Bulletin of the Chemical Society of Ethiopia最新文献_第5页

Synthesis of biologically active xanthene, chromene, thiazole, thiophene, pyrazole, and isoxazole derivatives from camphor 以樟脑为原料合成具有生物活性的杂蒽、铬烯、噻唑、噻吩、吡唑和异恶唑衍生物

4区化学

Bulletin of the Chemical Society of Ethiopia Pub Date : 2023-09-19 DOI: 10.4314/bcse.v37i6.18

Ensaf Sultan Alwan, Rafat Milad Mohareb

{"title":"Synthesis of biologically active xanthene, chromene, thiazole, thiophene, pyrazole, and isoxazole derivatives from camphor","authors":"Ensaf Sultan Alwan, Rafat Milad Mohareb","doi":"10.4314/bcse.v37i6.18","DOIUrl":"https://doi.org/10.4314/bcse.v37i6.18","url":null,"abstract":"ABSTRACT. Xanthene, chromene, thiazole, thiophene, pyrazole, and isoxazole derivatives were synthesized from camphor-D monoterpene using multi-component reactions. Camphor has anti-bacterial, anti-fungal and anti-inflammatory properties. It is also used to mitigate pain, treat skin diseases, and improve respiratory functions. In this research, we focus on the effectiveness of the produced compounds from the biologically active camphor. The produced compounds were formed according to various reactions such as a Knoevenagel condensation, Michael adduct, Gewald reaction, a nucleophilic attack, substitution, addition, elimination and cyclization reactions. Furthermore, the novel produced compounds have been tested towards the six cancer cell lines namely A549, MKN-45, U87MG, HT-29, H460 and SMMC-772. Compounds 5, 11, 15b, 16, 25b and 27b displayed the highest inhibitions compounds toward the mentioned cancer cell lines. In addition, compounds 3, 13, 15a, 22a, 27a and 28 showed moderate inhibitory effects against the cancer cell lines. KEY WORDS: Camphor, Xanthenes, Pyrimidine, Heterocyclic, Anti-cancer Bull. Chem. Soc. Ethiop. 2023, 37(6), 1539-1552. DOI: https://dx.doi.org/10.4314/bcse.v37i6.18","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135109395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical analysis and biological activities of two oil-bearing extracts from fresh Pistacia lentiscus 两种新鲜黄连木含油提取物的植物化学分析及生物活性研究

4区化学

Bulletin of the Chemical Society of Ethiopia Pub Date : 2023-09-19 DOI: 10.4314/bcse.v37i6.15

Omayma Abidi, Zaineb Abdelkafi-Koubaa, Nadia Fares-Zagrouba, Salem Elkahoui, Lamjed Toumi, Lamjed Marzouki, Ouajdi Souilem

{"title":"Phytochemical analysis and biological activities of two oil-bearing extracts from fresh Pistacia lentiscus","authors":"Omayma Abidi, Zaineb Abdelkafi-Koubaa, Nadia Fares-Zagrouba, Salem Elkahoui, Lamjed Toumi, Lamjed Marzouki, Ouajdi Souilem","doi":"10.4314/bcse.v37i6.15","DOIUrl":"https://doi.org/10.4314/bcse.v37i6.15","url":null,"abstract":"ABSTRACT. This study aims to investigate the anti-cancer, antimicrobial and antioxidant activities of Pistacia lentiscus L. (P. lentiscus) extracts, as well as their phyto-chemical profile. The GC-MS crude chemical profile provided new chemotypes of fixed oil (FO) and essential oil (EO) extracts. Secondary metabolites screened high levels of polyphenols and condensed tannins in EO, while FO had the highest flavonoids content. A potent anti-proliferative activity of both extracts was shown on two human breast cancer cells (EO-IC50 = 5.2 mg/mL MDA-MB-231 cells). The antimicrobial activity showed that only EO was active against six multidrug resistant bacteria (inhibition zone 20-8 mm) and two fungi strains (inhibition zone 3-4 mm). Also, the highest in vitro antioxidant free-radical scavenging ability was in the case of EO (125.5 μg/mL). In vivo P. lentiscus EO provided corrective effect vs the tamoxifen (Txf) induced oxidative damage in liver and kidney in C57BL/6 in female mouse. These findings confirm that EO inhibits cell proliferation, induces bacterial death and has a potential antioxidant activity. KEY WORDS: Phytotherapy, Pistacia lentiscus, Antioxidant, Antimicrobial activity, Breast cancer Bull. Chem. Soc. Ethiop. 2023, 37(6), 1487-1501. DOI: https://dx.doi.org/10.4314/bcse.v37i6.15","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":"160 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135109401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-component synthesis of pyrazolo[1,5-a]quinazoline, thiazole and thiophene derivatives as cytotoxic agents 吡唑啉[1,5-a]、喹唑啉、噻唑和噻吩衍生物的多组分合成

4区化学

Bulletin of the Chemical Society of Ethiopia Pub Date : 2023-09-19 DOI: 10.4314/bcse.v37i6.17

Rafat M. Mohareb, Maher H. E. Helal, Amany E. Mayhoub, Amira E. M. Abdallah

{"title":"Multi-component synthesis of pyrazolo[1,5-a]quinazoline, thiazole and thiophene derivatives as cytotoxic agents","authors":"Rafat M. Mohareb, Maher H. E. Helal, Amany E. Mayhoub, Amira E. M. Abdallah","doi":"10.4314/bcse.v37i6.17","DOIUrl":"https://doi.org/10.4314/bcse.v37i6.17","url":null,"abstract":"ABSTRACT. This study demonstrated the synthesis of a number of pyrazolo[1,5-a]quinazoline derivatives about 24 products based on the starting material 4-(2-phenylhydrazono)-4H-pyrazol-3-amine derivatives 1a-f. Moreover, other ring systems including thiophene, pyrazole, thiazole and pyran (16 compounds) were prepared based on another starting compounds 2-(furan-2-ylmethylene)cyclohexane-1,3-dione 10 and 5,5-dimethyl-3-phenyl-2-thioxo-2,3,5,6-tetrahydrobenzo[d]thiazol-7(4H)-one 18. The multi-component reaction was used to prepare all the previous compounds. The structures of all the synthesised compounds were confirmed by the analytical and spectral data. Some selected compounds were chosen to test their anticancer activity against six cancer cell lines, namely A549, HT-29, MKN-45, U87MG, SMMC-7721 and, H460 utilizing foretinib as the positive control and the standard MTT assay in vitro. Toward the tested cell lines, nine compounds were the most cytotoxic compounds. The results obtained revealed that the synthesized compounds are good cytotoxic agents and of great impact for future work. KEY WORDS: Multi-component reactions, Pyrazolo[1,5-a]quinazoline, Thiophene, Thiazole, Cytotoxicity Bull. Chem. Soc. Ethiop. 2023, 37(6), 1521-1538. DOI: https://dx.doi.org/10.4314/bcse.v37i6.17","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135109403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of voltammetric sensors for taurine detection from Cu(II)-loaded carbon materials 负载Cu(II)碳材料制备牛磺酸检测伏安传感器

4区化学

Bulletin of the Chemical Society of Ethiopia Pub Date : 2023-09-19 DOI: 10.4314/bcse.v37i6.20

Fatma Bilge Emre

{"title":"Preparation of voltammetric sensors for taurine detection from Cu(II)-loaded carbon materials","authors":"Fatma Bilge Emre","doi":"10.4314/bcse.v37i6.20","DOIUrl":"https://doi.org/10.4314/bcse.v37i6.20","url":null,"abstract":"ABSTRACT. In this study, for the detection of taurine in philological fluids, modified electrodes were prepared from glassy carbon electrodes with MWCNT (multi-wall carbon nanotube) + Cu(NO3)2 + carbon-based material. A carbon-based material was obtained by carbonization of Pinus sylvestris branch needles (CPS). Cu(NO3)2 and MWCNT structure (Cu(NO3)2/MWCNT) were added to the carbon-based material and the obtained mixture was used in the modification of the glassy carbon electrode surface. The surface morphology and structure of the prepared electrodes were characterized by electron microscopy scanning (SEM) and atomic force microscopy (AFM). Taurine detection with a modified electrode was made by cyclic voltammetry (CV) in 0.1 M KCl (vs. Ag/AgCl). The calibration curve of the modified electrode for taurine in the 10-150 µM range showed a linear response, and R2 value was 0.976. Limit of detection (LOD) and limit of quantification (LOQ) of the modified electrode were found 19 µM and 9.75 µM, respectively. The application of the electrode as a chemical sensor was carried out with commercially available energy drink samples. Satisfactory results have been obtained from the samples. The sensor can be used for routine taurine analysis. This electrode can quickly determine the amount of taurine in real samples with 90% accuracy in two minutes. KEY WORDS: Taurine detection, Modified electrode, MWCNT, Sensor, Cyclic voltammetry Bull. Chem. Soc. Ethiop. 2023, 37(6), 1565-1576. DOI: https://dx.doi.org/10.4314/bcse.v37i6.20","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":"184 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135109664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of phosphorus by phosphorus molybdenum blue spectrophotometry by bismuth antimony sensitization 铋锑敏化磷钼蓝分光光度法测定磷

4区化学

Bulletin of the Chemical Society of Ethiopia Pub Date : 2023-09-19 DOI: 10.4314/bcse.v37i6.1

Qing-Zhou Zhai

{"title":"Determination of phosphorus by phosphorus molybdenum blue spectrophotometry by bismuth antimony sensitization","authors":"Qing-Zhou Zhai","doi":"10.4314/bcse.v37i6.1","DOIUrl":"https://doi.org/10.4314/bcse.v37i6.1","url":null,"abstract":"ABSTRACT. The determination of phosphorus in rain water is of great significance. In this paper the optimum conditions of phosphorus molybdenum blue spectrophotometric method for the determination of phosphorus content were obtained. At the maximum absorption wavelength 690 nm, the apparent molar absorptivity is ε690 nm = 1.44 × 104 L·mol-1·cm-1. Beer’s law is followed over the range of 0.02-1.8 μg·mL-1 for phosphorus(V) content. Bismuth(III) and antimony(III) as the sensitizer has a sensitization effect on the phosphomolybdenum blue photometry. The addition of both simultaneously increases the sensitivity by 71.3%. The present method has been used for the determination of phosphorus in water samples. The recovery of method is between 99.20 - 100.1% and the relative standard deviation is between 1.31-1.33% for eleven determination. The results determined by the present method were in agreement with those of atomic absorption spectrometry. This method can avoid the harm of organic reagent to human body and to environmental pollution without organic solvent extraction. This method does not need heating with room temperature color development. Compared with other methods, it has the advantages that the operation is simple, fast and the sensitivity is high. Bull. Chem. Soc. Ethiop. 2023, 37(6), 1307-1313.  DOI: https://dx.doi.org/10.4314/bcse.v37i6.1","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135109665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring novel coral reef-like RuO2 oxides: Synthesis and physicochemical characterizations of gatifloxacin-based Ru(III) complexes 探索新型珊瑚礁状RuO2氧化物:基于加替沙星的Ru(III)配合物的合成和理化表征

4区化学

Bulletin of the Chemical Society of Ethiopia Pub Date : 2023-09-19 DOI: 10.4314/bcse.v37i6.12

Khaled Althubeiti

{"title":"Exploring novel coral reef-like RuO2 oxides: Synthesis and physicochemical characterizations of gatifloxacin-based Ru(III) complexes","authors":"Khaled Althubeiti","doi":"10.4314/bcse.v37i6.12","DOIUrl":"https://doi.org/10.4314/bcse.v37i6.12","url":null,"abstract":"ABSTRACT. Two mixed-ligand complexes of Ru(III) ions were synthesized and used to generate nanostructured RuO2 oxide. Complex A contains gatifloxacin (L1), the amino acid glycine (L2), and Ru(III) ions in a 1:1:1 ratio. Complex B contains gatifloxacin (L1), the amino acid alanine (L3), and Ru(III) ions in a 1:1:1 ratio. The synthesized complexes were characterized using UV-Visible and IR spectroscopies, molar conductance, elemental analyses, thermogravimetry, XRD, and SEM-EDX techniques. In both complexes, the L1 ligand acts as a bidentate and uses the nitrogen atoms of the piperazine ring to capture the Ru(III) ions, while the L2 and L3 ligands capture the Ru(III) ions using their oxygen atom of the carboxylate group and the nitrogen atom of the amino group. The atmosphere around the Ru(III) ion is octahedral, and the complexes were formulated as [RuL1L2(H2O)2]Cl2 and [RuL1L3(H2O)2]Cl2 for Complex A and Complex B, respectively. Complex A was directly decomposed in air at 600 °C for 3 h to produce RuO2 oxide (Oxide A), and complex B was decomposed under the same conditions to produce RuO2 oxide (Oxide B). Morphologically, oxide A and oxide B have a coral reef-like texture with large holes and cavities. KEY WORDS: Gatifloxacin, Ru(III) ion, Glycine, Alanine, Morphology, RuO2 oxide Bull. Chem. Soc. Ethiop. 2023, 37(6), 1443-1457. DOI: https://dx.doi.org/10.4314/bcse.v37i6.12","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135109799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isatin/thiosemicarbohydrazone hybrids: Facile synthesis, and their evaluation as anti-proliferatıve agents and metabolıc enzyme inhibitors Isatin/硫代半碳腙杂化物：简易合成及其作为抗增殖剂和代谢酶抑制剂的评价

IF 1.2 4区化学

Bulletin of the Chemical Society of Ethiopia Pub Date : 2023-07-03 DOI: 10.4314/bcse.v37i5.14

Hasan Yakan, M. Azam, S. Kansız, H. Muğlu, M. Ergül, Parham Taslimi, Ümit M. Koçyiğit, M. Karaman, Saud I. Al-Resayes, Kim Min

{"title":"Isatin/thiosemicarbohydrazone hybrids: Facile synthesis, and their evaluation as anti-proliferatıve agents and metabolıc enzyme inhibitors","authors":"Hasan Yakan, M. Azam, S. Kansız, H. Muğlu, M. Ergül, Parham Taslimi, Ümit M. Koçyiğit, M. Karaman, Saud I. Al-Resayes, Kim Min","doi":"10.4314/bcse.v37i5.14","DOIUrl":"https://doi.org/10.4314/bcse.v37i5.14","url":null,"abstract":"ABSTRACT. We are reporting a novel series of thiosemicarbazone derivatives derived from isatin (1-6), structural determination, and investigation of the inhibitory properties against proliferative, carbonic anhydrase, and cholinesterase enzymes. The anti-proliferative effects of the compounds were measured by XTT assay against MCF-7 and MDA-MB-231 cancerous cell lines. Compound 3 showed significant cytotoxic effects on both MCF-7 and MDA-MB-231 cell lines, with IC50 values of 8.19 μM and 23.41 μM, respectively. In addition, the compounds (1-6) inhibited the hCA I and II, their Ki values 2.01 ± 0.35 – 21.55 ± 2.56 and 1.24 ± 0.33 – 25.03 ± 5.48 µM, respectively. AChE was also successfully inhibited by these compounds (1-6), with Ki values ranging from 40.37 ± 8.23 to 125.43 ± 24.93 µM. The best Ki values for 3, 6, and 4 for α-glycosidase were 564.35 ± 72.06, 594.38 ± 52.04, and 683.437 ± 66.58 µM, respectively. Binding affinities were determined to be -6.697 kcal/mol, -8.251 kcal/mol, -9.932 kcal/mol, and -4.946 kcal/mol for hCA I, hCA II, AChE, and α-glucosidase enzymes, respectively. These findings reveal that the formed compounds containing isatin moieties were crucial in the enzyme inhibition. \u0000 \u0000KEY WORDS: Isatin, Thiosemicarbazone, Anti-proliferative activity, Enzyme inhibition, Molecular docking \u0000 \u0000Bull. Chem. Soc. Ethiop. 2023, 37(5), 1221-1236. \u0000DOI: https://dx.doi.org/10.4314/bcse.v37i5.14","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47181192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasound-assisted dispersive liquid-liquid microextraction approach for preconcentration of acyclovir as antiviral drug in dosage forms prior to spectrophotometric determination 超声辅助分散液-液微萃取法在分光光度测定前预浓缩阿昔洛韦作为抗病毒药物的剂型

IF 1.2 4区化学

Bulletin of the Chemical Society of Ethiopia Pub Date : 2023-06-30 DOI: 10.4314/bcse.v37i5.2

Amal H. Al-Bagawi, Ragaa El Sheikh, Osama M.A. Salem, Ghada M. Abdel Fattah, Mohannad M. Garoub, Ayman A. Gouda

{"title":"Ultrasound-assisted dispersive liquid-liquid microextraction approach for preconcentration of acyclovir as antiviral drug in dosage forms prior to spectrophotometric determination","authors":"Amal H. Al-Bagawi, Ragaa El Sheikh, Osama M.A. Salem, Ghada M. Abdel Fattah, Mohannad M. Garoub, Ayman A. Gouda","doi":"10.4314/bcse.v37i5.2","DOIUrl":"https://doi.org/10.4314/bcse.v37i5.2","url":null,"abstract":"ABSTRACT. For acyclovir (ACV) determination in bulk and dosage forms, quick, sensitive, straightforward, and eco-friendly ultrasound-assisted dispersive liquid-liquid microextraction (UA-DLLME)-based spectrophotometric method has been created and validated. ACV with 1,2-naphthoquine-4-sulfonate (NQS) react in alkaline medium to produce a yellow-colored product, which is the basis of the newly created method. Investigation and optimization were done on the crucial experimental variables influencing ACV's extraction effectiveness. At λmax = 495 nm, the minuscule organic droplets were detected. The linearity was present from 0.1 to 3.0 μg/mL under ideal circumstances, with a linear correlation coefficient of 0.9995. The detection limit was 0.03 μg/mL and quantification limit was 0.1 μg/mL. 22.50 was the enrichment factor. Relative standard deviation (RSD%) as accuracy at 2.0 μg/mL of ACV was 1.0%, with good recovery (99.30%). The developed UA-DLLME method was effectively used to determine the ACV in dosage forms, and the validation was evaluated. Results from the suggested technique for dosage forms and pure ACV were in excellent agreement with the results from the official method. \u0000 \u0000KEY WORDS: Ultrasound-assissted, Dispersive liquid–liquid microextraction, Acyclovir, Spectrophotometry, Dosage forms \u0000Bull. Chem. Soc. Ethiop. 2023, 37(5), 1081-1092. \u0000DOI: https://dx.doi.org/10.4314/bcse.v37i5.2","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45076783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and spectroscopic investigations of Au(III) seleno-organic complexes 金(III)硒有机配合物的合成及光谱研究

4区化学

Bulletin of the Chemical Society of Ethiopia Pub Date : 2023-06-30 DOI: 10.4314/bcse.v37i5.7

Shams H. Abdel-Hafez, Moamen S. Refat

{"title":"Synthesis and spectroscopic investigations of Au(III) seleno-organic complexes","authors":"Shams H. Abdel-Hafez, Moamen S. Refat","doi":"10.4314/bcse.v37i5.7","DOIUrl":"https://doi.org/10.4314/bcse.v37i5.7","url":null,"abstract":"ABSTRACT. Heterocyclic pyridazine continues to attract great interest, mainly arising from a large variety of interesting pharmacological activities, herbicides, insecticides, and fungicides. On the other hand, the current interest in selenium-containing heterocycles is a result of their chemical properties and biological activities. In addition to the many recent publications dealing with the pharmacological potential of a selenium compound, new active formulations are an attractive target for chemical research. 2-((3-cyano-4,6-dimethylpyridin-2-yl)selanyl) acetic acid (pyd-Se), 2-((4-cyano-5,6-diphenylpyridazin-3-yl)selanyl)acetic acid (pydz-Se) and 2-((4,6-dimethyl quinolin-2-yl)selanyl)acetic acid (quin-Se) reacts with gold(III) chloride to produce metal ion complexes of specific composition. These synthesized complexes were characterized by elemental analyses, molar conductivity, FTIR, 1H NMR and transmission electron microscopy (TEM) investigations. The complexes were found to have the formulas [Au(pyd-Se)2]Cl, [Au(pydz-Se)2]Cl and Au(quin-Se)2]Cl, respectively.  KEY WORDS: Au(III), Organoselenium, Complexation, FTIR, 1H NMR, TEM Bull. Chem. Soc. Ethiop. 2023, 37(5), 1141-1150.  DOI: https://dx.doi.org/10.4314/bcse.v37i5.7","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136300403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Design and synthesis of indole-benzimidazole hybrid molecules and evaluation of their in-vitro cytotoxic activities 吲哚-苯并咪唑杂化分子的设计合成及其体外细胞毒活性评价

IF 1.2 4区化学

Bulletin of the Chemical Society of Ethiopia Pub Date : 2023-06-30 DOI: 10.4314/bcse.v37i5.13

S. Hamza, Sherif, Y. Murthy*

{"title":"Design and synthesis of indole-benzimidazole hybrid molecules and evaluation of their in-vitro cytotoxic activities","authors":"S. Hamza, Sherif, Y. Murthy*","doi":"10.4314/bcse.v37i5.13","DOIUrl":"https://doi.org/10.4314/bcse.v37i5.13","url":null,"abstract":"ABSTRACT. Cancer is one of the most deadly diseases worldwide, challenging the world for effective treatment of the diseases, to tackle this problem a vast amount of therapeutic candidates are being investigated. Indole-benzimidazole structures have recently gained considerable attention, because compounds containing these structure exhibit a very good anticancer property. Two series of novel indole-benzimidazole hybrids molecules viz., 2-(5-substituted-1H-indol-3-yl)-5-substituted-1H-benzo[d]imidazole 5(a-f) and 2-(5-substituted-1-(3-methylbut-2-enyl)-1H-indol-3-yl)-5-substituted-1H-benzo[d]imidazole 6(a-f) were synthesized and characterized by spectroscopic techniques. The twelve target molecules have been investigated for their in-vitro cytotoxic activity against human ovarian carcinoma cells (SKOV-3), human prostate cancer cells (PC-3), human cervical cancer cells (HeLa) and human acute monocytic leukemia cells (THP-1) using MTT assay. Compound; 2-(5-bromo-1H-indol-3-yl)-5-methyl-1H-benzo[d]imidazole (5e) was interesting with IC50 (μM) values of 23.69 (SKOV-3), 73.05 (PC-3), 64.66 (HeLa) and 39.08 (THP-1), respectively. \u0000 \u0000KEY WORDS: Indole, Benzimidazole, Hybrid molecules, Anticancer activity \u0000 \u0000Bull. Chem. Soc. Ethiop. 2023, 37(5), 1209-1220. \u0000DOI: https://dx.doi.org/10.4314/bcse.v37i5.13 ","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43914962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0