Case Reports in Dermatological Medicine最新文献

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Treatment of Subcorneal Pustular Dermatosis without Dapsone: A Case Report and Review of the Literature 不使用达哌酮治疗角质层下脓疱性皮肤病:病例报告和文献综述
Case Reports in Dermatological Medicine Pub Date : 2024-04-02 DOI: 10.1155/2024/8140483
Lindsey J Wanberg, B. Schultz, A. Goyal
{"title":"Treatment of Subcorneal Pustular Dermatosis without Dapsone: A Case Report and Review of the Literature","authors":"Lindsey J Wanberg, B. Schultz, A. Goyal","doi":"10.1155/2024/8140483","DOIUrl":"https://doi.org/10.1155/2024/8140483","url":null,"abstract":"Subcorneal pustular dermatosis (SPD) is a rare neutrophilic dermatosis characterized by pustules on the trunk and intertriginous areas. While oral dapsone is the first-line treatment for SPD, alternative options are necessary for patients with glucose-6-phosphate dehydrogenase deficiency, drug hypersensitivity reactions, or refractory disease. To date, no consensus exists regarding next-best agents for SPD. In this report, we present a patient with significant SPD who developed dapsone hypersensitivity syndrome and then was successfully treated with colchicine and adalimumab. We propose that colchicine should be considered as a second-line treatment for SPD and present a therapeutic algorithm for clinicians to utilize when patients are not candidates for dapsone, have side effects requiring drug discontinuation, or have refractory disease.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140752413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Diltiazem-Induced Pustular Rash in an 83-Year-Old Female 一名 83 岁女性的地尔硫卓诱发脓疱性皮疹病例
Case Reports in Dermatological Medicine Pub Date : 2024-04-02 DOI: 10.1155/2024/9547206
Ayrton I Bangolo, Karen Yelton-Torres, Atharv Mahajan, Vrushant Patel, Laiba Sajjad, Prince Ofori Ansong, Monisha Kashyap, Umesh Batura, Madhavi Ravulapalli, Ayodya Perera, Simcha I Weissman
{"title":"A Case of Diltiazem-Induced Pustular Rash in an 83-Year-Old Female","authors":"Ayrton I Bangolo, Karen Yelton-Torres, Atharv Mahajan, Vrushant Patel, Laiba Sajjad, Prince Ofori Ansong, Monisha Kashyap, Umesh Batura, Madhavi Ravulapalli, Ayodya Perera, Simcha I Weissman","doi":"10.1155/2024/9547206","DOIUrl":"https://doi.org/10.1155/2024/9547206","url":null,"abstract":"Acute generalized exanthematous pustulosis (AGEP) is a rare, acute skin eruption characterized by the development of numerous nonfollicular sterile pustules. Most cases are caused by drug reactions, among which Diltiazem has been incriminated. Herein, we present an 83-year-old female who presented for evaluation of generalized skin rash 3 days after initiation of Diltiazem. She was eventually diagnosed with AGEP, Diltiazem was discontinued, and systemic steroids were administered with the resolution of symptoms. This case report has the objective of encouraging clinicians to include AGEP in the differential diagnosis of skin eruption following the initiation of Diltiazem.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"60 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140755208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Saudi Woman with Ceftriaxone Induced Fixed Drug Eruption. 一名沙特妇女因头孢曲松诱发固定药物喷发。
Case Reports in Dermatological Medicine Pub Date : 2024-03-15 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9975455
Rehab Y Al-Ansari, Leena Abdulrahman Almuhaish, Khaled Abdullah Hassan, Tawasoul Fadoul, Alexander Woodman
{"title":"A Saudi Woman with Ceftriaxone Induced Fixed Drug Eruption.","authors":"Rehab Y Al-Ansari, Leena Abdulrahman Almuhaish, Khaled Abdullah Hassan, Tawasoul Fadoul, Alexander Woodman","doi":"10.1155/2024/9975455","DOIUrl":"10.1155/2024/9975455","url":null,"abstract":"<p><strong>Background: </strong>A fixed drug eruption (FDE) is an immunological cutaneous adverse reaction, classified as a cutaneous adverse drug reaction (CADR) and characterized by well-defined lichenoid lesions that occur at the same site each time. Ceftriaxone is a third-generation antibiotic of cephalosporin antibiotics of the beta-lactam antibiotic family, which has typical <i>in vitro</i> activity against many Gram-negative aerobic bacteria. This is the first clinical case from Saudi Arabia and the fifth in the world to document a woman's experience with recurrent FDE after repeated ceftriaxone use. <i>Case Report</i>. A 25-year-old Saudi woman with a known case of sickle cell anemia (SCA) with a history of avascular necrosis of the right hip after replacement was hospitalized with a pain crisis triggered by an upper respiratory tract infection. The patient denied having a history of allergy previously. Due to fever, leukocytosis, and active follicular tonsillitis, ceftriaxone was started. However, a few hours later she developed lip edema and a fixed drug eruption measuring 7 × 11 cm on the left side of her back. The lesion reformed over a hyperpigmented lesion (4 × 8 cm) that the patient did not report upon initial examination. It turned out that this was due to the intravenous administration of ceftriaxone, a year ago in another hospital. An allergy to ceftriaxone was considered, and steroids and antihistamines were started. The case was labeled as ceftriaxone induced FDE.</p><p><strong>Conclusion: </strong>Ceftriaxone induced FDE is an uncommon type of allergic reaction that has been reported infrequently. Understanding this condition and the mechanism by which FDE becomes recurrent with the same previous fixed lesion is of great importance for both academic and future research purposes.</p>","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2024 ","pages":"9975455"},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140206303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sporadic Pemphigus Foliaceus in a 3-Year-Old Vietnamese Girl: A Case Report and Literature Review 一名 3 岁越南女孩的散发性丘疹性红斑狼疮:病例报告和文献综述
Case Reports in Dermatological Medicine Pub Date : 2024-02-16 DOI: 10.1155/2024/6748340
Trinh Thi Diem Nguyen, Trinh Ngoc To Chau, Phuong Thi Doan Vo, H. Nguyen
{"title":"Sporadic Pemphigus Foliaceus in a 3-Year-Old Vietnamese Girl: A Case Report and Literature Review","authors":"Trinh Thi Diem Nguyen, Trinh Ngoc To Chau, Phuong Thi Doan Vo, H. Nguyen","doi":"10.1155/2024/6748340","DOIUrl":"https://doi.org/10.1155/2024/6748340","url":null,"abstract":"Pemphigus foliaceus is an uncommon autoimmune intraepidermal blistering disease characterized by immunoglobulin (Ig) G autoantibodies that attack desmoglein-1 in the epidermis. There are two predominant forms of pemphigus foliaceus, sporadic and endemic. Sporadic pemphigus foliaceus is known to be more prevalent in middle-aged and elderly people and to be extremely rare in children. Less than 40 nonendemic pediatric pemphigus foliaceus cases have been documented in the literature. This report documents a case of sporadic pemphigus foliaceus in a 3-year-old Vietnamese girl who presented with generalized scaling and crusted erosions over the body.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139961617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case Study of Furunculosis following an Ayurvedic Oil Massage, Sudation Therapy, and Lessons to Learn. 阿育吠陀精油按摩、须弥疗法后的疖病病例研究,以及应吸取的教训。
Case Reports in Dermatological Medicine Pub Date : 2024-02-08 eCollection Date: 2024-01-01 DOI: 10.1155/2024/3660064
Satyajit Pandurang Kulkarni, Pallavi Satyajit Kulkarni, S Kumar
{"title":"A Case Study of Furunculosis following an Ayurvedic Oil Massage, Sudation Therapy, and Lessons to Learn.","authors":"Satyajit Pandurang Kulkarni, Pallavi Satyajit Kulkarni, S Kumar","doi":"10.1155/2024/3660064","DOIUrl":"10.1155/2024/3660064","url":null,"abstract":"<p><p>India has a long history of using sudation therapy and oil massage as Ayurvedic treatments. However, nothing is known about its side effects, and just two studies have identified side effects as cutaneous adverse drug reactions brought on by Ayurvedic oil massage. We are presenting the example of a 72-year-old adult man who visited our hospital and had his right knee massaged with Nirgudi oil followed by sudation therapy. Erythema, papules, itchiness, and scorching pain were some of his symptoms. However, these sensations only partially abated once we quit sudation therapy. Our investigation demonstrates that a Nirgudi oil massage or sudation causes the skin reaction associated with furunculosis. This case report illustrates the necessity of being aware of Panchakarma-related consequences and suggests that medical practitioners, patients, and product makers take into account the likelihood of such a reaction following Nirgudi oil massage and sudation therapy as a precaution.</p>","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2024 ","pages":"3660064"},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10869181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutaneous Neuroendocrine Metastases of Visceral Origin Responsive to Surgical Resection and Targeted Radionuclide Therapy. 对手术切除和放射性核素靶向治疗敏感的内脏源皮肤神经内分泌转移瘤
Case Reports in Dermatological Medicine Pub Date : 2024-02-06 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8873822
Eleanor Tung-Hahn, Ghassan El-Haddad, Jonathan Strosberg
{"title":"Cutaneous Neuroendocrine Metastases of Visceral Origin Responsive to Surgical Resection and Targeted Radionuclide Therapy.","authors":"Eleanor Tung-Hahn, Ghassan El-Haddad, Jonathan Strosberg","doi":"10.1155/2024/8873822","DOIUrl":"10.1155/2024/8873822","url":null,"abstract":"<p><p>Neuroendocrine neoplasms (NENs) encompass a diverse range of biologically and behaviorally distinct epithelial malignancies that derive from neuroendocrine cells. These neoplasms are able to secrete a variety of bioactive amines or peptide hormones. The majority of NENs are well-differentiated and are defined as neuroendocrine tumors (NETs). While NETs are known to frequently metastasize to lymph nodes, liver, and lungs, spread to the skin is extremely rare and is often a late finding. Because cutaneous metastasis from a visceral site represents distant tumor dissemination, prompt histologic diagnosis is critical in terms of selecting further treatment options and ultimately impacts subsequent prognosis. This report presents a man with painful cutaneous NET metastases initially on the face then scalp. He had a prior history of longstanding and progressive stage IV visceral disease. Multimodal therapy with initial surgical resection of the larger facial lesion and radionuclide infusion therapy was undertaken. Excision fully removed the temple lesion and resolved pain. Peptide receptor radionuclide therapy (PRRT) with <sup>177</sup>Lu-DOTATATE, a radiolabeled somatostatin analog that targets somatostatin receptors on NETs, was given along with maintenance lanreotide therapy, which resolved the scalp lesion, prevented recurrence of prior lesions and development of new cutaneous metastases, and controlled his visceral disease. PRRT has not been previously described in the management of cutaneous NET metastases. Due to the rare nature of cutaneous NET metastases, there is no consensus regarding optimal management. As such, we propose novel multimodal therapy involving excision and targeted radionuclide therapy as a possible effective option.</p>","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2024 ","pages":"8873822"},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139729089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metastatic Esophageal Adenocarcinoma Presenting as Neck Dermal Metastasis. 表现为颈部真皮转移的转移性食管腺癌
Case Reports in Dermatological Medicine Pub Date : 2024-01-16 eCollection Date: 2024-01-01 DOI: 10.1155/2024/7951391
Sara Ibrahim-Shaikh, Noah Shaikh, Nour Daboul, Esra Alshaikhnassir, Maria Hafez, Monika E Freiser
{"title":"Metastatic Esophageal Adenocarcinoma Presenting as Neck Dermal Metastasis.","authors":"Sara Ibrahim-Shaikh, Noah Shaikh, Nour Daboul, Esra Alshaikhnassir, Maria Hafez, Monika E Freiser","doi":"10.1155/2024/7951391","DOIUrl":"10.1155/2024/7951391","url":null,"abstract":"<p><p>Dermal metastasis is a rare manifestation of visceral disease, and esophageal adenocarcinomas represent around only 1% of primaries that present with cutaneous metastasis. In this case, we discuss a patient who presented with a painless submental mass and extensive right neck cutaneous induration and erythema. Core needle biopsy demonstrated poorly differentiated adenocarcinoma. Blood testing also demonstrated elevated carbohydrate antigen 19-9, carcinoembryonic antigen, and alkaline phosphatase. PET/CT followed by esophagoscopy led to the diagnosis of esophageal signet-cell adenocarcinoma primary with isolated dermal metastasis. The patient was started on palliative radiotherapy and passed away two months later from a suspected thoracic fistula and hydropneumothorax.</p>","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2024 ","pages":"7951391"},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10805548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139541935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retinoid Therapy in a Case of Harlequin Ichthyosis with a Short Literature Review. 视黄醇疗法在一例 Harlequin 鱼鳞病病例中的应用及简短文献综述。
Case Reports in Dermatological Medicine Pub Date : 2024-01-12 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8729318
Emad Bahashwan, Jaber Alfaifi, Sahar Elmaghawri Mohamed Moursi, Youssef Elbayoumi Soliman
{"title":"Retinoid Therapy in a Case of Harlequin Ichthyosis with a Short Literature Review.","authors":"Emad Bahashwan, Jaber Alfaifi, Sahar Elmaghawri Mohamed Moursi, Youssef Elbayoumi Soliman","doi":"10.1155/2024/8729318","DOIUrl":"10.1155/2024/8729318","url":null,"abstract":"<p><p>Harlequin ichthyosis (HI) is a genetically inherited epidermal disorder due to the mutation of the ABCA12 gene, which is responsible for lipid transportation, and presents with large keratinised scales characterised by deep erythematous fissures, with ectropion and eclabium. A moderate number of cases and a high mortality rate have been recorded. In this case report, a pregnant lady gave birth to a 33-week-old premature foetus with characteristic symptoms of HI. After admitting him to the NICU, a multidisciplinary treatment approach was conducted with paediatric dermatologists, ophthalmologists, urologists, and dieticians. The prognosis is positive, with desquamation of the hyperkeratotic plate revealing an erythematous and shiny skin. A short literature review on HI characteristics, diagnostic aids, and management has also been added.</p>","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2024 ","pages":"8729318"},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10798836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139512027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bullous Hemorrhagic Dermatosis Induced by Enoxaparin: About a Case in Madagascar. 依诺肝素致大疱性出血性皮肤病:马达加斯加1例。
Case Reports in Dermatological Medicine Pub Date : 2023-11-02 eCollection Date: 2023-01-01 DOI: 10.1155/2023/5710870
Fenohasina Rakotonandrasana, Fandresena Arilala Sendrasoa, Andrianandrianina Mbolatiana Kiady Armando Rakotomanana, Herin'Ny Fitiavana Princia Andriatahina, Voahanginirina Nathalie Ralimalala, Samson Léophonte Ramily, Moril Sata, Onivola Raharolahy, Malalaniaina Andrianarison, Irina Mamisoa Ranaivo, Lala Soavina Ramarozatovo, Fahafahantsoa Rapelanoro Rabenja
{"title":"Bullous Hemorrhagic Dermatosis Induced by Enoxaparin: About a Case in Madagascar.","authors":"Fenohasina Rakotonandrasana, Fandresena Arilala Sendrasoa, Andrianandrianina Mbolatiana Kiady Armando Rakotomanana, Herin'Ny Fitiavana Princia Andriatahina, Voahanginirina Nathalie Ralimalala, Samson Léophonte Ramily, Moril Sata, Onivola Raharolahy, Malalaniaina Andrianarison, Irina Mamisoa Ranaivo, Lala Soavina Ramarozatovo, Fahafahantsoa Rapelanoro Rabenja","doi":"10.1155/2023/5710870","DOIUrl":"10.1155/2023/5710870","url":null,"abstract":"<p><p>Bullous hemorrhagic dermatosis is an adverse reaction occurring within 5 to 21 days after anticoagulation; the diagnosis is to be evoked in the presence of hemorrhagic bullous lesions at a distance from the injection site in the days following the introduction of anticoagulant; this is a diagnosis of exclusion. It is a rare pathology that mainly affects the elderly. A 54-year-old man presented with bullous hemorrhagic lesions on the left upper limb starting at the 4th day after enoxaparin injection, diagnosed as a bullous hemorrhagic dermatosis induced by enoxaparin. We report the first case of bullous hemorrhagic dermatosis induced by enoxaparin in Madagascar.</p>","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2023 ","pages":"5710870"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89716993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is Exploration of Alternate Immune Pathways Needed in Hidradenitis Suppurativa? A Case of Atopic Dermatitis and Concurrent Hidradenitis Suppurativa Responding to Dupilumab. 是否需要探索化脓性痢疾的替代免疫途径?一例对Dupilumab有反应的特应性皮炎和并发化脓性腮腺炎。
Case Reports in Dermatological Medicine Pub Date : 2023-10-23 eCollection Date: 2023-01-01 DOI: 10.1155/2023/5189034
Sean McCormack, Noor Tazudeen, Benjamin C Garden
{"title":"Is Exploration of Alternate Immune Pathways Needed in Hidradenitis Suppurativa? A Case of Atopic Dermatitis and Concurrent Hidradenitis Suppurativa Responding to Dupilumab.","authors":"Sean McCormack,&nbsp;Noor Tazudeen,&nbsp;Benjamin C Garden","doi":"10.1155/2023/5189034","DOIUrl":"https://doi.org/10.1155/2023/5189034","url":null,"abstract":"<p><p>Hidradenitis suppurativa (HS) is an inflammatory dermatosis associated with overactive T helper 1/T helper 17 (Th1/Th17) cells. HS has been effectively treated with biologic medications; however, many such biologics lack large randomized controlled trials. Only one such biologic, adalimumab, has been approved by the US Food and Drug Administration (FDA) for the treatment of HS. Other such biologics currently being studied for HS downregulate Th1/Th17 inflammatory pathways. We describe a patient with atopic dermatitis (AD) and comorbid HS, both of which improved several months into treatment with dupilumab. Interestingly enough, dupilumab targets Th2-mediated inflammatory skin conditions through the inhibition of IL-4/IL-13 cytokines. While dupilumab is known for its success in treating Th2-mediated inflammation, this presents a paradox as HS is a Th1/Th17 inflammatory condition. This case highlights how the inflammatory process of HS is not fully understood and how biologic pharmacologic interventions need to be further studied to determine their efficacy in treating HS.</p>","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2023 ","pages":"5189034"},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71421020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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