Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz最新文献

[Evidence-based drug information for children and adolescents in Germany-Are we moving in the right direction?] 德国儿童和青少年的循证药物信息——我们是否在朝着正确的方向前进？］

IF 1.5 4区医学

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz Pub Date : 2026-05-08 DOI: 10.1007/s00103-026-04239-1

Ramona Möhrle, Sonja Eberl, Ursula Gramlich, Julia Haering-Zahn, Gabriele Ahne, Tjitske van der Zanden, Saskia de Wildt, Wolfgang Rascher, Antje Neubert

{"title":"[Evidence-based drug information for children and adolescents in Germany-Are we moving in the right direction?]","authors":"Ramona Möhrle, Sonja Eberl, Ursula Gramlich, Julia Haering-Zahn, Gabriele Ahne, Tjitske van der Zanden, Saskia de Wildt, Wolfgang Rascher, Antje Neubert","doi":"10.1007/s00103-026-04239-1","DOIUrl":"https://doi.org/10.1007/s00103-026-04239-1","url":null,"abstract":"Introduction: Children and adolescents are disadvantaged when it comes to drug therapy, as drugs are frequently used off-label for this age group. Despite regulatory measures such as the EU Paediatric Regulation, off-label use in paediatrics remains widespread. Since 2021, the online platform \"Kinderformularium.DE\" has been providing evidence-based dosing recommendations for on- and off-label drug use in Germany, establishing itself as reliable source of information in paediatric practice. This study aims to analyse the scope of age-appropriate (off-label) dosage recommendations provided and to evaluate usage patterns and user satisfaction.Methods: Drug monographs were examined to determine the availability and licensing status of age-specific dosing recommendations, taking into account different indications and routes of administration. A user survey was conducted between November 2024 and February 2025 and analysed using a mixed-methods approach.Results: Kinderformularium.DE contains 637 monographs with 5536 individual age-specific dosage recommendations. Both the number of dosage recommendations and the licensing status vary by age: there is less dosage information available for preterm and newborn infants, and this information is more frequently classified as off-label. The survey confirms the platform's high level of acceptance-it is used frequently, particularly by doctors-and highlights its importance in the care of paediatric patients.Discussion: With its age-specific (off-label) dosage recommendations, Kinderformularium.DE is an important tool for ensuring medication safety in paediatric clinical practice in Germany. The platform must continue to be updated and expanded on an ongoing basis.","PeriodicalId":9562,"journal":{"name":"Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Development and pilot testing of the Lower Saxony drinking water incident register NITRIS to enhance situational awareness and provide a knowledge base]. [下萨克森州饮用水事故登记册NITRIS的开发和试点测试，以增强态势感知并提供知识库]。

IF 1.5 4区医学

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz Pub Date : 2026-05-07 DOI: 10.1007/s00103-026-04244-4

Manuel Döhla, Fabian Feil, Ricarda Maria Schmithausen

引用次数: 0

[Doping in recreational sports]. [在休闲运动中使用兴奋剂]。

IF 1.5 4区医学

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz Pub Date : 2026-05-07 DOI: 10.1007/s00103-026-04245-3

Pavel Dietz, Rolf Ulrich, Perikles Simon

{"title":"[Doping in recreational sports].","authors":"Pavel Dietz, Rolf Ulrich, Perikles Simon","doi":"10.1007/s00103-026-04245-3","DOIUrl":"https://doi.org/10.1007/s00103-026-04245-3","url":null,"abstract":"Doping is commonly perceived as being primarily associated with professional sports rather than recreational sports. This article is a discussion paper and addresses doping in recreational sports from conceptual, methodological, and empirical perspectives. Established doping definitions, particularly those of the World Anti-Doping Agency, are only partially transferable to recreational sports contexts due to their strong focus on organizational affiliation and competitive settings. For large segments of recreational sport, the concept of performance-enhancing substance use therefore provides a more appropriate description.Assessing the prevalence of such use is methodologically challenging due to the sensitive nature of the topic and the lack of control mechanisms. Indirect survey techniques reduce socially desirable responding and yield more realistic estimates. The unrelated question model (UQM) is a randomized response technique that ensures full anonymity and enables robust prevalence estimates of sensitive behaviors at the population level.Empirical findings using the UQM among recreational athletes in endurance, fitness, and bodybuilding contexts indicate that the use of performance-enhancing substances is not a marginal phenomenon. Prevalence estimates suggest a relevant and stable level over time. Strong associations are observed with non-therapeutic use of pain medication and an increasing medicalization of performance optimization. Evidence of access via healthcare structures highlights the structural embedding of this phenomenon. Overall, the use of performance-enhancing substances in recreational sport represents a socially and medically relevant field of action that requires differentiated prevention strategies and greater integration into medical education and training.","PeriodicalId":9562,"journal":{"name":"Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Evidence generation and methodological consultation by the project "EVAluation research based on data from routine clinical care 4 the Medical Informatics Initiative" (EVA4MII)]. [“基于常规临床护理数据的评估研究”项目（EVA4MII）的证据生成和方法学咨询]。

IF 1.5 4区医学

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz Pub Date : 2026-05-04 DOI: 10.1007/s00103-026-04243-5

Michelle Pfaffenlehner, Miriam Kesselmeier, Kai Günther, Kathrin Ungethüm, Viktoria Rücker, Flavia Remo, Harald Binder, André Scherag, Peter Heuschmann, Nadine Binder

{"title":"[Evidence generation and methodological consultation by the project \"EVAluation research based on data from routine clinical care 4 the Medical Informatics Initiative\" (EVA4MII)].","authors":"Michelle Pfaffenlehner, Miriam Kesselmeier, Kai Günther, Kathrin Ungethüm, Viktoria Rücker, Flavia Remo, Harald Binder, André Scherag, Peter Heuschmann, Nadine Binder","doi":"10.1007/s00103-026-04243-5","DOIUrl":"https://doi.org/10.1007/s00103-026-04243-5","url":null,"abstract":"Routine data from healthcare are gaining importance for evidence generation. In Germany, new structures have been established in recent years to support their use. As part of the Medical Informatics Initiative (MII), data integration centres (DIZ) have been set up at all university hospitals, where patient data are made available in a pseudonymized, standardized and operationalized form. Since routine data, unlike primary data, are collected for healthcare purposes, aspects of the original data collection must be considered when formulating the research question, planning and analysing the study, and interpreting the results.The EVAluation research based on data from routine clinical care 4 the MII (EVA4MII) project supports researchers in analysing nationwide clinical routine data, for example through training programs and a central advisory service. This support is provided by an interdisciplinary team with methodological-statistical, data-technical, and clinical-epidemiological expertise in close coordination with data-providing institutions. The service covers the entire research process, from study planning and formal requirements to implementation, analysis, evaluation, and publication, and is available to projects within the MII and beyond.The aim of this article is to highlight the importance of methodological support in the analysis of clinical routine data and to identify key stages in the research process where such support is particularly relevant. Finally, an outlook on future advisory needs is provided, including the potential role of artificial intelligence as a supportive tool.","PeriodicalId":9562,"journal":{"name":"Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Medical students in hospital emergency preparedness in the wake of the COVID-19 pandemic: a qualitative analysis of the ESCAPE study]. [COVID-19大流行后医学生在医院应急准备：ESCAPE研究的定性分析]。

IF 1.5 4区医学

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz Pub Date : 2026-05-04 DOI: 10.1007/s00103-026-04236-4

Lucien Torlot, Johanna Huber, Carla Nau, Franziska Jahns, Bernhard Zwißler, Martin R Fischer, Ines Schroeder

{"title":"[Medical students in hospital emergency preparedness in the wake of the COVID-19 pandemic: a qualitative analysis of the ESCAPE study].","authors":"Lucien Torlot, Johanna Huber, Carla Nau, Franziska Jahns, Bernhard Zwißler, Martin R Fischer, Ines Schroeder","doi":"10.1007/s00103-026-04236-4","DOIUrl":"https://doi.org/10.1007/s00103-026-04236-4","url":null,"abstract":"Background: Hospitals should plan a staffing surge capacity to prepare for a new pandemic or disaster. As medical students are a possible surge capacity resource, this study investigated whether including students in surge capacity plans is desirable and under which conditions it is feasible.Methods: We performed two retrospective multicentre observational trials in 2023 by enrolling medical students from 20 German faculties and leadership from critical areas of inpatient care at two university hospitals. We investigated the integration of medical students in the COVID-19 effort, assessed the willingness to include students in future preparedness plans, and explored possible requirements for such a deployment.Results: Both leadership staff (n = 72) and students (n = 1249) displayed a clear willingness for cooperation in the context of preparedness plans (81.9% and 90.8% approval respectively). Most agreed on delegating diagnostic, medical assistance, nursing and logistical tasks to the surge capacity help force. Students addressed financial compensation, clearance of academic obligations and sufficient training as prerequisites for their deployment. Leadership staff also emphasized the need for adequate training. Both parties cited students' academic obligations amongst the main limiting factors.Conclusion: Both surveys display a high acceptance for including students into the surge capacity workforce. These results support the need for predefined roles for surge capacity helpers and emphasize the necessity of pre-emptive preparedness training and the clarification of academic obligations ahead of time.","PeriodicalId":9562,"journal":{"name":"Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Advances in integrated antimicrobial resistance diagnostics: quantitative, qualitative and AI-driven approaches]. [综合抗菌素耐药性诊断的进展：定量、定性和人工智能驱动方法]。

IF 1.5 4区医学

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz Pub Date : 2026-05-01 Epub Date: 2026-03-20 DOI: 10.1007/s00103-026-04220-y

Benjamin Berinson, Moritz Hentschke, Holger Rohde

{"title":"[Advances in integrated antimicrobial resistance diagnostics: quantitative, qualitative and AI-driven approaches].","authors":"Benjamin Berinson, Moritz Hentschke, Holger Rohde","doi":"10.1007/s00103-026-04220-y","DOIUrl":"10.1007/s00103-026-04220-y","url":null,"abstract":"The rapid global increase in antimicrobial resistance complicates the treatment of life-threatening infections and makes fast, reliable antimicrobial susceptibility testing (AST) essential. While phenotypic methods such as broth dilution, agar diffusion, gradient diffusion and automated systems remain the diagnostic standard, they are limited by long turnaround times. Rapid phenotypic AST (RAST) approaches shorten the time to first results to 4 to 8 h and allow earlier optimisation of anti-infective therapy, although their clinical benefit has not yet been conclusively demonstrated and their use is restricted to validated pathogens and substances.In parallel, molecular methods such as PCR, isothermal amplification and, increasingly, whole-genome sequencing enable rapid detection of key resistance determinants (e.g., mecA/C, vanA/B, extended-spectrum beta-lactamases [ESBL] and carbapenemase genes), thereby particularly supporting the workup of positive blood cultures and surveillance investigations. Their predictive value is high for Gram-positive pathogens but limited for Gram-negative organisms due to the diversity of resistance mechanisms. Artificial intelligence (AI) offers additional potential for automated interpretation of phenotypic tests, analysis of complex genomic data and mass-spectrometry-based resistance prediction models, but faces challenges regarding standardisation, generalisability and data quality.Overall, novel RAST, molecular and AI-supported approaches usefully complement but do not replace classical methods. Their clinical impact depends on targeted implementation and integration into effective antibiotic and diagnostic stewardship structures.","PeriodicalId":9562,"journal":{"name":"Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz","volume":" ","pages":"537-545"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Development and spread of antibiotic resistance in the environment due to increased anthropogenic input of antibiotic residues and resistant pathogens]. [由于抗生素残留和耐药病原体的人为输入增加，环境中抗生素耐药性的发展和传播]。

IF 1.5 4区医学

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz Pub Date : 2026-05-01 Epub Date: 2026-04-13 DOI: 10.1007/s00103-026-04223-9

Merit Maren Prüß, Sebastian Guenther

{"title":"[Development and spread of antibiotic resistance in the environment due to increased anthropogenic input of antibiotic residues and resistant pathogens].","authors":"Merit Maren Prüß, Sebastian Guenther","doi":"10.1007/s00103-026-04223-9","DOIUrl":"10.1007/s00103-026-04223-9","url":null,"abstract":"The use of antibiotics for antimicrobial therapy revolutionized medical practice. However, the frequent and sometimes inappropriate use of these drugs in both human and veterinary medicine has had significant consequences. This article provides an overview of the pathways by which antibiotics enter the environment and their impacts.Through wastewater, sewage sludge, and agricultural fertilizers, antibiotics and their degradation products enter various environmental compartments such as soil and water, where they promote the emergence and spread of antimicrobial resistance (AMR) via subinhibitory concentrations of antibiotics. Worldwide, exceedances of ecotoxicological threshold values (predicted no effect concentrations; PNECs) have repeatedly been detected in municipal wastewater treatment plants, surface waters, and agricultural soils.In addition, subinhibitory environmental concentrations act as stress factors that alter the structure and function of microbial communities, thereby disrupting biogeochemical cycles. Bidirectional interactions between climate change and AMR have already been postulated, since altered microbial metabolic processes may trigger climate-relevant feedback mechanisms, while extreme weather events such as floods can further facilitate the dissemination of AMR. The resistance problem therefore requires an integrated, globally coordinated approach in the sense of One Health and Planetary Health.","PeriodicalId":9562,"journal":{"name":"Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz","volume":" ","pages":"521-527"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Requirements for the rational use of antibiotics based on antibiotic stewardship]. 【基于抗生素管理的抗生素合理使用要求】。

IF 1.5 4区医学

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz Pub Date : 2026-05-01 Epub Date: 2026-03-30 DOI: 10.1007/s00103-026-04224-8

Katja de With, Rika Draenert, Dennis Nurjadi, Stefan Hagel, Ulrike Trost, Jan Fahrenkrog-Petersen, Winfried V Kern, Evelyn Kramme

{"title":"[Requirements for the rational use of antibiotics based on antibiotic stewardship].","authors":"Katja de With, Rika Draenert, Dennis Nurjadi, Stefan Hagel, Ulrike Trost, Jan Fahrenkrog-Petersen, Winfried V Kern, Evelyn Kramme","doi":"10.1007/s00103-026-04224-8","DOIUrl":"10.1007/s00103-026-04224-8","url":null,"abstract":"Given the inadequate and excessive use of antibiotics and the critical development of resistance, the rational prescription of antibiotics has become a key priority in human medicine. A broad range of initiatives to optimize antibiotic use has already been implemented in Germany. These include comprehensive antibiotic stewardship (ABS) training leading to the certification of ABS specialists; the development of a guideline for ABS programs in hospitals; the establishment of regional ABS networks integrating expertise from clinical practice, pharmacy, and microbiology; and the execution of funded interventional studies within the outpatient sector. There is significant potential for improvement in the establishment and financing of ABS teams, infectious disease consultation services, and infection boards in hospitals as well as in the promotion of innovative microbiological diagnostics and the development of sustainable concepts for outpatient care. The systematic integration of microbiological and pharmaceutical expertise into ABS programs is essential, as is the ongoing implementation and further development of modern electronic prescription systems. All these measures substantially improve prescription quality and support key strategies for targeted therapy and shorter treatment durations. To ensure the long-term establishment of these new structures and their further development at intersectoral interfaces, political support and substantial investment are indispensable.","PeriodicalId":9562,"journal":{"name":"Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz","volume":" ","pages":"556-566"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13133214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum zu: Sexuelle Ablehnungskompetenz als Schlüsselfaktor für die sexuelle Gesundheit von trans und nicht-binären Menschen in Deutschland – Quantitative Ergebnisse einer partizipativen Querschnittsbefragung. 性别认同：跨性别者和非二元性别者性健康的关键因素——参与性横断面调查的定量结果。

IF 1.5 4区医学

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz Pub Date : 2026-05-01 DOI: 10.1007/s00103-026-04226-6

Kathleen Pöge, Michael Brandl, Manuel Ricardo Garcia, Alexander Hahne, Jonas Hamm, Silvia Rentzsch, Christoph Schuler, Chris Spurgat, Uwe Koppe

引用次数: 0

[Use of vaccines to prevent the development of bacterial resistance]. [使用疫苗防止细菌产生耐药性]。

IF 1.5 4区医学

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz Pub Date : 2026-05-01 Epub Date: 2026-04-07 DOI: 10.1007/s00103-026-04228-4

Alexander Klimka, Liza Marie Maus

{"title":"[Use of vaccines to prevent the development of bacterial resistance].","authors":"Alexander Klimka, Liza Marie Maus","doi":"10.1007/s00103-026-04228-4","DOIUrl":"10.1007/s00103-026-04228-4","url":null,"abstract":"Vaccinations against bacterial pathogens play a crucial role in infection prevention, especially given the growing prevalence of antibiotic resistance. Historically, vaccines against cholera, diphtheria, and pertussis (whooping cough) marked the first significant advances in the fight against bacterial diseases. Later, vaccines against meningococcus and tetanus, among others, were added. These active immunizations expose the immune system to components of the pathogen, stimulating the production of antibodies, T helper cells, B cells, and memory cells, thereby providing long-term protection. The targeted development of new vaccines, even against difficult-to-treat bacterial pathogens, is enabled by a wide range of vaccine types, including inactivated, toxoid-based, and recombinant vaccines, as well as modern approaches such as reverse vaccinology and messenger Ribonucleic Acid (mRNA) technologies combined with enhancing adjuvants. In addition to active immunization, passive immunization, in which pathogen-specific antibodies are administered directly, also plays an important role.At the population level, clear epidemiological effects of vaccination programs are evident, as vaccinations protect not only individuals but also communities, thus contributing to public health. Despite the clear medical and economic advantages of vaccination programs, their acceptance among the population must be significantly increased through objective information policies. Currently, numerous vaccines are under development, which, through innovative technologies, are opening up new avenues for effectively preventing and controlling bacterial infections-a crucial step in an era of increasing antibiotic resistance.","PeriodicalId":9562,"journal":{"name":"Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz","volume":" ","pages":"597-606"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0