Bulletin of the Chemical Society of Ethiopia最新文献

Target-based anticancer glycyrrhetinic derivatives: Design, synthesis, biological assessment and molecular docking studies 基于靶点的抗癌甘草酸苷衍生物：设计、合成、生物学评估和分子对接研究

IF 1.3 4区化学

Bulletin of the Chemical Society of Ethiopia Pub Date : 2024-07-12 DOI: 10.4314/bcse.v38i5.14

Gaber O. Moustafa, A. Kalmouch, Somaia S. Abd El-Karim, Eman S. Nossier, Marwa M. Mounier, Heba El-Sayed, Abdulrahman A. Almehizia, Ahmed M. Naglah, Amer A. Zen

{"title":"Target-based anticancer glycyrrhetinic derivatives: Design, synthesis, biological assessment and molecular docking studies","authors":"Gaber O. Moustafa, A. Kalmouch, Somaia S. Abd El-Karim, Eman S. Nossier, Marwa M. Mounier, Heba El-Sayed, Abdulrahman A. Almehizia, Ahmed M. Naglah, Amer A. Zen","doi":"10.4314/bcse.v38i5.14","DOIUrl":"https://doi.org/10.4314/bcse.v38i5.14","url":null,"abstract":"18-Glycyrrhetinic acid (GA) is regarded as the principal active component isolated from the Chinese medicinal plant of licorice root, and it has considerable anticancer actions. This work was built on the discovery and design of brand-new 18-glycyrrhetinic acid (GA) amino acid peptides and peptide ester analogs. The cytotoxic evaluation exhibited that despite the promising cytotoxic activity of the tested peptides 2, 3, 4, 6, and 7 in MCF-7 and HCT-116 cancer cells, with IC50 values ranging from 5.1-7.4 and 6.6-72.7 µg/mL, respectively. Furthermore, all freshly produced GA-peptides with moderate to high activity on tumor cell lines produced a favorable safety profile versus typical human dermal fibroblasts (BJ-1) cellular lineage. Interestingly, 2, 4 and 6 demonstrated excellent multitargeting inhibitory profiles against CDK-2, VEGFR-2, and PDGFR-α kinases. Moreover, since peptide 6 was the most active cytotoxic agent, it was chosen as an illustrative candidate to examine its influence on many apoptotic markers in invitro studies, including Bax, caspase-3 and 7, DNA fragmentation, BCl-2, p53, and tubulin polymerization inhibition. All novel analogs were tested for their antimicrobial efficacy versus a panel of microbial strains. The peptide 6 was also subjected to molecular docking simulations in the active sites of the prior kinases. \u0000KEY WORDS: Peptides, Glycyrrhetinic acid, Anticancer, Cytotoxicity, Molecular docking, Antimicrobial activity \u0000Bull. Chem. Soc. Ethiop. 2024, 38(5), 1369-1392. \u0000DOI: https://dx.doi.org/10.4314/bcse.v38i5.14","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141834315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and characterization of potential antioxidant agent of novel pyridylazo ligand and its palladium complex 新型吡啶偶氮配体及其钯配合物潜在抗氧化剂的合成与表征

IF 1.3 4区化学

Bulletin of the Chemical Society of Ethiopia Pub Date : 2024-07-12 DOI: 10.4314/bcse.v38i5.12

Hasan Shamran Mohammed, Atica Sultan

{"title":"Synthesis and characterization of potential antioxidant agent of novel pyridylazo ligand and its palladium complex","authors":"Hasan Shamran Mohammed, Atica Sultan","doi":"10.4314/bcse.v38i5.12","DOIUrl":"https://doi.org/10.4314/bcse.v38i5.12","url":null,"abstract":"A new azo dye ligand namely ((E)-1-(4-hydroxy-3-(pyridin-3-yldiazenyl)phenyl)ethan-1-one) (HPPE) was synthesized by the coupling reaction of diazoinium salt of 3-aminopyridine and 4-hydroxyacetophenone. The palladium complex was prepared by reacting palladium chloride with the HPPE ligand. These compounds were characterized by different techniques such as mass, 1H-NMR, infrared, UV-Vis spectroscopies. The infrared data reveal that azo ligand reacting as bidentate via oxygen and nitrogen atom of azo group and it reveals the important functions as carbonyl group, methyl group, and azo group in the ligand and the complex such. The palladium complex is square planer. The ligand showed a visible colorimetric pH sensitive chemosensor, fast response time and is fully reversible and exhibited a large wavelength shift more than170 nm accompanied by excellent sensitivity of pH in the range of 3-9. The HPPE ligand and palladium complex showed potential antioxidant activity especially the ligand showed activity so close to the ascorbic acid. \u0000KEY WORDS: Antioxidant, Palladium complex, Pyridyl, Azo dye, Acidity \u0000Bull. Chem. Soc. Ethiop. 2024, 38(5), 1301-1310. \u0000DOI: https://dx.doi.org/10.4314/bcse.v38i5.9 ","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141834513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liquid-combustion synthesis of spinel LiMn2O4 cathode material for enhanced electrochemical performance lithium-ion batteries 用于增强锂离子电池电化学性能的尖晶石锰酸锂正极材料的液态燃烧合成技术

IF 1.3 4区化学

Bulletin of the Chemical Society of Ethiopia Pub Date : 2024-07-12 DOI: 10.4314/bcse.v38i5.18

Yu Sun, Chaofan Li, Hongcheng Gao, Jiaming Li, Jiabin Hao

{"title":"Liquid-combustion synthesis of spinel LiMn2O4 cathode material for enhanced electrochemical performance lithium-ion batteries","authors":"Yu Sun, Chaofan Li, Hongcheng Gao, Jiaming Li, Jiabin Hao","doi":"10.4314/bcse.v38i5.18","DOIUrl":"https://doi.org/10.4314/bcse.v38i5.18","url":null,"abstract":"A cubic spinel LiMn2O4 cathode material with nanoscale was synthesized via a facile liquid-combustion method at 600, 750 and 850 ℃. The crystal structure and surface morphology of LiMn2O4 electrodes have been characterized by using X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) technique. The samples have an average diameter of 200 nm with an octahedral structure with high crystallinity. Benefiting from the excellent structure, the sample prepared at 750 ℃ delivers the highest first discharge capacity of 115.3 mAh·g−1 with remaining 101.5 mAh·g−1 after 400 cycles at 1 C. Moreover, it exhibits a good cycling performance at 55 ℃, still had the capacity of 105.4 mAh·g−1 with a capacity retention of 71.2% following 282 cycles. The facilely synthesized octahedral LiMn2O4 provides a practical application strategy for lithium-ion batteries. \u0000KEY WORDS: Spinel LiMn2O4, Liquid-combustion method, Lithium-ion batteries \u0000Bull. Chem. Soc. Ethiop. 2024, 38(5), 1429-1437. \u0000DOI: https://dx.doi.org/10.4314/bcse.v38i5.18 ","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141834154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure and magnetism of a chiral Perovskite-like dicyanamidometallate framework 手性 Perovskite 类双氰胺金属铝框架的结构和磁性

IF 1.3 4区化学

Bulletin of the Chemical Society of Ethiopia Pub Date : 2024-07-12 DOI: 10.4314/bcse.v38i5.5

Da-Chuan Ge, Wen Zhu, Yu-Xuan Li, Feng Zhang, Yun Chen, Jian-Hua Sun, Zhao-Xi Wang

{"title":"Structure and magnetism of a chiral Perovskite-like dicyanamidometallate framework","authors":"Da-Chuan Ge, Wen Zhu, Yu-Xuan Li, Feng Zhang, Yun Chen, Jian-Hua Sun, Zhao-Xi Wang","doi":"10.4314/bcse.v38i5.5","DOIUrl":"https://doi.org/10.4314/bcse.v38i5.5","url":null,"abstract":"Perovskite-like compounds have attracted great attention because of their good properties, such as electrical, optical, and magnetic properties, etc. Herein, a new perovskite-like anionic dicyanamidometallate, namely (Bu3MeP)[Ni(dca)3] (1) (Bu3MeP = tributylmethylphosphine cation, dca = dicyanamide), was synthesized and structurally characterized by elemental analysis, IR spectrum, thermogravimetric analysis, and single-crystal X-ray diffraction. The compound crystallizes in the tetragonal crystal system with the chiral space group P43212, and exhibits a three-dimensional anionic dicyanamidometallate framework from Ni2+ units bridged by dicyanamides, in which tributylmethylphosphine cations are accommodated in the voids. The butyl groups present two conformations in the tributylmethylphosphine cation, resulting in chirality character occurred in compound 1. Variable-temperature magnetic susceptibility analysis indicates that weak ferromagnetic interaction exists between the nickel(II) ions coupling by μ1,5-bridings. \u0000KEY WORDS: Perovskite-like, Dicyanamidometallate, Crystal structure, Magnetic properties \u0000Bull. Chem. Soc. Ethiop. 2024, 38(5), 1251-1260. \u0000DOI: https://dx.doi.org/10.4314/bcse.v38i5.5 ","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141834159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, evaluation, and structural characterization of antioxidant diorganotin(IV) Complexes derived from ampicillin: a comprehensive study 源自氨苄西林的抗氧化剂二甘锡（IV）络合物的合成、评估和结构特征：一项综合研究

IF 1.3 4区化学

Bulletin of the Chemical Society of Ethiopia Pub Date : 2024-07-12 DOI: 10.4314/bcse.v38i5.8

Rafid Ryyis Arraq, Hadeer Jasem, Angham G. Hadi

{"title":"Synthesis, evaluation, and structural characterization of antioxidant diorganotin(IV) Complexes derived from ampicillin: a comprehensive study","authors":"Rafid Ryyis Arraq, Hadeer Jasem, Angham G. Hadi","doi":"10.4314/bcse.v38i5.8","DOIUrl":"https://doi.org/10.4314/bcse.v38i5.8","url":null,"abstract":"This study offerings the preparation, structural analysis, and estimation of novel diorganotin(IV) complexes derived from an ampicillin as a ligand in terms of their antioxidant activity. The diorganotin complexes were yielded by a direct reaction between ampicillin and a different number of diorganotin(IV) chloride precursors. Various spectroscopic techniques, including CHNS, FTIR and nuclear magnetic resonance (1H, 13C, 119Sn NMR), were used to explain the molecular structures of the produced complexes. Through in vitro experiments such as the CUPRAC and DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging technique, the novel diorganotin complexes' antioxidant activity were assessed. The results were compared to that of ligand antioxidants to evaluate the effectiveness of the complexes that were produced. The structural properties of the complexes were linked to their antioxidant capacity to identify the connection between molecular structure and biological function. \u0000KEY WORDS: Ampicillin, DPPH method, Diorganotin(IV) complexes, Antioxidants \u0000Bull. Chem. Soc. Ethiop. 2024, 38(5), 1291-1300. \u0000DOI: https://dx.doi.org/10.4314/bcse.v38i5.8 ","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141834360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of cost-effective dispersive liquid-liquid micro-extraction technique for preconcentration of multi-residue herbicides in environmental waters prior to Chromatographic analysis 开发具有成本效益的分散液-液微萃取技术，用于在色谱分析前预浓缩环境水体中的多残留除草剂

IF 1.3 4区化学

Bulletin of the Chemical Society of Ethiopia Pub Date : 2024-07-12 DOI: 10.4314/bcse.v38i5.1

Habtamu Bekele, Abi Legesse, W. Yohannes, Negussie Megersa

{"title":"Development of cost-effective dispersive liquid-liquid micro-extraction technique for preconcentration of multi-residue herbicides in environmental waters prior to Chromatographic analysis","authors":"Habtamu Bekele, Abi Legesse, W. Yohannes, Negussie Megersa","doi":"10.4314/bcse.v38i5.1","DOIUrl":"https://doi.org/10.4314/bcse.v38i5.1","url":null,"abstract":"High-density dispersive liquid-liquid microextraction method coupled with high-performance liquid chromatography with a diode array detector (HD-DLLME-HPLC-DAD) was developed for extraction and determination of six commonly used sulfonylurea herbicides in matrices of environmental waters. For simultaneous extraction of the target herbicides, the optimum experimental parameters that 024influence extraction efficiency were investigated. Under optimized conditions, the limit of detection (LOD) and quantification (LOQ) were 0.8-1.5 and 1.9-5.1 ng mL−1, respectively. The precisions in terms of relative standard deviations (% RSDs) of both intra-day and inter-day precisions (n = 6) were found to be 2.92 to 7.08 and 3.01 to 8.13, respectively. Furthermore, applicability of the developed method was investigated by analyzing spiked tap, lake, river and underground water samples and satisfactory recoveries were obtained in the range of 84.3–101.7% with RSDs < 9.8% (n = 6) and the target analytes were not detected in real samples. The proposed method offered several attractive features including fast analysis time, simplicity, sensitivity, and selectivity. Therefore, the trace level enrichment and assessment of sulfonylurea herbicides residues from environmental water matrices using HD-DLLME-HPLC-DAD could be utilized as a reliable alternative in routine laboratory analysis of contaminated environmental waters. \u0000KEY WORDS: Environmental water, High-density dispersive liquid-liquid microextraction, HPLC-DAD, Miniaturization analytical technique, Sulfonylurea herbicides, Trace level enrichment \u0000Bull. Chem. Soc. Ethiop. 2024, 38(5), 1189-1204. \u0000DOI: https://dx.doi.org/10.4314/bcse.v38i5.1 ","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141834401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation on sulfur substituted cadmium ions with superhydrophobic nature and long-term anticorrosion performance 具有超疏水性和长期防腐性能的硫代镉离子研究

IF 1.3 4区化学

Bulletin of the Chemical Society of Ethiopia Pub Date : 2024-07-12 DOI: 10.4314/bcse.v38i5.23

Sultan M Althahban, Mohammed Kuku, Y. Jazaa, Haewon Byeon

{"title":"Investigation on sulfur substituted cadmium ions with superhydrophobic nature and long-term anticorrosion performance","authors":"Sultan M Althahban, Mohammed Kuku, Y. Jazaa, Haewon Byeon","doi":"10.4314/bcse.v38i5.23","DOIUrl":"https://doi.org/10.4314/bcse.v38i5.23","url":null,"abstract":"Cadmium sulfide nanoparticles (CdS) were effectively prepared using ultrasonication-assisted synthesis. The high hydrophobicity and excellent dispersibility of the synthesised CdS nanoparticles in ethanol could increase their anti-penetrant effect against corrosive media. We evaluated and examined the corrosion prevention properties of CdS nanoparticle coatings on MS steel using Tafel polarisation and electrochemical impedance spectroscopy in HCl, NaCl, and KOH. The experimental results demonstrated that CdS nanoparticle coatings had higher corrosion performance than uncoated MS plates. Besides, CdS nanoparticles may be adsorbed on steel to produce a hydrophobic anti-corrosion layer, enhancing corrosion resistance. The impedance of CdS coatings increased continuously during electrolyte immersion. The results show that CdS acted as a suitable inhibitor and this inhibition efficiency and the polarization curves indicated that CdS nanoparticles performed as mixed inhibitors. The inhibition effect on the surface of the MS plate using CdS nanoparticle coating was investigated with inhibitors confirmed by nanoindentation techniques. The revolutionary approach for creating hydrophobic CdS nanoparticles suggested in this exertion may stimulate the development of high-performance anticorrosion materials and their corrosive protection applications. \u0000KEY WORDS: CdS nanoparticles, Mild steel plate coating, Anticorrosion applications \u0000Bull. Chem. Soc. Ethiop. 2024, 38(5), 1493-1507. \u0000DOI: https://dx.doi.org/10.4314/bcse.v38i5.23 ","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141834509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and characterization of some transition metal complexes with Schiff base derived from 2,6-diaminopyridine 一些过渡金属与 2,6-二氨基吡啶衍生希夫碱配合物的合成与表征

IF 1.3 4区化学

Bulletin of the Chemical Society of Ethiopia Pub Date : 2024-07-12 DOI: 10.4314/bcse.v38i5.9

Rana A.S. Al-Quaba, Esraa A. Hasan, Amaal Y. Al-Assafe

{"title":"Synthesis and characterization of some transition metal complexes with Schiff base derived from 2,6-diaminopyridine","authors":"Rana A.S. Al-Quaba, Esraa A. Hasan, Amaal Y. Al-Assafe","doi":"10.4314/bcse.v38i5.9","DOIUrl":"https://doi.org/10.4314/bcse.v38i5.9","url":null,"abstract":"Schiff base labeled as H2L1 was synthesized, which was derived from pyridine-2,6-diamine and 2-hydroxynaphthaldehyde. Types of complexes [ML]Cl2 and [ML(py)2]Cl2, were formed with Co2+, Ni2+, Cu2+, and Zn2+. Additionally, adduct complexes [ML(py)2] were prepared in a ratio of 2:1. Diverse analytical techniques, elemental analyses, (FT-IR, UV-Vis, 1H NMR), conductance measurements, and magnetic susceptibility, were employed to characterize these complexes and adducts. The data acquired validated that the ligands donor atoms act as (ONNO) tetra-dentate bibasic chelating ligands with metal ions. Depending on spectral and magnetic measurements, the suggested shapes of these complexes were reported to be either tetrahedral/octahedral in geometry. Density functional theory (DFT) was used to get some theoretical data about the generated complexes. The data obtained includes the energy of the highest and lowest occupied molecular orbitals (HOMO and LUMO), electron density, ionization potential (IP), electron affinity (EA), electronegativity (En), electrophilicity (ὠ), chemical hardness (η), and dipole moment (μ). Different characteristics of the complexes have been investigated and explained based on these studied parameters. The molecular docking of target microorganisms of these complexes will be studied. The interaction of DNA gyrase 4ckk with the compounds visualized by LigPlot software. \u0000KEY WORDS: 2,6-Diaminopyridine, 2-Hydroxynaphthaldehyde, Metal complexes, Spectral studies \u0000Bull. Chem. Soc. Ethiop. 2024, 38(5), 1337-1350. \u0000DOI: https://dx.doi.org/10.4314/bcse.v38i5.12","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141834528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the electrical potential of whey using a river sediment microbial fuel cell 利用河流沉积物微生物燃料电池研究乳清的电势

IF 1.3 4区化学

Bulletin of the Chemical Society of Ethiopia Pub Date : 2024-07-12 DOI: 10.4314/bcse.v38i5.22

Esra Ateş, Selim Latif Sanin

引用次数: 0

A synthesis of 1,3-dienes using a Ni(II) mediated Suzuki-Miyaura reaction 利用 Ni(II) 介导的 Suzuki-Miyaura 反应合成 1,3-二烯

IF 1.3 4区化学

Bulletin of the Chemical Society of Ethiopia Pub Date : 2024-07-12 DOI: 10.4314/bcse.v38i5.16

Yassir S. Al-Jawaheri, Nameer S. Ezzat

引用次数: 0