Case Reports in Dermatological Medicine最新文献

A Case of Erythrodermic Psoriasis Successfully Treated With Ixekizumab Combined With Low-Dose Methotrexate to Ensure Sustained Clearance: A Case Report. 伊谢珠单抗联合低剂量甲氨蝶呤成功治疗红皮病型银屑病1例，确保持续清除：1例报告。

Case Reports in Dermatological Medicine Pub Date : 2025-05-29 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/8810497

Jennifer Lavina Ngo, Lily Lyralin Tumalad, Patricia Anne Tinio, Rogelio Balagat

引用次数: 0

15 Years of Intermittent Therapy With Hydroxychloroquine Without Any Loss of Efficacy in Reticular Erythematous Mucinosis. 15年羟氯喹间歇治疗网状红斑性黏液病无任何疗效损失。

Case Reports in Dermatological Medicine Pub Date : 2025-05-22 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/8309221

Nicolò Di Giuli, Alice Bonelli, Martina Volonté, Eugenio Isoletta, Valeria Brazzelli

{"title":"15 Years of Intermittent Therapy With Hydroxychloroquine Without Any Loss of Efficacy in Reticular Erythematous Mucinosis.","authors":"Nicolò Di Giuli, Alice Bonelli, Martina Volonté, Eugenio Isoletta, Valeria Brazzelli","doi":"10.1155/crdm/8309221","DOIUrl":"10.1155/crdm/8309221","url":null,"abstract":"Reticular erythematous mucinosis (REM) is a rare dermatological condition characterized by erythematous, reticulated patches and plaques with a slightly infiltrated appearance. REM is classified among cutaneous mucinoses, which are characterized by the accumulation of mucin in the subcutaneous tissues, leading to the formation of characteristic reticulated patches on the skin. The pathogenesis is still debated, but the association with sun exposure seems to play an important role. We present the case of a 54-year-old individual with a history of recurrent erythema on the chest and back. The patient came to our attention in 2007 due to a worsening of symptoms after sun exposure. On clinical examination, the patient presented with pruritic, erythematous patches with a reticulated appearance. A biopsy was performed, which showed the presence of a moderate lymphocytic infiltrate in the dermis, with a perivascular and periappendageal distribution, consisting mainly of T lymphocytes, and deposits of mucin in the superficial dermis, dissecting the collagen bundles. A diagnosis of REM was made, and the patient began treatment with hydroxychloroquine 200 mg per day, with rapid improvement of symptoms. Considering the resolution of symptoms, the therapy was discontinued after 3 months. The patient remained in remission until the following summer when the condition recurred, requiring a new cycle of hydroxychloroquine therapy. The patient has experienced recurrences over the past 15 years during the summer, which responded to hydroxychloroquine therapy, consistently achieving rapid symptom resolution without ever experiencing loss of efficacy or side effects.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2025 ","pages":"8309221"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Severe Generalized Granuloma Annulare Responding Well to Tofacitinib. 托法替尼治疗严重广泛性肉芽肿1例。

Case Reports in Dermatological Medicine Pub Date : 2025-05-10 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/3593724

Saman Al-Zahawi, Narges Ghandi, Vahidesadat Azhari, Kamran Balighi

引用次数: 0

Pachydermodactyly: An Underdiagnosed Condition in Adolescence-A Case Report and Literature Review. 厚皮性：青春期一种未被诊断的疾病——一例报告及文献复习。

Case Reports in Dermatological Medicine Pub Date : 2025-05-08 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/5560071

Mishari T Alrubaiaan, Yousef H Alharthi, Suliman Alfaraj

引用次数: 0

Closed Keloid Therapy Supplying Water (by Gel) and Avoiding Air (by Being Wrapped With PERMEROLL): A Case Report. 闭合性瘢痕疙瘩治疗：供水（凝胶）和避免空气（用PERMEROLL包裹）1例报告。

Case Reports in Dermatological Medicine Pub Date : 2025-04-28 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/1258930

Haruyoshi Yamada

{"title":"Closed Keloid Therapy Supplying Water (by Gel) and Avoiding Air (by Being Wrapped With PERMEROLL): A Case Report.","authors":"Haruyoshi Yamada","doi":"10.1155/crdm/1258930","DOIUrl":"https://doi.org/10.1155/crdm/1258930","url":null,"abstract":"Keloids and hypertrophic scars share the same pathology, with immoderate collagen production being their main characteristic. Moreover, keloids and hypertrophic scars may occur as sequential disorders. Many studies have developed methods for treating these diseases; however, none have become the golden standard treatment. In this case study, closed keloid therapy using PERMEROLL (Nitoms, Inc., Tokyo, Japan) was administered to a 71-year-old female who presented with bacillus Calmette-Guerin keloids on her shoulder that had persisted for approximately 60 years. The gel (ITO Co., Ltd., Tokyo, Japan) was attached to the lesion, and the keloidal lesion was covered with PERMEROLL. Ten months following treatment, the hardness of the lesion, especially at its centre, had softened, its colour had lightened compared with the periphery and the thickness of the keloidal lesion had decreased. Overall, satisfactory results were noted. Closed keloid therapy with PERMEROLL enables the complete enclosure of the lesion and is an easier and cheaper method than the former treatment agent. Moreover, decreasing the level of thymic stromal lymphopoietin may be crucial for treating keloids.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2025 ","pages":"1258930"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unusual Presentation of Epidermodysplasia Verruciformis (EV) in Non-Sun Exposed Area: A Case Report. 疣状表皮发育不良（EV）在非阳光照射区域的异常表现：1例报告。

Case Reports in Dermatological Medicine Pub Date : 2025-03-26 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/7801944

Nidal Jebrini, Majed Dwaik, Mohanad Jaber, Sami Jabari, Raghad Razem, Man Sarahna, Rashad Alzaro, Feras Aljabari, Mohamed Aqel, Husein Sarahneh

{"title":"Unusual Presentation of Epidermodysplasia Verruciformis (EV) in Non-Sun Exposed Area: A Case Report.","authors":"Nidal Jebrini, Majed Dwaik, Mohanad Jaber, Sami Jabari, Raghad Razem, Man Sarahna, Rashad Alzaro, Feras Aljabari, Mohamed Aqel, Husein Sarahneh","doi":"10.1155/crdm/7801944","DOIUrl":"10.1155/crdm/7801944","url":null,"abstract":"Introduction and Importance: Epidermodysplasia verruciformis (EV), a rare hereditary skin disorder linked to HPV immunity, increases the risk of squamous cell carcinoma (SCC), typically in sun-exposed areas. This case highlights an extraordinary instance of SCC in a Sun-shielded region, marking the second documented case globally. Methods: The medical records and histopathological slides of the case were retrospectively reviewed. This work has been reported based on the CARE criteria. Case Presentation: A 28-year-old Palestinian woman, who adheres to a sun-protective Hijab due to her Muslim faith and has limited sun exposure working in a clothing store, with painful scalp lesions presented at the dermatology clinic. She and her siblings were diagnosed with EV. Three years ago, a painful, enlarging lesion on her scalp led to a diagnosis of trichoblastic carcinoma, followed by the development of six similar lesions. A year later, she returned with multiple painful, pus-producing lesions exhibiting features of trichoblastic and verrucous carcinoma, posing a challenging clinical scenario. Clinical Discussion: EV is a rare genetic skin disorder linked to EVER1/TCM6 or EVER2/TCM8 gene mutations, causing widespread warts due to specific HPV types. It heightens the risk of nonmelanoma skin cancer (NMSC), mainly SCC, often associated with beta-HPVs 5 and 8. Notably, atypical cases challenge the sun-exposure SCC concept. The reatment involves UV protection, retinoids, and close monitoring, critical to prevent lesion recurrence and aggressive malignancy interventions upon therapy discontinuation. Conclusion: In this unique case, a patient with EV developed SCC in an uncommonly sun-protected skin area, highlighting the extreme rarity of such an event within the context of this condition's complications.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2025 ","pages":"7801944"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11964711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Petechiae and a Persistent Violaceous Nodule: A Presentation of Blastic Plasmacytoid Dendritic Cell Neoplasm to Dermatology. 斑点和持久的紫色结节：皮肤病学上的一种母浆细胞样树突状细胞肿瘤。

Case Reports in Dermatological Medicine Pub Date : 2025-03-18 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/8628105

Madison Anzelc, Christina Druskovich, Austin Cusick, Matthew Franklin

引用次数: 0

A Clinical Case of Idiopathic Atrophoderma of Pasini and Pierini With Literature Review. 帕西尼、皮里尼特发性萎缩性皮病1例并文献复习。

Case Reports in Dermatological Medicine Pub Date : 2025-03-14 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/8886954

Raksha Pathak, Poshan Neupane, Samir Shrestha

引用次数: 0

A Case of Highly Recurrent DFSP: Treatment Dilemmas and Considerations. 1例高复发性DFSP：治疗困境与考虑。

Case Reports in Dermatological Medicine Pub Date : 2025-03-14 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/6640596

Ty Theriot, Christopher Haas

{"title":"A Case of Highly Recurrent DFSP: Treatment Dilemmas and Considerations.","authors":"Ty Theriot, Christopher Haas","doi":"10.1155/crdm/6640596","DOIUrl":"10.1155/crdm/6640596","url":null,"abstract":"Dermatofibrosarcoma protuberans (DFSP) is a rare, slow-growing soft tissue tumor affecting the dermis and subcutaneous tissues, with potential involvement of muscle and fascia. This case report describes a 68-year-old Caucasian male with a history of recurrent DFSP on the left cheek, initially excised 36 years ago, with multiple recurrences despite wide local excisions (WLEs), eventually requiring left orbital enucleation, presenting to the clinic with a 10-year history of a slow-growing lesion on the left temporal scalp. Examination revealed a 2 cm flesh-colored, firm nodule, which biopsy confirmed as DFSP. Despite two subsequent WLEs, positive margins persisted. The patient refused further surgical intervention and was referred for imatinib and radiation therapy, which he also declined. MRI revealed additional nodules near the left zygomatic arch and sternocleidomastoid. DFSP is diagnosed via biopsy, often confirmed with CD34 immunohistochemistry. Optimal treatment is Mohs micrographic surgery (MMS), but WLE is also used. The recurrence rate is high, especially in head and neck locations. This case underscores the necessity for multidisciplinary management and highlights the critical role of thorough physical and histopathologic examinations. Close clinical follow-up is essential due to the high recurrence risk within the first three years post-treatment. This report emphasizes the importance of early detection and comprehensive care strategies to manage DFSP effectively.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2025 ","pages":"6640596"},"PeriodicalIF":0.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric Presentations of Granulomatosis With Polyangiitis: A Double Case Study. 肉芽肿病合并多血管炎的儿科表现：双病例研究。

Case Reports in Dermatological Medicine Pub Date : 2025-03-14 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/6052518

Marina Handal, Amit Sharma, Mara Ernst, Krystina Khalil, Eduardo Weiss

{"title":"Pediatric Presentations of Granulomatosis With Polyangiitis: A Double Case Study.","authors":"Marina Handal, Amit Sharma, Mara Ernst, Krystina Khalil, Eduardo Weiss","doi":"10.1155/crdm/6052518","DOIUrl":"10.1155/crdm/6052518","url":null,"abstract":"Granulomatosis with polyangiitis (GPA) is an ANCA-associated necrotizing vasculitis that causes granulomatous inflammation of small vessels in the respiratory tract and mucosa; GPA in childhood is a rare occurrence that presents distinctly as either a chronic, granulomatous disease that is clinically localized or as an acute vasculitis with rapidly progressive pulmonary or renal hemorrhage. We present two distinct cases of GPA in pediatric patients whose diagnoses were confirmed according to clinical presentation and scoring guidelines offered by the ACR/EULAR GPA Criteria. Despite a negative cANCA result, Patient 1 demonstrated a score of 9 based on the ACR/EULAR criteria for GPA diagnosis. This was based on the patient's physical examination, which revealed tender nodules and plaques along the face as well as a crusted ulceration in the left concha. A punch biopsy of the left lateral forehead revealed necrotizing angiitis with neutrophil-predominant inflammatory infiltrate and giant cells on pathological analysis. In contrast, Patient 2 displayed a score of 13 as reflected in the extent of systemic disease involvement, with ulcerations and nodules scattered along the torso, extremities, and genitalia. Laboratory workup revealed ANCA positivity. Additionally, this patient experienced granuloma formation of the right optic nerve, ethmoid sinus infiltration with damage to the nasal septum, and bilateral cavitary masses on CXR. There is a paucity of data in characterizing GPA in childhood, as evidence is based on small cohort studies and case reports in this unique demographic. The clinical presentations in our report underscore the need for early disease detection and comprehensive workup, as timely diagnosis and optimal treatment regimens may improve the prognoses of pediatric patients with GPA.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2025 ","pages":"6052518"},"PeriodicalIF":0.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0