Cardiology Research and Practice最新文献

{"title":"The Relationship Between the Fibrinogen-to-Albumin Ratio and Short-Term Mortality in Chinese Patients With Chronic Heart Failure: A Retrospective Cohort Analysis.","authors":"Lei Lei Guo, Ping Liu, Li Na Cai, Li Hu, Yue Shan Zhou","doi":"10.1155/crp/9292002","DOIUrl":"10.1155/crp/9292002","url":null,"abstract":"<p><p><b>Background:</b> Recent studies have identified an association between the fibrinogen-to-albumin ratio (FAR) and the prognosis of coronary heart disease; however, evidence regarding its significance in heart failure patients remains limited. This study aims to examine the relationship between the FAR and short-term mortality among individuals with heart failure. <b>Methods:</b> In this retrospective cohort study, we conducted an analysis of clinical data from patients with heart failure who were hospitalized at Zigong Fourth People's Hospital from December 2016 to June 2019. The primary exposure variable was the FAR, while the outcomes of interest were mortality rates at 28 days and 3 months. Multivariate logistic regression evaluated FAR's independent association with short-term mortality, with predictive accuracy assessed via ROC curves and subgroup consistency through stratified analyses. Furthermore, smooth curve fitting was utilized to investigate the linear relationship, and a series of sensitivity analyses were conducted to validate the robustness of the findings. <b>Results:</b> The analysis included 1880 participants, of whom 58.1% were females and 54.1% were aged 60-80 years. Our study showed that a one standard deviation rise in the FAR was linked to a 45% increase in 28-day mortality (OR = 1.45, 95% CI = 1.02-2.06, <i>p</i>=0.04) after adjusting for potential confounding factors. The 28-day mortality rate was markedly elevated in the high FAR group (FAR > 0.126) compared to the low FAR group (OR = 4.01, 95% CI = 1.17-13.82, <i>p</i>=0.028). Comparable findings were noted at the 3-month mark. There were no significant interactions found in the subgroup analysis. A linear association was identified between FAR and short-term mortality. The optimal FAR cutoff value for predicting 28-day mortality was 0.156 (sensitivity 68.0%, specificity 59.4%, AUC = 0.654), while for 3-month mortality, it was 0.156 (sensitivity 68.0%, specificity 58.3%, AUC = 0.647). Sensitivity analyses corroborated the robustness of our findings. <b>Conclusion:</b> A positive correlation exists between the FAR and short-term mortality among Chinese patients with heart failure. These findings underscore the necessity for further investigation into the underlying pathophysiological mechanisms and potential therapeutic interventions associated with FAR in the context of heart failure.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2025 ","pages":"9292002"},"PeriodicalIF":1.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acoustic Intensity as a Potential Indicator for Congestive Heart Failure Exacerbation: An Exploratory Pilot Study.","authors":"Eran Hadad, Jon Våbenø, Herald Reiersen, Michael Czaplik, Martin Mengel, Doron Adler","doi":"10.1155/crp/3540332","DOIUrl":"10.1155/crp/3540332","url":null,"abstract":"<p><p><b>Background:</b> Congestive heart failure (CHF) requires continuous monitoring, especially during exacerbation phases. Pulse oximetry, commonly used for critical patient surveillance, has shown diagnostic potential in acute heart failure. In this exploratory pilot study, we investigated oxygen saturation (SpO₂) data and respiratory sounds from CHF patients to uncover their relationship and to assess the potential of respiratory sound intensity in telehealth or self-monitoring systems, with a view toward future predictive applications. <b>Methods:</b> The relationship between SpO₂ and acoustic intensity was explored by collecting physiological and acoustic data, including infrasound, from 25 CHF patients using an electronic pickup device. These patients had been enrolled in a larger clinical trial that aimed to explore disease exacerbation across various chronic diseases. Four patients experienced exacerbation phases (SpO₂ < 92%), and for each phase, we computed Pearson correlations in two frequency ranges (audible, audible + infrasound). Eight prespecified correlations were assessed, with unadjusted and adjusted <i>p</i> values (Bonferroni, FDR) and effect sizes reported. <b>Results:</b> Significant negative correlations between specific acoustic frequency ranges and SpO₂ variations were found in several patients. In all four patients, inclusion of the infrasound range increased the correlation magnitude compared to the audible range alone, with lower <i>p</i> values in all cases. Adjusted analyses retained significance in Patients 2 and 4 across both frequency ranges. <b>Conclusion:</b> This pilot work identifies consistent moderate-to-strong negative correlations between acoustic intensity and SpO₂ during CHF exacerbations. While not confirmatory, these results support the potential of acoustic intensity as a candidate indicator for early detection, warranting validation in larger studies and predictive modeling frameworks. <b>Trial Registration:</b> EUDAMED Clinical Investigation (CIV) Identification: CIV-NO-21-10-037926.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2025 ","pages":"3540332"},"PeriodicalIF":1.8,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Safety and Efficacy Profile of Magnesium-Based Bioresorbable Coronary Stents as Compared to Poly-L-Lactic Acid-Based Bioresorbable and Contemporary Drug-Eluting Coronary Stents-A Systematic Review.","authors":"Liam Marsden Back, Aleksandra Gentry-Maharaj, Andrew Ladwiniec","doi":"10.1155/crp/7481956","DOIUrl":"10.1155/crp/7481956","url":null,"abstract":"<p><p><b>Background:</b> Bioresorbable coronary stents (BRS) were designed with the aim of reducing the risk of late adverse events of permanent drug-eluting stents (DES) by dissolving once vessel patency had been restored and the requirement for acute mechanical support resolved. Bioresorbable poly-L-lactic acid (PLLA) scaffold designs, while initially appearing as promising technology, were unsuccessful in widespread clinical use due to an observed high rate of late stent thrombosis. Magnesium-based BRS (MgBRS) have provided an alternative to this original design and have shown promise in early-phase clinical trials. This review aims to address the clinical question: How does the current safety and efficacy evidence for MgBRS in all patients requiring percutaneous coronary intervention compare with the randomised data assessing PLLA-BRS and contemporary DES? <b>Methods:</b> Two parallel systematic reviews were performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, utilising MEDLINE, EMBASE and Web of Science: the first assessing clinical outcomes of all observational and randomised MgBRS trials, the second assessing clinical outcomes of PLLA-BRS versus DES in randomised clinical trials. The primary safety and efficacy outcomes collected were cardiac death, target vessel failure (TVF) and stent thrombosis. <b>Results:</b> A total of 3582 MgBRS patients (24 trials), 6370 PLLA-BRS and 5413 DES patients (16 trials) were included for analysis. Cardiac death was similar across all three stent designs in all time intervals. MgBRS performed similarly to contemporary DES and superiorly to PLLA-BRS at 12- and 24-month intervals with regard to TVF and stent thrombosis. Longer follow-up was suggestive of a poorer performance of MgBRS relative to DES, although with limited patient numbers. <b>Conclusion:</b> MgBRS appear to perform similarly to DES and superiorly to PLLA-BRS at 12 and 24 months in regard to key clinical safety and efficacy measures. Further randomised studies are required before recommending this technology for widespread clinical use over DES.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2025 ","pages":"7481956"},"PeriodicalIF":1.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture Improves Myocardial Fibrosis in Association With Intestinal Flora and Metabolic Modulation in Mice.","authors":"Xueyun Que, Feiyu He, Qida He, Jieying Lim, Xiaoshuang Li, Xianjun Meng, Zongbao Yang","doi":"10.1155/crp/7765150","DOIUrl":"10.1155/crp/7765150","url":null,"abstract":"<p><p><b>Objective:</b> This study investigates the reparative effect of electroacupuncture on myocardial fibrosis (MF) in mice and explores its impact on intestinal flora and metabolism profile. This examines an investigation into the biological mechanisms underlying electroacupuncture's efficacy in treating MF in mice. <b>Methods:</b> Twenty-four male Kunming mice (27-34 g) were randomized into three groups: normal control (NC, <i>n</i> = 8), MF model (MF, <i>n</i> = 8), and electroacupuncture treatment (EA, <i>n</i> = 8). MF and EA groups received daily subcutaneous ISO injections (25 mg/kg) at the nape for 5 days; NC mice received saline. The EA group underwent 14 days of EA at PC6 (Neiguan). Cardiac function, intestinal flora, and metabolites were assessed post-treatment. <b>Results:</b> EA significantly reduced cardiac weight index (CWI), collagen volume fraction (CVF), and serum procollagen III N-terminal propeptide (PIIINP) and improved left ventricular ejection fraction (LVEF) and shortening fraction (LVFS) (<i>p</i> < 0.05). Gut microbiota analysis revealed distinct composition shifts: EA restored <i>Bacteroidota</i> abundance and lowered <i>Firmicutes</i>/<i>Bacteroidota</i> ratios, resembling NC profiles. Notably, differential bacteria (e.g., <i>Staphylococcus lentus</i>, <i>Xylanophilum</i>) correlated with PIIINP, CVF, and cardiac function. Metabolomics identified reduced TMAO, phenylalanine, acetone, and lactic acid in EA vs. MF (<i>p</i> < 0.05). Negative correlations included <i>Stricto-1</i> vs. phenylalanine and <i>Rodentium</i> vs. acetone. <b>Conclusion:</b> EA ameliorates ISO-induced MF in mice by modulating gut microbiota structure and metabolic profiles, suggesting a microbiota-metabolite axis mediates its therapeutic effects.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2025 ","pages":"7765150"},"PeriodicalIF":1.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145013765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Beat, Next-Generation Sequencing Discovery of Novel <i>RYR2</i> Gene Variant in Long QT Syndrome.","authors":"Samira Kalayinia, Amir Ghaffari Jolfayi, Amirali Soheili, Majid Maleki, Mohammad Dalili, Mahdieh Soveizi, Saba Komijani","doi":"10.1155/crp/1928541","DOIUrl":"10.1155/crp/1928541","url":null,"abstract":"<p><p><b>Background:</b> Long QT syndrome (LQTS) is an inherited cardiac channelopathy marked by QT interval prolongation and increased risk of life-threatening arrhythmias. While variants in <i>KCNQ1</i>, <i>KCNH2</i>, and <i>SCN5A</i> explain most cases, many remain genetically unexplained. This study emphasizes the value of genetic testing in diagnosis and individualized therapy. <b>Methods:</b> A 9-year-old boy with recurrent syncope was evaluated for LQTS. Clinical workup included history, physical exam, ECG, echocardiography, exercise testing, electrophysiology studies (EPS), Holter monitoring, and cardiac MRI. Family history was assessed. Genetic testing involved whole-exome sequencing (WES) and Sanger confirmation, followed by bioinformatic pathogenicity analysis. <b>Results:</b> The boy's ECG showed a QTc of 470 ms, extending to 500 ms during EPS. No structural cardiac defects were detected. WES revealed a heterozygous missense variant, NM_001035.2:c.12370A > C (p.Ser4124Arg), in the <i>RYR2</i> gene. <i>In silico</i> tools predicted it to be pathogenic, and Sanger sequencing confirmed it. The variant was also identified in the patient's mother, who had a history of syncope, but not in the father. The patient responded well to propranolol and remained symptom-free for 18 months. <b>Conclusion:</b> Identification of a pathogenic <i>RYR2</i> variant expands the known genetic spectrum of LQTS. The patient's clinical and familial findings highlight the need to consider <i>RYR2</i> in genetic testing panels, especially for atypical LQTS cases. Continued research is essential to further clarify the genetics of LQTS and guide targeted management.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2025 ","pages":"1928541"},"PeriodicalIF":1.8,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12408128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Potential of Carnosine in Ischemia-Reperfusion Injury: A Preclinical Study in Muscle Tissue.","authors":"Gokhan Erol, Hakan Kartal, Ertan Demirdaş, Gokhan Arslan, Tayfun Ozdem, Basak Yavuz","doi":"10.1155/crp/2496873","DOIUrl":"10.1155/crp/2496873","url":null,"abstract":"<p><p><b>Background:</b> Ischemia-reperfusion (IR) injury, a process involving the disruption and subsequent restoration of blood flow, is a significant contributing factor to both cardiovascular diseases and broader tissue damage. Carnosine, a natural dipeptide notably abundant in muscle tissue and recognized for its antioxidant attributes, may offer protective benefits against the deleterious effects of IR injury. <b>Methods:</b> A total of 24 rats were randomly allocated into four distinct groups: control, carnosine control, IR, and Carnosine + IR. The IR and Carnosine + IR groups underwent a simulated blood flow blockage lasting 120 min, followed by 120 min of reperfusion. Animals in the carnosine-treated groups received 250 mg/kg of carnosine via intraperitoneal injection prior to the experimental procedure. Muscle tissue samples were subsequently analyzed to quantify markers indicative of oxidative stress, inflammation, and cellular demise. <b>Results:</b> Our findings demonstrated that, when compared to control groups, the IR group exhibited a significant elevation in key markers of oxidative stress (total oxidant status [TOS], Oxidative Stress Index [OSI]), inflammation (myeloperoxidase [MPO]), and cell death (TUNEL, Necrosis, Edema). Specifically, the IR group presented with a TOS of 8.72 ± 0.97 μmol/L, an OSI of 2.03 ± 0.18, and an MPO level of 75.93 ± 5.72 U/L, contrasting with control values of 4.23 ± 0.56 μmol/L, 1.01 ± 0.13, and 43.26 ± 5.7 U/L, respectively. Histopathological assessments corroborated these findings, revealing severe necrosis (2.50 ± 0.55), edema (2.00 ± 0.63), and notable inflammatory cell infiltration (2.67 ± 0.52) within the IR group. Furthermore, apoptosis (quantified by TUNEL assay) was significantly increased to 18.83 ± 1.47% in the IR group. Carnosine administration in the Carnosine + IR group led to a substantial reduction in all these adverse markers, bringing their levels closer to those observed in the control groups. For instance, in the Carnosine + IR group, TOS decreased to 5.63 ± 0.87 μmol/L, OSI to 1.24 ± 0.25, and MPO to 55.91 ± 3.45 U/L. Similarly, histopathological scores for necrosis, edema, and inflammatory cell infiltration were markedly lower in the Carnosine + IR group. <b>Conclusion:</b> Our experimental findings strongly suggest that exogenously administered carnosine significantly reduces oxidative stress, suppresses inflammation, and attenuates cell death in skeletal muscle subjected to IR injury. These results highlight carnosine's promising therapeutic potential as a pharmacological agent for mitigating tissue damage in ischemic conditions.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2025 ","pages":"2496873"},"PeriodicalIF":1.8,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time to Mortality and Predictive Factors Among Adult Heart Failure Patients: Lessons From a Resource-Limited Setting.","authors":"Elsah Tegene Asefa, Tamirat Godebo Woyimo, Hikma Fedlu Bame, Eyob Girma Abera","doi":"10.1155/crp/3968055","DOIUrl":"10.1155/crp/3968055","url":null,"abstract":"<p><p><b>Background:</b> Heart failure (HF) is a major cause of morbidity and mortality in low-resource settings like Ethiopia. This study aimed to assess time to mortality and identify key predictors among adult HF patients at Jimma Medical Center (JMC). <b>Methods:</b> A retrospective cohort study was conducted on 356 adult HF patients admitted to JMC between 2022 and 2023. Survival probabilities were estimated using the Kaplan-Meier method, and Cox proportional hazard regression was used to identify mortality predictors. <b>Results:</b> Among 356 HF patients, 15.7% (95% CI: 12.2%-19.8%) died during the study period. The median hospital stay was 11 days (IQR: 7-17), and the median age was 55 years (IQR: 38-65). Key predictors of higher mortality included hypertension (AHR: 4.6, 95% CI: 1.88-11.61, <i>p</i> < 0.001), pneumonia (AHR: 4.3, 95% CI: 1.15-15.78, <i>p</i> = 0.031), anemia (AHR: 3.3, 95% CI: 1.17-9.06, <i>p</i> = 0.023), acute myocardial infarction (AMI) (AHR: 4.4, 95% CI: 1.9-10.09, <i>p</i> < 0.001), and hyponatremia (AHR: 2.9, 95% CI: 1.44-5.99, <i>p</i> = 0.003). Each unit increase in systolic blood pressure (SBP) and diastolic blood pressure (DBP) was linked to a 7% and 4% lower mortality risk, respectively (<i>p</i> = 0.035). A higher pulse rate was associated with a 4% increased mortality risk. Patients with heart failure with reduced ejection fraction (HFrEF) had a six-fold higher mortality risk compared to those with preserved ejection fraction (HFpEF) (AHR: 6.1, 95% CI: 1.79-24.4, <i>p</i> = 0.008). <b>Conclusion:</b> This study identifies key mortality predictors for HF patients in a resource-limited setting, including hypertension, pneumonia, anemia, AMI, and hyponatremia. The findings emphasize the need for targeted interventions, improved management strategies, and policies to reduce HF mortality in low-resource environments. Further research is needed to refine these findings and enhance care for HF patients in such settings.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2025 ","pages":"3968055"},"PeriodicalIF":1.8,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12352995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing a Predictive Model for the Occurrence of CI-AKI After PCI in Patients With Coronary Heart Disease Based on Serum-Derived Biomarkers.","authors":"Qin-Yu Sun, Min-Jia Tang, Lin Shi, Yi-Fan Deng, Zhen Fang, Jun Ji, Sheng-Hu He, Jing Zhang","doi":"10.1155/crp/9997784","DOIUrl":"10.1155/crp/9997784","url":null,"abstract":"<p><p><b>Objective:</b> To identify risk factors for contrast-induced acute kidney injury (CI-AKI) post-PCI in coronary heart disease (CHD) patients, analyze novel inflammatory markers, and develop a predictive model. <b>Methods:</b> CHD patients admitted to Northern Jiangsu People's Hospital in Yangzhou, Jiangsu Province, China, from January 1, 2019, to December 31, 2022, were selected, and a total of 628 patients were included in this study by collecting the general information, past history, and relevant laboratory test results of all patients and excluding those with imperfect relevant medical records, including 142 cases in the CI-AKI group and 486 cases in the non-CI-AKI group. According to the ratio of 7:3, they were randomly divided into a training group (<i>n</i> = 439) and a validation group (<i>n</i> = 189). Independent risk factors for the occurrence of postoperative CI-AKI were screened by unifactorial and multifactorial logistic regression analyses in the training group, a clinical prediction model was established, and the prediction efficiency and applicability of the prediction model were analyzed by ROC curves, DCA curves, and H-L curves in the two groups. <b>Results:</b> Regression analysis suggested that neutrophil count, low-density lipoprotein, and PLR were independent risk factors for CI-AKI (<i>p</i> < 0.05); a model for predicting CI-AKI was established based on the above indexes, and the areas under the ROC curves of the model in the training and validation groups were 0.73 (0.67-0.78) and 0.71 (0.62-0.79), respectively; the H-L curve suggests that the predicted situation of the model is consistent with the actual occurrence, and the DCA curve suggests that patients in the training group and the validation group will have the greatest clinical benefit when the thresholds for the occurrence of postoperatively induced acute kidney injury are 0.26-0.82 and 0.30-0.97, respectively. <b>Conclusion:</b> This CI-AKI prediction model demonstrates good accuracy and clinical applicability, aiding early high-risk patient identification and intervention. <b>Trial Registration:</b> Chinese Registry of Clinical Trials: ChiCTR2500099751.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2025 ","pages":"9997784"},"PeriodicalIF":1.8,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Herceptin-Mediated Cardiotoxicity: Assessment by Cardiovascular Magnetic Resonance\".","authors":"","doi":"10.1155/crp/9818679","DOIUrl":"https://doi.org/10.1155/crp/9818679","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/2022/1910841.].</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2025 ","pages":"9818679"},"PeriodicalIF":1.8,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise-Based Cardiac Rehabilitation Improves Left Ventricular Dysfunction, Mitophagy, and Oxidative Stress Postmyocardial Infarction.","authors":"Changyong Wu, Haojie Li, Shuangfeng Zhao, Jiang Liu, Ruijie Li, Huang Sun, Suli Bao, Menghan Li, Yunzhu Peng","doi":"10.1155/crp/7778063","DOIUrl":"10.1155/crp/7778063","url":null,"abstract":"<p><p><b>Aim:</b> Left ventricular dysfunction, disturbed mitophagy, and persistent oxidative stress after myocardial infarction (MI) are critical drivers of myocardial injury and cardiac remodeling. Exercise-based cardiac rehabilitation (CR) is a cornerstone of post-MI treatment and management, yet its mechanistic effects on myocardial repair remain incompletely elucidated. This study aimed to the effect of exercise-based CR on the left ventricular dysfunction, mitophagy, and oxidative stress post-MI. <b>Methods:</b> Mendelian randomization analysis elucidated causal relationship between six physical activities and MI. Subsequently, 70 MI patients were randomized to control or exercise-based CR groups (moderate-to-vigorous physical activity intensity, 3 days/week, 10-50 min/day, 12 weeks); left ventricular function, cardiopulmonary function, and SF-36 quality of life scale were assessed pre-/postintervention using standardized protocols. Additionally, 21 rats were allocated to Sham, MI, or MI + treadmill running groups (high-intensity interval exercise training, 5 days/week, 30-50 min/day, 10-25 m/min, 4 weeks); left ventricular function, mitophagy, and oxidative stress were detected postintervention. <b>Results:</b> Genetically predicted moderate-to-vigorous intensity physical activity was significantly associated with lower risk of MI (IVW OR = 0.66, 95% CI: 0.54-0.81), with no causal links for other activities. Critically, clinical and animal studies demonstrated that exercise-based CR improved left ventricular systolic function (LVEF) after MI. Four-week exercise in MI rats enhanced mitophagy levels (LC3, FUNDC1, PINK1, and Parkin) and attenuated oxidative injury (MDA, GSH, SOD2, and GPX4) post-MI. Additionally, exercise-based CR also improved cardiopulmonary function (peak VO₂/kg, peakVO₂/pred%, and MET) in patients with MI and ameliorated mitochondrial damage in MI rats. However, GLS, secondary cardiopulmonary parameters (Wmax, HRR1min, peakVO₂/HR, and peakVO₂/HRpred%), and SF-36 (PCS and MCS) showed no significant changes, which may be associated with shorter duration of exercise intervention. <b>Conclusion:</b> Exercise-based CR significantly ameliorated left ventricular dysfunction, enhanced mitophagy levels, and attenuated oxidative stress post-MI, establishing its role in critical pathological mechanisms. Future studies should validate long-term sustainability of exercise-based CR and explore the interaction mechanism between mitophagy and oxidative stress in cardiac remodeling, providing personalized and precise exercise protocols for people at high risk of exercise.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2025 ","pages":"7778063"},"PeriodicalIF":1.8,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}