Synthesized and hypothesized schiff base ligand and its metal(II) complexes DNA binding mode

IF 1.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Bulletin of the Chemical Society of Ethiopia Pub Date : 2023-06-30 DOI:10.4314/bcse.v37i5.6

G. Puthilibai, V. Devatarika, Byeon Haewon, Shyam Sundar Behura, Hitendra Kumar Lautre, V. Subha, P. Sangwan, J. Sunil

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Abstract

ABSTRACT. Metal complexes play an important role in agriculture, pharmacology, medicine, and industrial chemistry. Schiff base metal compounds are the fusion products of propene and aldehydes, require a metal surrounded by an ion or cluster of molecules to form. Metal complexes of Co(II), Ni(II), Cu(II), and Zn(II) have also been created. Elemental analysis is used to analyses the structure and related compounds of the produced Schiff base ligand. According to deoxyribose nucleic acid (DNA) binding tests, Schiff base metal(II) complexes attach to DNA in an intercalative form with weak covalent connections. The predicted DNA binding mode supports an increase in the complexes' binding activity in the presence of newly generated ligand. The cleavage activities of the DNA were recorded using gel-electrophoresis in the presence and absence of the complexes. The findings of the cleavage experiment show that all of the produced chelates can successfully cut DNA. KEY WORDS: Schiff base ligand, DNA, Metal(II) complex, Hetero-ligand cobalt(II), Aldehydes Bull. Chem. Soc. Ethiop. 2023, 37(5), 1133-1139. DOI: https://dx.doi.org/10.4314/bcse.v37i5.6

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合成和假设的希夫碱配体及其金属(II)配合物DNA结合模式

摘要。金属配合物在农业、药理学、医学和工业化学中发挥着重要作用。席夫碱金属化合物是丙烯和醛的融合产物，需要一种被离子或分子簇包围的金属才能形成。还产生了Co（II）、Ni（II），Cu（II）和Zn（II）的金属络合物。元素分析用于分析所产生的席夫碱配体的结构和相关化合物。根据脱氧核糖核酸（DNA）结合测试，席夫碱金属（II）复合物以弱共价连接的嵌入形式附着在DNA上。预测的DNA结合模式支持在新产生的配体存在下复合物结合活性的增加。在存在和不存在复合物的情况下，使用凝胶电泳记录DNA的切割活性。切割实验结果表明，所有制备的螯合物都能成功切割DNA。关键词：希夫碱配体，DNA，金属（II）配合物，杂配位体钴（II），醛类公牛。化学。Soc.Ethiop。2023，37（5），1133-1139.DOI:https://dx.doi.org/10.4314/bcse.v37i5.6

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来源期刊

Bulletin of the Chemical Society of Ethiopia 化学-化学综合

CiteScore

2.20

自引率

8.30%

发文量

113

审稿时长

6-12 weeks

期刊介绍： The Bulletin of the Chemical Society of Ethiopia (BCSE) is a triannual publication of the Chemical Society of Ethiopia. The BCSE is an open access and peer reviewed journal. The BCSE invites contributions in any field of basic and applied chemistry.