Cardiology Research and Practice最新文献

{"title":"Comparing the Performances of Support Vector Machines and Artificial Neural Networks for Predicting Coronary Artery Diseases: A Cross-Sectional Study.","authors":"Sahar Shariatnia, Abdolhalim Rajabi, Majid Ziaratban, Aref Salehi, Mohammadali Vakili","doi":"10.1155/crp/5575296","DOIUrl":"10.1155/crp/5575296","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery disease (CAD) is recognized as an inflammatory condition and remains a leading cause of morbidity and mortality worldwide. Cardiovascular disease (CVD), more broadly, is a major contributor to global death and disability. This study aimed to compare the diagnostic performance of various noninvasive techniques for detecting CAD.</p><p><strong>Methods: </strong>A cross-sectional study was conducted involving 758 participants, including 508 patients diagnosed with CAD and 250 without the disease. The diagnostic performance of two machine learning models-artificial neural networks (ANNs) and support vector machines (SVMs)-was evaluated. The classification models were assessed using receiver operating characteristic (ROC) curves, sensitivity, specificity, and overall accuracy.</p><p><strong>Results: </strong>The study included a total of 758 participants. Among them, 250 individuals (33.6% male and 66.4% female) were diagnosed as non-CAD cases, while 508 participants (64% male, 36% female) were identified as having CAD. The area under the ROC curve (AUC) for CAD prediction was 0.752 (95% CI: 0.682-0.823) using the ANN model and 0.793 (95% CI: 0.733-0.853) using the SVM model. A statistically significant difference was observed between the performance of the two models in predicting CAD (<i>p</i> = 0.03), with the SVM model demonstrating superior predictive performance (AUC = 0.793, 95% CI: 0.733-0.853).</p><p><strong>Conclusions: </strong>SVMs demonstrated superior performance compared to ANNs in predicting the risk of CAD using simple clinical predictors.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"5575296"},"PeriodicalIF":2.1,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13189446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147986673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Systemic Immune-Inflammation Index (SII) in Hospital Readmission Following Acute Myocardial Infarction: A Four-Year Analysis.","authors":"Yasaman Borghei, Bahare Gholami-Chaboki, Nasibe Goli, Fatemeh Baharvand, Arsalan Salari","doi":"10.1155/crp/6967879","DOIUrl":"10.1155/crp/6967879","url":null,"abstract":"<p><strong>Background: </strong>Acute myocardial infarction (AMI) initiates an inflammatory response essential for cardiac repair. Several novel inflammatory markers have been identified as indicators of systemic inflammation, including the systemic immune-inflammation index (SII). This study aimed to evaluate the relationship between SII levels and readmission rates in AMI patients.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed 1147 AMI patients admitted between 2019 and 2021. The optimal SII cutoff was determined as 694.3 × 10⁹/L, categorizing patients into high SII (≥ 694.3) and low SII (< 694.3) groups. The association between SII levels and readmission risk was assessed using a logistic regression model.</p><p><strong>Results: </strong>Over 4 years, 454 patients were readmitted, with higher readmission rates (34.4%) observed in the high SII group. Statistically significant differences were noted in primary outcomes, with higher SII patients experiencing increased incidence of major adverse cardiovascular events (MACEs) (<i>p</i> < 0.05). The Cox proportional hazards model indicated that individuals with prior CABG had a 40% higher risk of readmission.</p><p><strong>Conclusion: </strong>Although patients with high SII demonstrated higher hospital readmission rates, primarily due to recurrent MI, no statistically significant association was observed.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"6967879"},"PeriodicalIF":2.1,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13189477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147986680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Fasting Blood Glucose and Myocardial Infarction Risk: Findings From the 2015-2018 NHANES Database and Mendelian Randomization Studies.","authors":"Bo Peng, Jianheng Liang, Lechong Yuan, Donglin Lin, Xiaoping Fan","doi":"10.1155/crp/6984101","DOIUrl":"10.1155/crp/6984101","url":null,"abstract":"<p><strong>Introduction: </strong>Fasting blood glucose and myocardial infarction share some common pathophysiological risk factors, but the exact relationship between them remains unclear. This study aims to provide evidence for the association between fasting blood glucose and myocardial infarction by analyzing data from the National Health and Nutrition Examination Survey (NHANES) 2015-2018 and Mendelian randomization (MR) analysis.</p><p><strong>Methods: </strong>A two-sample MR study was conducted to explore the causal relationship between fasting blood glucose and myocardial infarction using summary statistics from genome-wide association studies (GWAS). The inverse variance weighted (IVW) method and other supplementary MR methods were mainly used to verify the causal association, and sensitivity analysis was performed to confirm the robustness of the results. In addition, weighted multivariable adjusted logistic regression analysis was used to evaluate the relationship between fasting blood glucose and the myocardial infarction-related multivariable association model constructed with HDL as the core indicator based on NHANES data from 2015 to 2018.</p><p><strong>Results: </strong>A total of 4807 participants were included in the observational study based on NHANES data. Weighted multivariable adjusted logistic regression analysis showed a positive correlation between fasting blood glucose and the myocardial infarction model, with an odds ratio (OR) of -0.027 and a 95% confidence interval (CI) of [-0.042, -0.011]. MR analysis also indicated a causal relationship between myocardial infarction and fasting blood glucose (IVW: OR = 1.0026, 95% CI = 1.0006-1.0046, <i>p</i> = 0.0098). Sensitivity analysis further confirmed the robustness and reliability of these study results (all <i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>There is a causal relationship between fasting blood glucose and myocardial infarction.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"6984101"},"PeriodicalIF":2.1,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13093073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiotherapy Reprograms Intermediate Monocytes Into Proinflammatory Drivers of Systemic Inflammation in Radiation-Induced Heart Disease.","authors":"Jinchen He, Dejun Kong, Chengwei Zhang, Qiuhong Chen, Hong Yang, Yuyuan Wang, Tianqi Wu, Qi Wu","doi":"10.1155/crp/1117746","DOIUrl":"10.1155/crp/1117746","url":null,"abstract":"<p><p>Radiation-induced heart disease (RIHD) is a serious complication of thoracic radiotherapy, and its pathogenesis involves systemic immune alterations. To elucidate these mechanisms, we profiled peripheral blood mononuclear cells (PBMCs) from patients before and after thoracic radiotherapy using single-cell RNA sequencing (scRNA-seq), with key findings validated via multiparameter flow cytometry and ELISA assays. Our analysis revealed that radiotherapy markedly reshaped the immune composition, expanding innate myeloid cells (monocytes and neutrophils) and reducing lymphocytes (T and NK cells); these compositional shifts were independently confirmed by flow cytometric analysis. Cell-cell communication networks showed that postradiotherapy monocytes evolved into central signaling hubs, exhibiting heightened proinflammatory ligand-receptor interactions. Consistent with this, monocytes showed broad transcriptional reprogramming with upregulation of canonical inflammatory pathways (IL-6/STAT3, TNF/NF-κB) and metabolic regulators (mTORC1, glycolysis). ELISA assays corroborated these transcriptomic signatures, demonstrating significantly elevated plasma levels of IL-6 and TNF-α post-treatment. Notably, scRNA-seq identified a selective expansion of the highly plastic intermediate (CD14++CD16+) monocyte subset, a specific population shift further verified by flow cytometry. These intermediate monocytes exhibited an immature, progenitor-like profile and were enriched at the origin of a Monocle3 pseudotime trajectory. Trajectory analysis indicated they differentiate into mature classical monocytes that upregulate proinflammatory effector genes such as S100A8, S100A9, and S100A12. Furthermore, pseudotime gene clustering revealed a functional bifurcation in monocyte behavior: one module drove inflammatory activation, while a second module simultaneously engaged oxidative stress responses and antioxidant defenses (e.g., glutathione metabolism). In summary, by integrating single-cell transcriptomics with experimental validation, we demonstrate that radiotherapy drives a systemic immune shift characterized by intermediate monocyte expansion and bifurcated programs of inflammation and stress adaptation. Intermediate monocytes emerge as key drivers of postradiotherapy inflammation, offering a potential cellular biomarker of RIHD risk and a target for immunomodulatory interventions to mitigate cardiovascular injury in cancer survivors.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"1117746"},"PeriodicalIF":2.1,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Biopsy: Imaging Frontiers in Cardiac Sarcoidosis.","authors":"Ibrahim Antoun, Jalal Assadi, Mustafa Zakkar, G Andre Ng, Sanjay S Bhandari","doi":"10.1155/crp/3738354","DOIUrl":"10.1155/crp/3738354","url":null,"abstract":"<p><p>Cardiac sarcoidosis (CS) represents an inflammatory infiltrative disease, which creates difficulties during diagnosis and prognosis. The identification and management of CS heavily depend on advanced cardiac imaging techniques. The article examines multimodality imaging in CS by evaluating cardiac magnetic resonance (CMR) imaging, positron emission tomography (PET) with computed tomography (CT), single-photon emission computed tomography (SPECT), echocardiography, CT and hybrid imaging approaches. This review examines each imaging modality with respect to its fundamental principles, diagnostic capabilities, benefits and drawbacks and references key research from the past decade. CMR stands as the primary diagnostic method for detecting myocardial scar and fibrosis in CS patients, providing essential prognostic information. The PET/CT system with 18-fluorodeoxyglucose (FDG) provides an effective method for detecting active inflammation and tracking treatment response. Echocardiography is a readily accessible screening tool that reveals the structural and functional effects of CS, while strain imaging techniques enable the detection of early disease involvement. The use of delayed-enhanced cardiac CT provides an alternative method for detecting myocardial scar. It helps identify patients who are ineligible for CMR and excludes coronary artery disease. Diagnostic confidence and disease activity assessment improve with hybrid imaging, particularly when PET/MR is used. The Discussion section integrates these findings with an evaluation of emerging quantitative imaging markers and novel tracers that show promise for enhancing CS evaluation. The implementation of multimodality imaging techniques has transformed the management of CS by enabling earlier diagnosis, risk assessment and treatment guidance. A personalised imaging approach that combines multiple diagnostic methods yields the best results for diagnosing CS and enhances patient-care outcomes.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"3738354"},"PeriodicalIF":2.1,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress of Nerve Injury-Induced Protein 1 in Cardiovascular Diseases.","authors":"Xiaohui Xu, Yuming Mu","doi":"10.1155/crp/9683634","DOIUrl":"10.1155/crp/9683634","url":null,"abstract":"<p><p>Nerve injury-induced protein 1 (Ninjurin 1) is a cell surface adhesion molecule that contains one extracellular adhesion domain and two transmembrane domains. Originally discovered in nerve injury, it has been extensively studied for its role in nerve regeneration. Ninj1 mediates the transendothelial migration of myeloid cells mainly through the extracellular adhesion domain, thereby aggravating the inflammation of the central nervous system. In addition to regulating the inflammatory phenotype of cells, Ninj1 actively mediates the rupture of the plasma membrane and regulates the programmed death of inflammatory cells, thereby participating in the host defense against exogenous infection. In recent years, Ninj1, an important protein associated with inflammasome activation, has garnered increasing attention from researchers regarding its mechanistic role and pathophysiological significance in cardiovascular diseases. Accumulating evidence suggests that Ninj1 not only participates in the regulation of inflammatory responses and cell death processes but also plays a critical role in the onset and progression of various cardiovascular conditions, including atherosclerosis, myocardial ischemia-reperfusion injury, and heart failure. Therefore, an in-depth exploration of the specific functions of Ninj1 in the cardiovascular system holds significant scientific and clinical value for elucidating the molecular mechanisms underlying these diseases and for developing novel therapeutic strategies. This review aims to summarize the research progress on Ninj1 in cardiovascular diseases and to outline its mechanisms in pathological processes.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"9683634"},"PeriodicalIF":2.1,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Cardiac Synovial Sarcoma (PCSS): Clinicopathologic Features of 6 Cases and Literature Comparison.","authors":"Yi-Xiang Cai, Sheng-Jun Liu, Qi Sun, Hui Li, Xiao-Le Meng","doi":"10.1155/crp/5272035","DOIUrl":"10.1155/crp/5272035","url":null,"abstract":"<p><p>Primary cardiac synovial sarcoma (PCSS) is an exceedingly rare tumor. This study presents a comprehensive analysis of six novel PCSS cases identified within our institutional cohort, compared with published literature cohorts, focusing on their clinical presentations, histopathological features, immunohistochemical and molecular characteristics, therapeutic interventions, and prognosis. Our institutional cohort included five male and one female patients, with a median age of 44 years. Presenting symptoms included dyspnea, chest tightness, back pain, and syncope. Tumors were located in the pericardium (four cases) and the cardiac wall (two cases). The tumor size ranged from 2.0 to 14.5 cm. Histopathologically, four cases were monophasic and two were biphasic. Immunohistochemical analysis revealed consistent expression of TLE1, vimentin, and BCL-2. Molecular analysis confirmed the presence of the <i>SS18-SSX</i> gene fusion through fluorescence in situ hybridization (FISH) in five cases, whereas one FISH-negative case was positive for the <i>SS18-SSX1</i> gene fusion through next-generation sequencing (NGS). All patients underwent surgical intervention (tumor excision) followed by adjuvant chemotherapy with doxorubicin and ifosfamide. At follow-up, four patients were alive without disease and two had died. This case series highlights the clinicopathologic and molecular features of PCSS. Overall, <i>SS18 (SYT)</i> gene rearrangement and TLE1 expression are crucial diagnostic markers for differentiating PCSS from other neoplasms.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"5272035"},"PeriodicalIF":2.1,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13074430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Efficacy and Outcomes of Transcatheter Aortic Valve Replacement Versus Surgical Aortic Valve Replacement in Low- to Intermediate-Risk Aortic Regurgitation Patients: A Comprehensive Clinical Comparison.","authors":"Xiaoxue Zhang, Chenxi Yan, Shiliang Li, Cai Cheng","doi":"10.1155/crp/9978726","DOIUrl":"10.1155/crp/9978726","url":null,"abstract":"<p><strong>Background: </strong>Transcatheter aortic valve replacement (TAVR) has been established as an alternative to surgery for high-risk aortic regurgitation (AR) patients. However, its applicability to low- and intermediate-risk populations remains under investigation. This study evaluates the clinical outcomes, quality of care, and patient-centered implications of TAVR versus surgical aortic valve replacement (SAVR) in this population.</p><p><strong>Methods: </strong>Between 2021 and 2024, clinical data were retrospectively analyzed from 70 AR patients at our center, including 37 who underwent TAVR and 33 who received SAVR with bioprosthetic valves. Baseline characteristics, perioperative metrics, and major clinical outcomes were assessed. International registry data (FRANCE-TAVI and ALIGN-AR) were utilized for external validity comparisons.</p><p><strong>Results: </strong>Baseline characteristics were comparable between groups. TAVR was associated with shorter operation time (<i>p</i> = 0.001), reduced blood use (<i>p</i> < 0.001), and shorter hospital stays (<i>p</i> = 0.021). No 30-day mortality was observed in TAVR, whereas four deaths occurred in the SAVR group (<i>p</i> = 0.029). Conduction abnormalities differed, with complete left bundle branch block (CLBBB) more frequent in TAVR (<i>p</i> = 0.025) and complete right bundle branch block (CRBBB) in SAVR (<i>p</i> = 0.029). Despite its minimally invasive nature, ICU observation time remained similar (<i>p</i> = 0.339) due to perioperative complications. Economic analysis suggests potential cost savings with TAVR in specific scenarios.</p><p><strong>Conclusion: </strong>TAVR offers favorable short-term outcomes for low- to intermediate-risk AR patients, yet challenges in perioperative care require optimization. Long-term studies and multicenter trials are needed to refine patient selection and postprocedural management strategies.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"9978726"},"PeriodicalIF":2.1,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13074356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinically Relevant Doses of Remimazolam Modulate Cardiac Electrophysiology: Late Repolarization Prolongation and Increased Conduction Dispersion With Preserved QTc.","authors":"Zijun Wang, Ying Cao, Gao Su, Yanyan Feng, Rongfeng Yang, Xue Bai, Hong Gao","doi":"10.1155/crp/9479974","DOIUrl":"10.1155/crp/9479974","url":null,"abstract":"<p><strong>Background: </strong>Remimazolam, an ultra-short-acting benzodiazepine with rapid metabolism and cardiovascular stability, is increasingly used for anesthesia, yet its cardiac electrophysiologic effects are incompletely characterized.</p><p><strong>Methods: </strong>We conducted a multimodal evaluation in Langendorff-perfused guinea pig hearts and human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), using surface electrocardiogram (ECG), multielectrode mapping, optical mapping, and whole-cell patch-clamp across remimazolam doses (0, 1, 2, 3 mg/kg/h).</p><p><strong>Results: </strong>High-dose remimazolam (3 mg/kg/h) prolonged the PR interval (<i>p</i> = 0.027), and T-wave duration was prolonged at 2 and 3 mg/kg/h (<i>p</i> = 0.017 and <i>p</i> < 0.001), while QT interval and corrected QT interval (QTc) remained unchanged (<i>p</i> > 0.1). Multielectrode mapping showed prolonged activation time at 2 and 3 mg/kg/h versus NC (<i>p</i> = 0.02 and 0.003) and increased conduction dispersion at 2 and 3 mg/kg/h (<i>p</i> = 0.0193 and 0.0101). Conduction velocity (CV) was reduced at 3 mg/kg/h compared with NC and 1 mg/kg/h (<i>p</i> = 0.01 and 0.02). Optical mapping demonstrated prolonged action potential duration at 90% repolarization (APD₉₀) (NC: 107.93 ± 0.63 ms vs 3 mg/kg/h: 118.94 ± 1.83 ms, <i>p</i> < 0.001) and calcium transient duration at 90% recovery (CTD₉₀) (NC: 116.20 ± 1.04 ms vs 3 mg/kg/h: 125.63 ± 1.15 ms, <i>p</i> < 0.001), accompanied by increased APD₉₀ interquartile range (APD₉₀-IQR; <i>p</i> ≤ 0.02 vs NC) and increased CTD₉₀ interquartile range (CTD₉₀-IQR; <i>p</i> = 0.005). In hiPSC-CMs, 1500 ng/mL remimazolam selectively prolonged APD₉₀ (<i>p</i> = 0.04) without significant effects on action potential amplitude, upstroke velocity, or early repolarization indices (all <i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>These findings indicate that at higher clinically relevant exposures, remimazolam selectively lengthens late repolarization and increases conduction heterogeneity-features consistent with an arrhythmogenic substrate-while QT and QTc remains stable, supporting cautious use and ECG monitoring in at-risk populations.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"9479974"},"PeriodicalIF":2.1,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13074361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Socioeconomic Status and Mortality Risk in CKM Stage 0-3 Patients: Analysis of Inflammatory Mediation.","authors":"Wenlong Ding, Fachao Shi, Lei Fang, Qin Cui, Zheng Wang, Caoyang Fang","doi":"10.1155/crp/8849559","DOIUrl":"10.1155/crp/8849559","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate whether socioeconomic status (SES) influences the risk of all-cause and cardiovascular mortality among patients with cardiovascular-kidney-metabolic (CKM) syndrome stages 0-3 through the systemic inflammation response index (SIRI). The investigation utilized a nationally representative sample from the U.S. National Health and Nutrition Examination Survey (NHANES) database and employed mediation analysis for systematic assessment.</p><p><strong>Methods: </strong>Data were derived from NHANES surveys conducted between 1999 and 2018, enrolling adults who met the classification criteria for CKM stages 0-3. SES was defined by the stratified family income-to-poverty ratio (PIR), with SIRI serving as the mediator. The primary outcomes were all-cause and cardiovascular mortality. Methodological approaches included weighted multivariable Cox regression, subgroup analyses, sensitivity analyses, and bootstrap-based mediation analysis.</p><p><strong>Results: </strong>The study included 15,623 participants who were followed for a mean duration of 115 months, during which 1788 all-cause deaths and 405 cardiovascular deaths were recorded. After comprehensive adjustment for potential confounders, each unit increase in PIR was associated with a significantly reduced risk of all-cause mortality (HR = 0.88, 95% CI: 0.84-0.92) and cardiovascular mortality (HR = 0.85, 95% CI: 0.77-0.95). Participants in the high SES group demonstrated substantially lower risks for both all-cause mortality (HR = 0.57, 95% CI: 0.47-0.69) and cardiovascular mortality (HR = 0.50, 95% CI: 0.34-0.73) compared to their low SES counterparts. Notably, mediation analysis revealed that SIRI accounted for 63.67% of the association between SES and all-cause mortality, and 60.45% of the association between SES and cardiovascular mortality after full adjustment for confounding variables.</p><p><strong>Conclusion: </strong>SES significantly impacts the risk of all-cause and cardiovascular mortality among patients with CKM stages 0-3, with a substantial portion of this effect mediated through systemic inflammation as measured by SIRI. These findings suggest that comprehensive interventions targeting both socioeconomic conditions and chronic inflammation may effectively enhance long-term health outcomes in this vulnerable population.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"8849559"},"PeriodicalIF":2.1,"publicationDate":"2026-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13071174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}