Case Reports in Psychiatry最新文献_第2页

Autism Spectrum Disorder, Temporal Lobe Epilepsy, and Treatment-Resistant Schizophrenia With Media-Themed Delusions and Impaired Insight: A Case Report. 自闭症谱系障碍，颞叶癫痫和治疗难治性精神分裂症与媒体主题妄想和洞察力受损：一例报告。

Case Reports in Psychiatry Pub Date : 2026-09-11 eCollection Date: 2026-01-01 DOI: 10.1155/crps/2386844

Myles Turkson, Marian Taiwo, Matthew Polden, Jeremy Greening

{"title":"Autism Spectrum Disorder, Temporal Lobe Epilepsy, and Treatment-Resistant Schizophrenia With Media-Themed Delusions and Impaired Insight: A Case Report.","authors":"Myles Turkson, Marian Taiwo, Matthew Polden, Jeremy Greening","doi":"10.1155/crps/2386844","DOIUrl":"10.1155/crps/2386844","url":null,"abstract":"This case report describes a male patient in his 30s diagnosed with autism spectrum disorder (ASD), childhood-onset temporal lobe epilepsy paired with nonepileptic seizures (NES), and treatment-resistant schizophrenia (TRS). The patient was diagnosed with temporal lobe epilepsy in childhood and demonstrated features of ASD during adolescence. His psychiatric symptoms emerged during adolescence, including paranoid delusions, auditory and visual hallucinations, and pseudo-seizures precipitated by psychosocial stressors. He has remained institutionalized in psychiatric care for over two decades due to severe impairments in reality testing and persistent, complex delusions, which are strongly influenced by ASD-related hyperfixations on fictional characters. His symptoms include attributing personal experiences to fictional characters and engaging in media-influenced spiritual battles. Treatment with clozapine has provided partial control of his psychotic symptoms, while sodium valproate has effectively managed his epilepsy. This case highlights the clinical intricacies associated with the coexistence of ASD, epilepsy, and TRS, underscoring the need for patient-specific, multidisciplinary approaches to diagnosis and long-term management.","PeriodicalId":9631,"journal":{"name":"Case Reports in Psychiatry","volume":"2026 ","pages":"2386844"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13563498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148954852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clozapine-Induced Gastrointestinal Hypoperfusion Leading to Bowel Ischemia and Secondary Atrial Fibrillation: A Case Report. 氯氮平诱导的胃肠道低灌注导致肠缺血和继发性心房颤动1例报告。

Case Reports in Psychiatry Pub Date : 2026-09-10 eCollection Date: 2026-01-01 DOI: 10.1155/crps/8484558

Shreya Kumar, Meera Chatterjee

{"title":"Clozapine-Induced Gastrointestinal Hypoperfusion Leading to Bowel Ischemia and Secondary Atrial Fibrillation: A Case Report.","authors":"Shreya Kumar, Meera Chatterjee","doi":"10.1155/crps/8484558","DOIUrl":"10.1155/crps/8484558","url":null,"abstract":"Introduction: Clozapine is a highly effective antipsychotic for treatment-resistant schizophrenia but carries a risk of rare and serious adverse events. This case highlights a potentially fatal episode of clozapine-induced gastrointestinal hypoperfusion leading to bowel ischemia and secondary atrial fibrillation in a patient with chronic schizophrenia.Main symptoms and clinical findings: A middle-aged male with longstanding schizophrenia presented with abdominal pain, vomiting, nausea, and persistent tachycardia. He was diagnosed with bowel ischemia from hypoperfusion and new-onset atrial fibrillation.Intervention and outcome: Clozapine was discontinued. The patient underwent emergency laparotomy and supportive ICU care. His psychiatric management was shifted to haloperidol and olanzapine, and he returned close to his psychiatric baseline over time.Conclusion: This case emphasizes the importance of monitoring for rare gastrointestinal complications associated with clozapine, including hypoperfusion-mediated bowel ischemia, and supports early recognition and prompt discontinuation to reduce morbidity and mortality.","PeriodicalId":9631,"journal":{"name":"Case Reports in Psychiatry","volume":"2026 ","pages":"8484558"},"PeriodicalIF":0.0,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Consequences of Inadvertent Intramuscular Administration of Subcutaneous Risperidone Formulation. 不慎肌肉注射皮下利培酮制剂的临床后果。

Case Reports in Psychiatry Pub Date : 2026-09-09 eCollection Date: 2026-01-01 DOI: 10.1155/crps/7485684

Emma Ashley, Arnela Aalomerovic, Kyle Blackmer, Rif S El-Mallakh

引用次数: 0

Breaking the Cycle: A Case of Delayed Diagnosis and Sustained Remission Following Definitive Surgical Treatment of Premenstrual Dysphoric Disorder (PMDD). 打破循环：经前烦躁不安障碍（PMDD）的最终手术治疗后延迟诊断和持续缓解的案例。

Case Reports in Psychiatry Pub Date : 2026-09-07 eCollection Date: 2026-01-01 DOI: 10.1155/crps/8233699

Daniel J Deaton, Susannah L Deaton

{"title":"Breaking the Cycle: A Case of Delayed Diagnosis and Sustained Remission Following Definitive Surgical Treatment of Premenstrual Dysphoric Disorder (PMDD).","authors":"Daniel J Deaton, Susannah L Deaton","doi":"10.1155/crps/8233699","DOIUrl":"10.1155/crps/8233699","url":null,"abstract":"Premenstrual dysphoric disorder (PMDD) is a hormone-sensitive mood disorder characterized by cyclical psychiatric and physical symptoms that impair functioning. Despite inclusion in DSM-5 and ICD-11, PMDD is frequently misdiagnosed or overlooked due to clinical unfamiliarity, lack of structured assessment, and systemic minimization of hormone-linked distress. Women routinely face delays in diagnosis and often only receive definitive treatment through self-advocacy. This report describes a 35-year-old cisgender female with treatment-resistant PMDD, whose symptoms began after menarche and worsened over two decades. Despite multiple psychiatric and medical encounters, her condition was misattributed to obesity, mood disorders, or trauma. After a diagnostic delay and multiple first and second-line treatment failures, a trial of leuprolide acetate confirmed a hormonal etiology of her symptoms, and she subsequently underwent total hysterectomy with bilateral salpingo-oophorectomy. Although she experienced a severe depressive episode in the immediate postoperative period, she has since remained in sustained symptom remission on an SSRI and estrogen replacement. This case demonstrates the need to recognize cyclic symptom patterns and potential hormonal etiology in treatment-resistant mood disorders.","PeriodicalId":9631,"journal":{"name":"Case Reports in Psychiatry","volume":"2026 ","pages":"8233699"},"PeriodicalIF":0.0,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hallucinogen Persisting Perception Disorder in a Young Adult Case Report. 致幻剂持续知觉障碍1例青年报告。

Case Reports in Psychiatry Pub Date : 2026-09-03 eCollection Date: 2026-01-01 DOI: 10.1155/crps/6605265

Sonali Notani, Vikas Srinivasa, Serena Chaudhry, Ashley Weiss

{"title":"Hallucinogen Persisting Perception Disorder in a Young Adult Case Report.","authors":"Sonali Notani, Vikas Srinivasa, Serena Chaudhry, Ashley Weiss","doi":"10.1155/crps/6605265","DOIUrl":"10.1155/crps/6605265","url":null,"abstract":"Hallucinogen persisting perception disorder (HPPD) is a rare psychiatric diagnosis encompassing a range of perceptual disturbances caused by the lingering effects of hallucinogens. There are two major subtypes of the disorder: HPPD I and II. HPPD II is considered a more severe form that is generally longer-term, distressing, and requiring more intense treatment. In the limited available literature, many of the affected patients have multiple psychiatric comorbidities. The following case describes a 24-year-old college student, WA, who was diagnosed with HPPD II along with comorbid bipolar I disorder and generalized anxiety disorder. WA presented with an escalation of manic symptoms, psychosis, and two lysergic acid diethylamide (LSD) uses prior to hospitalization. He was treated with olanzapine, leading to mood stabilization and remission of psychosis. Post treatment, WA continued to experience perceptual disturbances and \"visual snow.\" Medications clonidine and clonazepam were trialed for HPPD. While symptoms fluctuated in severity, they never fully resolved. Despite this, WA achieved acceptance of his symptoms, mood stability, and a functional recovery. WA's case is an example of the clinical complexity in accurate diagnosis and treatment of HPPD, including the distinction of the symptoms from psychosis. As LSD-assisted therapies continue to be investigated for conditions such as anxiety and depression, recognition and management of persistent adverse effects such as HPPD are becoming increasingly important in both psychiatric and general medical practice. This case demonstrates the limited effectiveness and lack of knowledge on HPPD treatments as well as the need for longitudinal assessments in management.","PeriodicalId":9631,"journal":{"name":"Case Reports in Psychiatry","volume":"2026 ","pages":"6605265"},"PeriodicalIF":0.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13539430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

When Silence Masks Autism: Delayed Autism Diagnosis in an Adolescent With Deafness. 当沉默掩盖自闭症：失聪青少年的延迟自闭症诊断。

Case Reports in Psychiatry Pub Date : 2026-08-30 eCollection Date: 2026-01-01 DOI: 10.1155/crps/8974477

Stephanie E King, Erika Ryst

{"title":"When Silence Masks Autism: Delayed Autism Diagnosis in an Adolescent With Deafness.","authors":"Stephanie E King, Erika Ryst","doi":"10.1155/crps/8974477","DOIUrl":"10.1155/crps/8974477","url":null,"abstract":"A 13-year-old adolescent male was referred for an interdisciplinary autism assessment. His complex medical history included a traumatic delivery (with drop in heartrate and nuchal cord), neonatal hyperbilirubinemia, diagnosis of profound congenital hearing loss, diminished bile ducts on liver biopsy at 1 month of age, and a seizure disorder. Later, he was diagnosed with a significant global developmental delay with minimal communication in any modality. The youth received cochlear implants at the age of 2 years but was unable to tolerate them. Despite early intervention services and multiple stays in urban academic medical centers, he was not considered for a diagnosis of autism because his problematic behaviors, sensory sensitivities, and social and communication delays were attributed to his hearing loss and intellectual disability. It was not until the age of 13 that he was confirmed to have autism via a comprehensive interdisciplinary assessment based on adapted, standardized, evidence-based tools and expert clinical observations. This case highlights the importance of understanding and identifying the differences between hearing loss related behaviors and possible symptoms of a co-occurring neurodevelopmental disorder as well as the peril of diagnostic overshadowing in children with hearing loss.","PeriodicalId":9631,"journal":{"name":"Case Reports in Psychiatry","volume":"2026 ","pages":"8974477"},"PeriodicalIF":0.0,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lurasidone-Associated Urinary Retention in a Patient With Bipolar Affective Disorder: A Case Report. 鲁拉西酮相关性尿潴留在双相情感障碍患者：1例报告。

Case Reports in Psychiatry Pub Date : 2026-08-27 eCollection Date: 2026-01-01 DOI: 10.1155/crps/7779671

Andrew Ridge, Kyle Williams, Bastian Seidel

{"title":"Lurasidone-Associated Urinary Retention in a Patient With Bipolar Affective Disorder: A Case Report.","authors":"Andrew Ridge, Kyle Williams, Bastian Seidel","doi":"10.1155/crps/7779671","DOIUrl":"10.1155/crps/7779671","url":null,"abstract":"Atypical antipsychotics, including lurasidone, are increasingly prescribed due to their perceived lower risk of side effects. We present the case of a 65-year-old woman with longstanding BPAD who developed symptoms of urinary retention (UR), confirmed on bladder ultrasound, soon after beginning lurasidone monotherapy for bipolar affective disorder (BPAD) management. Despite dose reduction and addition of tamsulosin, symptoms of UR persisted and only resolved with cessation of lurasidone. The causal relationship between lurasidone and UR was assessed using the Naranjo Adverse Drug Reaction (ADR) Probability Scale, yielding a score of 8, indicating a highly 'probable' ADR. A literature review revealed only two prior reports of lurasidone-associated UR, highlighting the rarity of this presentation. This case underscores the need for clinicians to remain vigilant for UR in patients prescribed lurasidone, or other atypical antipsychotics, despite their generally favourable side effect profile. Early recognition and management are critical to prevent complications and ensure appropriate ongoing treatment of BPAD.","PeriodicalId":9631,"journal":{"name":"Case Reports in Psychiatry","volume":"2026 ","pages":"7779671"},"PeriodicalIF":0.0,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13519949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148839192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent Catatonia in the Setting of Sickle Cell Pain Crises: Case Report. 镰状细胞性疼痛危像中的复发性紧张症：病例报告。

Case Reports in Psychiatry Pub Date : 2026-08-24 eCollection Date: 2026-01-01 DOI: 10.1155/crps/9882696

Mary Nance, Miracline Ebijoyeldhas, Mariam Khan, Kathleen A Crapanzano

引用次数: 0

Possible Cognitive Dysfunction Associated With High-Dose Fluoxetine in a Patient on Lithium. 锂离子治疗患者高剂量氟西汀可能导致认知功能障碍

Case Reports in Psychiatry Pub Date : 2026-08-21 eCollection Date: 2026-01-01 DOI: 10.1155/crps/5566104

Adina Tanen, Amy Rajan, Alan Kahn

{"title":"Possible Cognitive Dysfunction Associated With High-Dose Fluoxetine in a Patient on Lithium.","authors":"Adina Tanen, Amy Rajan, Alan Kahn","doi":"10.1155/crps/5566104","DOIUrl":"10.1155/crps/5566104","url":null,"abstract":"Antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine, are widely prescribed medications. Fluoxetine is considered a first-line pharmacological treatment for common psychiatric conditions such as anxiety, depression, and obsessive-compulsive disorder (OCD). In large clinical trials, fluoxetine has consistently demonstrated a strong safety and tolerability profile over the past 30 years. This case describes a 36-year-old Caucasian female with a history of autism spectrum disorder (ASD) and bipolar I disorder treated with lithium, who developed new-onset cognitive dysfunction following the up-titration of fluoxetine. Her fluoxetine dose was gradually titrated to 80 mg/day over several weeks, in accordance with dosing guidelines. At that dose, she began experiencing progressive memory loss and confusion, ultimately requiring hospitalization. Extensive evaluation ruled out other potential psychiatric or medical causes of cognitive decline. Upon discontinuation of fluoxetine and reduction of her longstanding lithium dose, her cognitive function improved after 2 weeks and returned to baseline within 4 weeks. While SSRIs are generally well-tolerated compared to other antidepressant classes, isolated reports suggest fluoxetine may be associated with reversible memory impairment in certain populations. This is the first documented case of reversible memory loss requiring hospitalization associated with fluoxetine in a middle-aged adult with complex comorbid psychiatric conditions-a demographic frequently prescribed this medication. When prescribing fluoxetine to patients with comorbid psychiatric conditions on lithium, clinicians may consider slow titration and proactive cognitive monitoring.","PeriodicalId":9631,"journal":{"name":"Case Reports in Psychiatry","volume":"2026 ","pages":"5566104"},"PeriodicalIF":0.0,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Electroconvulsive Therapy for Treatment-Resistant Schizophrenia in a Patient Unable to Tolerate Clozapine Due to Clozapine-Associated Hyponatremia: A Case Report. 由于氯氮平相关性低钠血症而不能耐受氯氮平的难治性精神分裂症患者使用电休克疗法：1例报告。

Case Reports in Psychiatry Pub Date : 2026-08-20 eCollection Date: 2026-01-01 DOI: 10.1155/crps/6269931

Andrew Hartley, Michael P Greenage, Justin B White, Tracey W Criss

{"title":"Use of Electroconvulsive Therapy for Treatment-Resistant Schizophrenia in a Patient Unable to Tolerate Clozapine Due to Clozapine-Associated Hyponatremia: A Case Report.","authors":"Andrew Hartley, Michael P Greenage, Justin B White, Tracey W Criss","doi":"10.1155/crps/6269931","DOIUrl":"10.1155/crps/6269931","url":null,"abstract":"Clozapine is regarded as the most effective treatment for patients with treatment-resistant schizophrenia (TRS). However, serious adverse effects such as hyponatremia may necessitate discontinuation, leaving limited therapeutic alternatives. This case report describes a middle-aged male with chronic schizophrenia who developed clinically significant hyponatremia during clozapine titration, leading to its discontinuation prior to achievement of therapeutic serum concentrations. Despite prior antipsychotic trials with haloperidol, asenapine, olanzapine, and chlorpromazine, the patient had persistent auditory hallucinations and paranoid delusions. Given the patient's clozapine intolerance and persistent psychosis, a course of bifrontal electroconvulsive therapy (ECT) was initiated three times weekly over a 24-day inpatient series. The patient demonstrated progressive reduction in auditory hallucinations and paranoid ideation throughout treatment, with resolution of hallucinations and marked improvement in paranoia by discharge. Treatment was well tolerated, with only mild transient headaches and no clinically significant cognitive adverse effects observed on serial mental status examinations. At 5 months post-ECT, he remained free from readmission and without recurrence of his positive symptoms. This case highlights the potential role of ECT as a therapeutic consideration for select patients with refractory psychosis when clozapine cannot be safely continued due to medically significant adverse effects such as hyponatremia.","PeriodicalId":9631,"journal":{"name":"Case Reports in Psychiatry","volume":"2026 ","pages":"6269931"},"PeriodicalIF":0.0,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13492052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0