Cancer Management and Research最新文献

{"title":"Distinct Lung Adenocarcinoma-Associated Microbiota Are Associated with Inflammatory Immune Landscapes and Tumor Cell Proliferation via LCIIAR-ISG15 Regulatory Networks.","authors":"Shipu Liu, Zijian Zhang","doi":"10.2147/CMAR.S520098","DOIUrl":"10.2147/CMAR.S520098","url":null,"abstract":"<p><strong>Introduction: </strong>Emerging research emphasizes the critical role of local microbiota in shaping the tumor microenvironment (TME) and influencing cancer progression. Lung adenocarcinoma (LUAD) is distinguished by unique bacterial communities that appear to regulate immune responses, gene expression, and patient outcomes.</p><p><strong>Methods: </strong>We compiled microbiome profiles from several cancer types-including LUAD, lung squamous cell carcinoma (LUSC), breast carcinoma (BRCA), and thyroid carcinoma (THCA)-using public databases. Non-negative matrix factorization (NMF) was employed to categorize LUAD cases based on TME features, while DESeq2 was used to pinpoint bacterial taxa with differing abundance. Multi-omics networks were developed to integrate microbial, transcriptomic, and clinical data. For in vitro verification, we conducted siRNA-mediated knockdown of the long non-coding RNA LCIIAR and ISG15 in Lewis lung carcinoma cells, followed by proliferation assays.</p><p><strong>Results: </strong>In contrast to LUSC, BRCA, and THCA, LUAD exhibited distinct microbial populations, with notable enrichment of Cylindrospermopsis, Cyanothece, and Sulfolobus. NMF clustering identified two LUAD subtypes with differing prognoses. One longer survival cluster, marked by reduced bacterial presence and stronger antitumor immunity-reflected in stronger immune response, increased effector T cells activity, and greater immune cell infiltration. A competing endogenous RNA (ceRNA) network analysis established a link between LCIIAR and ISG15, both overexpressed in LUAD and associated with worse survival outcomes. Knockdown LCIIAR or ISG15 through siRNA significantly inhibited lung cancer cell proliferation, pointing to their roles in tumor growth and ceRNA-mediated regulation.</p><p><strong>Conclusion: </strong>LUAD features a distinctive microbiota that engages with inflammatory and ceRNA regulatory pathways. These observations underscore the value of targeting microbiome-influenced mechanisms, such as the LCIIAR-ISG15 axis, as a promising approach to enhance treatment outcomes in lung adenocarcinoma.</p>","PeriodicalId":9479,"journal":{"name":"Cancer Management and Research","volume":"17 ","pages":"1315-1328"},"PeriodicalIF":2.5,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12238177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Analysis of the Timing of Radiotherapy Intervention After Induction Chemoimmunotherapy in Unresectable Locally Advanced Lung Squamous Cell Carcinoma.","authors":"Li Zeng, Yu Zhang, Aiju Zeng, Daiyuan Ma","doi":"10.2147/CMAR.S517837","DOIUrl":"10.2147/CMAR.S517837","url":null,"abstract":"<p><strong>Background: </strong>The optimal combination of immune checkpoint inhibitors (ICIs), radiotherapy, and chemotherapy for unresectable locally advanced lung squamous cell carcinoma (LA-LUSC) remains undefined. This study evaluated induction chemoimmunotherapy followed by radiotherapy ± consolidation ICI in unresectable LA-LUSC, specifically exploring radiotherapy timing impact.</p><p><strong>Methods: </strong>We retrospectively analyzed 54 unresectable LA-LUSC patients receiving induction chemoimmunotherapy followed by radiotherapy. Patients were grouped by radiotherapy timing: Early (after 2-3 induction cycles, n = 18) and Late (after 4-6 cycles, n = 36). Survival analysis (Kaplan-Meier, Log-rank) compared progression-free survival (PFS), local PFS (LPFS), distant metastasis-free survival (DMFS), overall survival (OS), and safety. Prognostic factors for PFS/OS were explored.</p><p><strong>Results: </strong>Median follow-up was 30.7 months. Median PFS for all patients was 21.9 months. Early radiotherapy improved PFS (HR = 0.43, p = 0.024) and LPFS (HR = 0.36, p = 0.038). Radiotherapy after 2-3 induction cycles was an independent predictor of improved PFS (p = 0.040). Overall treatment tolerance was good; grade ≥3 pneumonitis incidence was 5.56%. After propensity score matching, OS was significantly longer in patients receiving induction plus consolidation ICI versus induction ICI alone (HR = 0.51, p = 0.038).</p><p><strong>Conclusion: </strong>Induction chemoimmunotherapy followed by radiotherapy demonstrates promising efficacy and manageable toxicity in unresectable LA-LUSC. Initiating radiotherapy earlier (after 2-3 induction cycles) improves PFS and LPFS and is an independent favorable prognostic factor. Consolidation ICI after combined chemoimmunotherapy and radiotherapy further extends OS compared to induction ICI alone.</p>","PeriodicalId":9479,"journal":{"name":"Cancer Management and Research","volume":"17 ","pages":"1301-1311"},"PeriodicalIF":2.5,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated Traditional Chinese and Western Medicine in Lung Adenocarcinoma with Rare EGFR Mutation and Nephrotic Syndrome: A Case Report.","authors":"Lirong Zhang, Liye Cai, Luwei Ruan, Jie Li","doi":"10.2147/CMAR.S526571","DOIUrl":"10.2147/CMAR.S526571","url":null,"abstract":"<p><p>This case report presents a 67-year-old male diagnosed with stage IV lung adenocarcinoma harboring rare EGFR exon 18/20 mutations (Gly719Cys/Ser768Ile) and a concurrent TP53 mutation, complicated by nephrotic syndrome. The scarcity of approved EGFR-TKIs targeting rare EGFR mutations in NSCLC, coupled with nephrotic syndrome-induced renal impairment, hypoalbuminemia, and massive pleural effusion refractory to conventional management, prompted the development of a personalized multimodal approach.A multimodal therapeutic regimen incorporating albumin-bound paclitaxel, intrathoracic perfusion of Endostar (recombinant human endostatin), and traditional Chinese medicine (TCM) was implemented, achieving effective disease control. Notably, the treatment resulted in significant tumor shrinkage (reduction rate: 48.1% by RECIST 1.1), complete resolution of malignant pleural effusion, and marked improvement in nephrotic syndrome parameters. The synergistic effects of targeted chemotherapy, anti-angiogenic therapy, and TCM-based symptom modulation highlight the potential of integrative approaches in managing advanced malignancies with complex molecular profiles and multisystem complications.</p>","PeriodicalId":9479,"journal":{"name":"Cancer Management and Research","volume":"17 ","pages":"1293-1299"},"PeriodicalIF":2.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Social Determinants on Quality of Life in Socioeconomically Disadvantaged Cancer Survivors: A Mixed-Methods Study.","authors":"Mohammed Almutairi, Ashwaq A Almutairi, Abdulaziz M Alodhialah","doi":"10.2147/CMAR.S515781","DOIUrl":"10.2147/CMAR.S515781","url":null,"abstract":"<p><strong>Background: </strong>Socioeconomic disparities significantly impact cancer survivorship, influencing quality of life (QoL) outcomes. This study investigates the role of social determinants of health (SDH) in shaping QoL among socioeconomically disadvantaged cancer survivors in Riyadh City, Saudi Arabia.</p><p><strong>Methods: </strong>A mixed-methods design was employed, combining quantitative and qualitative approaches. The quantitative component included 200 participants who completed validated SDH and WHOQOL-BREF questionnaires. Pearson's correlation and multiple regression analyses were conducted to explore relationships between SDH domains and QoL outcomes. The qualitative component involved in-depth interviews with 20 purposively selected participants. Thematic analysis was performed to capture survivors' experiences and perceptions.</p><p><strong>Results: </strong>Quantitative findings revealed significant negative correlations between financial instability and QoL domains, particularly physical health (r = -0.45, p < 0.001). Multiple regression analysis identified financial instability (β = -0.50, p < 0.001) and lack of social support (β = -0.28, p < 0.05) as key predictors of reduced QoL. Qualitative findings highlighted three major themes: financial and structural barriers, psychological impacts, and coping mechanisms. Participants reported significant challenges related to healthcare access, fear of recurrence, and social isolation, while emphasizing the importance of family and community support.</p><p><strong>Conclusion: </strong>SDH significantly influence QoL among socioeconomically disadvantaged cancer survivors. Addressing financial, structural, and social barriers through equity-driven and culturally sensitive interventions is essential to improving survivorship outcomes.</p>","PeriodicalId":9479,"journal":{"name":"Cancer Management and Research","volume":"17 ","pages":"1271-1292"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latent Profile Analysis of Emotional Expression Conflicts and Associated Influencing Factors in Breast Cancer Patients Receiving Postoperative Chemotherapy.","authors":"Zhaoxia Tian, Ruishan Sheng, Yutong Zhang, Hongmei Li","doi":"10.2147/CMAR.S509857","DOIUrl":"10.2147/CMAR.S509857","url":null,"abstract":"<p><strong>Purpose: </strong>Emotional expression conflicts, characterized by approach-avoidance dilemmas in self-disclosure, are prevalent among breast cancer patients undergoing postoperative chemotherapy. This study identifies emotional expression conflict subtypes and their predictors to inform targeted interventions.</p><p><strong>Methods: </strong>This cross-sectional study employed convenience sampling to recruit 238 postoperative breast cancer patients. The assessment protocol comprised three validated instruments: the Ambivalence over Emotional Expressiveness Questionnaire-G28 for emotional conflict evaluation, the Cognitive Fusion Questionnaire for cognitive assessment, and the Family Resilience Assessment Scale for family dynamics measurement. Latent profile analysis was conducted to characterize distinct emotional expression conflict subtypes, with subsequent multivariate logistic regression modeling to identify significant predictors.</p><p><strong>Results: </strong>Three distinct emotional expression conflict profiles emerged: (a) Low conflict-emotion expression (33.6%): Proactive emotional sharing with minimal ambivalence. (b) Medium conflict-emotion expression (42.4%): Context-dependent disclosure with moderate ambivalence. (c) High conflict-expression blocked (23.9%): Suppression-dominated behavior with severe ambivalence. Younger age, lower education, reduced income, poor sleep quality, and higher cognitive fusion significantly increased the likelihood of high emotional conflict. Conversely, stronger family resilience was associated with reduced conflict risk.</p><p><strong>Conclusion: </strong>This study highlights the clinical significance of heterogeneity in emotional expression conflicts among breast cancer patients. By targeting modifiable factors (such as sleep quality, cognitive fusion), oncology nursing may advance personalized psychosocial support to address these conflicts. Such strategies demonstrate global applicability for effectively alleviating patient distress and enhancing patient-centered care outcomes.</p>","PeriodicalId":9479,"journal":{"name":"Cancer Management and Research","volume":"17 ","pages":"1259-1269"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Scalp Cooling: (Ultra)Structural Follicular Characteristic and Restorative Advances.","authors":"Doerthe Schaffrin-Nabe, Anke Josten-Nabe, Adrian Heinze, Andrea Tannapfel, Merle Schaffrin, Rudolf Voigtmann","doi":"10.2147/CMAR.S526775","DOIUrl":"10.2147/CMAR.S526775","url":null,"abstract":"<p><strong>Background: </strong>Scalp cooling has emerged as a promising intervention for mitigating chemotherapy-induced alopecia, particularly in patients undergoing anthracycline- and taxane-based regimens typically associated with complete hair loss. Despite a visible hair retention rate of 53%, efficacy varies significantly among individuals, influenced by modifiable factors including general health, hair follicle characteristics, and treatment protocols.</p><p><strong>Methods: </strong>This study evaluated 81 breast cancer patients treated with Epirubicin/Cyclophosphamide followed by weekly Paclitaxel application. Hair preservation was assessed using a cross-section trichometer (Cohen Hair Mass Index [HMI]), light microscopy, and scanning electron microscopy. Key parameters evaluated included pre- and posttherapeutic trichological characteristics such as bulb diameter, shaft diameter, anagen rate, as well as grade of hair shaft damage.</p><p><strong>Results: </strong>A total of 53% of patients retained visible hair post-treatment (HMI ≥ 50). Trichological factors-particularly bulb diameter, shaft diameter, and anagen rate-strongly predicted hair preservation outcomes. Additionally, hair shaft integrity, specifically surface damage grading, emerged as a critical determinant of clinically meaningful hair retention.</p><p><strong>Conclusion: </strong>Scalp cooling's protective effect extends beyond aesthetics, significantly supporting psychological well-being during cancer treatment. Emerging strategies, including cell cycle modulation, antioxidant-based treatments, offer promising avenues to enhance follicular and shaft resilience. While these require further clinical validation, the findings highlight the potential to improve scalp cooling outcomes and raise the standard of supportive oncologic care.</p>","PeriodicalId":9479,"journal":{"name":"Cancer Management and Research","volume":"17 ","pages":"1245-1257"},"PeriodicalIF":2.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Associations Between Postoperative Symptom Clusters and Functional Status in Lung Cancer Patients: A Cross-Sectional Study [Corrigendum].","authors":"","doi":"10.2147/CMAR.S549121","DOIUrl":"https://doi.org/10.2147/CMAR.S549121","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.2147/CMAR.S507420.].</p>","PeriodicalId":9479,"journal":{"name":"Cancer Management and Research","volume":"17 ","pages":"1243-1244"},"PeriodicalIF":2.5,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological Features and Prognostic Factors of Renal Cell Carcinoma in Young Patients Under 45 Years: A Single-Center Retrospective Study.","authors":"Yu Gao, Haisheng Yan, Tao Zhang, Guanjun Lu, Lianghong Ma","doi":"10.2147/CMAR.S526583","DOIUrl":"10.2147/CMAR.S526583","url":null,"abstract":"<p><strong>Objective: </strong>To explore the clinicopathological characteristics, diagnostic approaches, and therapeutic strategies for renal cell carcinoma (RCC) in young patients under 45 years of age, aiming to provide insights for early detection and improved prognosis.</p><p><strong>Methods: </strong>We retrospectively analyzed the clinical data of 150 RCC patients aged 18 to 45 years treated at the General Hospital of Ningxia Medical University from 2011 to 2023. Clinicopathological features, surgical outcomes, and long-term follow-up data were evaluated.</p><p><strong>Results: </strong>The study included 82 males and 68 females, with a mean age of 38.89 ± 5.56 years. Clear cell RCC was the most common subtype (72.6%), followed by chromophobe RCC (12%) and papillary RCC (4%). Other rare subtypes included XP11.2 translocation/TFE3 gene fusion - associated RCC (2.7%) and collecting duct RCC (0.7%). In terms of clinical staging, 89% of patients were classified as T1 stage. Follow - up data, ranging from 12 to 153 months, showed that 11 patients died of the disease and 14 exhibited metastasis. Postoperative glomerular filtration rate (GFR) and serum creatinine (CREA)) levels were lower than preoperative levels, and patients who underwent radical nephrectomy (RN) had worse renal function than those who underwent partial nephrectomy (PN). The 3 - year and 5 - year survival rates for the asymptomatic group were 100% and 97%, respectively, while for the symptomatic group, they were 94% and 83%, respectively. Single - factor Cox regression analysis revealed that symptoms, hypertension, clinical stage, pathological grade, and pathological type were independent risk factors for overall survival in young renal cancer patients.</p><p><strong>Conclusion: </strong>Young RCC patients present with unique clinicopathological characteristics and prognostic factors. Although the overall prognosis is relatively favorable, rare subtypes such as XP11.2 translocation/TFE3 gene fusion - associated RCC and collecting duct RCC are associated with worse outcomes. Early detection through regular physical examinations and prompt treatment are crucial for improving outcomes. PN should be prioritized when feasible, and effective management of comorbidities like hypertension is essential.</p>","PeriodicalId":9479,"journal":{"name":"Cancer Management and Research","volume":"17 ","pages":"1233-1242"},"PeriodicalIF":2.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary Analysis of PSA and BCR-Free Survival in Asian Prostate Cancer Patients.","authors":"Xin Gao, Yijun Fu, Zimei Mo, Yongtong Ruan","doi":"10.2147/CMAR.S527092","DOIUrl":"10.2147/CMAR.S527092","url":null,"abstract":"<p><strong>Background: </strong>Prostate cancer remains a significant global health burden, with biochemical recurrence (BCR) affecting 20-50% of patients post-radical prostatectomy. This study aimed to investigate the relationship between preoperative PSA levels and BCR-free survival in Asian populations.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of 3,092 prostate cancer patients who underwent radical prostatectomy at Yonsei University College of Medicine, Korea (1992-2014). The exposure variable was preoperative PSA level, and the primary outcome was BCR-free survival. Covariates included age, Gleason score, pathological stage, surgical margins, and other clinical factors. Patients were followed quarterly for two years post-surgery, semi-annually for three years, then annually thereafter (median follow-up: 66 months).</p><p><strong>Results: </strong>Using piecewise linear regression, we identified a significant threshold effect at PSA 5.1 ng/mL. Above this threshold, each unit increase in LnPSA was associated with a 6.10-month reduction in BCR-free survival (95% CI: -7.64 to -4.56, P<0.0001). Higher PSA levels correlated with increased adverse pathological features and shorter BCR-free survival across all risk groups.</p><p><strong>Conclusion: </strong>This study establishes a critical PSA threshold of 5.1 ng/mL for BCR risk stratification in Asian populations. Above this threshold, each unit increase in LnPSA correlates with a 6.10-month reduction in BCR-free survival, providing valuable guidance for post-operative monitoring and personalized treatment strategies.</p>","PeriodicalId":9479,"journal":{"name":"Cancer Management and Research","volume":"17 ","pages":"1205-1214"},"PeriodicalIF":2.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Intravenous Fish Oil Lipid Emulsion on Short-Term Postoperative Outcomes in Rectal Cancer Patients Following Neoadjuvant Therapy: A Propensity Score-Matched Study.","authors":"Liping Yang, Feng Pi, Zhengqiang Wei, Xudong Peng","doi":"10.2147/CMAR.S529363","DOIUrl":"10.2147/CMAR.S529363","url":null,"abstract":"<p><strong>Purpose: </strong>Previous studies lack a consensus on the role of fish oil lipid emulsion in postoperative complications and recovery in rectal cancer patients post-neoadjuvant therapy. This study aimed to evaluate the impact of intravenous fish oil lipid emulsion on short-term clinical outcomes in these patients.</p><p><strong>Patients and methods: </strong>This retrospective study included patients who underwent radical surgery for RC after NT between November 2018 and April 2022. Patients were divided into two groups: the fish oil group (receiving fish oil treatment) and the control group (not receiving fish oil treatment). Propensity Score Matching was used to analyze and compare postoperative complications and other relevant clinical indicators between the two groups. A total of 208 patients were included, with 33 patients in each group after PSM.</p><p><strong>Results: </strong>The results showed no significant differences between the two groups in terms of time to first flatus, time to first defecation, or time to first liquid diet intake (p > 0.05). However, compared to the control group, the fish oil group had significantly lower rates of postoperative complications, shorter hospital stays, and earlier tolerance to solid food (p < 0.05). Additionally, the fish oil group effectively suppressed the decline in postoperative albumin levels (p < 0.05).</p><p><strong>Conclusion: </strong>These findings suggest that perioperative intravenous supplementation of fish oil may effectively reduce postoperative complications, accelerate recovery, and improve postoperative nutritional status in rectal cancer patients post-neoadjuvant therapy.</p>","PeriodicalId":9479,"journal":{"name":"Cancer Management and Research","volume":"17 ","pages":"1195-1203"},"PeriodicalIF":2.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}