Canadian journal of ophthalmology. Journal canadien d'ophtalmologie最新文献

{"title":"Left homonymous hemianopsia secondary to intravenous tenecteplase.","authors":"Elayna G Bruce, Blake Archer, Saif Aldeen Alryalat, Osama Thiabat, Andrew G Lee","doi":"10.1016/j.jcjo.2024.12.014","DOIUrl":"10.1016/j.jcjo.2024.12.014","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periocular humidity with different forms of face masking.","authors":"Michele Zaman, Davin Johnson","doi":"10.1016/j.jcjo.2025.01.017","DOIUrl":"https://doi.org/10.1016/j.jcjo.2025.01.017","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mixed vascular lesion presenting as isolated vertical diplopia.","authors":"Fanghan Anna Yang, Leanne Stunkel, Manu S Goyal, Gregory P Van Stavern","doi":"10.1016/j.jcjo.2025.01.011","DOIUrl":"10.1016/j.jcjo.2025.01.011","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful resolution of early fibrin occlusion of PreserFlo MicroShunt with Nd:YAG laser treatment.","authors":"Rodolfo Bonatti, Kevin Hodgson, Marcelo Nicolela","doi":"10.1016/j.jcjo.2025.01.003","DOIUrl":"10.1016/j.jcjo.2025.01.003","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute angle-closure glaucoma risk: a comparative study of escitalopram and antidepressants.","authors":"Haaris M Khan, Steven Schendel, Frederick S Mikelberg, Mahyar Etminan","doi":"10.1016/j.jcjo.2025.01.004","DOIUrl":"10.1016/j.jcjo.2025.01.004","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into the effects of subretinal voretigene neparvovec-rzyl in RPE65-associated Leber congenital amaurosis.","authors":"Alaa Tayyib, Deepika C Parameswarappa, Peter J Kertes, Rajeev Muni, Anupreet Tumber, Gregory Costain, Alex Schramm, Heather MacDonald, Regan Klatt, Ajoy Vincent, Elise Héon","doi":"10.1016/j.jcjo.2024.12.006","DOIUrl":"10.1016/j.jcjo.2024.12.006","url":null,"abstract":"<p><strong>Objective: </strong>Assess safety and effectiveness of subretinal gene replacement therapy at 18 months post treatment.</p><p><strong>Design: </strong>Retrospective, longitudinal study conducted at the Hospital for Sick Children in Toronto, Canada.</p><p><strong>Participants: </strong>Patients with bi-allelic RPE65 variants, early onset retinal degeneration, and residual viable retina who underwent voretigene neparvovec r-zyl gene replacement therapy.</p><p><strong>Methods: </strong>Data collected included demographic information, molecular genetic results, and comprehensive ocular assessment results from preoperataive and postoperative visits up to 18 months. To assess the treatment's efficacy, postoperative best corrected visual acuity, full-field stimulus test (FST), visual field (VF) area, optical coherence tomography, and global satisfaction were compared to preoperative findings.</p><p><strong>Results: </strong>The procedures were safe with no complications. There was no significant improvement in visual acuity. Three eyes showed a slight reduction in VF area. All showed a reduction in ellipsoid zone thickness and area, but the outer nuclear layer thickness and area were stable. All had a significant improvement in retinal sensitivity, as per FST, allowing better navigation in a dim environment. All 3 patients reported being \"very satisfied\".</p><p><strong>Conclusion: </strong>Following a safe gene replacement therapy, the 3 first Canadian cases had an improvement in retinal sensitivity as per FST, and our patients described their experience as positively life changing.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the performance of Microsoft Copilot, GPT-4 and Google Gemini in ophthalmology.","authors":"Meziane Silhadi, Wissam B Nassrallah, David Mikhail, Daniel Milad, Mona Harissi-Dagher","doi":"10.1016/j.jcjo.2025.01.001","DOIUrl":"10.1016/j.jcjo.2025.01.001","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the performance of large language models (LLMs), specifically Microsoft Copilot, GPT-4 (GPT-4o and GPT-4o mini), and Google Gemini (Gemini and Gemini Advanced), in answering ophthalmological questions and assessing the impact of prompting techniques on their accuracy.</p><p><strong>Design: </strong>Prospective qualitative study.</p><p><strong>Participants: </strong>Microsoft Copilot, GPT-4 (GPT-4o and GPT-4o mini), and Google Gemini (Gemini and Gemini Advanced).</p><p><strong>Methods: </strong>A total of 300 ophthalmological questions from StatPearls were tested, covering a range of subspecialties and image-based tasks. Each question was evaluated using 2 prompting techniques: zero-shot forced prompting (prompt 1) and combined role-based and zero-shot plan-and-solve+ prompting (prompt 2).</p><p><strong>Results: </strong>With zero-shot forced prompting, GPT-4o demonstrated significantly superior overall performance, correctly answering 72.3% of questions and outperforming all other models, including Copilot (53.7%), GPT-4o mini (62.0%), Gemini (54.3%), and Gemini Advanced (62.0%) (p < 0.0001). Both Copilot and GPT-4o showed notable improvements with Prompt 2 over Prompt 1, elevating Copilot's accuracy from the lowest (53.7%) to the second highest (72.3%) among the evaluated LLMs.</p><p><strong>Conclusions: </strong>While newer iterations of LLMs, such as GPT-4o and Gemini Advanced, outperformed their less advanced counterparts (GPT-4o mini and Gemini), this study emphasizes the need for caution in clinical applications of these models. The choice of prompting techniques significantly influences performance, highlighting the necessity for further research to refine LLMs capabilities, particularly in visual data interpretation, to ensure their safe integration into medical practice.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complication rates in cataract surgery before and during the COVID-19 pandemic.","authors":"Lee-Wing Nathan, Stockl Frank, Wiens James","doi":"10.1016/j.jcjo.2024.12.001","DOIUrl":"https://doi.org/10.1016/j.jcjo.2024.12.001","url":null,"abstract":"<p><strong>Objective: </strong>To assess the cataract surgery (CS) complication rates before and during the COVID-19 pandemic.</p><p><strong>Design: </strong>Retrospective, cross sectional study.</p><p><strong>Methods: </strong>Medical records of patients undergoing CS at two surgery centers in Winnipeg from January 2018 to April 2022 were reviewed. The study periods were pre-COVID-19 (January 1, 2018 to March 31, 2020) and COVID-19 (April 1, 2020 to April 30, 2022). Complication rates for endophthalmitis, sulcus-positioned intraocular lens (IOL) implant, anterior chamber IOL (ACIOL) implant, capsular tension ring (CTR) insertion, cumulative dissipated phacoemulsification energy (CDE), posterior capsular rupture (PCR), unplanned anterior vitrectomy, and return to the OR within one month of surgery were compared.</p><p><strong>Results: </strong>45,559 patients were included. Pre-COVID-19 rates were compared to COVID-19 rates and stated as per 100 cataract surgeries. Endophthalmitis rates increased from 0.008 to 0.028 (RR 0.27, p=0.09). Sulcus IOL implant rates increased from 0.61 to 1.00 (RR 0.61, p<0.0001). ACIOL implant rates increased from 0.53 to 0.68 (RR 0.78, p=0.05). CTR usage rates increased from 0.48 to 0.75 (RR 0.63, p=0.001). Average CDE increased from 4.6 to 6.7 (p=0.0030). PCR rates decreased from 0.49 to 0.38 (RR 1.3, p=0.14). Unplanned anterior vitrectomy rates decreased from 0.43 to 0.36 (RR 1.18, p=0.35). Return to OR rates remained unchanged at 0.59 and 0.58 (RR 1.01, p=0.93).</p><p><strong>Conclusions: </strong>Our study found significant increases in some CS complication rates when comparing the defined pre-COVID interval to the COVID interval.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exudative subretinal fluid associated with tebentafusp immunotherapy","authors":"Joana Andoh,&nbsp;Loka Thangamathesvaran,&nbsp;J. Fernando Arevalo","doi":"10.1016/j.jcjo.2024.08.003","DOIUrl":"10.1016/j.jcjo.2024.08.003","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"60 1","pages":"Pages e170-e173"},"PeriodicalIF":3.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes and characterization of intraocular foreign body injuries from a Canadian centre: a 20-year retrospective study and literature review","authors":"Abdullah Al-Ani ,&nbsp;Mohamed S Bondok ,&nbsp;Kian Madjedi ,&nbsp;Shellina Kherani ,&nbsp;Amin Kherani","doi":"10.1016/j.jcjo.2024.05.019","DOIUrl":"10.1016/j.jcjo.2024.05.019","url":null,"abstract":"<div><h3>Objectif</h3><div>Analyser l’évaluation et la prise en charge des corps étrangers intraoculaires (CEIO) en milieu urbain au Canada pour générer une perspective clinique précieuse afin de replacer la prise en charge dans son contexte.</div></div><div><h3>Méthodes</h3><div>Examen rétrospectif des dossiers médicaux des patients d'un seul chirurgien datés de janvier 2002 à janvier 2023 comprenant les caractéristiques démographiques de patients qui ont eu un CEIO, leurs examens, leurs traitements, leurs complications et leur meilleure acuité visuelle corrigée (MAVC).</div></div><div><h3>Résultats</h3><div>Notre étude a porté sur la présence d'un CEIO dans 32 yeux de 31 patients (96,8 % des patients étaient de sexe masculin). La taille du CEIO variait de 1 à 12 mm; 28 corps étrangers (87,5 %) étaient en métal; il s'agissait d'un accident de travail dans 15 cas (46,9 %). Dans le cadre de l'examen diagnostique, 19 patients (61,3 %) ont fait l'objet d'une tomographie assistée par ordinateur (TAO), et 8 patients (25,8 %), d'une échographie oculaire (B-scan). La TAO a permis de déceler les CEIO dans 100 % des cas, et les B-scans, dans 87,5 % des cas. Lors du suivi final, la MAVC de 17 yeux (53,1 %) était ≥ 20/40, comparativement à 7 yeux (23,3 %) au départ. Une MAVC ≥ 20/200 lors de l'examen initial était associée à une MAVC finale ≥ 20/40 (<em>p</em> = 0,027). Le CEIO a pu être retiré dans 27 yeux (84,4 %), est demeuré en place dans 4 yeux (12,5 %) et a entraîné l’énucléation de 1 œil (3,1 %). Des antibiotiques ont été administrés par voie intravitréenne dans 19 yeux (59,4 %), ce qui a donné lieu à 1 cas présumé de toxicité médicamenteuse. Des complications sont survenues dans 30 yeux (93,8 %) pour un total de 119, dont 72 (60,5 %) sont apparues pendant les 24 premières heures. La cataracte post-traumatique était la complication la plus fréquente (27 yeux; 84,4 %). Les complications moins fréquentes comprenaient la sidérose oculaire et le décollement de la rétine s'accompagnant d'une vitréorétinopathie proliférante (chacune ayant touché 1 œil; 3,1 %). Enfin, un glaucome secondaire est apparu dans 4 yeux (12,5 %), dont 3 où le CEIO était demeuré en place ou avait été extrait tardivement.</div></div><div><h3>Conclusions</h3><div>Les caractéristiques des CEIO et les paramètres démographiques des patients cadrent avec ceux d'autres régions. La TAO était l'outil d'examen le plus efficace. On recommande un suivi prolongé pour surveiller les complications, surtout en cas de rétention du CEIO ou lorsque son extraction est significativement retardée.</div></div>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"60 1","pages":"Pages e83-e91"},"PeriodicalIF":3.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}