Case Reports in Dermatological Medicine最新文献

Amyopathic Dermatomyositis in a Patient With Breast Cancer in Remission: A Case Report and a Systematic Review of the Literature. 乳腺癌缓解期患者的淀粉性皮肌炎：1例报告和文献的系统回顾。

Case Reports in Dermatological Medicine Pub Date : 2025-09-28 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/9193986

Rym Afiouni, Reine Merhy, Maria Farhat, Hampig Kourie, Roland Tomb

引用次数: 0

Regenerative Potential of Adipose Tissue-Derived Exosomes in Treating Hair Shaft Abnormalities: A Case Report. 脂肪组织来源的外泌体在治疗毛干异常中的再生潜力：一例报告。

Case Reports in Dermatological Medicine Pub Date : 2025-09-11 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/8838962

Mohammad Ali Nilforoushzadeh, Amirhossein Heidari, Nazila Heidari, Niloufar Najar Nobari

{"title":"Regenerative Potential of Adipose Tissue-Derived Exosomes in Treating Hair Shaft Abnormalities: A Case Report.","authors":"Mohammad Ali Nilforoushzadeh, Amirhossein Heidari, Nazila Heidari, Niloufar Najar Nobari","doi":"10.1155/crdm/8838962","DOIUrl":"10.1155/crdm/8838962","url":null,"abstract":"Hair shaft abnormalities, often linked to genetic or acquired conditions, present significant treatment challenges with limited and inconsistent therapeutic success. This report describes an eight-year-old female with severe hair shaft abnormality, unresponsive to standard treatments, including topical minoxidil and platelet-rich plasma therapy, who demonstrated marked improvement following a single session of adipose tissue (AT)-derived exosome therapy. The exosomes were administered via intradermal scalp injections, resulting in significant enhancement in hair structure, strength, and growth within 3 months, with no adverse effects observed. AT-derived exosomes, leveraging mechanisms such as Wnt/β-catenin activation and vascular endothelial growth factor expression, hold substantial promise for promoting hair follicle regeneration. This case highlights the potential of exosome therapy as an innovative and effective treatment for hair shaft abnormalities, emphasizing the need for further clinical studies to validate its efficacy and safety.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2025 ","pages":"8838962"},"PeriodicalIF":0.0,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Squamous Cell Carcinoma of the Vulva in Geriatric With Clinical Features of Papillomatous Plaque Resembling Anogenital Warts Caused by Human Papillomavirus Types 6 and 11. 老年外阴鳞状细胞癌伴由人乳头瘤病毒6型和11型引起的类似肛门生殖器疣的乳头状斑块的临床特征

Case Reports in Dermatological Medicine Pub Date : 2025-08-27 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/1730469

Pati Aji Achdiat, Fathia Rianty, Risa Miliawati Nurul Hidayah, Miranti Pangastuti, Hermin Aminah Usman, Ida Ayu Made Niki Putri Ashrita, Retno Hesty Maharani

{"title":"Squamous Cell Carcinoma of the Vulva in Geriatric With Clinical Features of Papillomatous Plaque Resembling Anogenital Warts Caused by Human Papillomavirus Types 6 and 11.","authors":"Pati Aji Achdiat, Fathia Rianty, Risa Miliawati Nurul Hidayah, Miranti Pangastuti, Hermin Aminah Usman, Ida Ayu Made Niki Putri Ashrita, Retno Hesty Maharani","doi":"10.1155/crdm/1730469","DOIUrl":"10.1155/crdm/1730469","url":null,"abstract":"Squamous cell carcinoma (SCC) of the vulva is caused by disturbances in the proliferation and differentiation of the squamous epithelium, which can be associated with human papillomavirus (HPV) infection. Vulvar SCC is usually caused by high-risk HPV types, although there are some cases that are caused by low-risk HPV types. The clinical manifestations of vulvar SCC vary, one of which can resemble anogenital warts. A case of vulvar SCC was reported in a 75-year-old woman with a lesion that appeared as a yellowish-white papillomatous plaque on the vulva. From the history taking, it was found that the skin disorder had a chronic course. A skin biopsy was performed on the patient and from histopathological examination found hyperplastic, parakeratotic, and acanthotic stratified squamous epithelial cells with koilocytosis. In addition, there was evidence of tumor cell invasion in the connective tissue stroma with polymorphic and hyperchromatic nuclei, supporting a diagnosis of well-differentiated vulvar SCC. Genotyping polymerase chain reaction revealed the presence of HPV types 6 and 11 deoxyribonucleic acid. The risk of malignancy in low-risk HPV must be considered, especially in the elderly. HPV-dependent SCC caused by low-risk HPV types 6 and 11, though uncommon but still possible, with clinical manifestations that resemble anogenital warts.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2025 ","pages":"1730469"},"PeriodicalIF":0.0,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12408127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-Level Laser Therapy as an Effective Intervention for Facial Pigmentation: A Case Report of Ephelides and Lentigines in Syrian Women. 低水平激光治疗作为面部色素沉着的有效干预：叙利亚妇女黄斑和黄斑1例报告。

Case Reports in Dermatological Medicine Pub Date : 2025-08-10 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/8197442

Kawthar Shurrab, Juliana Nabil Alzghayar

{"title":"Low-Level Laser Therapy as an Effective Intervention for Facial Pigmentation: A Case Report of Ephelides and Lentigines in Syrian Women.","authors":"Kawthar Shurrab, Juliana Nabil Alzghayar","doi":"10.1155/crdm/8197442","DOIUrl":"10.1155/crdm/8197442","url":null,"abstract":"Facial pigmentation disorders such as ephelides (commonly known as freckles) and solar lentigines are chronic dermatological conditions associated with sun exposure that can impact cosmetic appearance. This case report presents low-level laser therapy (LLLT) as an effective intervention for two different pigmentary disorders in Syrian women: one with ephelides and another with solar lentigines. The first case involved a 34-year-old woman with Fitzpatrick skin type II presenting with facial ephelides, while the second case featured a 49-year-old woman with Fitzpatrick skin type III diagnosed with solar lentigo. Both patients underwent 12 sessions from June 1 to August 1, 2023, using a red diode laser (660 nm) at a power density of 15.6 mW/cm2 and a dose of 5.6 J/cm2, applied for 6 min per session, with one pass per treatment area. The results demonstrated a marked reduction in pigmentation intensity and lesion size, with no reported side effects or lesion recurrence during a 1-year follow-up. These results suggest that LLLT may serve as an effective and safe therapeutic modality for selected facial pigmentary disorders.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2025 ","pages":"8197442"},"PeriodicalIF":0.0,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Treatment of Traumatic Tattooing With Dermabrasion: A Case Report. 外伤性文身的磨皮治疗：1例报告。

Case Reports in Dermatological Medicine Pub Date : 2025-08-06 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/4084268

Khalifa Al Alawi, Alreem Al Khayarin, Hanaa Al Kalbani, Sultan Al Shaqsi

{"title":"Acute Treatment of Traumatic Tattooing With Dermabrasion: A Case Report.","authors":"Khalifa Al Alawi, Alreem Al Khayarin, Hanaa Al Kalbani, Sultan Al Shaqsi","doi":"10.1155/crdm/4084268","DOIUrl":"10.1155/crdm/4084268","url":null,"abstract":"Traumatic tattoos result from foreign particles embedding into the dermis, often following industrial accidents or explosions. Among available treatments, including laser therapy and surgical excision, dermabrasion remains a cost-effective and widely accessible option. We present the case of a 49-year-old female construction supervisor who sustained extensive facial traumatic tattooing from the explosion of a hydraulic cement mixer. Clinical examination identified deeply embedded cement particles with localized erythema and edema on the left face. Following stabilization, she underwent acute dermabrasion under general anesthesia, employing staged removal of superficial and partial dermal layers to optimize particle clearance while preserving viable tissue. At 3-month follow-up, the patient demonstrated substantial reduction of pigmentation, minimal scarring, and high satisfaction. Dermabrasion, traditionally applied to superficial dermal lesions, proved particularly effective in this acute context by limiting chronic pigmentation, fibrosis, and textural irregularities. Compared to laser therapy, which requires multiple sessions and carries risk of incomplete clearance in particulate-laden wounds, or surgical excision, which may cause contour deformity, dermabrasion offers immediate, broad-surface intervention with relatively low morbidity. This case underscores dermabrasion's value as a first-line modality for acute traumatic tattoos, especially where resources constrain advanced laser platforms. Prompt recognition and intervention are critical to outcome, and while further research should refine timing, technique, and adjunctive care, dermabrasion remains a pragmatic, effective option in managing acute dermal trauma with embedded particulate matter.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2025 ","pages":"4084268"},"PeriodicalIF":0.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12349978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144844531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Newly Documented Rare Case of Pachyonychia Congenita II in a Three-Month-Old Baby. 新记录的罕见病例先天性厚甲甲虫II在一个三个月大的婴儿。

Case Reports in Dermatological Medicine Pub Date : 2025-07-12 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/8876939

Zeinab Youness, Marwa Hallal, Rita Makhoul

引用次数: 0

Er:YAG Laser Therapy for Xanthelasma Palpebrarum: A Retrospective Case Series Evaluating Clinical Efficacy, Safety, and Patient Outcomes in Periocular Lesion Management. Er:YAG激光治疗睑黄斑：回顾性病例系列评估眼周病变管理的临床疗效、安全性和患者预后。

Case Reports in Dermatological Medicine Pub Date : 2025-06-09 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/4616721

Saman Al-Zahawi, Sara Masoomi, Ifa Etesami

{"title":"Er:YAG Laser Therapy for Xanthelasma Palpebrarum: A Retrospective Case Series Evaluating Clinical Efficacy, Safety, and Patient Outcomes in Periocular Lesion Management.","authors":"Saman Al-Zahawi, Sara Masoomi, Ifa Etesami","doi":"10.1155/crdm/4616721","DOIUrl":"10.1155/crdm/4616721","url":null,"abstract":"Xanthelasma palpebrarum (XP) is a benign condition of the eyelid skin, characterized by the appearance of well-defined, bilateral, yellow-colored papules or plaques in the periorbital area. Although patients often seek dermatological consultation for cosmetic reasons, the associated medical implications, especially in younger individuals, hold significant medical importance. XP can be treated through various methods such as surgical removal, trichloroacetic acid (TCA) 70% application, cryotherapy, and laser procedures. Among the laser therapies (CO2, pulsed dye laser, and Er:YAG), which have proven effective due to their convenient application and fewer complications, the Er:YAG laser stands out for its potential to deliver faster recovery, fewer pigmentation changes, minimal scarring, and a shorter period of postlaser redness. This study evaluated Er:YAG laser for XP in four cases. Three laser sessions effectively treated the lesions, leading to patient satisfaction despite incomplete clearance, with no recurrence in 12 months and no side effects. The study concluded that Er:YAG laser is preferred over other lasers for this condition due to its superior healing profile.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2025 ","pages":"4616721"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Erythrodermic Psoriasis Successfully Treated With Ixekizumab Combined With Low-Dose Methotrexate to Ensure Sustained Clearance: A Case Report. 伊谢珠单抗联合低剂量甲氨蝶呤成功治疗红皮病型银屑病1例，确保持续清除：1例报告。

Case Reports in Dermatological Medicine Pub Date : 2025-05-29 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/8810497

Jennifer Lavina Ngo, Lily Lyralin Tumalad, Patricia Anne Tinio, Rogelio Balagat

引用次数: 0

15 Years of Intermittent Therapy With Hydroxychloroquine Without Any Loss of Efficacy in Reticular Erythematous Mucinosis. 15年羟氯喹间歇治疗网状红斑性黏液病无任何疗效损失。

Case Reports in Dermatological Medicine Pub Date : 2025-05-22 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/8309221

Nicolò Di Giuli, Alice Bonelli, Martina Volonté, Eugenio Isoletta, Valeria Brazzelli

{"title":"15 Years of Intermittent Therapy With Hydroxychloroquine Without Any Loss of Efficacy in Reticular Erythematous Mucinosis.","authors":"Nicolò Di Giuli, Alice Bonelli, Martina Volonté, Eugenio Isoletta, Valeria Brazzelli","doi":"10.1155/crdm/8309221","DOIUrl":"10.1155/crdm/8309221","url":null,"abstract":"Reticular erythematous mucinosis (REM) is a rare dermatological condition characterized by erythematous, reticulated patches and plaques with a slightly infiltrated appearance. REM is classified among cutaneous mucinoses, which are characterized by the accumulation of mucin in the subcutaneous tissues, leading to the formation of characteristic reticulated patches on the skin. The pathogenesis is still debated, but the association with sun exposure seems to play an important role. We present the case of a 54-year-old individual with a history of recurrent erythema on the chest and back. The patient came to our attention in 2007 due to a worsening of symptoms after sun exposure. On clinical examination, the patient presented with pruritic, erythematous patches with a reticulated appearance. A biopsy was performed, which showed the presence of a moderate lymphocytic infiltrate in the dermis, with a perivascular and periappendageal distribution, consisting mainly of T lymphocytes, and deposits of mucin in the superficial dermis, dissecting the collagen bundles. A diagnosis of REM was made, and the patient began treatment with hydroxychloroquine 200 mg per day, with rapid improvement of symptoms. Considering the resolution of symptoms, the therapy was discontinued after 3 months. The patient remained in remission until the following summer when the condition recurred, requiring a new cycle of hydroxychloroquine therapy. The patient has experienced recurrences over the past 15 years during the summer, which responded to hydroxychloroquine therapy, consistently achieving rapid symptom resolution without ever experiencing loss of efficacy or side effects.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2025 ","pages":"8309221"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Severe Generalized Granuloma Annulare Responding Well to Tofacitinib. 托法替尼治疗严重广泛性肉芽肿1例。

Case Reports in Dermatological Medicine Pub Date : 2025-05-10 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/3593724

Saman Al-Zahawi, Narges Ghandi, Vahidesadat Azhari, Kamran Balighi

引用次数: 0