CARTILAGE最新文献

{"title":"Cir-DNA Sequencing Revealed the Landscape of Extrachromosomal Circular DNA in Articular Cartilage and the Potential Roles in Osteoarthritis.","authors":"Wei Xiang, Tongyi Zhang, Song Li, Yunquan Gong, Xiaoqing Luo, Jing Yuan, Yaran Wu, Xiaojing Yan, Yan Xiong, Jiqin Lian, Guangyu Zhao, Changyue Gao, Liang Kuang, Zhenhong Ni","doi":"10.1177/19476035231205690","DOIUrl":"10.1177/19476035231205690","url":null,"abstract":"<p><strong>Objective: </strong>Extrachromosomal circular DNA (eccDNA) has been shown to be involved in several physiological and pathological processes including immunity, inflammation, aging, and tumor. However, the expression of eccDNA in cartilage has not been reported until now. In this study, we aimed to investigate the landscape of eccDNA in articular cartilage and analyze the potential roles in osteoarthritis (OA).</p><p><strong>Methods: </strong>The samples of articular cartilage were obtained from total knee arthroplasty (TKA) donors with OA. The mitochondrial DNA (mtDNAs) and the linear DNAs from chondrocytes of articular cartilage were removed. Then the eccDNAs were enriched for cir-DNA sequencing. After quality control evaluation, we systematically revealed the identified eccDNA data including size distribution, the size range, and sequence pattern. Moreover, we explored and discussed the potential roles of eccDNA in OA via motif analysis and Gene Ontology (GO)/Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis.</p><p><strong>Results: </strong>The chondrocytes from OA cartilage contained an abundance of eccDNAs, which was termed as OC-eccDNAs (OA cartilage-derived eccDNA). The characteristics of OC-eccDNAs were tissue-specific, including the distribution, the size range, and sequence pattern. Moreover, the functional analysis indicated that eccDNA may be involved in the homeostasis maintenance of chondrocytes and participated in the process of OA.</p><p><strong>Conclusions: </strong>Our data first showed the landscape of eccDNA in articular cartilage and preliminarily indicated the potential roles of eccDNA in OA.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"100-107"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41232506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteochondral Repair with Autologous Cartilage Transplantation with or without Bone Grafting: A Short Pilot Study in Mini-Pigs.","authors":"Dong Woo Shim, Kyoung-Mi Lee, Donghyun Lee, Jun Sik Kim, Yeon Seop Jung, Sung Suk Oh, Si Wook Lee, Jin Woo Lee, Bom Soo Kim","doi":"10.1177/19476035231199442","DOIUrl":"10.1177/19476035231199442","url":null,"abstract":"<p><strong>Objective: </strong>Treatment strategies for osteochondral defects, for which particulated autologous cartilage transplantation (PACT) is an emerging treatment strategy, aim to restore the structure and function of the hyaline cartilage. Herein, we compared the efficacy of PACT with control or human transforming growth factor-β (rhTGF-β), and clarified the necessity of bone graft (BG) with PACT to treat shallow osteochondral defects in a porcine model.</p><p><strong>Design: </strong>Two skeletally mature male micropigs received 4 osteochondral defects in each knee. The 16 defects were randomized to (1) empty control, (2) PACT, (3) PACT with BG, or (4) rhTGF-β. Animals were euthanized after 2 months and histomorphometry, immunofluorescence analysis, semiquantitative evaluation (O'Driscoll score), and magnetic resonance observation of cartilage repair tissue (MOCART) score were performed.</p><p><strong>Results: </strong>Hyaline cartilages, glycosaminoglycan synthesis, and collagen type II staining were more abundant in the PACT than in the control and rhTGF-β groups. The O'Driscoll score was significantly different between groups (<i>P</i> < 0.001), with both PACT groups showing superiority (<i>P</i> = 0.002). PACT had the highest score (<i>P</i> = 0.002), with improved restoration of subchondral bone compared with PACT with BG. The MOCART score showed significant differences between groups (<i>P</i> = 0.021); MOCART and O'Driscoll scores showed high correlation (r = 0.847, <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Treatment of osteochondral defects with PACT improved tissue quality compared with that with control or rhTGF-β in a porcine model. BG, in addition to PACT, may be unnecessary for shallow osteochondral defects. <i>Clinical Relevance.</i> BG may not be necessary while performing PACT.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"61-70"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10204733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Grading of Cartilage Damage in Degenerative Knee Osteoarthritis Based on Quantitative Parameters of the Infrapatellar Fat Pad: A Cross-Sectional Study.","authors":"Ju Zeng, Decui Liang, Guangyan Tang","doi":"10.1177/19476035251320747","DOIUrl":"10.1177/19476035251320747","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;The aim of this research was to investigate the relationship between quantitative texture parameters and degenerative cartilage damage in knee osteoarthritis (KOA) by conducting a full-volume texture analysis of infrapatellar fat pad (IFP). In addition, this study also explored if the quantitative texture parameter models outperform semi-quantitative model in cartilage damage classification tasks.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;This retrospective study involved 202 patients who were diagnosed with KOA using imaging and clinical examinations. Texture parameters of the IFP were extracted from sagittal FSE PDWI fat-suppressed sequence images, and least absolute shrinkage and selection operator regression was used for feature selection. Spearman correlation analysis was conducted to assess the relationship between semi-quantitative parameter (Hoffa-synovitis score), quantitative parameters, and cartilage damage. Five multi-classification logistic regression models were developed to predict cartilage damage grade by using Hoffa-synovitis score, texture parameters, and clinical characteristics as independent variables. Subsequently, the performance of these models was compared.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Eight texture features were screened out in this study. Correlation analysis showed that Hoffa synovitis score, texture parameters, and cartilage damage grade were significantly correlated (all &lt;i&gt;P&lt;/i&gt; &lt; 0.05). The strongest correlation was found between Hoffa-synovitis score and cartilage damage, demonstrating a moderate positive relationship (&lt;i&gt;r&lt;/i&gt; = 0.62). In terms of texture features, the Correlation parameter exhibited a moderate positive correlation with cartilage damage (&lt;i&gt;r&lt;/i&gt; = 0.49), while other texture parameters had a slight positive correlation degree of positive or negative correlation. In the task of classifying cartilage damage, the model's macro-average area under the curve (AUC) only using the Hoffa-synovitis score was 0.73 (95% confidence interval (CI): 0.64, 0.83), while the model using only selected texture parameters achieved a macro-average AUC of 0.84 (95% CI: 0.68, 0.94). Furthermore, the model that combined texture parameters and clinical features also achieved a macro-average AUC of 0.84 (95% CI: 0.72, 0.94). By integrating the Hoffa-synovitis score, texture parameters, and clinical features, the model's macro-average AUC experienced a slight improvement to 0.85 (95% CI: 0.74, 0.93). Notably, the model combining only Hoffa-synovitis score and texture parameters had the best classification performance, with a macro-average AUC of 0.88 (95% CI: 77, 0.97). The performance of the 4 models incorporating texture parameters outperformed that of the Hoffa-synovitis score alone (all &lt;i&gt;P&lt;/i&gt; &lt; 0.05), however with no significant statistical difference observed among the 4 models (all &lt;i&gt;P&lt;/i&gt; &gt; 0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;There existed a correlation between the textu","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035251320747"},"PeriodicalIF":2.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cartilage Organoids from Articular Chondroprogenitor Cells and Their Potential to Produce Neo-Hyaline Cartilage.","authors":"Daphne M A Menssen, Jeske C A Feenstra, Rob P A Janssen, Florencia Abinzano, Keita Ito","doi":"10.1177/19476035241313179","DOIUrl":"10.1177/19476035241313179","url":null,"abstract":"<p><strong>Introduction: </strong>The use of autologous human primary articular chondrocytes (hPACs) for repairing damaged cartilage is the golden standard; however, their 2-dimensional (2D) expansion induces dedifferentiation, making it challenging to create hyaline cartilage. Spinner flasks are efficient for generating cartilage organoids, allowing hPACs to proliferate without dedifferentiation; however, porcine notochordal cell-derived matrix (NCM) is needed for aggregation, limiting clinical application. Human articular chondroprogenitor cells (hACPCs) can be expanded many fold while maintaining chondrogenic potential. Therefore, the scalable production of hACPC cartilage organoids without NCM in spinner flasks was investigated in this study.</p><p><strong>Methods: </strong>hPAC organoids with NCM and hACPC organoids using bone morphogenetic protein 9 (BMP-9) were produced in spinner flasks in 14 days. Thereafter, approximately 20 organoids were fused in low adhesive wells for 21 days. Organoids underwent mechanical testing, and both organoids and fused constructs were evaluated using biochemical, histological, and immunohistochemical analysis.</p><p><strong>Results: </strong>The hACPCs self-assembled and synthesized abundant extracellular matrix once stimulated with BMP-9. The hPAC and hACPC organoids showed similar mechanical properties, but hACPC organoids and fused constructs showed a more uniform matrix and cell distribution.</p><p><strong>Conclusion: </strong>The hACPC organoids fused into a neo-hyaline cartilage-like tissue, demonstrating their potential for improved, scalable cartilage tissue repair.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035241313179"},"PeriodicalIF":2.7,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Femoral Condyle Radius of Curvature at the Chondral Surface Shows Significant Correlation With the Anterior-Posterior Length.","authors":"Saeed Jerban, Suzanne M Tabbaa, Paul E Caldwell, Kristofer J Jones, William Bugbee, Dennis C Crawford, Eric Y Chang","doi":"10.1177/19476035251314109","DOIUrl":"10.1177/19476035251314109","url":null,"abstract":"<p><strong>Background: </strong>Accurate donor-recipient matching of the femoral condyle radius of curvature (ROC) in osteochondral allograft (OCA) transplantation may aid in minimizing articular surface incongruities. Matching linear femorotibial dimensions, such as the femoral condyle anterior-posterior length (APL), femoral condyle width (lateral-medial length, LML), femoral hemicondyle width (HCW), and tibial plateau width (TPW), can provide similar results if they correlate well with ROC. This study investigates the relationship between femorotibial dimensions and ROC at the cartilage surface using magnetic resonance imaging (MRI).</p><p><strong>Methods: </strong>Deidentified MRI images of 63 patients (35 men, 33 ± 10 years old, and 28 women, 27 ± 8 years old) were analyzed. Axial images were used for APL, LML, and TPW (TPW-Ax) measurements, while coronal images were used for HCW and TPW (TPW-Cor) measurements. Cartilage was segmented in true sagittal images at the medial femoral condyle (MFC) and lateral femoral condyle (LFC) to calculate their specific cartilage surface ROCs. Linear regression models were used to determine the relationship between the femorotibial dimensions and ROC.</p><p><strong>Results: </strong>Cartilage ROC was significantly correlated with all the linear femorotibial dimensions at the MFC (<i>P</i> < 0.01, <i>R</i>² = 0.78, 0.69, 0.67, 0.59, and 0.37 for ROC correlations with APL, LML, TPW-Ax, TPW-Cor, and HCW, respectively), and the LFC (<i>P</i> < 0.01, <i>R</i>² = 0.81, 0.61, 0.56, 0.54, and 0.41 for ROC correlations with APL, LML, TPW-Ax, TPW-Cor, and HCW, respectively).</p><p><strong>Conclusions: </strong>The APL was the most predictive femorotibial dimension of the cartilage surface ROC. Donor-recipient APL matching in OCA transplantation may provide a similar level of matching to that achievable by direct ROC measurements. The APL matching may help reduce cartilage incongruities, particularly for patients with large osteochondral lesions, in which the ROC measurement cannot be accurately determined.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035251314109"},"PeriodicalIF":2.7,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11780605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Texture Analysis of Cartilage Repair Tissue Maturation: Comparison of Two Cartilage Repair Methods and Correlation with MOCART 2.0.","authors":"Veronika Janacova, Pavol Szomolanyi, Diana Sitarcikova, Alexandra Kirner, Siegfried Trattnig, Vladimir Juras","doi":"10.1177/19476035241313047","DOIUrl":"10.1177/19476035241313047","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to assess the maturation of matrix-associated autologous chondrocyte transplantation (MACT) grafts up to 2 years after the surgery using gray-level co-occurrence matrix (GLCM) texture analysis of quantitative T₂ maps, compare the results with the microfracturing technique (MFX) control group, and relate these results to the morphological MOCART 2.0 score.</p><p><strong>Design: </strong>A subcohort of 37 patients from prospective, multi-center study underwent examination on a 3T MR scanner, including a T₂ mapping sequence at 3, 12, and 24 months after surgery. Changes between the time-points in the mean T₂ values and 20 GLCM features extracted from T₂ maps were assessed in repair tissue, tissue adjacent to the repair site, and the reference cartilage for both procedures.</p><p><strong>Results: </strong>Significant correlations were found between the MOCART 2.0 and GLCM features for both surgical procedures. There were no significant differences between MACT and MFX. We identified significant intra-group changes in T₂ and autocorrelation (3M-12M: <i>P</i> = 0.002; 3M-24M: <i>P</i> = 0.004), dissimilarity (3M-24M: <i>P</i> = 0.01), homogeneity (3M-24M: <i>P</i> = 0.013), and correlation (3M-24M: <i>P</i> = 0.036), sum average (3M-12M: <i>P</i> = 0.001; 3M-24M: <i>P</i> = 0.002), and information measure (3M-24M: <i>P</i> < 0.001) in the MACT repair tissue. MACT models revealed differences in GLCM between all combinations of ROI types at almost all time-points. In the case of MFX, the significant differences were mainly between repair and reference tissue at 12 months.</p><p><strong>Conclusion: </strong>Texture analysis provides a useful extension to T₂ mapping. Texture features are correlated to the morphological outcome and reveal differences in the process of maturation between MACT and MFX.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035241313047"},"PeriodicalIF":2.7,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11780626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hinge Position Dominance Over Osteotomy Inclination in Medial Open-Wedge High Tibial Osteotomy: A Key Factor in Posterior Tibial Slope Changes.","authors":"Eva A Bax, H Chien Nguyen, Nienke van Egmond, Cornelis H Slump, Moyo C Kruyt, Roel J H Custers, Edsko E G Hekman","doi":"10.1177/19476035241311233","DOIUrl":"10.1177/19476035241311233","url":null,"abstract":"<p><strong>Objective: </strong>A medial open-wedge high tibial osteotomy (MOWHTO) may increase the posterior tibial slope (PTS). The purpose of this study was to determine the effect of the osteotomy inclination angle (in the sagittal plane) in combination with different hinge positions (in the transverse plane) on the change in PTS due to a MOWHTO.</p><p><strong>Methods: </strong>We developed a mathematical approach to determine the effect of the osteotomy inclination angle combined with different hinge positions. The change in PTS was determined for different osteotomy inclination angles, hinge positions, and intended wedge angles. Anterior-inclined, parallel, and posterior-inclined osteotomy inclination angles were simulated. Hinge positions varied between 5° anterolateral and -45° posterolateral. The wedge angles were 5°, 10°, and 15°. Moreover, 2 in silico osteotomies were performed to verify the results of the mathematical model.</p><p><strong>Results: </strong>The PTS was maintained when the osteotomy cut was performed parallel to the tibial plateau with a lateral hinge position. The PTS changed when the osteotomy was not aligned in the sagittal plane, ranging between 0.0° and 0.6°. Different hinge positions, however, had a large effect on postoperative PTS change, ranging between 0.1° and 10.7°.</p><p><strong>Conclusions: </strong>Our mathematical approach showed that the hinge position has a strong effect on the PTS. The sagittal osteotomy inclination angle had little effect on the PTS. An inclination angle parallel to the medial tibial plateau combined with a lateral hinge position does not change the PTS.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035241311233"},"PeriodicalIF":2.7,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-Articular Administration of Ganglioside Sugars Protects Cartilage from Progressive Degeneration in an Instability OA Rabbit Model.","authors":"Masanari Hamasaki, Tomohiro Onodera, Junichi Furukawa, Masahiro Todoh, Yuma Sakai, Taku Ebata, Mohamad Alaa Terkawi, Kentaro Homan, Norimasa Iwasaki","doi":"10.1177/19476035241311542","DOIUrl":"10.1177/19476035241311542","url":null,"abstract":"<p><strong>Objective: </strong>Osteoarthritis (OA) is a degenerative joint disease that has no cure, and current therapies are intended to minimize pain. There is, therefore, a need for effective pharmacologic agents that reverse or slow the progression of joint damage. We report herein on an investigation of the effects of intra-articular injections of ganglioside sugars on the progression of OA in an experimental rabbit model.</p><p><strong>Design: </strong>Knee OA was induced Japanese in White rabbits by anterior cruciate ligament transection (ACLT). Ganglioside sugars at concentrations of 0.1, 0.3, and 0.9 mg/ml were then intra-articularly injected as a possible treatment for OA. Controls received intra-articular injections of saline. Knees were assessed macroscopically, histologically, and mechanically at 13 weeks after ACLT induction.</p><p><strong>Results: </strong>Macroscopically, knees of the groups that received ganglioside sugars at concentrations of 0.3 and 0.9 mg/ml exhibited milder cartilage degradation compared to the controls. Consistent with these results, histological scores for these knees were significantly higher than the corresponding values for the control knees. Lectin histochemistry staining revealed that the treatment with ganglioside sugars at concentrations of 0.3 and 0.9 mg/ml was associated with a remarkable increase in the levels of GalNAc-positive chondrocytes in cartilage. Coefficient of friction testing also demonstrated that cartilages treated with ganglioside sugars had a lower coefficient of frictions than the values for the control group.</p><p><strong>Conclusions: </strong>Intra-articular injections of ganglioside sugars prevented cartilage degeneration in an OA-instability model. These results highlight the promising therapeutic potential for using ganglioside sugars in the treatment of progressive OA.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035241311542"},"PeriodicalIF":2.7,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associated Anatomic Abnormalities in Patients Undergoing Rotational Tibial Osteotomies for Patellofemoral Pathology and Implications for the Level of Correction.","authors":"Mohammad Haikal, Nishant Singh, Renjit Issac, Gwithyen Silk, Martyn Snow","doi":"10.1177/19476035241311548","DOIUrl":"10.1177/19476035241311548","url":null,"abstract":"<p><strong>Purpose: </strong>Tibial rotational deformity is a known risk factor for patellofemoral joint (PFJ) disorders. However, it is commonly associated with other abnormalities which affect the PFJ. The purpose of this study was to describe the prevalence of associated factors known to affect PFJ in patients undergoing rotational tibial osteotomy and their implication for the correction level.</p><p><strong>Methods: </strong>All patients with PFJ disorder, who underwent rotational tibial osteotomy between July 2009 and February 2020, were included. Patients were excluded if there were no preoperative computed tomography (CT)/magnetic resonance imaging (MRI). Scans were analyzed by 2 observers. Parameters of interest were femoral version, tibial torsion, trochlear dysplasia, lateral trochlear inclination (LTI), tibial tuberosity-trochlear groove (TT-TG) distance, Insall-Salvati (IS), and Caton Deschamps Index (CDI).</p><p><strong>Results: </strong>The search resulted in 80 knees, which had a mean femoral version of 21.0 ± 11.7, tibial torsion of 45.9 ± 9.1, TT-TG of 18.3 ± 5.5, and LTI of 11.4 ± 14.7. In total, 42.5% had TT-TG value of ≥ 20 mm. Patella alta/baja was found in 54% based on CDI or IS >1.2 and <0.8. High-grade trochlear dysplasia was found in 25%. In total, 29% had a tibial torsion abnormality but normal TT-TG and patella height. In total, 18% had abnormal TT-TG but normal patellar height.</p><p><strong>Conclusion: </strong>Based on the associated abnormalities of patella height and tubercle lateralization, 18% of the population were suitable for supratubercle osteotomy, and 29% of patients were suitable for diaphyseal or distal tibial osteotomy. A tibial tubercle osteotomy was required in 54% of patients, making a through-tubercle approach the most appropriate option for most patients.</p><p><strong>Level of evidence: </strong>Radiological cross-sectional study.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035241311548"},"PeriodicalIF":2.7,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of Chondral Fracture During Implantation of Distal Femur Osteochondral Autograft Plugs: A Human Cadaveric Comparison of Four Different Donor Regions.","authors":"Patrick A Massey, Daniel Hayward, Christian Bonner, Wayne Scalisi, Ryan Taylor, Elise Vincent, Robert W Rutz, Giovanni F Solitro","doi":"10.1177/19476035241308535","DOIUrl":"10.1177/19476035241308535","url":null,"abstract":"<p><strong>Introduction: </strong>Distal femoral cartilage lesions can be treated using osteochondral autograft transfer (OAT). When impacting plugs into a recipient site, the cartilage may fracture. This study aimed to analyze OAT donor regions and impaction energies to identify characteristics that lead to fracture.</p><p><strong>Methods: </strong>Fifteen cadaver femurs were used with OAT plugs harvested from the following regions: lateral and medial trochlea (LT and MT), lateral and medial intercondylar notch (LIN and MIN). Plugs were impacted into a bone surrogate block using a custom anvil-type system with pre-determined impact heights; 30, 50, 70, and 90 mm. Each plug's cartilage was examined and determined to be intact or fractured. Chi-square was used to compare the rate of chondral fracture for each region.</p><p><strong>Results: </strong>In all, 221 plugs were included. The overall rate of chondral fracture was 45.7%. There was a significant difference in the rate of fracture between regions, with LIN, MIN, LT, and MT, having a fracture rate of 46.6%, 62.7%, 25.0%, and 51.9%, respectively (<i>P</i> = 0.001). An impact height of 30 mm resulted in a fracture rate of 17.7%. Increasing the impact height from 30 to 50 mm resulted in significantly increased chondral fracture risk (<i>P</i> = 0.001).</p><p><strong>Conclusion: </strong>Different donor regions have varying rates of chondral fracture during OAT plug impaction, with the lateral and medial trochlea being the most resistant to chondral fracture at lower forces. Increased impact energy increases risk of chondral fracture. Surgeons should maintain caution and utilize lower impact energy when inserting OAT plugs.</p>","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035241308535"},"PeriodicalIF":2.7,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11660097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}