Canadian journal of ophthalmology. Journal canadien d'ophtalmologie最新文献

{"title":"Geographic atrophy in Korean patients with dry age-related macular degeneration: incidence, phenotypes, and progression.","authors":"Ye Eun Han, Hoon Il Choi, Junyeop Lee, Yoon Jeon Kim, Joo Yong Lee, Srinivas R Sadda, Young Hee Yoon","doi":"10.1016/j.jcjo.2025.05.026","DOIUrl":"10.1016/j.jcjo.2025.05.026","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the characteristics of geographic atrophy (GA) in Korean patients, including incidence, phenotypes, progression patterns, and factors associated with progression rates.</p><p><strong>Design: </strong>Retrospective longitudinal cohort study.</p><p><strong>Participants: </strong>Korean patients with intermediate and advanced (prevalent GA) dry AMD, followed for ≥3 years.</p><p><strong>Methods: </strong>GA incidence was defined as the percentage of new GA emerging from the intermediate dry AMD group during the follow-up. Baseline phenotypes were evaluated in the prevalent GA group at the initial visit using fundus photography, spectral-domain optical coherence tomography, and fundus autofluorescence (FAF). Progression patterns were assessed by growth rates (mm²/year and mm/year using square-root treansformation [SQRT]), and the centripetal growth direction (foveal involvement of extrafoveal lesions). Linear regression was used to identify factors associated with progression rates.</p><p><strong>Results: </strong>In intermediate dry AMD group (395 eyes/241 patients), GA incidence was 6.8%, while wet conversion was 14.4%, during 60.5 ± 13.5 months. In prevalent GA group (70 eyes/46 patients), the mean lesion size was 7.2 ± 7.1 mm² (2.4 ± 1.3 mm [SQRT]), with bilateral involvement in 68.6%, banded/diffuse FAF patterns in 81.4%, extrafoveal and multifocal locations in 51.4% and 84.3%, and drusen and reticular pseudodrusen in 87.1% and 34.3%. The progression rate was 2.0 ± 1.3 mm²/year (0.3 ± 0.2 mm/year [SQRT]), with 69.4% exhibiting centripetal direction during 61.2 ± 14.5 months. Large lesion size, banded/diffuse FAF patterns, and extrafoveal locations were positively associated with progression rates (p = 0.006, 0.007, and 0.008).</p><p><strong>Conclusions: </strong>The 5-year incidence of GA in Korean patients with intermediate dry AMD was 6.8%, approximately half of the rate of wet conversion. The mean GA progression rate was 2.0 mm²/year (0.3 mm/year [SQRT]). Risk factors for fast progression were banded/diffuse FAF patterns, extrafoveal locations, and large lesion size.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fundus autofluorescence of black sunburst lesion in a sickle cell trait patient.","authors":"Bradley S Gundlach, Samuel Y Lee, David Hsu, David Sarraf","doi":"10.1016/j.jcjo.2025.05.023","DOIUrl":"10.1016/j.jcjo.2025.05.023","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ab-Interno Canaloplasty for the Management of Uncontrolled Pseudoexfoliation Glaucoma with Dislocated IOL.","authors":"Loukman Ghouti, Nir Shoham-Hazon","doi":"10.1016/j.jcjo.2025.06.001","DOIUrl":"10.1016/j.jcjo.2025.06.001","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of social determinants of health and medication burden on quality of life and disease severity in glaucoma.","authors":"Sakshi Shiromani, Jenny Bui, Grace Nguyen, David M Reed, Sachin Kedar, Deepta Ghate","doi":"10.1016/j.jcjo.2025.06.002","DOIUrl":"10.1016/j.jcjo.2025.06.002","url":null,"abstract":"<p><strong>Background: </strong>The interplay between social determinants of health (SDH), peripheral field loss in glaucoma, frailty, and medication burden impacts treatment outcomes and quality of life (QoL).</p><p><strong>Objective: </strong>To evaluate the interaction between SDH, glaucoma characteristics, frailty, QoL in an Atlanta cohort with peripheral field loss.</p><p><strong>Methods: </strong>Cross-sectional study including primary glaucoma subjects satisfying inclusion criteria. Electronic medical records provided age, zip code (for area deprivation, crime rate, poverty), visual acuity, binocular Visual Field Index (OU VFI), and number of medications. Glaucoma severity was classified by OU VFI: mild (>95%), mild to moderate (81-95%), moderate to severe (50-80%), and severe (<50%). Subjects completed surveys on demographics (race, sex, income, occupation, education), QoL (Short Form-36 and National Eye Institute-Visual Function Questionnaires), and frailty (FRAIL questionnaire).</p><p><strong>Results: </strong>Among 139 subjects (mean age 67 ± 11 years), glaucoma severity was greater in Black versus White individuals (OU VFI: 72 ± 25% vs 83 ± 19%; p = 0.01), and in men versus women (OU VFI: 72 ± 26% vs 83 ± 19%; p = 0.004). Severity correlated with visual acuity (ANOVA: p < 0.001); QoL (NEI-VFQ scores: r = 0.6; p < 0.001). Neither zip code indices nor frailty were associated with severity/QoL. Multivariate modeling identified glaucoma severity as the sole predictor of QoL; medication burden had no independent impact.</p><p><strong>Conclusions: </strong>Black race, male sex, visual acuity, and medication burden were associated with glaucoma severity. QoL was associated solely with glaucoma severity; medication burden had no independent impact. These findings inform glaucoma management strategies in Atlanta's diverse community.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal imaging of laser pointer maculopathy.","authors":"Alessandro Feo, Tal Eshkoly-Lior, David Sarraf","doi":"10.1016/j.jcjo.2025.05.009","DOIUrl":"10.1016/j.jcjo.2025.05.009","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A real-world population-based study on the association between cataracts and antipsychotics.","authors":"Moiz Lakhani, Angela T H Kwan, Emaan Chaudry, Marko Popovic, Jim Shenchu Xie, Amrit S Rai, Amandeep S Rai, Edward A Margolin, Roger S McIntyre","doi":"10.1016/j.jcjo.2025.05.021","DOIUrl":"10.1016/j.jcjo.2025.05.021","url":null,"abstract":"<p><strong>Objective: </strong>It is uncertain whether first- (FGAs) and second-generation antipsychotic (SGAs) drugs are associated with development of cataract. We conducted a real-world adverse event (AE) disproportionality analysis of cataracts in individuals exposed to antipsychotics.</p><p><strong>Design: </strong>An observational, population-based pharmacovigilance study.</p><p><strong>Participants: </strong>All reports of cataracts submitted to the U.S. Food and Drug Administration involving FGAs and SGAs.</p><p><strong>Methods: </strong>We searched the United States Food and Drug Administration Adverse Event Reporting System (FAERS) (2003 Q4-2024 Q1) for cataract reports associated with antipsychotics, analyzing data with OpenVigil 2.1. Reporting odds ratios (RORs), p values (with a Bonferroni-adjusted significance threshold of 0.0019), and Bayesian Confidence Propagation Neural Network information components (IC) were reported.</p><p><strong>Results: </strong>We retrieved 12,345,128 unique AE reports (5.4% females, 34.5% males), including 34,879 cataract reports and 372,107 antipsychotic reports (10,274 FGAs and 361,833 SGAs). Chlorpromazine (ROR: 7.60; 95%; confidence interval [CI] = 3.78%-15.29%; p < 0.0001; [lower limit of the 95% credibility interval for the information component] IC₀₂₅ = 1.23) and quetiapine (ROR1: 64; 95% CI = 1.44%-1.88%; p < 0.0001; IC₀₂₅ = 0.48) showed significantly higher odds of cataract reporting compared to all other drugs. No significantly higher reporting odds of cataracts were found for the 10 FGAs and 14 SGAs studied. However, increased cataract reporting was observed for chlorpromazine in females and for quetiapine in both sexes. This pattern also occurred in both drugs in the 18-44 and 45-64 age groups, with greater magnitude in the younger group CONCLUSIONS: Cataract development was disproportionately reported after the use of certain FGAs and SGAs. Although a cause-and-effect relationship cannot be established, these findings underscore the importance of clinical vigilance and regular ocular monitoring in individuals prescribed antipsychotics.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macular fibrosis in neovascular AMD: inter-reader and intermodality variability across four imaging modalities.","authors":"Andrea Coletto, Sonia Serafino, Chiara Olivieri, Valentina Marica, Pasquale Viggiano, Veronica Vallino, Paola Marolo, Enrico Borrelli, Michele Reibaldi","doi":"10.1016/j.jcjo.2025.05.019","DOIUrl":"10.1016/j.jcjo.2025.05.019","url":null,"abstract":"<p><strong>Objective: </strong>To assess inter-reader and intermodality variability in quantifying macular fibrosis in patients with neovascular age-related macular degeneration (AMD) using 4 imaging modalities: color fundus photography (CFP), near-infrared reflectance (NIR), structural optical coherence tomography (OCT), and MultiColor imaging.</p><p><strong>Design: </strong>Prospective, cross-sectional case series.</p><p><strong>Participants: </strong>Thirty eyes of 30 patients with neovascular AMD and macular fibrosis, previously treated with anti-vascular endothelial growth factor therapy.</p><p><strong>Methods: </strong>Imaging was performed using CFP, NIR, structural OCT, and MultiColor modalities. Two masked graders evaluated the size of macular fibrosis using each modality. The study assessed inter-reader agreement using the intraclass correlation coefficient (ICC), coefficient of variation (CV), and 95% coefficient of repeatability. Intermodality variability was analyzed using repeated measures ANOVA and pairwise comparisons.</p><p><strong>Results: </strong>Structural OCT demonstrated the highest inter-reader agreement (ICC = 0.983; CV = 0.04), while NIR exhibited the lowest (ICC = 0.461; CV = 0.26). The median macular fibrosis size was largest on structural OCT (4.87 mm²) and smallest on MultiColor imaging (2.03 mm²). Significant differences were observed between imaging modalities, with fibrosis measurements from different modalities not consistently comparable.</p><p><strong>Conclusions: </strong>Structural OCT is the most reliable modality for quantifying macular fibrosis in neovascular AMD. The observed intermodality variability highlights the need for standardized criteria in fibrosis assessment across imaging techniques, as differences can impact clinical interpretation and management.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastasis-free survival outcomes of uveal melanoma based on The Cancer Genome Atlas classification in 1585 cases.","authors":"Carol L Shields, Henry Nguyen, Shady Mina, Gabrielle E Kozlowski, Ayra Khan, Madison M Woods, Rolika Bansal, Hidayet Sener, Arupa Ganguly, Sara E Lally, Jerry A Shields","doi":"10.1016/j.jcjo.2025.05.017","DOIUrl":"10.1016/j.jcjo.2025.05.017","url":null,"abstract":"<p><strong>Background: </strong>Genetic testing for uveal melanoma and tumour size is important in prognostication.</p><p><strong>Methods: </strong>A review of 1 585 patients with uveal melanoma who had cytogenetic testing and classification, according to The Cancer Genome Atlas (TCGA), was performed. Kaplan-Meier (KM) metastasis-free survival at 1-, 3-, 5-, and 10-years were explored.</p><p><strong>Results: </strong>The findings revealed TCGA Group A (n = 781; 49%), Group B (n = 215; 14%), Group C (n = 329; 21%), or Group D (n = 260; 16%). The median patient age at diagnosis was 60 years, sex was male in 51%, and race was White in 95%. A comparison (TCGA Group A vs Group B vs Group C vs Group D) revealed a difference in median patient age at tumour diagnosis (59 vs 59 vs 63 vs 65 years; p < 0.01), and initial visual acuity (20/20-20/50: 80% vs 68% vs 69% vs 64%; p < 0.01). The median tumour thickness was 4 mm, and the median diameter was 12 mm. A comparison (TCGA Group A vs Group B vs Group C vs Group D) revealed differences in median tumour thickness (3 vs 5 vs 6 vs 7 mm; p < 0.01), tumour diameter (10 vs 13 vs 13 vs 16 mm; p < 0.01), distance to foveola (3 vs 3 vs 4 vs 5 mm; p < 0.01), and distance to optic disc (3 vs 4 vs 5 vs 4 mm; p < 0.01). The KM metastasis-free survival estimates (TCGA Group A vs Group B vs Group C vs Group D) revealed differences at 1 year, 3 years, 5 years, and 10 years (p < 0.01) for any metastasis and specific survival rates at 5 years (96% vs 86% vs 62% vs 37%; p < 0.01), and 10 years (93% vs 78% vs 50% vs not available; p < 0.01) significantly decreased from Group A to Group D. By multivariate analysis, the hazard ratio for metastasis-free survival revealed differences in Groups B vs A (3.67), Groups C vs B (5.73), and Groups D vs C (3.20) (p < 0.01), as well as differences per tumour thickness (1.06) and diameter (1.13) (p < 0.01).</p><p><strong>Conclusions: </strong>Genetic prognostication for metastatic risk from uveal melanoma using TCGA in this large cohort revealed that increasing TCGA category reduced the rate for metastasis-free survival.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of 11 years of glaucoma research funding: Glaucoma Research Society of Canada (2010-2020).","authors":"William J Herspiegel, Melina Moeinkhah, Anastasiya Vinokurtseva, Graham Trope, Cindy M L Hutnik","doi":"10.1016/j.jcjo.2025.05.022","DOIUrl":"10.1016/j.jcjo.2025.05.022","url":null,"abstract":"<p><strong>Objective: </strong>The Glaucoma Research Society of Canada (GRSC) is Canada's only nonprofit organization dedicated to funding peer-reviewed glaucoma research. This study evaluates the impact of GRSC-funded projects using established research productivity metrics.</p><p><strong>Design: </strong>Retrospective study.</p><p><strong>Methods: </strong>GRSC-funded grants from 2010 to 2020 were analyzed, including project details and funding amounts. Research productivity was assessed by (1) the number of peer-reviewed publications and (2) the number of conference presentations at major North American meetings. Publications were identified via PubMed searches of grant recipients, ensuring alignment with GRSC-funded topics. Conference presentations were determined by reviewing accepted abstracts from 5 key ophthalmology meetings: the Canadian Ophthalmological Society, American Society of Cataract and Refractive Surgery, American Academy of Ophthalmology, American Glaucoma Society, and Association for Research in Vision and Ophthalmology. Research output was analyzed in relation to funding costs.</p><p><strong>Results: </strong>Of 135 grants totaling $2,220,822, 84 (62%) led to at least one publication (92 total), while 67 (50%) resulted in conference presentations (85 total). The average research output per grant was 1.3, with costs of $12,547 per research output and $24,139 per publication. Research costs increased over time, with a slight decrease in 2019.</p><p><strong>Conclusions: </strong>GRSC-funded research consistently generates peer-reviewed knowledge, with over half of projects producing publications or presentations. Despite rising research costs, the high success rate in knowledge dissemination underscores GRSC's critical role in sustaining and advancing glaucoma research in Canada.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review and meta-analysis of Densiron-68 anatomic outcomes and complications in the surgical management of retinal detachment.","authors":"Grace S Yin, Alexa Fine, Marko M Popovic, Peter J Kertes, Rajeev H Muni","doi":"10.1016/j.jcjo.2025.05.018","DOIUrl":"10.1016/j.jcjo.2025.05.018","url":null,"abstract":"<p><strong>Objective: </strong>To summarize the anatomical reattachment rates, functional outcomes, and complications associated with Densiron-68 in retinal detachment (RD) surgery.</p><p><strong>Methods: </strong>Following a systematic literature search, primary studies evaluating outcomes associated with Densiron-68 in adult RD surgery between January 2000 and May 2022 were included. Exclusion criteria included secondary studies, non-English language, and those in pediatric populations. The primary endpoints of interest were anatomical reattachment rate, and reported complications associated with Densiron-68.</p><p><strong>Results: </strong>Twenty-eight studies (927 eyes) were included. Mean follow-up time was 41.9 weeks (IQR: 32.4-52.0 weeks). The weighted mean preoperative and postoperative BCVA was 1.38 ± 0.64 logMAR (20/500 Snellen) and 0.86 ± 0.55 logMAR (20/150 Snellen), respectively (p < 0.001). Anatomical reattachment rate after a single surgery was 72.5% overall (n = 672 eyes), with most redetachments occurring while Densiron-68 was in situ (46%; n = 81/255 eyes). Postoperatively, 29 complications were identified. The three most common were raised intraocular pressure (IOP) (n = 251 eyes; 27.1%), intraocular inflammation (n = 182 eyes; 19.6%), and emulsification (n = 160 eyes; 17.3%). Densiron-68 was significantly associated with an increased risk of elevated intraocular pressure postoperatively than traditional silicone oil (RR: 1.83 95% CI: 1.25-2.67; p = 0.001). The overall GRADE certainty of evidence for included studies was determined to be low due to the risk of bias, moderate imprecision in results due to wide confidence intervals, small studies, and few events within comparative studies, and moderate to high heterogeneity impacting consistency of evidence.</p><p><strong>Conclusions: </strong>Densiron-68 is a heavy silicone oil with clinical utility in retinal detachment surgery that has good primary anatomical reattachment rates and overall improvement in BCVA preoperatively to postoperatively. The authors highlight the anatomical and functional outcomes of Densiron-68 and the reported range of complications associated with its use, of which the majority were reversible or treatable with appropriate therapies.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}