CARTILAGE最新文献

{"title":"Commercial Insurance Payer Coverage Criteria for Meniscal Allograft Transplantation Poorly Reflect Modern Indications for the Procedure.","authors":"Jacob L Kotlier, Amir Fathi, Meng-Yung Ong, Cailan L Feingold, Eric H Lin, Ryan D Freshman, Ioanna K Bolia, Frank A Petrigliano, Joseph N Liu","doi":"10.1177/19476035251329223","DOIUrl":"10.1177/19476035251329223","url":null,"abstract":"<p><p>ObjectiveTo investigate whether insurance coverage criteria for meniscal allograft transplantation (MAT) are sufficiently supported in the policy documentation and whether these criteria represent current research and expert consensus on indications for the procedure.DesignThe top 11 United States (US)-based national commercial health insurance payers for MAT were identified. A Google search was performed to identify payer coverage policies. Cited references within policy documents were classified by type of reference and reviewed for level of evidence (LOE). Specific coverage criteria for each individual payer were then extracted and compared to assess for similarities among commercial payers. Finally, all references cited were examined to determine whether they supported the coverage criteria stated by policies for each specific payer.ResultsSeven of the 11 payers had accessible coverage policies. This study found that the majority of cited references were primary journal articles (20, 57.1%) and that the vast majority of references cited (27, 77.1%) were level IV evidence. Of the seven payers, only two (Cigna = 8, HCSC = 19) cited more than six sources. There was a high degree of homogeneity in coverage criteria among payers. The sources cited did not consistently support specific payer coverage criteria. Payer criteria also tended to be arbitrary and poorly supported by current evidence on MAT.ConclusionThis study demonstrates that insurance coverage policies for MAT frequently use outdated references or cite references inappropriately. In addition, these policies fail to reflect current research and consensus on indications for the procedure.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"312-321"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes After Initial Non-Operative Treatment of Osteochondral Lesions of the Talus (OLT) in Skeletally Immature Patients: A Cross-Sectional Study.","authors":"Jason A H Steman, Tristan M F Buck, Jari Dahmen, Peter A A Struijs, Sjoerd A S Stufkens, Gino M M J Kerkhoffs","doi":"10.1177/19476035251357214","DOIUrl":"10.1177/19476035251357214","url":null,"abstract":"<p><p>IntroductionLiterature on treatment outcomes in skeletally immature patients with osteochondral lesions of the talus (OLT) is scarce. As the healing of an OLT may be fundamentally different in a skeletally immature patient, more evidence is required focusing on this specific patient group. The primary aim of this study is to assess the conversion to surgery rate after initial non-operative management in skeletally immature patients with an OLT. The secondary aims of the present study are to assess and compare the clinical outcomes and reoperations after both non-operative and surgical treatment strategies at a mid- to long-term follow-up.MethodsAll skeletally immature patients at the moment of initial treatment, treated for their primary or non-primary OLT with a minimum follow-up duration of 2 years, were included in this study. Patients with concomitant injuries were excluded. All patients started with non-operative management. In case of failure of non-operative management, patients converted to Bone Marrow Stimulation (BMS) or fixation. The primary outcome was the conversion to surgery rate after initial non-operative management. Secondary outcomes consist of reoperations at mature and immature age, pain during weight bearing, measured by the numeric rating scale (NRS), NRS of pain during rest, NRS during stair climbing, Berndt and Harty outcome question, Foot and Ankle Outcome Score (FAOS) and Short Form-36 (SF-36) and the patient satisfaction rate regarding the received treatment.ResultsA total of 52 patients, 54% female, mean age of 13.6 years, were included in this study. Median follow-up duration was 81 months (range = 24-265 months). Seventeen patients received non-operative treatment as final treatment. In total, 35 (67%) out of 52 patients required surgical treatment after initial non-operative management, of which 14 underwent BMS and 20 had fixation while skeletally immature, 1 patient that had surgical treatment as an adult was excluded for further analysis. The median NRS of pain during weight bearing was 1 (interquartile range [IQR] = 0-2), 1 (IQR = 0-3), and 0 (IQR = 0-0.5) in the (sustained) non-operative, BMS, and fixation groups, respectively (<i>P</i> < 0.012). No significant differences in clinical outcomes between the different treatment groups could be observed. No complications occurred after surgical treatment. Reoperation rates were 21% and 20% in the BMS and fixation groups, respectively.ConclusionsThe most important finding of this study is that 67% of the patients receiving initial non-operative management for OLTs ultimately required surgery.Level of evidenceLevel III, cross-sectional comparative study.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"438-447"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Impact of Intralesional Bony Overgrowth on Opposing Cartilage Integrity: Five-Year Results Following Cartilage Repair.","authors":"Felix Ragnar Merlin Koenig, Marcus Raudner, Gregor Wollner, Vladimir Juras, Pavol Szomolanyi, Veronica Vetchy, Johannes Leitner, Victor Schmidbauer, Siegfried Trattnig","doi":"10.1177/19476035251335008","DOIUrl":"10.1177/19476035251335008","url":null,"abstract":"<p><p>ObjectivesThis study aimed to assess the impact of intralesional bony overgrowth (ILBO) after cartilage repair on the integrity of opposing articulating cartilage (OpAC) using T2 mapping and to correlate these findings with clinical outcomes.MethodsIn this multicenter study, magnetic resonance imaging (MRI) examinations were performed in the follow-up after cartilage repair (Microfracturing (MFX) and Matrix-Induced Autologous Chondrocyte Implantation (MACI)) in 45 patients up to 5 years after surgery. T2 values of the OpAC after 3, 12, and 60 months in patients with and without ILBO after 60 months were conducted along with clinical assessments (International Knee Documentation Committee (IKDC) and Knee injury and Osteoarthritis Outcome Score (KOOS)).ResultsAt 60 months post-surgery, 44.4% of patients presented with ILBO, which was associated with significantly higher T2 values in OpAC (<i>P</i> = 0.004). A tendency toward increased T2 values was observed after 12 months, although this did not reach statistical significance (<i>P</i> = 0.06). However, no significant differences were found in clinical outcomes between patients with or without ILBO, nor between those with or without T2 values comparable to reference cartilage.ConclusionILBO significantly affects the biophysical MRI properties of OpAC as indicated by higher T2 values after 60 months. These alterations, though not reflected in any clinical score, can suggest potential long-term implications for cartilage degeneration and may inform future monitoring strategies for cartilage repair. Further research is required to evaluate the long-term effects of these altered mechanical impacts on articulating cartilage and their clinical implications.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"358-367"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12037522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chondrocyte Response to Fresh Autologous Conditioned Serum Versus Freeze-Dried Allogenic Conditioned Serum.","authors":"Kevin Credille, Tristan J Elias, Sachin Allahabadi, Zachary Wang, Arnavaz Hakimiyan, Susan Chubinskaya, Brian J Cole, David Frisbie, Adam B Yanke","doi":"10.1177/19476035241261335","DOIUrl":"10.1177/19476035241261335","url":null,"abstract":"<p><p>ObjectiveTo investigate the cytokine release profile and histological response of human cartilage after exposure to autologous conditioned serum (ACS) and freeze-dried allogenic conditioned serum (FD-CS).DesignCartilage explants were collected from 6 patients undergoing total knee arthroplasty. ACS and FD-CS were created from patient serum samples. Cartilage samples were divided into 6 groups: (1) untreated control, (2) ACS, (3) FD-CS, (4) untreated interleukin (IL)-1β (5 ng/ml), (5) IL-1β + ACS, and (6) IL-1β + FD-CS. After 12 days, cartilage samples were analyzed with glycosaminoglycan (GAG) concentration normalized to wet weight while comparing cytokine concentrations, and histological scoring.ResultsThere was a significant decrease in pathology scoring for ACS (<i>P</i> = 0.0368) and FD-CS (<i>P</i> = 0.0368) in the IL-1β injury groups compared with the untreated IL-1β insult group. ACS and FD-CS significantly mitigate the IL-1β induced increase in basic fibroblast growth factor (bFGF) (<i>P</i> = 0.0009 and <i>P</i> = 0.0002, respectively). FD-CS showed a significant decrease in IL-1β concentration in the presence of IL-1β insult compared with the untreated IL-1β group (<i>P</i> < 0.0001). ACS-treated samples had significantly higher concentration of tumor necrosis factor (TNF)-α independent of IL-1β when compared with samples not treated with biologics (<i>P</i> = 0.0053).ConclusionsExplanted osteoarthritic cartilage responds favorably and equivalently to treatment with ACS and FD-CS from a histological perspective. Both ACS and FD-CS were able to mitigate the IL-1β-induced increases in bFGF and FD-CS lowered IL-1β concentration while increasing interleukin-1 receptor antagonist (IL-1Ra) concentration. Although the cytokine profile of cartilage tissue explants treated with FD-CS appears to be different than that of ACS, this difference does not seem to affect biologic activity of FD-CS.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"551-563"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-Articular Administration of Ganglioside Sugars Protects Cartilage from Progressive Degeneration in an Instability OA Rabbit Model.","authors":"Masanari Hamasaki, Tomohiro Onodera, Junichi Furukawa, Masahiro Todoh, Yuma Sakai, Taku Ebata, Mohamad Alaa Terkawi, Kentaro Homan, Norimasa Iwasaki","doi":"10.1177/19476035241311542","DOIUrl":"10.1177/19476035241311542","url":null,"abstract":"<p><p>ObjectiveOsteoarthritis (OA) is a degenerative joint disease that has no cure, and current therapies are intended to minimize pain. There is, therefore, a need for effective pharmacologic agents that reverse or slow the progression of joint damage. We report herein on an investigation of the effects of intra-articular injections of ganglioside sugars on the progression of OA in an experimental rabbit model.DesignKnee OA was induced Japanese in White rabbits by anterior cruciate ligament transection (ACLT). Ganglioside sugars at concentrations of 0.1, 0.3, and 0.9 mg/ml were then intra-articularly injected as a possible treatment for OA. Controls received intra-articular injections of saline. Knees were assessed macroscopically, histologically, and mechanically at 13 weeks after ACLT induction.ResultsMacroscopically, knees of the groups that received ganglioside sugars at concentrations of 0.3 and 0.9 mg/ml exhibited milder cartilage degradation compared to the controls. Consistent with these results, histological scores for these knees were significantly higher than the corresponding values for the control knees. Lectin histochemistry staining revealed that the treatment with ganglioside sugars at concentrations of 0.3 and 0.9 mg/ml was associated with a remarkable increase in the levels of GalNAc-positive chondrocytes in cartilage. Coefficient of friction testing also demonstrated that cartilages treated with ganglioside sugars had a lower coefficient of frictions than the values for the control group.ConclusionsIntra-articular injections of ganglioside sugars prevented cartilage degeneration in an OA-instability model. These results highlight the promising therapeutic potential for using ganglioside sugars in the treatment of progressive OA.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"729-737"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Vitrification of Human Osteochondral Dowels and Intact Femoral Condyle.","authors":"Mohammadhamed Shahsavari, Shannon Clark, Janet A W Elliott, Nadr M Jomha","doi":"10.1177/19476035251316715","DOIUrl":"10.1177/19476035251316715","url":null,"abstract":"<p><p>ObjectiveCryopreservation via vitrification of articular cartilage (AC) will increase the availability of graft tissue for treating large joint defects. To advance this research area, we compared the effects of 2 cryopreservation protocols in which 10-mm diameter human osteochondral dowels were cooled and stored in liquid nitrogen vapor.DesignDowels collected from healthy human knee joints (<i>n</i> = 3 donors) of deceased donors were randomly assigned to Protocol 8 (430 min) or Protocol 2BWF (410 min). Post-warming chondrocyte viability was assessed and normalized to fresh controls.ResultsBoth protocols resulted in high chondrocyte viability after loading, vitrification, and rewarming (~80% of fresh control). Protocol 2BWF was subsequently used to vitrify and rewarm 3 human intact lateral femoral condyles. After rewarming, metabolic activity, normalized chondrocyte viability, histology, and matrix productivity were experimentally measured. Results documented ~82% of fresh chondrocyte viability post vitrification and rewarming, with similar results to the fresh control group on the other AC quality criteria.ConclusionThese results demonstrate that both Protocol 8 and Protocol 2BWF can preserve the quality of vitrified human AC in osteochondral dowels and human intact femoral condyles.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"862-873"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Dimensionally Measured TT-TG Distance Remains After Medial Open-Wedge High Tibial Osteotomy and Correlates With Internal Rotation of Distal Tibial Segment Below the Osteotomy Site.","authors":"Se-Han Jung, Min Jung, Kwangho Chung, Hyun-Soo Moon, Sungjun Kim, So-Heun Lee, Chong-Hyuk Choi, Sung-Hwan Kim","doi":"10.1177/19476035251327025","DOIUrl":"10.1177/19476035251327025","url":null,"abstract":"<p><p>ObjectiveTo evaluate perioperative changes in anatomical parameters related to patellofemoral biomechanics, as well as cartilage repair outcomes following additional arthroscopic marrow stimulation for full-thickness trochlear cartilage defects (TCDs) during medial open-wedge high tibial osteotomy (MOWHTO).DesignA total of 38 patients (38 knees) who underwent arthroscopic marrow stimulation (microfracture or microdrilling) for TCDs combined with MOWHTO were retrospectively reviewed. The mean follow-up period was 27.0 months. Three-dimensional measurements of parameters associated with patellar biomechanics were performed. Magnetic resonance imaging and second-look arthroscopy were used to assess repaired cartilage, using Magnetic Resonance Observation of Cartilage Repaired Tissue (MOCART) knee score and International Cartilage Repair Society Cartilage repair assessment (ICRS CRA).ResultsIn 3-dimensional measurements, the tibial tubercle-trochlear groove (TT-TG) distance was maintained (mean difference: -0.6 mm, <i>P</i> = 0.227), whereas the modified Q-angle significantly decreased (mean difference: -1.9°, <i>P</i> = 0.002). The distal femur-distal tibial rotation (DF-DTR) decreased, indicating internal rotation of the distal tibial segment (mean difference: -5.3°, <i>P</i> < 0.001). TT-TG distance was associated with DF-DTR (<i>r</i> = 0.583, <i>P</i> = 0.001). Arthroscopic marrow stimulation for TCDs showed favorable cartilage repaired tissue, especially for the microdrilling group (median MOCART score, 70; ICRS CRA grade 1-2, 82.8%).ConclusionThe 3-dimensionally measured TT-TG distance was maintained after MOWHTO and was associated with internal rotation of the distal tibial segment below the osteotomy site. Arthroscopic marrow stimulation for TCDs in patients undergoing MOWHTO achieved favorable cartilage repaired tissue in short term.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"299-311"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mir-450a-5p Ameliorates IL-1β-Induced Chondrocyte Apoptosis, Inflammation, and Extracellular Matrix Degradation by Down-Regulating LITAF.","authors":"Guo-Feng Jia, Wei Tan, Xu Han","doi":"10.1177/19476035251344478","DOIUrl":"10.1177/19476035251344478","url":null,"abstract":"<p><p>ObjectiveOsteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation, causing severe pain and disability. Recent studies suggest that miR-450a-5p may regulate inflammatory pathways in OA. This study aimed to elucidate the role of miR-450a-5p in OA, providing a potential therapeutic target for the clinical treatment.MethodsCartilage tissues were collected from OA patients undergoing knee replacement surgery, and CHON-001 cells were treated with interleukin (IL)-1β to induce an OA model <i>in vitro</i>. Real-time quantitative polymerase chain reaction was used to detect the miR-450a-5p expression, and Western blot determined the lipopolysaccharide-induced tumor necrosis factor (TNF)-α factor (LITAF) expression. The targeting relationship between LITAF and miR-450a-5p was verified by dual-luciferase reporter assay. Cell proliferation and apoptosis were assessed using the Cell Counting Kit-8 assay and flow cytometry, respectively. Levels of IL-6, IL-10, and TNF-α were measured via enzyme-linked immunosorbent assay. In addition, Western blot was employed to detect the expressions of matrix metalloproteinase-3 (MMP-3), collagen III, and aggrecan in extracellular matrix (ECM).ResultsMiR-450a-5p expression was significantly down-regulated in OA tissues and IL-1β-induced CHON-001 cells (~60%), while LITAF expression was markedly increased (~1.8-fold). There was a negative correlation between miR-450a-5p and LITAF in OA tissues (r = -0.596, <i>P</i> < 0.01). MiR-450a-5p directly targeted and inhibited LITAF expression. Its overexpression promoted chondrocyte proliferation, reduced apoptosis and inflammatory cytokines, and mitigated ECM degradation.ConclusionsMiR-450a-5p inhibited LITAF expression, thereby attenuating apoptosis, inflammation, and ECM degradation in chondrocytes. It may serve as a promising therapeutic target for OA.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"605-615"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BMSC-Derived Exosomes Attenuate Rat Osteoarthritis by Regulating Macrophage Polarization Through PINK1/Parkin Signaling Pathway: Focus on Immune Responses in the Perichondrium.","authors":"Ilya Klabukov, Anastas Kisel, Daria Eygel, Elena Isaeva, Elena Yatsenko, Denis Baranovskii","doi":"10.1177/19476035251348308","DOIUrl":"10.1177/19476035251348308","url":null,"abstract":"","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"265-266"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Osteoarthritis Dynamics: Patient-Specific Cartilage Samples in an Organ-on-a-Chip Model.","authors":"Markus Pasztorek, Johanna Fischer, Alexander Otahal, Andrea de Luna, Stefan Nehrer, Julie Rosser","doi":"10.1177/19476035241277654","DOIUrl":"10.1177/19476035241277654","url":null,"abstract":"<p><p>ObjectiveThis study aims to tackle the existing challenges associated with the prediction and optimization of pharmaceutical interventions for osteoarthritis (OA). The primary objective is to develop an innovative tool that provides objective and patient-specific information regarding the most affected tissue in OA, articular cartilage.DesignWe employed an organ-on-a-chip (OoC) approach to replicate the 3D structure of cartilage in an <i>in vitro</i> setup. The study focused on assessing the individual drug responses of common medications using this innovative platform. Additionally, we conducted a biomarker analysis to gain insights into the variability of drug responses across patients.ResultsOur findings reveal that OA articular cartilage demonstrates an individualized response to pharmaceutical interventions. Despite the diverse nature of patient responses, our study indicates that Triamcinolone, a standard-of-care medication, consistently exhibits a robust anti-inflammatory response across patient tests. However, as seen in clinical studies, Triamcinolone was concurrently associated with degeneration. The biomarker analysis further underscores the importance of considering individual drug responses in developing effective treatment plans.ConclusionIn conclusion, this study introduces a valuable tool that not only mimics the 3D structure of cartilage but also provides crucial insights into the individualized responses of patients to various OA treatments. The application of an OoC approach may allow for a more accurate assessment of treatment efficacy. This objective biomarker analysis on patient-specific tissue offers clinicians a means to tailor treatment plans, thereby minimizing joint damage and advancing toward a more personalized approach in OA management.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"674-683"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}