Cardiology Research and Practice最新文献

{"title":"The Correlation Between Triglyceride-Glucose Index (TyG Index) With the Severity of Acute New-Onset Heart Failure (NOHF) Complications in Acute Myocardial Infarction Based on Killip Classification.","authors":"Levina Felicia, Nida Suraya, Ratu Purwanti","doi":"10.1155/crp/6997679","DOIUrl":"10.1155/crp/6997679","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease is the leading cause of morbidity and mortality in Indonesia, in which acute myocardial infarction (AMI) has an estimated mortality rate of 9.2%. Heart failure is the most common complication of AMI and increases the risk of death by 3-4 times. The Killip classification assesses the severity and prognosis of acute new-onset heart failure (NOHF) in AMI patients: Class I (6% mortality), Class II (17%), Class III (38%), and Class IV (81%). The triglyceride-glucose (TyG) index, a reliable marker for insulin resistance, is linked to cardiovascular disease pathogenesis. Several studies showed that the TyG index can predict the development of cardiovascular events.</p><p><strong>Aim: </strong>This study aims to determine the correlation between TyG index levels and the severity of acute NOHF complications in patients with acute myocardial infarction based on the Killip classification.</p><p><strong>Methods: </strong>This cross-sectional analytical observational study involved adult patients with AMI diagnoses in the ER of Dr. Hasan Sadikin Hospital, Bandung, in January-December 2023, who had fasting blood glucose and triglyceride examinations within 72 h of admission and had been assessed with Killip classification. Data analysis was performed using the Spearman test using SPSS software version 25.0.</p><p><strong>Results: </strong>This study included 100 AMI patients who met the inclusion and exclusion criteria. Significant relationships were found between comorbidities (diabetes mellitus, hypertension, and smoking) and patient outcomes against Killip classification. Killip Class I had the most improved outcomes (54 patients). Killip Class IV (10 patients) had the most deaths and highest triglycerides and glucose levels. The TyG index showed a strong positive correlation with acute NOHF severity in patients with AMI based on the Killip classification (<i>r</i> = 0.746, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>The TyG index has a strong positive correlation with the severity of acute NOHF in patients with acute myocardial infarction based on the Killip classification.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"6997679"},"PeriodicalIF":2.1,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13051901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between Early Arterial Lactate Levels, Arterial Bicarbonate Ion Levels, and the Lactate/Albumin Ratio and In-Hospital Mortality in Patients With Acute Myocardial Infarction Complicated With Cardiac Shock.","authors":"Jiao Wang, Meijuan Zheng, Yuchun Yang, Zhen Bao, Muhuyati Wulasihan","doi":"10.1155/crp/9995508","DOIUrl":"10.1155/crp/9995508","url":null,"abstract":"<p><strong>Background: </strong>To investigate the connection between early arterial lactate, arterial bicarbonate ion, lactate/albumin ratio (L/A) and in-hospital mortality in patients with acute myocardial infarction complicated with cardiac shock (AMICS).</p><p><strong>Methods: </strong>A receiver operating characteristic (ROC) curve was drawn to analyze the predictive value of these indicators for in-hospital mortality in 395 patients with AMICS. A Kaplan‒Meier survival curve was drawn to analyze the median survival time of each subgroup. A Cox fitted proportional risk model was used to verify the association between these indicators and all-cause mortality during hospitalization.</p><p><strong>Results: </strong>ROC curve analysis revealed that the areas under the curve for arterial bicarbonate ion level, arterial lactate level, and L/A were 0.707, 0.679, and 0.670, respectively, indicating that these parameters have certain value for predicting in-hospital mortality in patients with AMICS. The Kaplan‒Meier survival curve revealed that the median survival time of the low bicarbonate ion group was shorter than that of the high bicarbonate ion group, and the median survival time of the low lactic acid group and low L/A group was longer than that of the high lactic acid group and the high L/A group. The Cox proportional risk model indicated that higher arterial bicarbonate ion levels were a protective factor for in-hospital death in AMICS patients and that higher arterial lactate levels and a higher L/A were independent risk factors.</p><p><strong>Conclusion: </strong>Early arterial bicarbonate ion levels, arterial lactate levels, and the L/A were predictive of all-cause death in AMICS patients.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"9995508"},"PeriodicalIF":2.1,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13051906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Effects of Compound Dendrobium Candidum and Antihypertensive Medications on Refractory Hypertension in Spontaneously Hypertensive Rats.","authors":"Xiaoyu Chen, Cheng Tong, Jie Wang, Yue Wu, Tuo Feng, Jing Wang, Zedong Gong, Yingzhi Chen, Shiyong Chen, Xiaoming Jin, Sisi Chen, Zhongxiu Guo, Xuan Chen, Zeming Ren, Guanhai Dai, Yeling Tong, Xiyu Mei, Renzhao Wu, Xiaomin Xue","doi":"10.1155/crp/5582480","DOIUrl":"10.1155/crp/5582480","url":null,"abstract":"<p><strong>Background: </strong>Compound dendrobium candidum (CDC) is formulated from <i>Dendrobium candidum</i> and fragrant peony. Preliminary studies have demonstrated that the combination of CDC with conventional antihypertensive medications exhibits significant synergistic effects in lowering blood pressure. The objective of this study was to evaluate the synergistic effect of combining CDC with antihypertensive medications on refractory hypertension in spontaneously hypertensive rats (SHRs) and to elucidate the underlying mechanisms involved.</p><p><strong>Methods: </strong>SHRs were treated with either CDC alone or CDC combined with two or three antihypertensive agents including irbesartan, amlodipine, or terazosin, for a duration of 6 weeks. The alterations in blood pressure, angiotensin II (Ang II), insulin, blood sugar, angiotensin II type I receptor (AT₁R), angiotensin II type II receptor (AT₂R), insulin receptor, insulin <i>α</i> receptor, and insulin β receptor levels were assessed. Glomerular endothelial cells from refractory SHR were then taken for overexpression and knockdown of AT₂R gene and co-cultured with CDC serum to measure the expression levels of Ang II receptor gene and protein.</p><p><strong>Results: </strong>In comparison to the findings observed in the irbesartan + amlodipine + terazosin (IAT) group, the addition of CDC significantly enhanced antihypertensive efficacy. The rate of achieving blood pressure targets (< 150 mmHg) in SHRs with refractory hypertension increased from 0% to 100%. Treatment with CDC significantly reduced the compensatory increase in AT₁R and AT₂R levels caused by IAT treatment and showed a significant antihypertensive and synergistic effect. Primary glomerular endothelial cells extracted from SHRs and Wistar rats and treated with 0.5% CDC-containing serum showed significantly reduced AT₂R levels in the AT₂R-overexpression condition. The combination of CDC and antihypertensive drugs was effective in reducing the messenger RNA (mRNA) and protein expression levels of AT₁R and AT₂R in glomerular endothelial cells.</p><p><strong>Conclusions: </strong>CDC in combination with antihypertensive drugs showed a synergistic effect in controlling refractory hypertension. The mechanism of action may be related to the attenuation of excessive expression of AT₂R. This study offers a novel approach for the treatment of clinically resistant hypertension.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"5582480"},"PeriodicalIF":2.1,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"A Meta-Analysis of Randomized Controlled Trials (RCTs) Investigating the Efficacy and Safety of Acupuncture in Treating Myocardial Ischemia/Reperfusion (I/R) Injury\".","authors":"","doi":"10.1155/crp/9872431","DOIUrl":"https://doi.org/10.1155/crp/9872431","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/crp/9970541.].</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"9872431"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12950621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"MO Oxygen Therapy Prevents Doxorubicin-Induced Cardiotoxicity\".","authors":"","doi":"10.1155/crp/9874050","DOIUrl":"10.1155/crp/9874050","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/crp/2729462.].</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"9874050"},"PeriodicalIF":2.1,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12906694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146206642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of Peak Glycemia and No-Reflow Phenomenon in Patients Undergoing Primary Percutaneous Coronary Intervention.","authors":"Golrokh Ghaffari, Maryam Mehrpooya, Mohsen Faghihinia, Elnaz Shahmohamadi, Farnoosh Larti, Babak Geraiely","doi":"10.1155/crp/9919861","DOIUrl":"10.1155/crp/9919861","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates the effect of peak glycemia on the no-reflow phenomenon in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) to examine the relationship between elevated blood glucose (BG) levels and no-reflow.</p><p><strong>Method: </strong>A total of 252 STEMI patients (81.7% male) who underwent PPCI were enrolled. BG was measured by a glucometer every 6 h for 24 h, starting at the time of patient admission. The maximum measured BG was considered the peak glycemic level. A corrected TIMI frame count (CTFC) of less than 27 was used to define the no-reflow phenomenon in this study.</p><p><strong>Results: </strong>42.4% of participants experienced no flow, with a significant association between this condition and diabetes mellitus, peak glycemia, smoking history, and elevated LDL cholesterol levels. Specifically, peak glycemia levels above 180 mg/dL independently increased the odds of no-reflow occurrence (OR = 8.16, 95% CI = 4.1-16.2, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>The importance of monitoring BG levels in STEMI patients, as well as the critical role of a multidisciplinary approach, regardless of diabetic status, in mitigating the risk of no-reflow and improving clinical outcomes, should be highlighted.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"9919861"},"PeriodicalIF":2.1,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12905458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146200317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Gut-Heart Axis: A Comprehensive Review of Microbiota's Role in Cardiovascular Health and Disease and Emerging Therapeutic Strategies.","authors":"Maneeth Mylavarapu, Angad Tiwari, Harshaman Kaur, Roopeessh Vempati, Harendra Kumar, Lakshmi Sai Meghana Kodali, Kiyan Ghani Khan, Sriharsha Dadana, Israel Garcia, Fabio Enrique Parada Cabrera, Amninder Singh, Sai Lakhan Kyasa, Vikramjit S Purewal","doi":"10.1155/crp/9920016","DOIUrl":"10.1155/crp/9920016","url":null,"abstract":"<p><p>This review examines the bidirectional relationship between the gut microbiota and cardiovascular diseases (CVDs), aiming to understand how microbial dysbiosis contributes to CVDs, including atherosclerosis, hypertension, and heart failure. Recent research emphasizes the gut microbiota's role in modulating immunity via SCFAs and tryptophan metabolites, maintaining intestinal barrier integrity, and producing metabolites such as SCFAs (acetate, propionate, butyrate) and pro-atherogenic TMAO. Dietary patterns, particularly the Mediterranean versus Western diet, significantly influence gut microbiota composition and CVD risk. Polyphenols and exercise have shown positive effects on gut microbiota and cardiovascular outcomes. A significant interplay exists between gut microbiota and cardiovascular health. Dysbiosis and metabolites like TMAO and LPS are implicated in CVD, while SCFAs and a balanced microbiota offer protection. Future research should focus on precision medicine, next-gen probiotics, optimized FMT, and multiomics approaches to identify personalized CVD therapies.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"9920016"},"PeriodicalIF":2.1,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12886191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Dapagliflozin on Novel Inflammatory Markers in Heart Failure Patients.","authors":"Oktay Senoz, Mustafa Sezen","doi":"10.1155/crp/5537675","DOIUrl":"10.1155/crp/5537675","url":null,"abstract":"<p><strong>Background: </strong>Sodium-glucose cotransporter-2 (SGLT-2) inhibitors have been established to decrease hospitalizations and cardiac death within all heart failure groups. The exact mechanisms by which the oral antidiabetic medication dapagliflozin achieves this advantage are still unknown. The potential beneficial effects of dapagliflozin on inflammation and the immune system may contribute to these mechanisms.</p><p><strong>Method: </strong>The laboratory and echocardiographic data of 191 consecutive patients who were started on dapagliflozin due to heart failure were compared before and 6 months after the treatment began. The systemic immune-inflammation index (SII) and the systemic inflammation response index (SIRI) were calculated using the following formulae: (platelet × neutrophil)/lymphocyte and (neutrophil × monocyte)/lymphocyte, respectively.</p><p><strong>Results: </strong>The mean age of the patients included in the study was 66.17 ± 10.7 years. A total of 156 patients (81.7%) had diabetes mellitus. Seventy patients (36.6%) had heart failure with reduced ejection fraction (HFrEF), 31 (16.2%) had heart failure with mildly reduced ejection fraction (HFmrEF), and 90 (47.1%) had heart failure with preserved ejection fraction (HFpEF). While no significant change was observed in echocardiographic parameters with dapagliflozin treatment (<i>p</i> > 0.05), a significant decrease was detected in the SII and SIRI (1357.4 ± 1404.3 vs. 805.8 ± 586.7, <i>p</i> < 0.001 and 3.68 ± 3.6 vs. 2.19 ± 1.7, <i>p</i> < 0.001). In these indices, a consistently significant decrease was observed in all groups, irrespective of the type of heart failure and the presence of diabetes mellitus (<i>p</i> < 0.005).</p><p><strong>Conclusion: </strong>With dapagliflozin treatment, the most recent inflammation parameters, SII and SIRI, have significantly decreased. This effect may be one reason for the cardiovascular benefits of dapagliflozin treatment.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"5537675"},"PeriodicalIF":2.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12868381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Inflammatory Markers and Coronary Heart Disease in Different Gender Groups in Cohort NHANES 2003-2018.","authors":"Anmin Ren, Qianjun Liu, Qian Gan, Liming Lu, Xin Kai Qu","doi":"10.1155/crp/5555602","DOIUrl":"10.1155/crp/5555602","url":null,"abstract":"<p><strong>Background: </strong>Although previous studies have revealed the correlation between inflammatory markers and coronary heart disease (CHD), this study aims to explore the relationship between inflammatory markers and CHD in the male and female population, respectively.</p><p><strong>Methods: </strong>This study includes participants from the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2018. Inflammatory markers included the following: systemic immune-inflammation index (SII), lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR). Multivariate logistic regression was performed to investigate the correlation between these inflammatory markers and CHD. The trend test was employed to examine potential linear trend associations, and the restricted cubic splines (RCSs) were utilized to depict nonlinear relationships.</p><p><strong>Results: </strong>The NHANES database including 40,177 participants was stratified into two cohorts: the CHD group (<i>n</i> = 1667) and the non-CHD group (<i>n</i> = 38,510). With further gender stratification, we found that LMR, PLR, and SII all exhibited negatively significant correlation with CHD in the male group, while LMR and NLR were meaningful factors in the female group. We also detected that LMR, PLR, and SII all have nonlinear relationship with CHD in the male group (<i>p</i> for nonlinear < 0.05), while PLR had nonlinear relationship with CHD in the female group (<i>p</i> for nonlinear < 0.05).</p><p><strong>Conclusions: </strong>Our study revealed that LMR, PLR, and SII are significantly negative correlative markers of CHD in males, while LMR and NLR are more accurate predictors of CHD in females.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"5555602"},"PeriodicalIF":2.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12865318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arrhythmogenic Mechanisms of Novel Biomarkers in Cardiac Electrophysiology.","authors":"Jin Liu, Huijie Guo, Yanmin Liu, Jinchun Wu","doi":"10.1155/crp/2453934","DOIUrl":"10.1155/crp/2453934","url":null,"abstract":"<p><p>Arrhythmia is an important cause of cardiovascular disease deaths and a serious threat to human health, but the current means of identification are limited. Biomarkers, with the advantages of easy access and rapid detection, have shown significant value in arrhythmia risk prediction, precision diagnosis, and prognosis assessment. In recent years, with the development of molecular biology and multiomics technology, some novel biomarkers have made great breakthroughs in revealing the pathological mechanisms of arrhythmia. However, clinical translation still faces challenges such as a lack of standardization of assays and insufficient clinical prospective validation. This review comprehensively searched studies published between 2010 and 2025 in PubMed, Web of Science, Embase, and CENTRAL databases, focusing on the mechanisms underlying the role of arrhythmia biomarkers in inflammation, fibrosis, autoimmunity, and electrical remodeling and clinical translation potential. Future research should focus on the combined application of multiple biomarkers and the discovery of subtype-specific markers. Conducting large-scale, multicenter studies to validate these biomarkers and ultimately integrate them into clinical practice is crucial for advancing biomarker-guided individualized antiarrhythmic therapy.</p>","PeriodicalId":9494,"journal":{"name":"Cardiology Research and Practice","volume":"2026 ","pages":"2453934"},"PeriodicalIF":2.1,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12860222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146103732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}