Spectroscopic, thermal, and anticancer investigations of new cobalt(II) and nickel(II) triazine complexes

IF 1.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Bulletin of the Chemical Society of Ethiopia Pub Date : 2023-06-30 DOI:10.4314/bcse.v37i5.8

Amnah Mohammed Alsuhaibani, Abdel Majid A. Adam, M. S. Refat, Mohamed I. Kobeasy, S. B. Bakare, Eman Salah Bushara

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引用次数: 0

Abstract

ABSTRACT. The condensation of thiosemicarbazide with oxazolidinone produced 5-benzylidene-3-(4-chloro-phenyl)-6-oxo-5,6-dihydro-1H-[1,2,4]triazine-2-carbothioic acid amide (HL1). Co(II) and Ni(II) ions were reacted with the HL1 ligand. Elemental analysis and molar conductivity, along with mass, 1H-NMR, IR, UV-Vis, and X-ray powder diffraction spectral examinations, were used to reveal the chemical structure of the synthesized complexes. The stoichiometry of the complexes was determined to be 1:2 (metallic: moiety) using analytical, spectroscopic, and thermal data. The thermal properties of the complexes were explored using thermogravimetric (TG-DTG/DTA) methods, as well as the decomposition stages. Several kinetic thermodynamic parameters such as free activation energy (ΔG*), activation enthalpy (ΔH*), activation entropy (ΔS*), pre-exponential factor (A), and the activation energy (E*) were estimated. Inhibitory effects towards colon carcinoma cells (HCT cell line), hepatocellular carcinoma (Hep G2 cell line), and breast carcinoma (MCF-7 cell line) were verified using various concentrations of the samples. A colorimetric method was used to determine the cell viability percent in comparison to doxorubicin drug as a control. KEY WORDS: 1,2,4-Triazines, Thiosemicarbazide, Thermogravimetric analysis, Non-electrolytes, Anticancer Bull. Chem. Soc. Ethiop. 2023, 37(5), 1151-1162. DOI: https://dx.doi.org/10.4314/bcse.v37i5.8

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新的钴(II)和镍(II)三嗪配合物的光谱、热学和抗癌研究

摘要。氨基硫脲与恶唑烷酮缩合生成5-亚苄基-3-（4-氯-苯基）-6-氧代-5,6-二氢-1H-[1,2,4]三嗪-2-甲硫酰胺（HL1）。Co（II）和Ni（II）离子与HL1配体反应。元素分析和摩尔电导率，以及质量、1H-NMR、IR、UV-Vis和X射线粉末衍射光谱检查，用于揭示合成配合物的化学结构。使用分析、光谱和热数据确定配合物的化学计量为1:2（金属：部分）。用热重分析法（TG-DTG/DTA）研究了配合物的热性能以及分解阶段。估算了几个动力学热力学参数，如自由活化能（ΔG*）、活化焓（ΔH*）、激活熵（ΔS*）、指数前因子（A）和活化能（E*）。使用不同浓度的样品验证了对结肠癌细胞（HCT细胞系）、肝细胞癌（Hep G2细胞系）和乳腺癌（MCF-7细胞系）的抑制作用。与作为对照的阿霉素药物相比，使用比色法测定细胞活力百分比。关键词：1,2,4-三嗪，氨基硫脲，热重分析，非电解质，抗癌药物。化学。Soc.Ethiop。2023，37（5），1151-1162。DOI:https://dx.doi.org/10.4314/bcse.v37i5.8

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来源期刊

Bulletin of the Chemical Society of Ethiopia 化学-化学综合

CiteScore

2.20

自引率

8.30%

发文量

113

审稿时长

6-12 weeks

期刊介绍： The Bulletin of the Chemical Society of Ethiopia (BCSE) is a triannual publication of the Chemical Society of Ethiopia. The BCSE is an open access and peer reviewed journal. The BCSE invites contributions in any field of basic and applied chemistry.