Prevalence and Associated Factors of Ankle Osteoarthritis in Achondroplasia: A Retrospective Radiographic Assessment of 134 Patients.

IF 2.7 4区医学 Q1 ORTHOPEDICS

CARTILAGE Pub Date : 2024-12-20 DOI:10.1177/19476035241307862

Won Seok Choi, Jung Woo Shin, Sei Wook Son, Hak Jun Kim, Sang Hyeon Hwang, Sang Geon Park, Young Hwan Park

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引用次数: 0

Abstract

Objective: The primary aim of this study is to examine the prevalence of ankle osteoarthritis in patients with achondroplasia and to assess the impact of surgical correction of lower limb alignment on this prevalence. The secondary aim is to identify radiographic parameters associated with ankle osteoarthritis.

Design: This retrospective cohort study included 134 patients (268 ankles) who visited our institution between March 2014 and February 2023. Lower limb alignment was assessed using the mechanical axis deviation, lateral distal tibial angle, anterior distal tibial angle, and talar tilt angle. Ankle osteoarthritis was evaluated using the Van Dijk Osteoarthritis score and modified Kellgren-Lawrence (K-L) scale by 2 experienced orthopedic surgeons.

Results: The prevalence of ankle osteoarthritis in our study cohort was 29%, and that of advanced ankle osteoarthritis defined by Van Dijk Osteoarthritis scale III or modified K-L grade 4 was 0.8% (aged <40 years, 22%, and 0%; aged ≥40 years, 42% and 2%, respectively). Talar tilt angle was the only radiographic parameter that showed a significant correlation with the degree of ankle osteoarthritis (Van Dijk Osteoarthritis score, r_s = 0.403, P < 0.001; modified K-L grade, r_s = 0.385, P < 0.001).

Discussion: The prevalence of ankle osteoarthritis in achondroplasia is moderate, but the progression to advanced stages is uncommon. Ankle osteoarthritis in achondroplasia is strongly associated with increased talar tilt angle. This finding emphasizes caution regarding ankle osteoarthritis in achondroplasia with a nonparallel tibiotalar articular surface. Clinicians should, therefore, consider regularly assessing the talar tilt angle in patients with achondroplasia.

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软骨发育不全患者踝关节骨关节炎的患病率及相关因素：134例患者的回顾性影像学评估。

目的：本研究的主要目的是检查软骨发育不全患者踝关节骨关节炎的患病率，并评估手术矫正下肢直线对患病率的影响。第二个目的是确定与踝关节骨关节炎相关的影像学参数。设计：本回顾性队列研究纳入了2014年3月至2023年2月来我院就诊的134例患者（268踝关节）。使用机械轴偏差、胫骨远端外侧角、胫骨远端前角和距骨倾斜角评估下肢对中。2名经验丰富的骨科医生采用Van Dijk骨关节炎评分和改良的Kellgren-Lawrence （K-L）量表对踝关节骨关节炎进行评估。结果：本研究队列中踝关节骨关节炎患病率为29%，Van Dijk骨关节炎III级或改良K-L 4级定义的晚期踝关节骨关节炎患病率为0.8%(年龄s = 0.403, P < 0.001；改良K-L等级，rs = 0.385, P < 0.001)。讨论：踝关节骨关节炎在软骨发育不全中的患病率是中等的，但进展到晚期是罕见的。软骨发育不全的踝关节骨性关节炎与距骨倾斜角度增加密切相关。这一发现强调了对软骨发育不全伴胫骨关节面不平行的踝关节骨性关节炎的警惕。因此，临床医生应考虑定期评估软骨发育不全患者的距骨倾斜角度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CARTILAGE ORTHOPEDICS-

CiteScore

6.90

自引率

7.10%

发文量

期刊介绍： CARTILAGE publishes articles related to the musculoskeletal system with particular attention to cartilage repair, development, function, degeneration, transplantation, and rehabilitation. The journal is a forum for the exchange of ideas for the many types of researchers and clinicians involved in cartilage biology and repair. A primary objective of CARTILAGE is to foster the cross-fertilization of the findings between clinical and basic sciences throughout the various disciplines involved in cartilage repair. The journal publishes full length original manuscripts on all types of cartilage including articular, nasal, auricular, tracheal/bronchial, and intervertebral disc fibrocartilage. Manuscripts on clinical and laboratory research are welcome. Review articles, editorials, and letters are also encouraged. The ICRS envisages CARTILAGE as a forum for the exchange of knowledge among clinicians, scientists, patients, and researchers. The International Cartilage Repair Society (ICRS) is dedicated to promotion, encouragement, and distribution of fundamental and applied research of cartilage in order to permit a better knowledge of function and dysfunction of articular cartilage and its repair.