Hemoglobin-to-Red Cell Distribution Width Ratio as a Predictor of Gastrointestinal Bleeding Following Percutaneous Coronary Intervention.

Abstract

Background: Many patients with coronary heart disease receive percutaneous coronary interventions. These interventions are accompanied by gastrointestinal bleeding that aggravates the disease. The hemoglobin-to-red cell distribution width ratio (HRR) is a novel inflammatory marker. We investigated HRR as a predictor of gastrointestinal bleeding after percutaneous coronary interventions. Methods: Patients (n = 1647) received percutaneous coronary interventions from January 2022 to December 2022 in Longyan First Hospital. The HRR was measured before the interventions. Indicators of patient general condition, biochemical indicators, concomitant diseases, and medication status were collected. Gastrointestinal bleeding within 1 year was assessed. Patients were divided into four groups based on HRR. Kendall's tau-b graded correlation was used to analyze the correlation between hemoglobin (Hb), red blood cell distribution width (RDW), HRR, and gastrointestinal bleeding in peripheral blood after percutaneous coronary intervention. Ordered logistic regression was used for analysis, with gastrointestinal bleeding as the outcome variable and Hb, RDW, and HRR as independent variables. To identify independent risk factors for gastrointestinal bleeding, data were adjusted for age, heart failure, hypertension, diabetes, atrial fibrillation, dyslipidemia, RBC, total cholesterol, triglycerides, LDL-C, creatinine, blood urea nitrogen, and uric acid. Multiple linear regression analysis of HRR, RDW, and Hb predicted gastrointestinal bleeding. Results: Of the 1647 study participants, 20 had gastrointestinal bleeding, 1.2% probability. In the HRR classification, there was a greater probability of gastrointestinal bleeding in the low HRR group after percutaneous coronary intervention. Conclusion: We found a low HRR and a high probability of gastrointestinal bleeding after percutaneous coronary intervention. The HRR could be used as an independent predictor of gastrointestinal bleeding.