Cardiology Research and Practice最新文献

{"title":"Nutraceuticals for Preventing and Managing Cancer Chemotherapy-Induced Cardiotoxicity: An Updated Comprehensive Review.","authors":"Seyedeh-Tarlan Mirzohreh, Samad Ghaffari, Naimeh Mesri Alamdari, Erfan Banisefid, Melika Ghaffari, Arvin Namazi Shabestari, Armin Imanzadeh Ghazijahani, Neda Roshanravan, Faezeh Tarighat","doi":"10.1155/crp/5771319","DOIUrl":"10.1155/crp/5771319","url":null,"abstract":"<p><p>Chemotherapy-induced cardiotoxicity remains a major barrier to durable cancer control and survivor well-being, arising from oxidative stress, mitochondrial injury, inflammation, and emerging pyroptotic pathways. This updated narrative review integrates mechanistic and clinical data on nutraceuticals, including amino acids, fatty acids, vitamins, minerals, and polyphenols. Consistent clinical signals include omega-3 fatty acids, alpha-lipoic acid, vitamin D, coenzyme Q10, black seed oil, and vitamin E with levocarnitine, which primarily reduce oxidative stress to protect against cardiotoxicity. Additional preclinical and early clinical work highlights vitamin C-, taurine-, zingerone-, and rosemary-derived phenolics as candidates that target oxidative and inflammatory injury without compromising antitumor activity. Translation to care should be prevention-focused, pairing baseline risk assessment with surveillance that utilizes high-sensitivity troponin, natriuretic peptides, and advanced echocardiography, such as global longitudinal strain. Nutraceuticals should complement rather than replace established oncologic therapy and cardioprotection, with integration guided by individual risk and ongoing monitoring.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"5771319"},"PeriodicalIF":2.1,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13478796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocarditis in the Modern Era: Navigating Diagnosis, Innovative Treatments, the COVID-19 Challenge and the Role of Artificial Intelligence.","authors":"Kevin Mohee, Ibrahim Antoun, Robert Ambrogetti, Mahmoud Eldesouky, Riyaz Somani, André Ng, Sanjay S Bhandari","doi":"10.1155/crp/5956965","DOIUrl":"10.1155/crp/5956965","url":null,"abstract":"<p><p>Myocarditis is an inflammatory disease of the myocardium with diverse aetiologies, ranging from infections and autoimmune processes to drug-induced reactions. Clinical manifestations vary widely from mild chest discomfort to life-threatening complications such as acute heart failure, cardiogenic shock and sudden cardiac death. Although the diagnosis of myocarditis historically relied heavily on invasive biopsy, recent advances in noninvasive imaging modalities, notably cardiac magnetic resonance (CMR) imaging, have transformed clinical practice. The Lake Louise Criteria (LLC), supplemented by parametric imaging techniques, have significantly enhanced diagnostic accuracy. Furthermore, the emergence of COVID-19 has renewed interest in myocarditis due to its association with viral-induced myocardial injury. This review synthesises the current understanding of myocarditis, including epidemiological insights, its diverse aetiologies, diagnostic innovations including the importance of viral load quantification and contemporary management strategies.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"5956965"},"PeriodicalIF":2.1,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13454957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Coronary Artery Diseases Among Adult Women Residents of Tehran: A Cross-Sectional Report From Tehran Cohort Study (TeCS).","authors":"Amirhossein Heidari, Nazila Heidari, Arash Jalali, Yekta Ghane, Zahra Lotfi, Akbar Shafiee, Farshid Alaeddini, Hamidreza Raeisi-Dehkordi, Saeed Sadeghian, Mohammadali Boroumand, Abbasali Karimi, Oscar H Franco","doi":"10.1155/crp/1614045","DOIUrl":"10.1155/crp/1614045","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery disease (CAD) is the leading cause of death worldwide. Among women, CAD is often underestimated, resulting in underdiagnosis and undertreatment. This study aimed to assess the prevalence of CAD and its risk factors in adult women, using data from the Tehran Cohort Study (TeCS).</p><p><strong>Methods: </strong>We analyzed data from 4478 women with complete CAD information collected during the TeCS recruitment phase. The age-weighted prevalence of CAD was estimated using the 2016 national census data and previous CAD diagnoses. Logistic regression models were applied to identify factors independently associated with CAD in women.</p><p><strong>Results: </strong>The overall prevalence of CAD was 4.48% (mean age: 53.0 ± 12.37 years), with an age-weighted prevalence of 4.1% (95% CI: 3.1%-5.4%). Increasing age was strongly associated with CAD, with women aged ≥ 75 years showing markedly higher odds (OR: 11.94, 95% CI: 3.93-36.31, <i>p</i> < 0.001). Hypertension (OR: 2.58, 95% CI: 1.75-3.80, <i>p</i> < 0.001), hyperlipidemia (OR: 2.25, 95% CI: 1.55-3.24, <i>p</i> < 0.001), and diabetes mellitus (OR: 2.07, 95% CI: 1.49-2.88, <i>p</i> < 0.001) were also significant determinants of CAD. Older age groups exhibited a higher prevalence of CAD risk factors. Within the CAD group, a greater proportion of women had multiple comorbid risk factors compared with their non-CAD counterparts in the same age categories.</p><p><strong>Conclusion: </strong>The prevalence of CAD and its associated risk factors among women in Tehran is substantial. These findings highlight the need for targeted preventive strategies to reduce CAD incidence in vulnerable female populations.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"1614045"},"PeriodicalIF":2.1,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13448153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148688466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Central Role of Echocardiography in Mavacamten Therapy for Obstructive Hypertrophic Cardiomyopathy: A Comprehensive Review.","authors":"Ali Nizam, Ibrahim Antoun, Liz Hodson, G André Ng, Harshil Dhutia","doi":"10.1155/crp/8857701","DOIUrl":"10.1155/crp/8857701","url":null,"abstract":"<p><p>Mavacamten is a cardiac myosin inhibitor used in adults with symptomatic obstructive hypertrophic cardiomyopathy (HCM). Echocardiography is central to selecting suitable patients, confirming left ventricular outflow tract (LVOT) obstruction, excluding inappropriate use when left ventricular ejection fraction (LVEF) is < 55% and guiding dose titration during treatment. This narrative review summarises the practical echocardiographic approach to mavacamten therapy, with emphasis on reproducible LVOT gradient assessment, goal-directed Valsalva manoeuvres, LVEF monitoring, mitral valve and systolic anterior motion assessment, mitral regurgitation, diastolic function and left atrial size. Current regulatory monitoring requires echocardiographic assessment during early titration and permits 6-monthly maintenance surveillance only in stable patients meeting defined criteria, including LVEF ≥ 55% and Valsalva LVOT gradient < 30 mmHg, or a decision not to uptitrate. The review also discusses unresolved issues, including exercise echocardiography, global longitudinal strain, atrial fibrillation, reverse remodelling, implementation variability and the broader emergence of cardiac myosin inhibitors such as aficamten. Standardised acquisition and reporting are essential to ensure that treatment decisions reflect true physiological response rather than technical variability.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"8857701"},"PeriodicalIF":2.1,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13448511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148688459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epicardial Fat Tissue Volume Within 1 mm of the Left Atrium Combined With Left Atrial Appendage Volume is Associated With Thrombus in Nonvalvular Atrial Fibrillation: A CCTA-Based Risk Stratification Model.","authors":"Enyuan Zhang, Xiaoyan Wu, Fengmin Lu, Yitong Yin, Shuo Liang, Le He, Henan Zhang, Dongyan Wu, Jing Xu, Qingliang Chen, Wei Ma","doi":"10.1155/crp/4276622","DOIUrl":"10.1155/crp/4276622","url":null,"abstract":"<p><strong>Background: </strong>Accurate prediction of left atrial appendage thrombus (LAAT) is critical for stroke prevention in patients with nonvalvular atrial fibrillation (AF). We investigated the incremental value of epicardial fat tissue (EFT) metrics derived from cardiac computed tomography angiography (CCTA) beyond conventional risk factors.</p><p><strong>Methods: </strong>In this retrospective study of 287 AF patients prior to ablation, CCTA was used to measure left atrial appendage volume (LAAV) and EFT volume within 1 mm of the left atrium (EFT1). Multivariate logistic regression analysis identified predictors of LAAT or prethrombotic state (thrombus/spontaneous echo contrast), which were incorporated into a nomogram. Model performance was evaluated using the area under the curve (AUC), calibration plots, and decision curve analysis.</p><p><strong>Results: </strong>The thrombus group exhibited significantly larger LAAV (15.07 ± 2.7 mL vs. 11.94 ± 2.55 mL, <i>p</i> < 0.001) and EFT1 volume (6.39 ± 1.38 mL vs. 5.36 ± 1.47 mL, <i>p</i> < 0.001) compared to the normal/SEC group. Multivariate analysis identified EFT1 (odds ratio [OR] = 1.57 per mL), LAAV (OR = 1.56 per mL), and the CHA₂DS₂-VA score (OR = 1.34 per point) as independent predictors. The resulting nomogram demonstrated excellent discrimination for LAAT (AUC = 0.851) and for thrombus/SEC (AUC = 0.819), with good calibration and clinical utility.</p><p><strong>Conclusion: </strong>EFT1, the EFT volume immediately adjacent to the left atrium, is strongly associated with LAAT. The novel nomogram integrating EFT1, LAAV, and the CHA₂DS₂-VA score provides enhanced risk stratification for thrombotic and prethrombotic states in patients with AF.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"4276622"},"PeriodicalIF":2.1,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13438171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Honokiol Inhibits Arsenic Trioxide-Induced Cardiomyopathy by Modulating Ferroptosis via SIRT3 Signaling Pathway.","authors":"Qing-Qing Wei, An-Liang Huang, Ning-Yi Liu, Yi-Ran Zhang, Fan Yang","doi":"10.1155/crp/8878178","DOIUrl":"10.1155/crp/8878178","url":null,"abstract":"<p><p>Ferroptosis has recently been identified as a critical mechanism underlying arsenic trioxide (ATO)-induced cardiotoxicity. This study aimed to determine whether Honokiol (HKL) protects against ATO-induced cardiac injury by inhibiting ferroptosis and to investigate the role of the SIRT3 signaling pathway in this process. Using 129S1/SvImJ wild-type (WT) and SIRT3-knockout (SIRT3^-/-) mice, we demonstrated that HKL attenuates ATO-induced myocardial injury and hypertrophy in a SIRT3-dependent manner. Mechanistically, HKL reduced oxidative stress through the SIRT3/SOD2 pathway, as evidenced by decreased mitochondrial ROS production and SOD2 acetylation, along with preserved mitochondrial ATP generation capacity. Furthermore, HKL inhibited ferroptosis, indicated by reduced iron content, MDA levels, and 4-HNE expression, along with restored GPX4 and GSH levels. Notably, HKL restored autophagic flux impaired by ATO, and this effect was associated with its antiferroptotic and cardioprotective actions. Pharmacological or genetic inhibition of SIRT3 or autophagic flux abolished the protective effects of HKL. Autophagic flux is closely associated with the protective effect of Honokiol on ATO-induced ferroptosis. These findings reveal that HKL protects against ATO-induced cardiomyopathy by restoring autophagic flux and inhibiting ferroptosis via the SIRT3 signaling pathway.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"8878178"},"PeriodicalIF":2.1,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13430285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148668430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing the Achieve Catheter in Different Branches of Pulmonary Vein as a Routine Approach During Cryoballoon Ablation of Atrial Fibrillation.","authors":"Mingyu Sun, Zhen Jin, Ming Liang, Zulu Wang, Zhiqing Jin","doi":"10.1155/crp/7868137","DOIUrl":"10.1155/crp/7868137","url":null,"abstract":"<p><strong>Background: </strong>Cryoballoon ablation (CBA) for pulmonary vein isolation (PVI) has demonstrated high procedural success rate and promising clinical outcome. How to expand the antrum ablation area and get better results is a challenging topic for patients with paroxysmal and persistent AF.</p><p><strong>Methods and results: </strong>We enrolled 709 patients with nonvalvular AF who underwent initial PVI with a second-generation CB between January 2020 and August 2022, including 293 CBA applications in different branches of each PV and 416 in the same branch of each PV. The orientation difference in the transverse plane was negatively correlated with the ostium-bifurcation distance. In the different-branch CBA group, after the first application in one branch, PV potentials could still be recorded in the other branch in 39 of the 293 patients (13.3%) and the PV foci could trigger AF in 7 of them. In a consecutive 30 patients by using 3D mapping system, the total antral surface lesions after the application in a second branch were larger than those after the first application (<i>p</i> < 0.001). The fluoroscopy time increased in the different-branch CBA group. The recurrence rate of atrial arrhythmia was statistically lower in the different-branch CBA group compared with that in the same-branch CBA group (<i>p</i> = 0.034) at a 2-year follow-up.</p><p><strong>Conclusion: </strong>CBA applications performed in different branches of each PV could create wide isolated antral surface areas and eliminate PV foci adequately. CBA in different branches of PVs with long ostium-bifurcation distances had less significance. The recurrence rate of atrial arrhythmia was statistically lower in the different-branch CBA group compared with that in the same-branch CBA group.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"7868137"},"PeriodicalIF":2.1,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13420312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation and the Heart: The Role of Traditional Factors.","authors":"Mostafa Cheraghi, Arash Amin, Solmaz Jabarzare, Toomaj Sabooteh, Parisa Moradi, Mostafa Dehghani, Mehrnoosh Sedighi, Fatemeh Hatami, Ali Rafieian, Tara Farshidfar","doi":"10.1155/crp/4623305","DOIUrl":"10.1155/crp/4623305","url":null,"abstract":"<p><p>About 50% of cardiac patients do not have typical cardiac risk factors. Therefore, it is important to search for additional factors that may be responsible for heart disease. If these factors are identified, the test could help predict high-risk cardiovascular patients. The studies about the etiology of coronary artery disease have led to the discovery of novel biomarkers. Recently, accumulating evidence has highlighted the critical role of both systemic and localized inflammatory markers accompanied by atherosclerosis and cardiac conditions. Particularly, higher levels of inflammatory biomarkers like CRP can lead to cardiovascular diseases. This article presents an analysis of the causes of heart disease, atherosclerosis, endothelial dysfunction, and plaque rupture, with a special focus on the role of inflammation as a contributing factor. Additionally, the article examines ways to reduce the inflammation associated with cardiovascular disease.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"4623305"},"PeriodicalIF":2.1,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13416769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbohydrate Antigen 125 as a Marker of Decongestion and Early Outcomes in Acute Decompensated Heart Failure: Insights From a Tertiary Hospital in Western Kenya.","authors":"Rebeccah Ayoti Abutika, Felix Ayub Barasa, David Lagat, Gideon Titus Ng'eno, Gerald S Bloomfield","doi":"10.1155/crp/7099401","DOIUrl":"10.1155/crp/7099401","url":null,"abstract":"<p><strong>Background: </strong>Acute decompensated heart failure (ADHF) is a major cause of morbidity and mortality, with congestion being the primary reason for hospitalization. Despite treatment, many patients are discharged with residual congestion, hence the growing interest in utilizing biomarkers as objective tools to guide decongestion therapy. Carbohydrate Antigen 125 (CA125) has emerged as a promising biomarker of systemic congestion, with potential advantages over routine markers. This study evaluated the relationship between CA125 changes and clinical congestion score (CCS) at discharge and assessed its association with 30-day outcomes.</p><p><strong>Methods: </strong>This was a prospective cohort study conducted over seven months at Moi Teaching and Referral Hospital, a tertiary hospital in Western Kenya. Patients with ADHF were enrolled. CA125 levels were measured at admission and discharge using an automated immunoassay. In addition, other markers of congestion, i.e., CCS, NT-proBNP levels, body weight, and inferior vena cava (IVC) diameter, were assessed at both admission and discharge. The 30-day outcomes, which included all-cause mortality and heart failure (HF) rehospitalizations, were recorded. Statistical analyses included correlation and generalized linear models.</p><p><strong>Results: </strong>A total of 213 patients were included, with an in-hospital mortality rate of 23.5%. There was a significant correlation between changes in CA125 levels and improvements in CCS at discharge (<i>p</i> = 0.018). Patients with in-hospital CA125 reductions had lower rates of the composite 30-day outcome (all-cause mortality or HF rehospitalization) at 15%, compared to 40% in those with rising CA125 levels.</p><p><strong>Conclusion: </strong>A reduction in CA125 levels during hospitalization is associated with better clinical decongestion and improved short-term outcomes.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"7099401"},"PeriodicalIF":2.1,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13401266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148590498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Short-Term Blood Pressure Variability on All-Cause Mortality in Patients With Acute Myocardial Infarction.","authors":"Ying Liu, Sijia Jiang, Wen Li, Shuoyan An, Wuqiang Che, Min Wang, Jingang Zheng, Gailing Chen","doi":"10.1155/crp/7788121","DOIUrl":"10.1155/crp/7788121","url":null,"abstract":"<p><strong>Background: </strong>Blood pressure variability (BPV) is recognized as an independent risk factor for cardiovascular morbidity and mortality. However, findings regarding the association between the coefficient of variation (CV) of 24-h blood pressure and mortality in patients with acute myocardial infarction (AMI) remain inconsistent. The aim of this study was to examine the association between 24-h CV and the risk of in-hospital, 30-day, 1-year, and 3-year mortality in AMI patients.</p><p><strong>Methods: </strong>This retrospective cohort study included AMI patients who were admitted to the intensive care unit (ICU) from the MIMIC-IV 2.0 database. The CV was calculated from blood pressure measurements taken during the first 24 h. Patients were divided into three groups according to tertiles of 24-h blood pressure CV. The relationship between 24-h CV and the risk of all-cause mortality in AMI patients was analyzed using logistic regression, Cox proportional hazards regression, and Kaplan-Meier survival analyses.</p><p><strong>Results: </strong>A total of 1291 eligible AMI patients were included. Compared with Q1 (lowest CV), Q3 (highest 24-h systolic blood pressure [SBP]-CV) was significantly associated with an increased risk of in-hospital (odds ratio [OR]: 3.333, 95% confidence interval [CI]: 1.725-6.439), 30-day (hazard ratio [HR]: 1.868, 95% CI: 1.201-2.904), and 1-year (HR: 1.420, 95% CI: 1.058-1.907) mortality. Both Q2 and Q3 of 24-h diastolic blood pressure (DBP)-CV were significantly associated with an increased risk of in-hospital, 30-day, 1-year, and 3-year mortality. Kaplan-Meier survival curves demonstrated that patients in Q3 had significantly lower 30-day, 1-year, and 3-year survival probabilities than those in other tertiles for both SBP and DBP.</p><p><strong>Conclusions: </strong>Our findings suggest that 24-h SBP-CV and DBP-CV are significantly associated with both short- and long-term outcomes in AMI patients. BPV may serve as a prognostic marker for all-cause mortality in AMI patients.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"7788121"},"PeriodicalIF":2.1,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13396695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148583507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}