Case Reports in Dermatological Medicine最新文献_第3页

Cutaneous Neuroendocrine Metastases of Visceral Origin Responsive to Surgical Resection and Targeted Radionuclide Therapy. 对手术切除和放射性核素靶向治疗敏感的内脏源皮肤神经内分泌转移瘤

Case Reports in Dermatological Medicine Pub Date : 2024-02-06 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8873822

Eleanor Tung-Hahn, Ghassan El-Haddad, Jonathan Strosberg

{"title":"Cutaneous Neuroendocrine Metastases of Visceral Origin Responsive to Surgical Resection and Targeted Radionuclide Therapy.","authors":"Eleanor Tung-Hahn, Ghassan El-Haddad, Jonathan Strosberg","doi":"10.1155/2024/8873822","DOIUrl":"10.1155/2024/8873822","url":null,"abstract":"Neuroendocrine neoplasms (NENs) encompass a diverse range of biologically and behaviorally distinct epithelial malignancies that derive from neuroendocrine cells. These neoplasms are able to secrete a variety of bioactive amines or peptide hormones. The majority of NENs are well-differentiated and are defined as neuroendocrine tumors (NETs). While NETs are known to frequently metastasize to lymph nodes, liver, and lungs, spread to the skin is extremely rare and is often a late finding. Because cutaneous metastasis from a visceral site represents distant tumor dissemination, prompt histologic diagnosis is critical in terms of selecting further treatment options and ultimately impacts subsequent prognosis. This report presents a man with painful cutaneous NET metastases initially on the face then scalp. He had a prior history of longstanding and progressive stage IV visceral disease. Multimodal therapy with initial surgical resection of the larger facial lesion and radionuclide infusion therapy was undertaken. Excision fully removed the temple lesion and resolved pain. Peptide receptor radionuclide therapy (PRRT) with 177Lu-DOTATATE, a radiolabeled somatostatin analog that targets somatostatin receptors on NETs, was given along with maintenance lanreotide therapy, which resolved the scalp lesion, prevented recurrence of prior lesions and development of new cutaneous metastases, and controlled his visceral disease. PRRT has not been previously described in the management of cutaneous NET metastases. Due to the rare nature of cutaneous NET metastases, there is no consensus regarding optimal management. As such, we propose novel multimodal therapy involving excision and targeted radionuclide therapy as a possible effective option.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2024 ","pages":"8873822"},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139729089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metastatic Esophageal Adenocarcinoma Presenting as Neck Dermal Metastasis. 表现为颈部真皮转移的转移性食管腺癌

Case Reports in Dermatological Medicine Pub Date : 2024-01-16 eCollection Date: 2024-01-01 DOI: 10.1155/2024/7951391

Sara Ibrahim-Shaikh, Noah Shaikh, Nour Daboul, Esra Alshaikhnassir, Maria Hafez, Monika E Freiser

引用次数: 0

Retinoid Therapy in a Case of Harlequin Ichthyosis with a Short Literature Review. 视黄醇疗法在一例 Harlequin 鱼鳞病病例中的应用及简短文献综述。

Case Reports in Dermatological Medicine Pub Date : 2024-01-12 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8729318

Emad Bahashwan, Jaber Alfaifi, Sahar Elmaghawri Mohamed Moursi, Youssef Elbayoumi Soliman

引用次数: 0

Bullous Hemorrhagic Dermatosis Induced by Enoxaparin: About a Case in Madagascar. 依诺肝素致大疱性出血性皮肤病:马达加斯加1例。

Case Reports in Dermatological Medicine Pub Date : 2023-11-02 eCollection Date: 2023-01-01 DOI: 10.1155/2023/5710870

Fenohasina Rakotonandrasana, Fandresena Arilala Sendrasoa, Andrianandrianina Mbolatiana Kiady Armando Rakotomanana, Herin'Ny Fitiavana Princia Andriatahina, Voahanginirina Nathalie Ralimalala, Samson Léophonte Ramily, Moril Sata, Onivola Raharolahy, Malalaniaina Andrianarison, Irina Mamisoa Ranaivo, Lala Soavina Ramarozatovo, Fahafahantsoa Rapelanoro Rabenja

引用次数: 0

Is Exploration of Alternate Immune Pathways Needed in Hidradenitis Suppurativa? A Case of Atopic Dermatitis and Concurrent Hidradenitis Suppurativa Responding to Dupilumab. 是否需要探索化脓性痢疾的替代免疫途径？一例对Dupilumab有反应的特应性皮炎和并发化脓性腮腺炎。

Case Reports in Dermatological Medicine Pub Date : 2023-10-23 eCollection Date: 2023-01-01 DOI: 10.1155/2023/5189034

Sean McCormack, Noor Tazudeen, Benjamin C Garden

{"title":"Is Exploration of Alternate Immune Pathways Needed in Hidradenitis Suppurativa? A Case of Atopic Dermatitis and Concurrent Hidradenitis Suppurativa Responding to Dupilumab.","authors":"Sean McCormack, Noor Tazudeen, Benjamin C Garden","doi":"10.1155/2023/5189034","DOIUrl":"https://doi.org/10.1155/2023/5189034","url":null,"abstract":"Hidradenitis suppurativa (HS) is an inflammatory dermatosis associated with overactive T helper 1/T helper 17 (Th1/Th17) cells. HS has been effectively treated with biologic medications; however, many such biologics lack large randomized controlled trials. Only one such biologic, adalimumab, has been approved by the US Food and Drug Administration (FDA) for the treatment of HS. Other such biologics currently being studied for HS downregulate Th1/Th17 inflammatory pathways. We describe a patient with atopic dermatitis (AD) and comorbid HS, both of which improved several months into treatment with dupilumab. Interestingly enough, dupilumab targets Th2-mediated inflammatory skin conditions through the inhibition of IL-4/IL-13 cytokines. While dupilumab is known for its success in treating Th2-mediated inflammation, this presents a paradox as HS is a Th1/Th17 inflammatory condition. This case highlights how the inflammatory process of HS is not fully understood and how biologic pharmacologic interventions need to be further studied to determine their efficacy in treating HS.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2023 ","pages":"5189034"},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71421020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-Induced Erythema Multiforme. 药物诱导的多型红斑。

Case Reports in Dermatological Medicine Pub Date : 2023-10-23 eCollection Date: 2023-01-01 DOI: 10.1155/2023/8706006

Peeyush Shivhare, Naqoosh Haidry, Anka Sharma, Deepali Agrawal, Abhishek Gupta, Shalini Subramanyam

引用次数: 0

Pemphigus Foliaceus after COVID-19 Vaccination: A Report of Two Cases. 新冠肺炎疫苗接种后对叶天疱疮：两例报告。

Case Reports in Dermatological Medicine Pub Date : 2023-10-19 eCollection Date: 2023-01-01 DOI: 10.1155/2023/1218388

Nguyen Nhat Pham, Thuy Thi Phan Nguyen, Thao Thi Phuong Vu, Hao Trong Nguyen

引用次数: 0

Reactive Granulomatous Dermatitis in a Child with Acute Lymphoblastic Leukemia. 儿童急性淋巴细胞白血病反应性肉芽肿性皮炎。

Case Reports in Dermatological Medicine Pub Date : 2023-10-12 eCollection Date: 2023-01-01 DOI: 10.1155/2023/3428162

Hannah C Tolson, Mariana McCune, Miranda Yousif, David DiCaudo, Elizabeth Dupuy

引用次数: 0

Clouston Syndrome: Report of a Jordanian Family with GJB6 Gene Mutation. Clouston综合征：一个患有GJB6基因突变的约旦家庭的报告。

Case Reports in Dermatological Medicine Pub Date : 2023-10-12 eCollection Date: 2023-01-01 DOI: 10.1155/2023/5577379

Rand Murshidi, Heba Al-Lala

{"title":"Clouston Syndrome: Report of a Jordanian Family with GJB6 Gene Mutation.","authors":"Rand Murshidi, Heba Al-Lala","doi":"10.1155/2023/5577379","DOIUrl":"10.1155/2023/5577379","url":null,"abstract":"Ectodermal dysplasias (ED) encompass a collection of conditions wherein the development of two or more structures derived from the ectoderm exhibits abnormal patterns. One example of such a rarity within the spectrum of ectodermal dysplasias is hidrotic ectodermal dysplasia, also known as Clouston syndrome. This particular variant is distinguished by a triad of clinical characteristics, which encompass partial-to-complete alopecia, nail dystrophy, and palmoplantar hyperkeratosis. It stands as a scarcely encountered autosomal-dominant inherited disorder, resulting from a mutation in the GJB6 gene that encodes the gap junction protein connexin 30. We hereby document the case of a forty-five-year-old Jordanian woman who presented with alopecia affecting the scalp, eyebrows, and eyelashes, in addition to nail dystrophy. Interestingly, she did not manifest palmoplantar keratoderma. It is worth mentioning that several members of her extended family also manifested similar clinical features. Subsequent genetic testing conclusively established the diagnosis of Clouston syndrome. In light of this diagnosis, comprehensive counseling was extended to the patient.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2023 ","pages":"5577379"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical Mal de Meleda in a Hispanic Patient. 一名西班牙裔患者的非典型Mal de Meleda。

Case Reports in Dermatological Medicine Pub Date : 2023-09-14 eCollection Date: 2023-01-01 DOI: 10.1155/2023/6640311

Mónica Guevara, Michelle Mafla, Camila Miño

{"title":"Atypical Mal de Meleda in a Hispanic Patient.","authors":"Mónica Guevara, Michelle Mafla, Camila Miño","doi":"10.1155/2023/6640311","DOIUrl":"https://doi.org/10.1155/2023/6640311","url":null,"abstract":"Mal de Meleda (MDM) is a rare autosomal palmoplantar keratoderma (PPK) skin disorder (estimated incidence of 1 per 100,000 people) commonly associated with consanguinity and early childhood onset. MDM is characterized by bilateral diffusion of PPK plaques with delimited yellowish lesions that transgredien to the dorsum of the hands and feet. Additional features include nail dystrophy, lichenoid lesions, hyperhidrotic maceration, involvement of the knees and elbows, malodor, fungal superinfections, and digital constrictions. A male patient aged 42 years presented with asymptomatic, chronic, and diffused PPK lesions that progressed to the dorsal surface of the hands and feet, along with knees and elbows involvement. On clinical examination, asymmetrical lesions were observed on the hands, the left palm with yellowish waxy hyperkeratotic plaques, and the right palm with erythematous scaling and hyperkeratotic interphalangeal rings. The soles of the feet presented with yellow waxy hyperkeratotic plaques. In addition, nail dystrophy and loss of dermatoglyphics were observed. Initially, symptomatic topical treatment was established. However, owing to the lack of clinical response, a biopsy was performed, which revealed thickened corneal layer, acanthosis, spongiosis, and perivascular lymphohistiocytic infiltrate. MDM diagnosis was confirmed based on a personal history of consanguinity, clinical presentation with absence of systemic symptoms, and transgredien pattern of the lesions. Systemic treatment with low doses of isotretinoin (10 mg orally everyday) was initiated, and two months later, slight clinical improvement has been observed until date. The present case report describes MDM in a Hispanic patient, who presented with asymmetric PPK lesions on the hands and received isotretinoin treatment.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2023 ","pages":"6640311"},"PeriodicalIF":0.0,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41128930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0