Case Reports in Dermatological Medicine最新文献_第2页

Urothelial Carcinoma of the Penile Urethra as a Potential Secondary Complication of Junctional Epidermolysis Bullosa: A Case Report and Review of the Literature. 阴茎尿道尿路上皮癌作为大疱性结缔组织表皮松解症的潜在继发性并发症：1例报告及文献复习。

Case Reports in Dermatological Medicine Pub Date : 2026-02-23 eCollection Date: 2026-01-01 DOI: 10.1155/crdm/5549697

Jessica McClatchy, Ingrid Winship, Laura Scardamaglia, Vanessa Morgan, Gayle Ross

{"title":"Urothelial Carcinoma of the Penile Urethra as a Potential Secondary Complication of Junctional Epidermolysis Bullosa: A Case Report and Review of the Literature.","authors":"Jessica McClatchy, Ingrid Winship, Laura Scardamaglia, Vanessa Morgan, Gayle Ross","doi":"10.1155/crdm/5549697","DOIUrl":"https://doi.org/10.1155/crdm/5549697","url":null,"abstract":"Junctional epidermolysis bullosa is a rare autosomal recessive genetic dermatosis which is characterised by cutaneous and mucosal blistering. Cutaneous squamous cell carcinomas arising in areas of chronic wounds and scarring are a well-recognised complication. Mucosal involvement of the respiratory, urogenital and gastrointestinal tract can occur, though reports of associated mucosal carcinomas are scarce. We present a case of an 81-year-old male with junctional epidermolysis bullosa, multiple metastatic cutaneous squamous cell carcinomas and a papillary urothelial carcinoma. He was diagnosed with an invasive, high-grade pT2 papillary urothelial carcinoma of the penile urethra at age 74. This was initially identified by the patient as a nonhealing ulcer adjacent to the penile meatus on a background of recurrent blistering of the glans penis. Staging imaging revealed no nodal enlargement or distant metastasis. Management included a partial urethrotomy of the penile urethra, and he is currently in remission. We hypothesise that the urothelial carcinoma may have developed secondary to a permissive tumour microenvironment, which results from chronic inflammation and fibrosis in junctional epidermolysis bullosa.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"5549697"},"PeriodicalIF":0.0,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12927908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous Tuberculosis Presenting as a Chronic Dermatologic Disorder. 皮肤结核表现为一种慢性皮肤病。

Case Reports in Dermatological Medicine Pub Date : 2026-02-11 eCollection Date: 2026-01-01 DOI: 10.1155/crdm/3172006

Olivia Spina, Henry Fraimow, Justin Green

{"title":"Cutaneous Tuberculosis Presenting as a Chronic Dermatologic Disorder.","authors":"Olivia Spina, Henry Fraimow, Justin Green","doi":"10.1155/crdm/3172006","DOIUrl":"10.1155/crdm/3172006","url":null,"abstract":"Cutaneous tuberculosis (CTB) is a rare manifestation of extrapulmonary tuberculosis that is frequently misdiagnosed due to its diverse clinical presentation and resemblance to other dermatological conditions. Tuberculosis verrucosa cutis (TBVC), one clinical manifestation of CTB, poses a particular diagnostic challenge, as lesions are often paucibacillary, resulting in negative culture and PCR results. We present the case of a 73-year-old woman with a 10-year history of recurrent skin lesions on her left hand, initially diagnosed as eczema and exacerbated by topical corticosteroid treatment. Despite repeated negative histopathological stains, mycobacterial cultures. and PCR for Mycobacterium tuberculosis, a strong positive QuantiFERON-TB Gold test established the diagnosis. This case emphasizes the diagnostic utility of interferon-gamma release assays (IGRAs) in paucibacillary forms of CTB. Management was complicated by adverse drug reactions (ADRs) to first-line antituberculosis therapy (HRZE), including myalgias, fatigue, and a pruritic rash attributed to pyrazinamide and rifampin. These agents were discontinued, and the patient was transitioned to an alternative regimen, which resulted in improved tolerability and marked clinical improvement. This case highlights the diagnostic pitfalls and therapeutic challenges in managing TBVC. It underscores the importance of maintaining a high index of clinical suspicion for CTB in chronic, verrucous skin lesions, even in patients without specific TB risk factors. It also emphasizes the need for individualized treatment strategies.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"3172006"},"PeriodicalIF":0.0,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12893390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146177895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of Mycosis Fungoides With Chlormethine Hydrochloride Gel in Combination With Systemic Therapies: A Case Series. 盐酸氯甲基凝胶联合全身治疗蕈样真菌病：一个病例系列。

Case Reports in Dermatological Medicine Pub Date : 2026-02-09 eCollection Date: 2026-01-01 DOI: 10.1155/crdm/8813008

Gabor Dobos, Constanze Jonak, Kai-Christian Klespe, Marion Wobser, Adèle de Masson, Johanna Hoffmann, Christina Mitteldorf

{"title":"Management of Mycosis Fungoides With Chlormethine Hydrochloride Gel in Combination With Systemic Therapies: A Case Series.","authors":"Gabor Dobos, Constanze Jonak, Kai-Christian Klespe, Marion Wobser, Adèle de Masson, Johanna Hoffmann, Christina Mitteldorf","doi":"10.1155/crdm/8813008","DOIUrl":"10.1155/crdm/8813008","url":null,"abstract":"Background: Mycosis fungoides (MF) is a subtype of T-cell lymphoma that is characterised by the infiltration of malignant T cells into the skin. Treatment approaches usually include skin-directed therapies for early-stage disease and, additionally, systemic therapies for advanced stages. Chlormethine hydrochloride gel is recommended as a first-line treatment option for adult patients with MF, with previous studies demonstrating its efficacy. Due to the rarity of this disease, available literature on the optimal treatment of MF with chlormethine gel is limited, creating challenges for making informed clinical decisions. Thus, we share our individual clinical experiences of selected patients on chlormethine combination treatments to increase the real-world evidence for chlormethine gel in patients with MF.Case presentation: We present the cases of five male and two female Caucasian patients above the age of 48 with Stage I-IV MF, presenting with symptoms of skin plaques and lesions. All patients were treated with chlormethine hydrochloride gel in combination with other skin-directed and systemic therapies, including bexarotene, methotrexate, topical steroids, extracorporeal photopheresis, donor lymphocyte infusion and interferon-α (IFN-α) 2a. In most cases, chlormethine combination treatment resulted in disease control, e.g., plaque reduction, stable disease, and partial or complete response. The combination regimens were generally well tolerated, with associated adverse events being inflammation, pruritus and erythema.Conclusions: This case series reports on the efficacy and safety of chlormethine hydrochloride gel in combination with other topical and systemic therapies in reducing the skin lesion severity in patients with Stage I-IV MF in different real-world settings.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"8813008"},"PeriodicalIF":0.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12884418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146156244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Different Patterns of Lichen Planus in Three Members of One Family. 一科三种扁平地衣的不同形态。

Case Reports in Dermatological Medicine Pub Date : 2026-02-08 eCollection Date: 2026-01-01 DOI: 10.1155/crdm/1177988

Bahareh Abtahi-Naeini, Maryam Khalili, Fahimeh Shirdel, Mahsa Pourmahdi-Boroujeni

{"title":"Different Patterns of Lichen Planus in Three Members of One Family.","authors":"Bahareh Abtahi-Naeini, Maryam Khalili, Fahimeh Shirdel, Mahsa Pourmahdi-Boroujeni","doi":"10.1155/crdm/1177988","DOIUrl":"10.1155/crdm/1177988","url":null,"abstract":"The pathogenesis of Lichen Planus (LP) and its variants, despite many investigative efforts, remains incompletely understood. The occurrence of the disease in siblings suggests a potential role for both genetic and shared environmental factors. Here, three Iranian siblings-one male and two females-who presented with various clinical forms of LP were introduced. Case No. 1 exhibited bilateral facial pigmentation and was diagnosed with Lichen Planus Pigmentosus (LPPigm). Case No. 2 presented with facial pigmentation accompanied by facial papules and was diagnosed with LPPigm and Lichen Planopilaris (LPP). Case No.3 had frontotemporal hairline recession and eyebrow sparsening and was diagnosed with Frontal Fibrosing Alopecia (FFA). Histopathological examination confirmed the diagnoses in all three patients. Patients were treated with an individualized plan that included sunscreen use, potent topical corticosteroids, topical pimecrolimus, minoxidil, and systemic finasteride. To our knowledge, no other family in the literature has been reported to have such a wide range of LP variants. This series underscores the need for further research into genetic and environmental factors contributing to the development of LP and its variants.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"1177988"},"PeriodicalIF":0.0,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12883553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146156252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling Giant Onychomatricoma: A Diagnostic and Therapeutic Challenge. 揭示巨大甲丘瘤：诊断和治疗的挑战。

Case Reports in Dermatological Medicine Pub Date : 2026-02-05 eCollection Date: 2026-01-01 DOI: 10.1155/crdm/7190051

Katherine Nicole Calderón Tiburcio, Winston Damian Brito, Mariel Isa Pimentel, Ana Arisleyda Núñez

{"title":"Unveiling Giant Onychomatricoma: A Diagnostic and Therapeutic Challenge.","authors":"Katherine Nicole Calderón Tiburcio, Winston Damian Brito, Mariel Isa Pimentel, Ana Arisleyda Núñez","doi":"10.1155/crdm/7190051","DOIUrl":"10.1155/crdm/7190051","url":null,"abstract":"Onychomatricoma is a rare benign tumor of the nail matrix that is often misdiagnosed due to its resemblance to other nail conditions, particularly onychomycosis. A giant variant, which affects the entire nail structure, is even more uncommon, with fewer than 20 cases documented. We present the case of a 62-year-old male with a 5-year history of a slow-growing, asymptomatic tumor on the third nail of his left hand. Clinical examination revealed a papillomatous mass originating from the nail matrix, accompanied by nail thickening and xanthonychia. Dermoscopy showed longitudinal yellow, white, and gray lines, splinter hemorrhages, and a honeycomb pattern. Mycological testing suggested onychomycosis, but due to the size and persistence of the lesion, a multidisciplinary team recommended a complete nail avulsion and proximal matricectomy. Histopathological analysis revealed fibroepithelial projections covered by squamous epithelium and thickened nail plate fragments, confirming the diagnosis of giant onychomatricoma. The patient underwent surgical management and has shown no signs of recurrence after 2 years of follow-up. This case highlights the diagnostic and therapeutic challenges posed by giant onychomatricoma, particularly when coexisting with fungal infection. It also underscores the need for thorough clinical, dermoscopic, and histopathological evaluation in cases of chronic nail deformities.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"7190051"},"PeriodicalIF":0.0,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12873628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146140808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fixed Drug Eruptions in Malagasy Children: Clinical Observations and Characteristics. 马达加斯加儿童固定药疹：临床观察和特点。

Case Reports in Dermatological Medicine Pub Date : 2026-01-31 eCollection Date: 2026-01-01 DOI: 10.1155/crdm/6580695

Fenohasina Rakotonandrasana, Fandresena Arilala Sendrasoa, Onivola Raharolahy, Stevy Desana, Voahanginirina Nathalie Ralimalala, Tsiory Iarintsoa Razafimaharo, Moril Sata, Malalaniaina Andrianarison, Lala Soavina Ramarozatovo, Fahafahantsoa Rapelanoro Rabenja, Irina Mamisoa Ranaivo

{"title":"Fixed Drug Eruptions in Malagasy Children: Clinical Observations and Characteristics.","authors":"Fenohasina Rakotonandrasana, Fandresena Arilala Sendrasoa, Onivola Raharolahy, Stevy Desana, Voahanginirina Nathalie Ralimalala, Tsiory Iarintsoa Razafimaharo, Moril Sata, Malalaniaina Andrianarison, Lala Soavina Ramarozatovo, Fahafahantsoa Rapelanoro Rabenja, Irina Mamisoa Ranaivo","doi":"10.1155/crdm/6580695","DOIUrl":"10.1155/crdm/6580695","url":null,"abstract":"Fixed drug eruption is a drug-induced hypersensitivity reaction characterized by recurrent erythematous-pigmented lesions at the same site after each exposure to the causative drug. The molecules most frequently implicated are sulfonamides, nonsteroidal anti-inflammatory drugs, anticonvulsants, and paracetamol. The first case involved a four-year-old boy with sickle cell disease who had presented with a recurrent hyperpigmented macule on the lip for 1 year. The second case involved a three-year-old girl with multiple pigmented, pruritic macules. The third case involved a ten-year-old boy presenting with pigmented plaques and flaccid bullae on his arm and left thigh. In all three cases, fixed drug eruption (including one bullous form) was diagnosed based on the patient history and recurrence. Management consisted of permanent withdrawing of the offending drug and providing symptomatic treatment with antihistamines and topical corticosteroids. There were favorable outcomes, but persistent residual pigmentation remained. These three cases illustrate the typical clinical presentation of fixed drug eruption in children in Madagascar. Recurrence of the same lesion at the same site is pathognomonic and requires discontinuation of the offending drug and reporting to pharmacovigilance.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"6580695"},"PeriodicalIF":0.0,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12860391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uncommon Manifestation of Basal Cell Carcinoma on the Fingers: A Case Report and Review of the Existing Literature. 手指基底细胞癌的罕见表现：1例报告及文献复习。

Case Reports in Dermatological Medicine Pub Date : 2026-01-31 eCollection Date: 2026-01-01 DOI: 10.1155/crdm/9392963

Bhakinai Temnithikul, Piyakan Limtanyakul, Teerasit Viyanant, Phyo Zaw Aung

{"title":"Uncommon Manifestation of Basal Cell Carcinoma on the Fingers: A Case Report and Review of the Existing Literature.","authors":"Bhakinai Temnithikul, Piyakan Limtanyakul, Teerasit Viyanant, Phyo Zaw Aung","doi":"10.1155/crdm/9392963","DOIUrl":"10.1155/crdm/9392963","url":null,"abstract":"Basal cell carcinoma (BCC) is a commonly occurring cutaneous malignancy predominantly affecting sun-exposed areas. While the face and neck are typical sites, distal extremity involvement is rare. This case report presents an atypical case of nodular-type BCC arising on the right ring finger of a 49-year-old male with a history of HIV infection and anabolic steroid use. The absence of any significant trauma and familial predisposition to skin cancer in this patient underscores the importance of considering alternative risk factors. A comprehensive literature review revealed that while sun exposure, scarring, and immunosuppression are established risk factors for finger BCC, our case highlights the potential role of occupational and iatrogenic factors, such as hot oil spillage and HIV, in the pathogenesis of this uncommon malignancy. Notably, the thumb is the most frequent site of finger BCC, with the nodular subtype being the predominant histological variant. Surgical excision, often employing Mohs micrographic surgery, remains the gold standard treatment. In this case, wide excision and dorsal metacarpal artery flap reconstruction were performed. This report expands our understanding of the diverse clinical presentation of BCC and emphasizes the need for a thorough evaluation of potential risk factors in atypical cases.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"9392963"},"PeriodicalIF":0.0,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12860216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146103487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autoimmunity to Collagen XVII (BP180-Ag2) in Pemphigoid Associated With Parkinson's Disease. 帕金森病相关类天疱疮患者对胶原XVII （BP180-Ag2）的自身免疫

Case Reports in Dermatological Medicine Pub Date : 2026-01-30 eCollection Date: 2026-01-01 DOI: 10.1155/crdm/3649019

Ricardo Cid-Puente, Ingrid-Gabriela Ornelas-Ramírez, Lorena González-Herrera, Juan-José Bollain-Y-Goytia, Esperanza Avalos-Diaz, Rafael Herrera-Esparza

{"title":"Autoimmunity to Collagen XVII (BP180-Ag2) in Pemphigoid Associated With Parkinson's Disease.","authors":"Ricardo Cid-Puente, Ingrid-Gabriela Ornelas-Ramírez, Lorena González-Herrera, Juan-José Bollain-Y-Goytia, Esperanza Avalos-Diaz, Rafael Herrera-Esparza","doi":"10.1155/crdm/3649019","DOIUrl":"10.1155/crdm/3649019","url":null,"abstract":"The association between Parkinson's disease and autoimmune disease is rare; in our population, there is 1 case per 10,000 inhabitants. Bullous pemphigoid has a much lower incidence, and consequently, the association of Parkinson's disease and bullous pemphigoid is rarer. We present the case of an 84-year-old patient with a 16-year history of Parkinson's disease, treated with rotigotine, levodopa, and carbidopa. The patient spontaneously developed tense blisters that spread to the trunk and extremities within 1 year of the first occurrence of dermatological symptoms. A lesional biopsy revealed a subepidermal blister with inflammatory infiltrates, and immunofluorescent evaluation of the biopsy revealed immune deposits of IgG at the basement membrane. The serum displayed antibasement membrane autoantibodies that reacted with monkey esophagus tissue, and immunofluorescence revealed that the patient was positive for antineuronal antibodies that reacted with mouse brain tissue. The molecular reactivity of the serum and fluid obtained from a bulla was positive for the BP180-Ag2 antigen, as determined by ELISA. Additionally, six Parkinson's serum samples without pemphigoid disease were tested as controls, and only one serum sample was reactive to BP180-Ag2. A critical review of the possible pathogenic mechanisms of this rare association is discussed.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"3649019"},"PeriodicalIF":0.0,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12857584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adipose-Derived Mesenchymal Stem Cell Secretome for Post-Steroid Hypopigmentation and Skin Atrophy: A Case Report. 脂肪源性间充质干细胞分泌组治疗类固醇后色素沉着和皮肤萎缩：一例报告。

Case Reports in Dermatological Medicine Pub Date : 2026-01-28 eCollection Date: 2026-01-01 DOI: 10.1155/crdm/8615178

Shannaz Nadia Yusharyahya, Valdi Ven Japranata, Endi Novianto

引用次数: 0

Fluconazole-Induced Fixed Drug Eruption With Cross-Reactivity to Clotrimazole-Confirmation With Patch Testing. 氟康唑致与氯霉唑交叉反应的固定药疹——用斑贴试验证实。

Case Reports in Dermatological Medicine Pub Date : 2026-01-28 eCollection Date: 2026-01-01 DOI: 10.1155/crdm/1152541

D S Sron, P Martinez, J Iacobelli, P Singh, B M Ricciardo

{"title":"Fluconazole-Induced Fixed Drug Eruption With Cross-Reactivity to Clotrimazole-Confirmation With Patch Testing.","authors":"D S Sron, P Martinez, J Iacobelli, P Singh, B M Ricciardo","doi":"10.1155/crdm/1152541","DOIUrl":"10.1155/crdm/1152541","url":null,"abstract":"First described in 1994, fixed drug eruption (FDE) to fluconazole is uncommon but possibly underdiagnosed. Of these, women with vaginal candidiasis remain the most affected, with on average more than four occurrences prior to diagnosis. We present a case of a 29-year-old female who presented after her third episode of an itchy, oedematous, blistering rash on her right hand that developed 2 h following ingestion of 150 mg of fluconazole. She reported two similar episodes in the 2 years prior, all following administration of fluconazole for vaginal candidiasis. Each episode resulted in a rash localized to her right hand, with each subsequent exposure resulting in faster onset of symptoms and signs. A FDE to fluconazole was suspected clinically, and lesional skin biopsies were consistent with this. The diagnosis was confirmed with a positive patch test to 5% fluconazole applied to the affected skin on the right hand. Cross-reactivity with clotrimazole was confirmed with a positive patch test to clotrimazole 5%. She was subsequently advised to avoid both fluconazole and clotrimazole. Although cross-reactivity between different azole antifungal agents has been described, cross-reactivity between fluconazole and clotrimazole is a novel finding. This case raises awareness of FDE to fluconazole, in particular for women being treated for vaginal candidiasis, and highlights the importance of patch testing to other antifungal agents to assess for cross-reactivity.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"1152541"},"PeriodicalIF":0.0,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12848594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0