Case Reports in Dermatological Medicine最新文献_第2页

Epidermotropic Metastatic Prostate Adenocarcinoma With Florid Squamous Transformation/Differentiation and Associated Acantholysis. An Unusual Clinicopathologic Entity. 表皮性转移性前列腺癌伴花状鳞状转化/分化及相关棘层溶解。一个不寻常的临床病理实体。

Case Reports in Dermatological Medicine Pub Date : 2026-09-03 eCollection Date: 2026-01-01 DOI: 10.1155/crdm/5879396

Sara J Hoffman, Kaviyon Sadrolashrafi, Narciss Mobini

{"title":"Epidermotropic Metastatic Prostate Adenocarcinoma With Florid Squamous Transformation/Differentiation and Associated Acantholysis. An Unusual Clinicopathologic Entity.","authors":"Sara J Hoffman, Kaviyon Sadrolashrafi, Narciss Mobini","doi":"10.1155/crdm/5879396","DOIUrl":"10.1155/crdm/5879396","url":null,"abstract":"Prostate adenocarcinoma is the most common carcinoma in men. Cutaneous metastasis of prostate adenocarcinoma, however, is rare, accounting for less than 1% of metastatic cutaneous carcinomas. This cutaneous spread most often occurs in the inguinal area and the penis, followed by the abdomen, head and neck, chest, extremities, and back. Metastatic prostate adenocarcinoma generally has a poor prognosis, emphasizing the importance of timely identification. We report a patient with an unusual clinicopathologic presentation of metastatic prostate adenocarcinoma manifesting as a scaly plaque on the left shin. This lesion was histopathologically characterized by marked epidermotropism, squamous differentiation, and acantholytic features, with a negative reaction to prostate-specific antigen and prostatic acid phosphatase immunostains. When evaluating metastatic cutaneous carcinomas displaying epidermotropism and squamoid appearances or squamous differentiation, it is essential to maintain a high index of suspicion and inquire about a history of prostate carcinoma. This history is especially relevant if hormonal therapy was utilized as part of the patient's management.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"5879396"},"PeriodicalIF":0.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13542698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous Intravascular Large B-Cell Lymphoma Presenting as Hemophagocytic Lymphohistiocytosis. 皮肤血管内大b细胞淋巴瘤表现为噬血细胞性淋巴组织细胞增多症。

Case Reports in Dermatological Medicine Pub Date : 2026-08-04 eCollection Date: 2026-01-01 DOI: 10.1155/crdm/4773671

Shamsu S Bello, Joseph J Mulvey, Joanna Harp, Cynthia M Magro

{"title":"Cutaneous Intravascular Large B-Cell Lymphoma Presenting as Hemophagocytic Lymphohistiocytosis.","authors":"Shamsu S Bello, Joseph J Mulvey, Joanna Harp, Cynthia M Magro","doi":"10.1155/crdm/4773671","DOIUrl":"10.1155/crdm/4773671","url":null,"abstract":"Intravascular large B-cell lymphoma (IVLBCL) is an uncommon and aggressive subtype of non-Hodgkin lymphoma defined by the proliferation of large malignant B cells confined within small blood vessels. This neoplasm can present with different nonspecific symptoms, including fever, altered mental status, livedoid skin rashes, hepatosplenomegaly, and cytopenias, often complicating its diagnosis. The main categories are classical (formerly designated as Western), hemophagocytic variant (formerly designated as Asian), and primary cutaneous IVLBCL. A distinctly severe manifestation is hemophagocytic lymphohistiocytosis (HLH), a hyperinflammatory syndrome characterized by exaggerated immune activation and macrophage activation manifested by phagocytosis of hematopoietic cells including neutrophils, red blood cells, and platelets. We describe a 72-year-old female who presented with features reminiscent of an autoinflammatory syndrome including fever and hyperferritinemia followed by clinical features concerning for HLH. She developed a reticulated skin rash. Following skin biopsy, a diagnosis was rendered of IVLBCL complicated by HLH. The pathophysiology and other aspects of the literature pertaining to IVLBCL and HLH are reviewed.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"4773671"},"PeriodicalIF":0.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13437949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dabrafenib-Induced Cutaneous Eruptions in a Patient With Langerhans Cell Histiocytosis. 达非尼诱发朗格汉斯细胞组织细胞增多症患者皮肤皮疹

Case Reports in Dermatological Medicine Pub Date : 2026-07-14 eCollection Date: 2026-01-01 DOI: 10.1155/crdm/5004676

Jaanvi Mehta, Julianna Tolotta, Eleanor Matthews, Daniel Joffe, Safiyyah Bhatti, Lauren Banner, Jenna Mandel, Molly Wallace, Timothy Webster, Jason B Lee, Neda Nikbakht

{"title":"Dabrafenib-Induced Cutaneous Eruptions in a Patient With Langerhans Cell Histiocytosis.","authors":"Jaanvi Mehta, Julianna Tolotta, Eleanor Matthews, Daniel Joffe, Safiyyah Bhatti, Lauren Banner, Jenna Mandel, Molly Wallace, Timothy Webster, Jason B Lee, Neda Nikbakht","doi":"10.1155/crdm/5004676","DOIUrl":"10.1155/crdm/5004676","url":null,"abstract":"Langerhans cell histiocytosis (LCH) is a rare malignancy marked by clonal proliferation of Langerhans cells, with BRAF V600E mutations identified in over 50% of the cases. BRAF inhibitors (BRAFi), such as dabrafenib, have shown efficacy in treating BRAF V600E-mutant LCH. However, BRAFi therapy is associated with cutaneous adverse effects, including the development of new melanocytic nevi, verrucae, and keratinocyte carcinoma (KC). This case report describes a 78-year-old woman with BRAF V600E-mutant LCH who developed multiple dermatologic side effects following dabrafenib salvage therapy. Seven weeks into treatment, the patient presented with eruptive palmoplantar nevi, verrucae, and a basal cell carcinoma (BCC). Biopsies revealed endophytic verruca vulgaris and acral junctional melanocytic nevus. A previous history of KC and photodamage likely contributed to the development of BCC. Additionally, the patient experienced arthralgias and Dupuytren's contracture, consistent with known BRAFi side effects. While the cutaneous manifestations observed here have been documented in BRAF V600E-mutant melanoma, this case is unique in its presentation in LCH patients. This report emphasizes the need for routine dermatologic monitoring and awareness of potential skin malignancies and other side effects in adults undergoing BRAFi therapy for LCH.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"5004676"},"PeriodicalIF":0.0,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13370105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148454767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Off-Label Uses of Deucravacitinib for Inflammatory Skin Conditions: Cases and Literature Review. Deucravacitinib在炎症性皮肤条件下的标签外使用：病例和文献综述。

Case Reports in Dermatological Medicine Pub Date : 2026-07-07 eCollection Date: 2026-01-01 DOI: 10.1155/crdm/9941426

Alexandra Nigro, Isabel C Silva, Benjamin Gerstein, Jasper Dayanan, Saakshi Khattri

{"title":"Off-Label Uses of Deucravacitinib for Inflammatory Skin Conditions: Cases and Literature Review.","authors":"Alexandra Nigro, Isabel C Silva, Benjamin Gerstein, Jasper Dayanan, Saakshi Khattri","doi":"10.1155/crdm/9941426","DOIUrl":"10.1155/crdm/9941426","url":null,"abstract":"Deucravacitinib is an oral, selective, allosteric tyrosine kinase 2 (TYK2) inhibitor approved for the treatment of moderate-to-severe plaque psoriasis and psoriatic arthritis. Deucravacitinib may offer a more selective approach compared to traditional Janus kinase (JAK) inhibitors. Emerging data support the use of deucravacitinib in inflammatory dermatoses beyond psoriatic disease. We present our clinical experience using deucravacitinib off-label in patients with challenging inflammatory skin disease and contextualize our findings within the current literature. We report three female patients aged 31-63 years with refractory inflammatory skin conditions, including two with dermatomyositis and one with pityriasis rubra pilaris (PRP). All patients had persistent disease despite multiple systemic therapies, such as oral corticosteroids (OCS), acitretin, azathioprine, mycophenolate mofetil (MMF), JAK inhibitors, intravenous immunoglobulin (IVIG), and/or rituximab. Deucravacitinib 6 mg daily was initiated as adjunctive or alternative therapy. Both patients with dermatomyositis experienced meaningful cutaneous improvement; one also demonstrated improved proximal muscle strength and a sustained response over 2 years without adverse events. The other showed gradual resolution of facial erythema but developed a mild acneiform eruption. The patient with PRP achieved marked improvement by 6 months and near-complete remission by 10 months, without reported adverse events. This case report supports the potential efficacy and adequate tolerability of deucravacitinib as an off-label option for refractory inflammatory dermatoses, specifically dermatomyositis and PRP. Larger prospective studies are needed to better define its long-term safety and therapeutic role beyond psoriasis.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"9941426"},"PeriodicalIF":0.0,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13338886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148403314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous Squamous Cell Carcinoma in the Sacral Region With Regression Attributed to an Abscopal Effect Induced by Nivolumab and Radiotherapy: A Case Report. 尼武单抗和放疗引起的骶区皮肤鳞状细胞癌消退：1例报告。

Case Reports in Dermatological Medicine Pub Date : 2026-07-01 eCollection Date: 2026-01-01 DOI: 10.1155/crdm/4943291

Tomomichi Shimizu, Akio Kondoh, Hinako Chiba, Shinpei Hamasaki, Sho Arai, Tomomi Inomata, Ayako Hirota, Fumikazu Yamazaki, Tomotaka Mabuchi

{"title":"Cutaneous Squamous Cell Carcinoma in the Sacral Region With Regression Attributed to an Abscopal Effect Induced by Nivolumab and Radiotherapy: A Case Report.","authors":"Tomomichi Shimizu, Akio Kondoh, Hinako Chiba, Shinpei Hamasaki, Sho Arai, Tomomi Inomata, Ayako Hirota, Fumikazu Yamazaki, Tomotaka Mabuchi","doi":"10.1155/crdm/4943291","DOIUrl":"10.1155/crdm/4943291","url":null,"abstract":"A 78-year-old Japanese man with a scar-like sacral lesion was referred to our hospital due to a red tumor that had developed in the region. Pathological examination of a partial skin biopsy revealed cutaneous SCC. The SCC was regarded as \"a Marjolin ulcer\" because the tumor developed on a chronic scar. After his first surgery, the tumor had recurred in his sacral region. He underwent a second surgical procedure; however, metastases developed in his inguinal lymph nodes. He was started on nivolumab therapy for four cycles; however, he developed local recurrence in the sacral region. He subsequently underwent local radiotherapy to the recurrent sacral lesion. After completion of local RT, nivolumab was continued for two additional cycles. Two months after his RT, his lymph node metastases surprisingly regressed, although direct radiation was not administered to his inguinal lymph nodes. The present case represents the first reported instance of cutaneous SCC (Marjolin ulcer) in the sacral region treated with nivolumab and RT in which an abscopal effect was observed.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"4943291"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13323849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facial Lichen Planopilaris Mimicking Melasma: A Case Report Emphasizing the Value of Clinicopathologic Correlation. 面部拟黄褐斑扁平苔藓1例：强调临床病理相关性的价值。

Case Reports in Dermatological Medicine Pub Date : 2026-06-28 eCollection Date: 2026-01-01 DOI: 10.1155/crdm/1703880

Maryam Hekmat, Negin Fazelzadeh Haghighi, Fatemeh Sari Aslani, Farideh Jokar

{"title":"Facial Lichen Planopilaris Mimicking Melasma: A Case Report Emphasizing the Value of Clinicopathologic Correlation.","authors":"Maryam Hekmat, Negin Fazelzadeh Haghighi, Fatemeh Sari Aslani, Farideh Jokar","doi":"10.1155/crdm/1703880","DOIUrl":"10.1155/crdm/1703880","url":null,"abstract":"Lichen planopilaris (LPP) is a rare, immune-mediated cicatricial alopecia characterized by perifollicular erythema, hyperkeratosis, and progressive hair follicle destruction, leading to permanent hair loss. While LPP typically affects the scalp and is classified into classic LPP, frontal fibrosing alopecia (FFA), and Graham-Little-Piccardi-Lassueur (GLPL) syndrome, atypical presentations involving extra-scalp regions, including the face, are exceedingly rare. We present a unique case of melasma-like LPP manifesting on the face, a highly unusual presentation that posed diagnostic challenges due to its resemblance to hyperpigmentary disorders. A 38-year-old man presented with an asymptomatic hyperpigmented patch on the cheek and forehead mimicking melasma. This case highlights the importance of considering LPP in the differential diagnosis of facial hyperpigmentation, particularly when conventional therapies for melasma fail. It should be noted that histopathology was a valuable tool for the diagnosis of the disease. We recommend including dermoscopic images in future studies to help dermatologists become familiar with the dermoscopic features of LPP and to differentiate between LPP and melasma using dermoscopy.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"1703880"},"PeriodicalIF":0.0,"publicationDate":"2026-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13310378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leukemia Cutis Exhibiting the Koebner Phenomenon: A Rare Clinical Presentation of Acute Myeloid Leukemia. 急性髓性白血病的一种罕见临床表现：白血病皮肤表现出Koebner现象。

Case Reports in Dermatological Medicine Pub Date : 2026-06-26 eCollection Date: 2026-01-01 DOI: 10.1155/crdm/6524620

Megan Hauptman, Joseph S Durgin, Ahmad Mattour, Shatha Farhan, Mio Nakamura, Michael Goldfarb

{"title":"Leukemia Cutis Exhibiting the Koebner Phenomenon: A Rare Clinical Presentation of Acute Myeloid Leukemia.","authors":"Megan Hauptman, Joseph S Durgin, Ahmad Mattour, Shatha Farhan, Mio Nakamura, Michael Goldfarb","doi":"10.1155/crdm/6524620","DOIUrl":"10.1155/crdm/6524620","url":null,"abstract":"Leukemia cutis with predilection for sites of prior cutaneous trauma, often described as a Koebner-like phenomenon, is a rare but recognized occurrence. We present a unique case of an, otherwise, healthy male who developed leukemia cutis at a prior unrelated biopsy site, leading to a new diagnosis of acute myeloid leukemia (AML). Certain AML subtypes with extramedullary propensity, particularly M4 and M5, as seen in our patient, are associated with an increased risk of leukemia cutis. Unlike their medullary counterparts, extramedullary AML cells preferentially migrate to and persist in tissues outside the bone marrow, where the local microenvironment may promote immune escape. Although the localization of leukemia cutis to the biopsy site is consistent with a Koebner-like response, it remains uncertain whether subclinical leukemic cells were already present at the time of the initial excision; therefore, a definitive causal relationship between trauma and leukemic infiltration cannot be established. Additionally, the prior keratoacanthoma and its excision may have created a localized immunocompromised cutaneous district, or locus minoris resistentiae, further predisposing the site to leukemic cell infiltration. The immunologic features of extramedullary AML, including impaired antigen presentation and T-cell exhaustion, overlap with this concept of localized immune dysregulation and may have facilitated site-specific leukemic infiltration. New infiltrative plaques at sites of prior skin trauma or biopsy warrant prompt biopsy and histopathological evaluation, even in patients without known hematologic malignancy. Leukemia cutis may represent the first manifestation of underlying acute leukemia, making early recognition critical for timely oncologic referral and treatment.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"6524620"},"PeriodicalIF":0.0,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13308720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overlapping Hyperpigmented and Poikilodermatous Mycosis Fungoides. 重叠的色素沉着和多角性皮肤真菌病。

Case Reports in Dermatological Medicine Pub Date : 2026-06-26 eCollection Date: 2026-01-01 DOI: 10.1155/crdm/6659374

Joan Somja, Arjen F Nikkels

{"title":"Overlapping Hyperpigmented and Poikilodermatous Mycosis Fungoides.","authors":"Joan Somja, Arjen F Nikkels","doi":"10.1155/crdm/6659374","DOIUrl":"10.1155/crdm/6659374","url":null,"abstract":"Primary cutaneous T-cell lymphomas (pCTCLs) are a heterogeneous group of rare clonal T-cell disorders, among which mycosis fungoides (MF) is the most common subtype. Several clinicopathologic variants of MF have been described, including poikilodermatous and hyperpigmented forms, with occasional overlap between variants. We report a 68-year old man with a 25-year history of slowly progressive, asymptomatic dark plaques involving the lower extremities and intergluteal fold consistent with overlapping hyperpigmented and poikilodermatous MF. Unlike the classically reticulated appearance of poikilodermatous MF, the lesions displayed extensive, sharply demarcated confluent hyperpigmentation. 18F-FDG PET/CT demonstrated no systemic involvement, although the cutaneous lesions displayed mild hypermetabolism. Histopathological examination revealed epidermotropic atypical lymphocytes with superficial dermal lymphohistiocytic infiltrates, vascular ectasia, erythrocyte extravasation, hemosiderin deposition, and dermal melanophages. Immunophenotypic studies supported the diagnosis of MF with monoclonal T-cell receptor rearrangement. Disease staging was T2N0M0B0 (Stage IB). Given the longstanding indolent course, absence of symptoms, and lack of extracutaneous disease, a watch-and-wait strategy was adopted. Although hyperpigmentation may be observed in poikilodermatous MF, the unusually marked and confluent pigmentation in our patient exceeded the degree typically associated with poikiloderma alone, suggesting overlap with the hyperpigmented variant of MF. This case highlights the importance of careful clinicopathologic correlation in atypical pigmentary presentations of MF.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"6659374"},"PeriodicalIF":0.0,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13307182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LC-OCT Features of Confluent and Reticulated Papillomatosis of Gougerot-Carteaud Syndrome. Gougerot-Carteaud综合征合并网状乳头状瘤的LC-OCT特征。

Case Reports in Dermatological Medicine Pub Date : 2026-06-19 eCollection Date: 2026-01-01 DOI: 10.1155/crdm/1417383

Daniele Omar Traini, Gerardo Palmisano, Andrea Paradisi, Mariarita Vigilante, Alessio Maccari, Alessandro Di Stefani

引用次数: 0

Secondary Syphilis With Concomitant Bullous Pemphigoid: A Case Report. 继发性梅毒伴大疱性类天疱疮1例。

Case Reports in Dermatological Medicine Pub Date : 2026-06-18 eCollection Date: 2026-01-01 DOI: 10.1155/crdm/1071116

Subi Rijal, Deekshanta Sitaula, Madhu Gyawalee, Vikash Paudel, Monique Kafle, Anupa Khadka, Sanjog Thapa Magar, Baruna Paudel, Aditya Jha, Amit Amatya, Bhaskar Kayastha

{"title":"Secondary Syphilis With Concomitant Bullous Pemphigoid: A Case Report.","authors":"Subi Rijal, Deekshanta Sitaula, Madhu Gyawalee, Vikash Paudel, Monique Kafle, Anupa Khadka, Sanjog Thapa Magar, Baruna Paudel, Aditya Jha, Amit Amatya, Bhaskar Kayastha","doi":"10.1155/crdm/1071116","DOIUrl":"10.1155/crdm/1071116","url":null,"abstract":"A 52-year-old woman presented with a three-month history of pruritic scaly palmoplantar eruptions that progressed to tense bullae over trunk and extremities along with genital mucosal involvement. Serology confirmed syphilis (VDRL reactive at 1:16 and TPHA positive), and biopsy with direct immunofluorescence (DIF) established bullous pemphigoid (BP). Treatment with benzathine penicillin led to resolution of palmoplantar and genital lesions, but there was no improvement of bullous lesions. Treatment with oral doxycycline and prednisolone significantly resolved the bullous eruptions. In adults, secondary syphilis can rarely be present as bullous eruptions, which may mimic autoimmune blistering disorders like BP, thereby posing a diagnostic dilemma. This case uniquely demonstrates BP persisting despite successful syphilis treatment (8-fold VDRL decrease), requiring ongoing immunosuppression. Unlike previously reported cases where bullous lesions resolved with antibiotics alone, this differential response confirms that syphilis can trigger independent, self-sustaining autoimmune bullous disease.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"1071116"},"PeriodicalIF":0.0,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13277756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148293568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0