIUrl":"10.1155/crps/8779524","url":null,"abstract":"Pica, the ingestion of nonnutritive substances, represents a complex and poorly understood phenomenon. Although it is inherently a psychiatric condition, it has an intricate relationship with other psychiatric, physiological, and pathological states, suggesting a highly multifactorial etiology. Recognizing and addressing pica in acute settings is crucial, as it poses significant health risks for patients, including the potential of toxic ingestion. Our presentation highlights the case of a 36-year-old woman with a complex psychiatric history who presented to the emergency department (ED) with severe symptomatic anemia. Her anemia was found to be macrocytic and a result of autoimmune-induced vitamin B12 deficiency. Further inquiry uncovered that, prior to admission, the patient exhibited a craving for smelling bleach powder that progressed to mouthing the toxic substance for more than a month. This is the first report of a case of bleach craving in a patient with vitamin B12 deficiency absent coexisting iron-deficiency. This unique presentation underscores the importance of psychiatric consultations as a part of comprehensive clinical assessments in emergency medical settings. We also suggest that pica presentations may be nuanced and thus it is critical to understand the biopsychosocial factors driving this behavior and target interventions in the appropriate medical domains.","PeriodicalId":9631,"journal":{"name":"Case Reports in Psychiatry","volume":"2025 ","pages":"8779524"},"PeriodicalIF":0.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the Imposter: Deciphering Capgras Syndrome and Multidisciplinary Management. 超越冒名顶替者：解读Capgras综合征和多学科管理。

Case Reports in Psychiatry Pub Date : 2025-08-11 eCollection Date: 2025-01-01 DOI: 10.1155/crps/5541100

Manuel Glauco Carbone, Tommaso Merati, Rossella Miccichè, Camilla Callegari, Beniamino Tripodi, Claudia Tagliarini, Icro Maremmani, Donatella Marazziti

{"title":"Beyond the Imposter: Deciphering Capgras Syndrome and Multidisciplinary Management.","authors":"Manuel Glauco Carbone, Tommaso Merati, Rossella Miccichè, Camilla Callegari, Beniamino Tripodi, Claudia Tagliarini, Icro Maremmani, Donatella Marazziti","doi":"10.1155/crps/5541100","DOIUrl":"10.1155/crps/5541100","url":null,"abstract":"Capgras syndrome (CS) presents a unique diagnostic and management challenge, particularly when associated with neurodegenerative conditions. This case report describes a 73-year-old female diagnosed with Lewy body dementia (LBD) who developed CS, manifesting as the delusional belief that her deceased husband had been replaced by an imposter. The clinical presentation was complex, including pronounced sleep disturbances, cognitive decline, behavioral anomalies, and visual hallucinations, necessitating a thorough differential diagnosis process. We detail the patient's history, clinical findings, and the investigations undertaken, including brain imaging and cognitive assessments. The management approach involved a personalized treatment plan integrating Lithium sulfate, Citalopram, and Lurasidone, alongside psychosocial interventions. While a partial improvement was observed, the case underscores the complexities of managing CS in the context of LBD, highlighting the need for tailored and multidisciplinary approaches to care. This case contributes to the limited literature on CS in LBD and provides practical insights for clinicians managing similar presentations.","PeriodicalId":9631,"journal":{"name":"Case Reports in Psychiatry","volume":"2025 ","pages":"5541100"},"PeriodicalIF":0.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12360872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 12-Year Longitudinal Case Report: Integrating Schema Therapy and Prolonged Exposure in Delayed-Onset PTSD Following the Great East Japan Earthquake. 一项12年的纵向病例报告：整合图式疗法和长时间暴露治疗东日本大地震后的延迟性PTSD。

Case Reports in Psychiatry Pub Date : 2025-08-06 eCollection Date: 2025-01-01 DOI: 10.1155/crps/9195824

Arinobu Hori, Emiko Ando, Akihiko Ozaki, Michio Murakami, Masaharu Tsubokura, Fumiyo Oshima

{"title":"A 12-Year Longitudinal Case Report: Integrating Schema Therapy and Prolonged Exposure in Delayed-Onset PTSD Following the Great East Japan Earthquake.","authors":"Arinobu Hori, Emiko Ando, Akihiko Ozaki, Michio Murakami, Masaharu Tsubokura, Fumiyo Oshima","doi":"10.1155/crps/9195824","DOIUrl":"10.1155/crps/9195824","url":null,"abstract":"Objectives: This case study examined the long-term course and treatment of posttraumatic stress disorder (PTSD) following the 2011 Great East Japan Earthquake (GEJE) and nuclear disaster. Specifically, this study investigated the role of early maladaptive schemas (EMSs) and coping modes in symptom persistence, the interplay between physical health issues and PTSD symptoms, and the efficacy of a staged treatment approach. Methods: We present a 12-year longitudinal case study of a woman with delayed-onset PTSD. The patient underwent a staged treatment comprising supportive therapy, schema therapy, and prolonged exposure (PE) therapy. Treatment progress and symptom manifestations were qualitatively analyzed, focusing on schema modifications, coping mode changes, and trauma processing. Results: The key findings were: (1) EMSs (e.g., enmeshment and subjugation) contributed to PTSD symptom maintenance and influenced postdisaster interpersonal patterns; (2) maladaptive coping modes played a role in symptom persistence and delayed disease onset; (3) the observed cyclical pattern of symptom exacerbation was particularly evident in the anniversary effect; (4) the staged treatment approach effectively addressed complex PTSD, with schema therapy facilitating subsequent trauma-focused interventions. Conclusion: This study highlights the potential of combining schema therapy and PE to treat complex delayed-onset PTSD following compound disasters. This underscores the importance of addressing the underlying cognitive structures and coping mechanisms alongside trauma-focused interventions. These findings have implications for postdisaster long-term mental healthcare planning and suggest directions for future research to optimize treatment approaches for persistent PTSD.","PeriodicalId":9631,"journal":{"name":"Case Reports in Psychiatry","volume":"2025 ","pages":"9195824"},"PeriodicalIF":0.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144844532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Generalized Myoclonus in an Elderly Patient on Risperidone: A Rare but Important Adverse Effect. 一位服用利培酮的老年人全身肌阵挛：罕见但重要的不良反应。

Case Reports in Psychiatry Pub Date : 2025-07-18 eCollection Date: 2025-01-01 DOI: 10.1155/crps/7576076

Özlem Totuk, Özge Gönül Öner

{"title":"Generalized Myoclonus in an Elderly Patient on Risperidone: A Rare but Important Adverse Effect.","authors":"Özlem Totuk, Özge Gönül Öner","doi":"10.1155/crps/7576076","DOIUrl":"10.1155/crps/7576076","url":null,"abstract":"Objective: Drug-induced myoclonus is a rare adverse effect associated with several drug classes, including antipsychotics. This case report describes a patient who developed generalized myoclonic jerks while on long-term risperidone therapy, in the context of concomitant sertraline use, without fulfilling clinical criteria for serotonin syndrome. Case Presentation: We present a 73-year-old male patient with a history of cerebrovascular disease and behavioral symptoms treated with sertraline and risperidone. The patient developed sudden, generalized myoclonic movements. Neurological examination and imaging studies excluded acute structural pathology and metabolic or infectious causes. Serotonin syndrome was ruled out based on clinical findings. The myoclonus resolved rapidly after discontinuation of risperidone, without any specific symptomatic treatment, suggesting a potential drug-related mechanism. Conclusion: This case highlights the importance of recognizing antipsychotic-related myoclonus as a potentially reversible condition. Clinicians should consider drug-induced myoclonus in the differential diagnosis and pay special attention to the risks posed by polypharmacy involving psychotropic agents.","PeriodicalId":9631,"journal":{"name":"Case Reports in Psychiatry","volume":"2025 ","pages":"7576076"},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12297136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Adolescent Female With Disordered Eating and Cannabis Use Found to Have Acute Intermittent Porphyria. 一名饮食失调和使用大麻的青春期女性被发现患有急性间歇性卟啉症。

Case Reports in Psychiatry Pub Date : 2025-06-25 eCollection Date: 2025-01-01 DOI: 10.1155/crps/8875138

Brooke Gertz, Mark Mullen, Tony Pesavento

{"title":"An Adolescent Female With Disordered Eating and Cannabis Use Found to Have Acute Intermittent Porphyria.","authors":"Brooke Gertz, Mark Mullen, Tony Pesavento","doi":"10.1155/crps/8875138","DOIUrl":"10.1155/crps/8875138","url":null,"abstract":"Background: Eating disorders and cannabinoid hyperemesis syndrome are increasingly common causes of nausea, vomiting, and weight loss in adolescent females. Acute intermittent porphyria (AIP) is rare but has considerable pathophysiological overlap with these conditions and requires a high index of suspicion. Purpose and Basic Procedures: We present the case of a 15-year-old girl who presented with nausea, vomiting, and decreased appetite in the context of cannabis use and disordered eating. She was initially discharged from the emergency department but returned the next day experiencing seizures and altered mental status. Medical workup revealed AIP, and she responded well to the appropriate treatment. Main Findings: To date, no literature exists about the overlap between cannabinoid hyperemesis syndrome and AIP, although they often present with similar features. There is scant information about the interplay between AIP and disordered eating. As our case report shows, an AIP diagnosis could be delayed by misattribution of presenting symptoms to cannabis use or disordered eating. Principal Conclusion: AIP is a rare but highly treatable cause of nausea, vomiting, and altered mental status in adolescents. Due to its symptomatologic overlap with more common conditions like cannabinoid hyperemesis syndrome and eating disorders, it is easily missed. Thus, a high index of suspicion is required to obtain an AIP diagnosis and initiate treatment.","PeriodicalId":9631,"journal":{"name":"Case Reports in Psychiatry","volume":"2025 ","pages":"8875138"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0