Case Reports in Dermatological Medicine最新文献

{"title":"Recognizing Pemphigus Vulgaris in a Low Prevalence Setting: A Journey Through Multiple Diagnoses.","authors":"Maria Emilia Adenike V Adedoja, Ma May Jasmin Ramos Yason, Melissa Aquino-Villamin","doi":"10.1155/crdm/9778760","DOIUrl":"https://doi.org/10.1155/crdm/9778760","url":null,"abstract":"<p><p>Pemphigus vulgaris (PV) is an autoimmune blistering disease that may present predominantly with mucosal involvement and is frequently misdiagnosed as infectious or inflammatory conditions. We describe a 72-year-old Filipino woman with a 3-month history of painful oral and genital ulcerations and subsequent flaccid bullae who was initially diagnosed and treated sequentially for candidiasis, disseminated herpes zoster infection, and Behçet's disease based on International Criteria for Behçet's Disease scoring. Despite multiple antimicrobial therapies, her symptoms progressed. Definitive evaluation revealed intraepidermal acantholysis on histopathology and intercellular IgG and C3 deposition in a characteristic \"fishnet\" pattern on direct immunofluorescence, with positive desmoglein 1 and 3 antibodies, confirming PV. Prompt initiation of systemic corticosteroids led to rapid clinical improvement. This case underscores how diagnostic anchoring and reliance on classification criteria can delay recognition of autoimmune blistering disease, highlighting the need for early biopsy and direct immunofluorescence in persistent mucocutaneous ulceration.</p>","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"9778760"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13130848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Silicosis to Systemic Sclerosis: Erasmus Syndrome in a Young Galamseyer-Case Report.","authors":"Solomon Gyabaah, Seth Kyei-Fram, Kojo Awotwi Hutton Mensah, Osei Yaw Asamoah, Clement Ohene Owusu, Divine Aseye Yao Amenuke, Yaw Adu-Boakye, Martin Kofi Agyei","doi":"10.1155/crdm/4538413","DOIUrl":"https://doi.org/10.1155/crdm/4538413","url":null,"abstract":"<p><p>Erasmus syndrome is an uncommon condition marked by the onset of systemic sclerosis (SSc) due to extended exposure to silica. In this case, we highlight the significant health risks associated with silica exposure in artisanal mining (galamsey), leading to the development of Erasmus syndrome. We present the case of a 33-year-old male artisanal miner with a 14-year work history who presented with a 2-year history of recurrent cough, difficulty breathing, and fever. He later developed hypopigmentation and skin thickening on his face, neck, torso, and knees, along with a productive cough and low-grade fever. He visited multiple healthcare facilities on account of the above complaints. At one of such visits, he was prescribed antituberculosis (TB) medication even though the sputum for GeneXpert was negative. On examination, he was in respiratory distress with an oxygen saturation of 78% on room air and required oxygen via a nonrebreather mask at 10 L/min, which raised the oxygen saturation to 94%, and had bronchial breath sounds in the right lung zones. Vocal resonance was increased bilaterally in the middle lung zones. He had salt-and-pepper dermopathy with tight and adherent skin on his face, chest, back, and knees. He additionally had microstomia, rat bite sign of the fingers, and Raynaud's phenomenon. Antinuclear antibody by indirect immunofluorescence on hep-2 cells was positive (1:320), and Antitopoisomerase 1 antibodies were also positive. Chest CT findings were consistent with complicated silicosis. The patient was diagnosed with Erasmus syndrome and started on immunosuppressive therapy. We highlight the significant health risks associated with silica exposure in artisanal mining (galamsey), leading to the development of Erasmus syndrome. Preventing silica exposure remains crucial, necessitating stringent workplace safety measures and occupational health practices to protect individuals in high-risk professions.</p>","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"4538413"},"PeriodicalIF":0.0,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13128982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Achieving Steroid-Sparing Remission in Refractory Pyoderma Gangrenosum With an Integrative Meta-Therapeutic System Based on Traditionally Engineered Nanomercury Sulfide: A Case Series.","authors":"Magesh Kirubakaran J P, Pooja Shrivastav, Sangeetha R, Surya Kumar K, Ayumi Saito, Sakthivel T","doi":"10.1155/crdm/9959087","DOIUrl":"https://doi.org/10.1155/crdm/9959087","url":null,"abstract":"<p><p>The management of pyoderma gangrenosum (PG) remains a formidable clinical challenge due to its complex, multipathway immunopathogenesis. Although conventional steroid therapy and advanced biologic agents have improved outcomes, a substantial proportion of patients, particularly those with severe, progressive ulceration, exhibit treatment-refractory disease, highlighting a critical unmet need for novel strategies capable of network-level immune modulation. To address this, we designed and implemented a self-regulating, integrative meta-therapeutic system centered on a nanostructured, herbo-metallic core of traditionally processed mercury sulfide (HgS) called Linga Chenduram, a compound characterized by its stable crystalline lattice and a toxicokinetic profile favoring particulate clearance. This system synergistically combines the nanocore with adjunctive phytocompounds (<i>Allium sativum</i> and <i>Aloe vera</i>), a transient low-dose glucocorticoid pulse, and an optimized anti-inflammatory, antioxidant-rich physiological milieu delivered within a stress-free environment. In a cohort of four patients with PG refractory to conventional immunosuppressants, this 30-day protocol elicited a rapid and profound clinical response. Objective metrics demonstrated a mean ulcer area reduction exceeding 61% by Day 30, progressing to complete and sustained re-epithelialization in all subjects. This robust cutaneous healing occurred concurrently with the normalization of systemic inflammation (C-reactive protein) and a significant restoration of functional capacity, evidenced by a mean improvement of 35 points on the Anterior Knee Pain Scale. Critically, clinical remission was maintained throughout a 6-month surveillance period, establishing a definitive steroid-sparing effect. We propose this multisystem improvements emerge from rational polypharmacology, wherein the nanoengineered HgS core serves as a pivotal immunomodulatory node, potentially engaging master regulatory pathways like NF-κB to disrupt dysregulated cytokine circuitry. It transcends conventional combination therapy, introducing a paradigm for managing refractory autoinflammation through integrative systems and compelling a rigorous reappraisal of pharmaceutically refined traditional nanomedicines. This preliminary evidence establishes a compelling rationale for future research to deconstruct the system's architecture and validate its therapeutic potential.</p>","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"9959087"},"PeriodicalIF":0.0,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13129219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Melanonychia as a Presenting Sign of Onychopapilloma: A Case Report and Review of the Literature.","authors":"Erandy Alicia Salcedo Elguea, Lizet Valles Montaño, Anna Karina Soto Posada, Jorge Alberto Guerra Villalobos","doi":"10.1155/crdm/3185082","DOIUrl":"https://doi.org/10.1155/crdm/3185082","url":null,"abstract":"<p><p>Onychopapilloma is a benign tumor of the nail unit characterized by broad clinical variability, which frequently delays diagnosis. It typically presents as longitudinal erythronychia, melanonychia, subungual hyperkeratosis, or a distal nail mass. We report a 65-year-old woman with a chronic single-digit nail lesion initially misdiagnosed as onychomycosis. Dermoscopy revealed distal hyperkeratosis and a subungual mass. Histopathological examination confirmed onychopapilloma, and complete surgical excision resulted in symptom resolution. This report underscores the importance of distinguishing this entity from malignant nail tumors and highlights the diagnostic value of dermoscopy and histopathology. Early recognition may prevent diagnostic delay and unnecessary treatments.</p>","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"3185082"},"PeriodicalIF":0.0,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13128983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pustular Rosacea in an 8-Year-Old Patient: A Rare Presentation of Pediatric Rosacea.","authors":"Razan Sharaf, Tasneem Assaf, Usra I Ghanem, Hadeel Abed Alhameed, Rabee Adwan","doi":"10.1155/crdm/6001322","DOIUrl":"https://doi.org/10.1155/crdm/6001322","url":null,"abstract":"<p><p>Pustular rosacea is a rare chronic inflammatory disease whose prevalence increases with age. We report a case of an 8-year-old patient who presented with a 3-year history of recurrent papulopustular facial eruptions associated with severe burning sensation, primarily affecting the cheeks, nose, and chin, exacerbated by hot weather and swimming. His condition was misdiagnosed as psoriasis, eczema, food allergy, or acne with limited benefit from treatment other than temporary relief from glucocorticoids. Skin biopsy showed hyperkeratosis and vascular ectasia with neutrophilic microabscesses consistent with papulopustular rosacea. He was successfully managed with lifestyle modifications and medications including azelaic acid, metronidazole, and ambroxol hydrochloride resulting in significant improvement. Diagnosing rosacea can be challenging due to its overlap with other conditions. Early diagnosis and treatment are crucial to prevent complications like scarring, persistent erythema, and psychological distress while ensuring a better quality of life and sustained remission.</p>","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"6001322"},"PeriodicalIF":0.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13111910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atrophying Pityriasis Versicolor: A Rare Presentation of a Common Dermatological Disorder and Literature Review.","authors":"Abdulrahman M Almalki, Sultan A Jaafari, Hasan Y Hannani, Khalid M Alattas, Radwan A Abutaleb, Amr M Gamaleldin, Abdulrahman K Daak","doi":"10.1155/crdm/4558804","DOIUrl":"https://doi.org/10.1155/crdm/4558804","url":null,"abstract":"<p><p>Pityriasis versicolor is a superficial fungal infection of the skin caused by fungi of the genus <i>Malassezia</i>. Typically, patients present with well-defined, hypopigmented, scaly macules, or patches over seborrheic areas. However, rare presentations include papular, confetti-like spots, and folliculocentric, atrophic, and inverse forms. Diagnosis may be established clinically with the help of noninvasive diagnostic tools such as dermoscopy, Wood's lamp, and direct microscopic examinations. However, skin biopsies are imperative in equivocal cases. To date, 34 cases have been reported. This study presents a rare presentation of atrophying skin lesions in a patient with pityriasis versicolor.</p>","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"4558804"},"PeriodicalIF":0.0,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13106942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Presentation of Scrotal Lymphangioma Circumscriptum: Case Report and Review of Literature.","authors":"Deeptara Pathak Thapa, Mohan Bhusal, Joshana Shrestha, Smriti Piya","doi":"10.1155/crdm/5563847","DOIUrl":"https://doi.org/10.1155/crdm/5563847","url":null,"abstract":"<p><p>Lymphangioma circumscriptum (LC) is a rare benign lymphatic malformation of deep dermis and subcutaneous layer. Although it commonly affects the trunk, axilla, thighs, and oral cavity, its appearance in the scrotum is extremely rare and can lead to considerable psychological distress, often due to concerns regarding sexually transmitted infections. We present a case of a 42-year-old married Nepali male who presented with multiple slow-growing, fluid-filled, grouped vesicular lesions on the scrotum that had gradually increased over 12 years. The diagnosis of LC was confirmed through clinical evaluation and histopathological findings. The patient was counseled regarding the condition and was referred for surgical management.</p>","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"5563847"},"PeriodicalIF":0.0,"publicationDate":"2026-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13071332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aseptic and Alopecic Nodule of the Scalp in a Young Female With Alopecia Areata.","authors":"Kara Turner, Arielle Carolina Mora Hurtado, Brittney DeClerck, Nada Elbuluk","doi":"10.1155/crdm/1835329","DOIUrl":"https://doi.org/10.1155/crdm/1835329","url":null,"abstract":"<p><p>Aseptic and alopecic nodules of the scalp (AANS) is a rare, likely underrecognized, nonscarring alopecia characterized by one or more alopecic nodules without evidence of microbial infection. AANS has a favorable prognosis and often responds well to treatments such as doxycycline, intralesional steroids, or drainage. We present a case of AANS in a young female with a history of biopsy-proven alopecia areata that achieved full resolution without recurrence with intralesional steroids. Recognition of this rare condition, including in the setting of other established alopecia diagnoses, may avoid a missed diagnosis as well as unnecessary surgery.</p>","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"1835329"},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Pityriasis Lichenoides Chronica Successfully Treated With Upadacitinib.","authors":"Olivia R Noble, David J Cohen, Lynn Cooper","doi":"10.1155/crdm/1118647","DOIUrl":"https://doi.org/10.1155/crdm/1118647","url":null,"abstract":"<p><p>Pityriasis lichenoides chronica (PLC) is a chronic cutaneous disorder of unknown cause that is thought to be a proliferation of T-cells in response to an antigen or infection. We introduce a case of a 62-year-old female who presented with an erythematous nonpainful eruption of well-demarcated annular and polycyclic papules and plaques with fine whitish peripheral scale distributed on the back, shoulders, chest, arms, and legs. Skin biopsy was consistent with PLC. After minimal improvement with systemic and topical corticosteroids, oral upadacitinib 15 mg once daily was started. Following 1 month of treatment with oral upadacitinib, the complete remission of PLC was observed. Thus, upadacitinib as a Janus kinase (JAK) inhibitor may be a novel treatment for PLC. However, more studies are needed to explore the efficacy and safety of JAK inhibitors for lichenoid disorders, such as PLC and others.</p>","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"1118647"},"PeriodicalIF":0.0,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary Intention Healing of Extensive Nasal Defects: A Multimodal Approach to Optimize Esthetic Outcomes.","authors":"Débora Barbosa Rocha Ribas, Yara Tavares Mendonça Garretto, Daniel Gontijo Ramos, Giovanni Indelicato Milano, Gisele Viana de Oliveira","doi":"10.1155/crdm/9822266","DOIUrl":"https://doi.org/10.1155/crdm/9822266","url":null,"abstract":"<p><strong>Introduction: </strong>Secondary intention healing (SIH) in the nasal region yields variable cosmetic results depending on the involved subunit. We report a case of a recurrent sclerodermiform basal cell carcinoma (BCC) resulting in an extensive surgical defect involving multiple subunits of the nose, eyelid, and cheek, traditionally requiring complex multistage flap reconstruction, successfully managed with SIH followed by a combination of laser technologies.</p><p><strong>Case presentation: </strong>A 75-year-old male with recurrent sclerodermiform BCC underwent excision resulting in a large facial defect affecting multiple nasal, eyelid, and cheek subunits. The wound was managed with SIH supported by sequential use of advanced dressings. After several weeks, the patient developed a small hypertrophic scar along the lateral nasal sidewall and malar region. A combined protocol using intense pulsed light (IPL), a fractional ablative erbium laser, and 5-fluorouracil (5-FU) drug delivery resulted in progressive remodeling and complete clinical resolution of the hypertrophic component, yielding a nearly imperceptible scar.</p><p><strong>Discussion: </strong>Early postoperative intervention with a multimodal laser approach may significantly enhance cosmetic outcomes following SIH, even in extensive defects involving multiple facial subunits. This case illustrates the potential of combined laser technologies and 5-FU as a minimally invasive strategy to optimize scarring and reduce the need for complex reconstructive surgery.</p>","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2026 ","pages":"9822266"},"PeriodicalIF":0.0,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12954547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147354005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}