Cardiology Research and Practice最新文献

{"title":"Natural Progression of Rheumatic Aortic Valve Disease Following Mitral Valve Intervention: A 16-Year Single-Center Experience.","authors":"Seok Hyun Kim, Ji Hoon Lim, Sang Hyun Lee, Mi Hee Lim, Chee-Hoon Lee, Min Ho Ju, Hyung Gon Je, Yong Hyun Park","doi":"10.1155/crp/6689214","DOIUrl":"10.1155/crp/6689214","url":null,"abstract":"<p><p><b>Background:</b> Recognizing the natural progression of the remaining valve disease following the intervention of a single valve is crucial in multiple rheumatic valvular diseases as often encountered in clinical practice. We aimed to investigate whether performing mitral valve (MV) intervention alone for multiple rheumatic MV and aortic valve (AV) disease is safe. <b>Hypothesis:</b> Rheumatic AV disease progresses slowly and severity does not differ significantly after MV intervention. <b>Methods:</b> We retrospectively investigated the progression of AV disease with rheumatic changes following MV intervention in a single tertiary center. Among 890 patients initially screened, 76 patients met the criteria for assessment. <b>Results:</b> Six patients fell under severe aortic stenosis (AS) definition-wisely and four of them were classified as low-flow low-gradient severe AS despite normal ejection fraction. Eventually, four patients were found to have true-severe AS at a median follow-up period of four years (mean 5.8 years) and only one of them underwent AV surgery for severe AS per se. None of the patients with aortic regurgitation deteriorated to severe. <b>Conclusions:</b> Only a small portion of rheumatic AV involvement progresses to severe AS after MV intervention, and performing MV intervention for severe mitral stenosis or mitral regurgitation in patients with concurrent mild or moderate AS or aortic regurgitation due to rheumatic changes is reasonable.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2025 ","pages":"6689214"},"PeriodicalIF":1.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fractal Laws for Bifurcation Quantitative Coronary Angiography to Assess Left Main Bifurcation Lesions.","authors":"Mattia Lunardi, Nozomi Kotoku, Carlo Briguori, Luc Maillard, Adam Kern, Franck Digne, Jacek Legutko, Maciej Lesiak, Adam Witkowski, Thierry Lefèvre, Anderzej Ochala, Wojciecj Jachec, Corrado Tamburino, Marco Contarini, Gilles Rioufol, Antonio Colombo, Javier Escaned, William Wijns, Yoshinobu Onuma, Patrick W Serruys, Robert Gil","doi":"10.1155/crp/7176161","DOIUrl":"10.1155/crp/7176161","url":null,"abstract":"<p><p><b>Background:</b> Visual angiographic assessment of left main (LM) bifurcation lesions is fraught with major limitations. Bifurcation-dedicated quantitative coronary angiography (Bif-QCA) assessment provides higher accuracy than standard QCA in bifurcation lesions. Fractal laws (e.g., Finet's and Murray's laws) can enhance the accuracy of reference diameter calculation when applied to angiography-derived algorithms and may serve as a surrogate for pressure-based assessment. <b>Aims:</b> To investigate the correlation between Bif-QCA, Finet's law derived Bif-QCA (Finet-QCA) and pressure-wire functional assessment for LM bifurcation stenosis. <b>Methods:</b> Using instantaneous wave-free ratio (iFR) as a reference standard (≤ 0.89), we compared the value of Bif-QCA and Finet-QCA (diameter stenosis ≥ 50%). Moreover, the differences in MEDINA classification according to site-reported visual assessment <i>vs</i> Bif-QCA or Finet-QCA were investigated. <b>Results:</b> Eighty-four patients were included in the analysis, of which 72 (85.7%) presented an abnormal iFR. Bif-QCA derived %DS was moderately correlated with iFR values; however, implementing Finet's law in the correlation resulted weak. Site-reported MEDINA (visual assessment) resulted in significant higher rate of 1,1,1 and lower rate of 1,0,0 patterns compared to Bif-QCA MEDINA (9.5% vs. 1.2%, <i>p</i> < 0.001 and 33.3% vs. 46.4%, <i>p</i> < 0.001, respectively) and to Finet-QCA MEDINA (9.5% vs. 2.4%, <i>p</i> < 0.001 and 33.3% vs. 40%, <i>p</i> < 0.001, respectively). <b>Conclusions:</b> The present study suggested that LM MEDINA bifurcation pattern should be based on QCA analysis rather than visual assessment, both in the context of clinical practice and clinical studies. Compared to conventional Bif-QCA, the implementation of fractal laws (Finet-QCA) did not appear to improve the determination of the reference diameters of the LM shaft.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2025 ","pages":"7176161"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To Explore the Key Subgroup and Their Immune Microenvironment During the Formation of Coronary Plaque With scRNA-seq.","authors":"Xinhan Li, Qiulai Li, Haiying Liu, Ying Zhang, Jie Xia, Xin Wang, Tao Lei, Jun Ma","doi":"10.1155/crp/3221767","DOIUrl":"10.1155/crp/3221767","url":null,"abstract":"<p><p><b>Background:</b> The most important pathological basis of coronary heart disease is atheroma formation. If atheromatous plaque occurs and is not treated promptly and effectively, the plaque will gradually grow, causing the lumen of the coronary arteries to gradually narrow until it is completely occluded, causing angina pectoris and even myocardial infarction, but its cellular heterogeneity is not fully understood. <b>Methods:</b> We utilized various techniques including single-cell RNA sequencing, CytoTRACE, monocle, slingshot, CellChat, and SCENIC to investigate the significant subgroup of NK cells in 15 specimens from individuals in order to understand their contributions to the development of coronary plaque. <b>Results:</b> The analysis revealed that studying the subgroup C1 RACK1+ NK cells was crucial for this paper. We investigated its effect on coronary plaque and then analyzed C1 RACK1+ NK cells to explore the expression of this subgroup in pseudotime trajectories, cell interactions, and transcription factors. <b>Conclusion:</b> Single-cell RNA sequencing could provide a deeper understanding of the factors that have an important impact on the development of coronary plaque, improved the understanding of the microenvironment of coronary plaque, provided enlightenment for the treatment of coronary plaque in the future, and helped to improve the diagnosis of coronary plaque and design the best treatment strategy.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2025 ","pages":"3221767"},"PeriodicalIF":1.8,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Real-World Study on Pulmonary Arterial Hypertension in Bulgaria: A Single-Center Retrospective Study From 2012 to 2022.","authors":"Vasil Velchev, Arman Postadzhiyan, Sarkis Kalustian, Simona Markova, Mihaela Manolova, Damyan Boychev, Daniel Penchev, Martina Nacheva, Elina Petrova","doi":"10.1155/crp/5579064","DOIUrl":"10.1155/crp/5579064","url":null,"abstract":"<p><p><b>Purpose:</b> This study aimed to analyze the epidemiological, clinical, and therapeutic characteristics of patients with pulmonary arterial hypertension (PAH) treated at a major reference center in Bulgaria and to assess treatment patterns, patient compliance, and overall survival. <b>Principal Results:</b> The epidemiological data revealed that 69.5% of the patients were female, with a mean age of 52 years. The majority of patients were diagnosed at advanced stages of PAH, with 92.1% classified as World Health Organization Functional Class III. Monotherapy was the most common treatment regimen, used by 61.4% of patients, despite advanced disease. Patients who adhered to treatment demonstrated significantly longer overall survival (78.9 months) compared to those lost to follow-up (50.8 months). The study also identified a 31% rate of noncompliance, with patients missing follow-up visits and becoming ineligible for further therapy. <b>Major Conclusions:</b> The findings highlight the need for earlier diagnosis and more aggressive treatment strategies, as monotherapy appears insufficient for optimal outcomes in advanced PAH. Establishing a national PAH registry and increasing disease awareness could facilitate earlier interventions and improve patient outcomes in Bulgaria.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2025 ","pages":"5579064"},"PeriodicalIF":1.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Power of Head-Up Tilt Test Enhanced by Autonomic ECG Parameters and Beat-to-Beat Hemodynamic Monitoring.","authors":"Mathias Klemm, Antonia Kellnar, Dominik Naumann, Stefan Brunner, Christopher Stremmel","doi":"10.1155/crp/5239630","DOIUrl":"10.1155/crp/5239630","url":null,"abstract":"<p><p><b>Objectives:</b> The head-up tilt test (HUTT) is a well-established diagnostic procedure used to differentiate between the types of syncope. Since its introduction in 1986, the protocol has undergone several refinements aimed at increasing diagnostic accuracy. Despite growing interest in advanced autonomic ECG parameters and beat-to-beat blood pressure monitoring, their integration into routine HUTT protocols remains limited. <b>Methods:</b> In this study, we compared the conventional HUTT protocol using two-minute interval monitoring with an advanced protocol incorporating autonomic ECG parameters-periodic repolarization dynamics (PRD) and deceleration capacity (DC)-as well as continuous beat-to-beat hemodynamic monitoring. <b>Results:</b> The extended protocol improves diagnostic resolution by detecting more pronounced hemodynamic fluctuations, enabling real-time trend analysis, and allowing earlier recognition of impending syncope. The tilt phase was characterized by a significant initial increase in PRD, and patients with syncope showed significantly higher PRD values during the tilt phase (8.14 vs. 3.91 deg², <i>p</i>=0.043). <b>Conclusions:</b> Continuous hemodynamic monitoring during HUTT improves the diagnostic quality by detecting changes at an early stage, thus allowing to anticipate syncope and to clearly identify its etiology. While beat-to-beat blood pressure monitoring is already recommended by current syncope guidelines, we propose the additional evaluation of autonomic ECG parameters as a valuable extension to standard protocols.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2025 ","pages":"5239630"},"PeriodicalIF":1.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers Interfere With Wide Usage of NOAC for Prevention of Thromboembolic Events Among Doctors in Sudan: A Cross-Sectional Survey February 2023.","authors":"Elaf Sabri Khalil, Asmaa Elfatih Hussein Omer, Wadaha Mohamed Nouh Mohamed, Mustafa Sabir Abakar Awad","doi":"10.1155/crp/5028924","DOIUrl":"10.1155/crp/5028924","url":null,"abstract":"<p><p><b>Background:</b> Ischemic heart disease and stroke kill 25% of people worldwide. Vitamin K antagonist (warfarin) is the most widely used oral anticoagulant. Although affordable and effective, its usage is limited in many patients due to anticoagulation level variability and other factors, its alternatives include new nonvitamin K antagonist oral anticoagulants (NOACs). The study aims to investigate NOAC usage barriers. <b>Methods:</b> This is an observational, cross-sectional study, involved 144 doctors from different specialties and different medical degrees in Khartoum state, the data were collected by an author designed close-ended questionnaire. Data were entered, cleared and analyzed using Statistical Package for Social Sciences (SPSS) V25.0 software. <b>Results:</b> Medicine was most common (45.8%) among 144 medical department participants. The most prevalent medical degrees were registrars (25%) and doctors (25%). Specialists (22.9%), then house officers (15.3%). Over half (51.4%) had worked less than 5 years. 50% did not know about the 2021 DOACs guideline. 60.4% claimed DOACs' unavailability inhibits prescription. The lack of a multidisciplinary team approach hinders DOACs prescription, said 70.2%. <b>Conclusion:</b> Sudanese clinicians' hurdles to using NOAC for thromboembolic episodes were explored. Lack of a reversal agent and multidisciplinary team approach hinder DOAC prescription. Lack of information about international guidelines, since most participant's preferred specialized advice or personal experience, and high DOAC costs and inaccessibility and unavailability are other important barriers. Medical practitioners should update guidelines and government insurance plans should include DOACs. Each department should start studies separately.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2025 ","pages":"5028924"},"PeriodicalIF":1.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors and Prognostic Implications of New-Onset Atrial Fibrillation Following Transcatheter Aortic Valve Replacement.","authors":"Jianyao Shen, Qiyuan Xu, Xianbao Liu, Jian'an Wang","doi":"10.1155/crp/1138311","DOIUrl":"10.1155/crp/1138311","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Background:&lt;/b&gt; Transcatheter aortic valve replacement (TAVR) has become a standard treatment for severe aortic stenosis. New-onset atrial fibrillation (NOAF) is a common complication after TAVR, with significant implications for patient outcomes. This study aimed to identify the risk factors for NOAF and assess its impact on long-term prognosis following TAVR. &lt;b&gt;Methods:&lt;/b&gt; This retrospective single-center study included 601 patients who underwent TAVR between 2013 and 2021 at the Second Affiliated Hospital of Zhejiang University School of Medicine. Patients were categorized into two groups: those who maintained sinus rhythm before and after TAVR (SR/SR) and those who developed NOAF after TAVR (SR/AF). Univariate logistic regression analysis was first performed to identify potential risk factors for NOAF, with variables showing a &lt;i&gt;p&lt;/i&gt; value &lt; 0.1 included in the multivariate logistic regression model. Multivariate analysis was then conducted to identify independent risk factors for NOAF. The impact of NOAF on clinical outcomes, including all-cause mortality, cardiovascular death, hospital readmissions, stroke, and other major adverse cardiac events (MACE), was evaluated using logistic regression models adjusted for potential confounders such as age, sex, comorbidities, and procedural factors. &lt;b&gt;Results:&lt;/b&gt; Of the 601 patients, 56 (9.3%) developed NOAF. Univariate analysis identified hypercholesterolemia, diabetes mellitus, severe tricuspid regurgitation, hydropericardium, and new-onset right bundle branch block (RBBB) as potential risk factors for NOAF (&lt;i&gt;p&lt;/i&gt; &lt; 0.1). Multivariate analysis confirmed new-onset RBBB (OR 3.45, 95% CI 1.72-6.93, &lt;i&gt;p&lt;/i&gt; &lt; 0.001), diabetes mellitus (OR 2.36, 95% CI 1.25-4.47, &lt;i&gt;p&lt;/i&gt;=0.008), hydropericardium (OR 2.74, 95% CI 1.38-5.45, &lt;i&gt;p&lt;/i&gt;=0.004), and severe tricuspid regurgitation (OR 3.52, 95% CI 1.57-7.93, &lt;i&gt;p&lt;/i&gt;=0.002) as independent risk factors for NOAF. Patients in the SR/AF group had significantly higher rates of heart failure, stroke, and mortality during follow-up compared to the SR/SR group. NOAF was also associated with increased hospital readmissions at 3 and 5 years post-TAVR (adjusted OR: 1.89, 95% CI: 1.12-3.18, &lt;i&gt;p&lt;/i&gt;=0.017; and adjusted OR: 1.95, 95% CI: 1.15-3.31, &lt;i&gt;p&lt;/i&gt;=0.013, respectively). However, there were no significant differences in all-cause mortality, cardiovascular death, stroke, or other MACE between the SR/AF and SR/SR groups at 1, 3, and 5 years. &lt;b&gt;Conclusions:&lt;/b&gt; NOAF is a common complication after TAVR and is associated with several independent risk factors, including new-onset RBBB, diabetes mellitus, hydropericardium, and severe tricuspid regurgitation. While NOAF did not significantly increase mortality in this cohort, it was associated with higher rates of hospital readmissions and recurrent cardiovascular events, highlighting the need for close monitoring and proactive management of NOAF in TAVR patients. These findings underscore the importan","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2025 ","pages":"1138311"},"PeriodicalIF":1.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Risk Estimation in Colombia Using Artificial Intelligence Techniques.","authors":"Jared Agudelo, Oscar Bedoya, Oscar Muñoz-Velandia, Kevin David Rodriguez Belalcazar, Alvaro Ruiz-Morales","doi":"10.1155/crp/2566839","DOIUrl":"10.1155/crp/2566839","url":null,"abstract":"<p><p><b>Introduction:</b> There is no information on the potential of machine learning (ML)-based techniques to improve cardiovascular risk estimation in the Colombian population. This article presents innovative models using five artificial intelligence techniques: neural networks, decision trees, support vector machines, random forests, and Gaussian Bayesian networks. <b>Methods:</b> The research is based on a cohort of 847 patients free of cardiovascular disease at baseline and followed for cardiovascular disease events over 10 years at the Central Military Hospital in Bogotá, Colombia. To enhance the robustness and reduce the risk of overfitting, model evaluation was conducted using a 5-fold cross-validation on the entire dataset. Discriminatory ability was evaluated with the area under a ROC curve (AUC-ROC) for each ML-based model and the Framingham model. <b>Results:</b> Experimental results showed that the neural network technique had the best discriminative ability to predict cardiovascular events, with an AUC-ROC of 0.69 (CI 95% 0.622-0.759) for unbalanced data and 0.67 (CI 95% 0.601-0.754) for balanced data. Other ML techniques also showed good discriminatory ability with AUC-ROC values between 0.56 and 0.65, superior to that observed for the Framingham model (0.53; CI 95% 0.468-0.607). <b>Conclusion:</b> Our study supports the flexible ML approaches to cardiovascular risk prediction as a way forward for cardiovascular risk assessment in Colombia. Our data even suggest that risk prediction using these techniques could be even more discriminative than widely used risk-stimulation models such as Framingham, adapted to the Colombian population. However, new prospective studies need to validate our data before general implementation.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2025 ","pages":"2566839"},"PeriodicalIF":1.8,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12086036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MO Oxygen Therapy Prevents Doxorubicin-Induced Cardiotoxicity.","authors":"Lingjun Zhang, Yanmin Liu","doi":"10.1155/crp/2729462","DOIUrl":"https://doi.org/10.1155/crp/2729462","url":null,"abstract":"<p><p><b>Background:</b> Micro-oxygen therapy can reduce the effects of doxorubicin (DOX) on left ventricular function, cardiac fibrosis, inflammation, and oxidative stress in SD rats. These results suggest the potential of DOX for clinical use. <b>Method:</b> 8-week-old SPF-grade SD male rats were randomly divided into four groups: control group (Ctrl) (<i>n</i> = 10), doxorubicin group (DOX) (<i>n</i> = 10), doxorubicin + conventional oxygen intervention group (DOX+CO) (<i>n</i> = 10), doxorubicin + micropressed oxygen group (DOX+MO)) (<i>n</i> = 10). Left ventricular function was assessed by echocardiography 3 weeks after the end of treatment, and histopathological analysis was conducted utilizing Masson and hematoxylin-eosin (HE) staining. The mRNA expression levels of TGF-β1 and Collagen I were quantified by quantitative real-time PCR (qRT-PCR). Additionally, inflammatory markers, including the concentrations of IL-1β, IL-6, and TNF-α, as well as the activities of SOD and GSH-Px, were measured using enzyme-linked immunosorbent assay (ELISA). <b>Results:</b> The DOX + MO group significantly improved the symptoms of heart failure caused by DOX. The specific results are as follows: The EF significantly increased to 78.037 ± 1.283 (63.259 ± 8.855 in the DOX, <i>p</i> ≤ 0.0001); the IVSs increased from 0.243 ± 0.036 to 0.324 ± 0.038 (<i>p</i> ≤ 0.001); the LVPWs increased from 0.263 ± 0.028 to 0.323 ± 0.036 (<i>p</i> ≤ 0.01); the IVSd and the LVPWd increased from 0.171 ± 0.019 to 0.2 ± 0.015 (<i>p</i> ≤ 0.05) and from 0.181 ± 0.032 to 0.234 ± 0.026 (<i>p</i> ≤ 0.01). Among cardiac function indexes, NT-proBNP in DOX + MO group was significantly different from that in DOX group (<i>p</i> ≤ 0.0001). Compared with DOX group, the degree of myocardial fibrosis in DOX + MO group was decreased, and qRT-PCR showed that MO oxygen effectively reduced the mRNA expression of TGF-β1 and collagen1 induced by DOX. In terms of inflammatory indicators, TNF-α (<i>p</i> ≤ 0.0001), IL-1β (<i>p</i> ≤ 0.0001), and IL-6 (<i>p</i> ≤ 0.0001) in DOX + MO group were significantly lower than those in DOX group. In terms of oxidative stress, serum levels of SOD and GSH-PX were decreased in the DOX group, and MO oxygen therapy effectively prevented the reduction of these indexes. On the other hand, the experimental results also showed that DOX + MO group was significantly better than DOX + CO group in terms of cardiac function, inflammation, and oxidative stress. <b>Conclusion:</b> Microbaric oxygen therapy can reduce the effects of DOX on left ventricular function, cardiac fibrosis, inflammation, and oxidative stress in SD rats. These results provide support for clinical studies to evaluate the potential of DOX in clinical applications.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2025 ","pages":"2729462"},"PeriodicalIF":1.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Hospital Stay After Acute Ischemic Stroke in Hospitalized Patients: Retrospective-Cohort Study.","authors":"Zenaw Debasu Addisu, Teshale Ayele Mega","doi":"10.1155/crp/7598035","DOIUrl":"10.1155/crp/7598035","url":null,"abstract":"<p><p><b>Background:</b> The length of hospital stay (LOS) is frequently recognized as an indicator of hospital management efficiency and the quality of care. Patients with acute ischemic stroke (AIS) who experience prolonged LOS are at a higher risk of developing complications such as hospital-acquired infections and gastrointestinal bleeding. These complications can adversely affect clinical outcomes, acting as a primary determinant of poor functional outcomes. However, evidence regarding predictors of the LOS after AIS in Ethiopia is lacking. <b>Objective:</b> Therefore, the objective of this study was to assess clinical predictors of the LOS after AIS among patients admitted to Tibebe Ghion and Felege Hiwot Comprehensive Specialized Hospitals. <b>Methods:</b> A retrospective cohort study was conducted among patients diagnosed with AIS and treated at Tibebe Ghion and Felege Hiwot hospitals from November 2018 to November 2021. Multivariate linear regression analysis was employed to explore predictors of LOS. The slope of regression line (<i>β</i>) with its 95% CI is used to declare statistical significance. <b>Results:</b> Of the 278 patients with AIS, 59.7% were male. Stroke-related complications (aspiration pneumonia and urinary tract infections occurred in the hospital in 57 (20.5%), and 12 (4.3%), patients, respectively. The most common neurological deficit observed during hospital admission was limb weakness, affecting 268 patients (96%). The median LOS was 5 days. Among the clinical characteristics, atrial fibrillation (<i>β</i> = 7.337, 95% CI: 1.226, 13.448), Limp weakness (<i>β</i> = 4.831, 95% CI: 2.330, 7.332), aspiration pneumonia (<i>β</i> = 2.089, 95%CI: 1.178, 3.000) and Male sex (<i>β</i> = 1.696, 95% CI: 0.851, 2.542), were significant predictors of LOS. <b>Conclusion:</b> In this study, the presence of AF and stroke-related complications, such as aspirational pneumonia, were found to be significant predictors of LOS. Therefore, implementing efficient prevention strategies targeting potentially modifiable risk factors is essential to mitigate the impact of these factors.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2025 ","pages":"7598035"},"PeriodicalIF":1.8,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}