Cancer Management and Research最新文献

{"title":"Integrating Machine Learning Algorithms to Construct a Triaptosis-Related Prognostic Model in Melanoma.","authors":"Jiaheng Xie, Min Zhang, Min Qi","doi":"10.2147/CMAR.S525738","DOIUrl":"10.2147/CMAR.S525738","url":null,"abstract":"<p><strong>Introduction: </strong>Melanoma is a highly aggressive skin cancer that accounts for a disproportionate number of skin cancer-related deaths due to early metastasis and therapy resistance. Programmed cell death (PCD), including ferroptosis and apoptosis, plays a crucial role in tumor progression and therapy response. Among these, triaptosis is a newly described form of PCD. It represents a novel mechanism of cell death with potential implications for cancer treatment. However, its role in melanoma remains largely unexplored.</p><p><strong>Methods: </strong>We explored the role of triaptosis in melanoma by integrating single-cell and bulk RNA sequencing data. Key triaptosis-related genes and pathways were identified and incorporated into machine learning models to construct a prognostic signature. The TCGA-SKCM cohort served as the training dataset, and GEO datasets were used for validation.</p><p><strong>Results: </strong>A robust prognostic model based on triaptosis-associated signature (TAS) was established using the SurvivalSVM algorithm. This model showed superior predictive performance, with consistently high concordance index (C-index) values across independent validation datasets. Kaplan-Meier survival analysis indicated that high-risk patients had significantly worse overall survival than low-risk patients. The model's predictive accuracy was confirmed through receiver operating characteristic (ROC) curve analysis and principal component analysis (PCA). Moreover, immune infiltration and tumor microenvironment (TME) analyses revealed significant associations between TAS and immune cell populations.</p><p><strong>Conclusion: </strong>Triaptosis-related gene expression patterns are closely linked with melanoma prognosis and immune infiltration. Our findings provide novel insights into triaptosis as a potential biomarker and therapeutic target, offering strategies to overcome treatment resistance in melanoma.</p>","PeriodicalId":9479,"journal":{"name":"Cancer Management and Research","volume":"17 ","pages":"1127-1141"},"PeriodicalIF":2.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of Chronic Cytokine Dysregulation in Cervical Cancer: Potential Biomarkers and Therapeutic Targets.","authors":"Emmanuel Ifeanyi Obeagu","doi":"10.2147/CMAR.S527913","DOIUrl":"10.2147/CMAR.S527913","url":null,"abstract":"<p><p>Cervical cancer progression is not solely driven by persistent human papillomavirus (HPV) infection but is profoundly influenced by the local immune microenvironment, particularly chronic cytokine imbalances. Unlike the acute cytokine storms observed in infections or sepsis, cervical cancer is characterized by a persistent, low-grade, \"smoldering inflammatory response\" that fuels tumor initiation, progression, and immune evasion. Pro-inflammatory cytokines such as IL-6, IL-1β, TNF-α, and IL-8 sustain a tumor-supportive milieu, promoting angiogenesis, epithelial-mesenchymal transition, and resistance to apoptosis, while immunosuppressive cytokines like IL-10 and TGF-β dampen anti-tumor immune responses and facilitate immune escape. This review explores chronic cytokine dysregulation in cervical cancer, examining how the prolonged, dysregulated cytokine network shapes the tumor microenvironment, remodels stromal interactions, and influences immune cell recruitment and function. We highlight key cytokines involved in these processes and discuss their clinical significance as potential diagnostic, prognostic, and predictive biomarkers. Understanding these sustained inflammatory processes is critical because they represent a distinct biological landscape compared to acute inflammatory reactions and offer unique windows for therapeutic intervention. The paper reviewed emerging therapeutic strategies targeting these chronic cytokine pathways, including cytokine blockade, immune modulation, and combination approaches integrating immunotherapies or nanomedicine. Addressing chronic cytokine dysregulation holds promise for improving cervical cancer management and patient outcomes.</p>","PeriodicalId":9479,"journal":{"name":"Cancer Management and Research","volume":"17 ","pages":"1113-1126"},"PeriodicalIF":2.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Postoperative Symptom Clusters and Functional Status in Lung Cancer Patients: A Cross-Sectional Study.","authors":"Yali Liu, Siya Lin, Meirong Bai, Huochun Yi","doi":"10.2147/CMAR.S507420","DOIUrl":"10.2147/CMAR.S507420","url":null,"abstract":"<p><strong>Background: </strong>Symptom clusters in cancer symptom management research, providing a scientific basis for developing effective strategies for symptom assessment and intervention aimed at improving patient quality of life and survival.</p><p><strong>Objective: </strong>To analyze symptom clusters in postoperative lung cancer patients, examine its influenced factor, and explore the relationship between postoperative symptom clusters and functional status in lung cancer patients.</p><p><strong>Methods: </strong>Between August 2023 and February 2024, 441 lung cancer patients who underwent surgical treatment in the Department of Thoracic Surgery at a tertiary hospital in Xiamen were selected. Data collection included a general information questionnaire, the Postoperative Patient-Reported Outcomes Scale for Early-Stage Lung Cancer Patients, the Tampa Scale for Kinesiophobia (TSK), and the Karnofsky Performance Status Scale (KPSS). Latent class analysis was employed to categorize the self-reported outcomes. Statistical analyses were performed on the relevant factors.</p><p><strong>Results: </strong>The self-reported postoperative symptoms in lung cancer patients were divided into two groups: high-symptom burden and low-symptom burden. Significant differences were observed between these groups concerning surgery duration, kinesiophobia score, personality traits, KPSS, and the use of analgesic pumps (<i>P</i> <0.005). After adjusting for sex, age, lifestyle, and health status, a multi-model approach confirmed a significant inverse relationship between higher KPSS levels and higher symptom burden (<i>P</i> < 0.001). High-symptom levels are negatively associated with functional status (<i>P</i> <0.005).</p><p><strong>Conclusion: </strong>Postoperative symptom clusters in lung cancer patients can be specifically categorized into high and low-symptom burdens. Surgery duration, kinesiophobia scores, personality traits, KPSS, and the use of analgesic pumps are significant risk factors affecting symptom burden. Postoperative symptom cluster assessment provides a scientific basis for developing effective management strategies, which may improve functional recovery and long-term outcomes in lung cancer patients.</p>","PeriodicalId":9479,"journal":{"name":"Cancer Management and Research","volume":"17 ","pages":"1099-1111"},"PeriodicalIF":2.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of Using New Indole- and Benzimidazo[1,2-C]quinazolines in Anticancer Therapy Based on Mesenchymal Stem Cells.","authors":"Elżbieta Radzikowska-Bűchner, Sebastian Radej, Ewa Niezabitowska, Robert Sitarz, Monika Szewc","doi":"10.2147/CMAR.S516593","DOIUrl":"10.2147/CMAR.S516593","url":null,"abstract":"<p><strong>Purpose: </strong>The study of the cytotoxic effect of variously substituted indole- and benzimidazo[1,2-c]quinazolines may prove particularly valuable in the context of developing new, effective anticancer therapies based on MSCs. The unique ability of MSCs to migrate and inhabit the tumor microenvironment makes them an ideal tool for transferring chemotherapeutic agents. The aim of this study was to evaluate the cytotoxic activity of 4-(6-indolo[1,2-c]quinazoline)2-methyl-benzene-1,3-diol (compound A) and 4-(6-benzimidazolo[1,2-c]quinazoline)2-methyl-benzene-1,3-diol (compound B) relative to the adipose-derived mesenchymal stem cells line (ASC52-telo) and the fibroblast line (HDFa).</p><p><strong>Materials and methods: </strong>The test was performed on commercial cell lines: ASC52-telo and HDFa which were incubated with compounds A and B at four concentrations: 1 μg/mL, 2 μg/mL, 4 μg/mL, 8 μg/mL for 48 and 72 hours. The MTT test was performed to assess the cytotoxicity and determine the IC₅₀ value of compounds A and B against both tested cell lines.</p><p><strong>Results: </strong>The results of the research indicate that both tested compounds showed stronger cytotoxic activity towards ASC52-telo than HDFa cells. In addition, compound A is characterized by greater cytotoxicity towards both tested cell lines compared to compound B.</p><p><strong>Conclusion: </strong>The indole- and benzimidazo[1,2-c]quinazolines used in the study could potentially be used in MSCs-based therapy. There is a need to further investigate the safety of using MSCs as drug carriers, and to examine the anticancer activity of the tested compounds, as well as to perform additional and valuable assays, such as enzymatic and toxicity tests.</p>","PeriodicalId":9479,"journal":{"name":"Cancer Management and Research","volume":"17 ","pages":"1087-1097"},"PeriodicalIF":2.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Multimodal Imaging Techniques for Evaluating and Predicting the Efficacy of Immunotherapy for NSCLC.","authors":"Jingyi Liu, Mei Xie, Jing Shen, Jie Yao, Xuwen Lin, Xinyu Bao, Xin Zhang, Yiran Liang, Yun Yang, Gege Jiang, Ximeng Diao, Wenya Han, Hai Du, Xinying Xue, Jianlin Wu","doi":"10.2147/CMAR.S522136","DOIUrl":"10.2147/CMAR.S522136","url":null,"abstract":"<p><p>Immunotherapy has emerged as a transformative treatment for non-small cell lung cancer (NSCLC), yet its clinical benefits remain variable among patients. Early and accurate evaluation of treatment response is critical to guide therapeutic adjustments and improve outcomes. This review synthesizes recent advancements in multimodal imaging techniques-computed tomography (CT), positron emission tomography (PET)/CT, magnetic resonance imaging (MRI), and radiomics-for evaluating and predicting immunotherapy efficacy in NSCLC. We analyze the strengths and limitations of conventional morphological criteria (eg, RECIST, iRECIST) and highlight emerging quantitative biomarkers, including CT texture analysis, metabolic parameters (MTV, TLG), and diffusion-weighted MRI metrics. Notably, radiomics demonstrates promise in decoding tumor heterogeneity, PD-L1 expression, and immune microenvironment features, while immuno-PET probes targeting immune checkpoints offer novel insights into immune activity in vivo. Challenges such as pseudo-progression, nodal immune flare, and discrepancies between imaging responses and pathological responses are critically discussed. By integrating morphological, metabolic, and microenvironmental data, multimodal imaging enhances precision in patient stratification and therapeutic monitoring. Future research should prioritize multicenter, AI-driven radiomics validation and targeted tracer development to optimize NSCLC immunotherapy management. This review provides clinicians and researchers with new directions for utilizing multimodal imaging techniques in developing personalized treatment strategies.</p>","PeriodicalId":9479,"journal":{"name":"Cancer Management and Research","volume":"17 ","pages":"1073-1086"},"PeriodicalIF":2.5,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12154533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long Non-Coding RNA TPTEP1 Exerts Tumor Suppressive Functions via Sequestering miR-4295 to Regulate Growth Arrest and DNA Damage-Inducible 45α Expression in Acute Myeloid Leukemia.","authors":"Xueni Liu, Yonghui Gui, Chao Wang, Kang Xia, Peng Yang","doi":"10.2147/CMAR.S486875","DOIUrl":"10.2147/CMAR.S486875","url":null,"abstract":"<p><strong>Introduction: </strong>Recent evidences show that long non-coding RNA (lncRNA) plays an essential role in physiology and pathophysiology. The purpose of this study was to determine the role and its potential underlying mechanisms of the lncRNA transmembrane phosphatase with tensin homology pseudogene 1 (TPTEP1) in acute myeloid leukemia (AML).</p><p><strong>Methods: </strong>We detected the TPTEP1 and miR-4295 expression levels in AML cells. The vitro effects of TPTEP1 and miR-4295 on AML cells were analyzed. The correlation between miR-4295 and TPTEP1 or Growth arrest and DNA damage-inducible 45α (GADD45α) was confirmed by a luciferase reporter assay and RNA immunoprecipitation. The expression of GADD45α was investigated by Western blotting.</p><p><strong>Results: </strong>TPTEP1 was down-regulated in AML cell lines and AML patients. Ectopic expression of TPTEP1 inhibited AML cells proliferation while promoted cells apoptosis. And we found that silencing miR-4295 produced the similar effect of TPTEP1 overexpression. TPTEP1 regulated the malignant behavior of AML cells by binding to miR-4295. In addition, overexpression of TPTEP up-regulated GADD45α, a direct target of miR-4295 which play a suppressive role in AML cells. Moreover, when AML cell lines were treated with a DNA methylation inhibitor, TPTEP1 expression was up-regulated.</p><p><strong>Conclusion: </strong>This study reveals that the lncRNA TPTEP1 regulates the expression of GADD45α by sponging miR-4295 in AML cells, which may represent a novel therapeutic target for AML.</p>","PeriodicalId":9479,"journal":{"name":"Cancer Management and Research","volume":"17 ","pages":"1059-1072"},"PeriodicalIF":2.5,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation-Induced Lymphopenia Prognosis and Risk Factors in Postmastectomy Radiotherapy Patients.","authors":"Wenjie Ni, Xiunan Wang, Qin Wang, Yongqing Ge, Xiaofeng Mu","doi":"10.2147/CMAR.S522807","DOIUrl":"10.2147/CMAR.S522807","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of radiation-induced lymphopenia (RIL) on survival in postmastectomy radiotherapy (RT) patients and identify relevant RIL predictive factors.</p><p><strong>Methods: </strong>Patients with breast cancer who received postmastectomy radiotherapy at the study hospital were enrolled over June 2016 to December 2022. The peripheral blood counts were obtained before and during treatment and at the first posttreatment follow-up. Lymphopenia was graded according to the degree of lymphocyte reduction. The Kaplan-Meier method was used to compare disease-free survival (DFS) and overall survival (OS) between grade 0-2 (G0-2) and grade 3 (G3) lymphopenia, and the Log rank test was used to compare between-group differences. DFS prognostic factors were determined through Cox regression analysis, and G3 lymphopenia predictive factors were assessed through logistic regression analysis.</p><p><strong>Results: </strong>156 patients with a median RT duration of 5.0 weeks were enrolled. During treatment, 29 (18.6%), 36 (23.1%), 67 (42.9%), and 24 (15.4%) patients had G0, G1, G2, and G3 lymphopenia, respectively. Over RT duration, the absolute lymphocyte counts continued to decrease until they reached the nadir at week 5. The median follow-up duration was 45.5 months. The 1, 3-, and 5-year DFS rates were 97.0%, 90.3%, and 87.4% in the G0-2 group, respectively; they were higher than those in the G3 group (83.3%, 69.2%, and 39.5%, respectively; <i>p</i> < 0.001). Cox univariate and multivariate analyses revealed that pathological stage and lymphopenia degree were independent prognostic factors for DFS (both <i>p</i> < 0.001). Logistic regression analysis revealed that low body mass index (BMI), integrated RT, and high heart (D_mean ≥ 6 Gy) and sternum (D_mean ≥ 20Gy) exposure dose were associated with G3 lymphopenia (all <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>G3 RIL led to poor DFS in postmastectomy radiotherapy patients. BMI, RT modality, and heart and sternum exposure dose were noted to be independent RIL risk factors.</p>","PeriodicalId":9479,"journal":{"name":"Cancer Management and Research","volume":"17 ","pages":"1047-1058"},"PeriodicalIF":2.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer Potential of Bioactive Compounds in <i>Premna serratifolia, Premna odorata</i>, and <i>Premna tomentosa</i>: A Review of In Vitro Evidence.","authors":"Raden Maya Febriyanti, Syauqi Nawwar Rafif, Nazwa Nuraizza Mikdar, Billa Nidia Hikmatiana, Intan Timur Maisyarah, Alfi Khatib, Muhaimin Muhaimin","doi":"10.2147/CMAR.S516204","DOIUrl":"10.2147/CMAR.S516204","url":null,"abstract":"<p><p>The genus <i>Premna</i> (Lamiaceae), widely distributed across tropical and subtropical regions, is renowned for its ethnomedicinal applications, including cardiotonic, antimicrobial, hepatoprotective, and antitumor properties. Despite these promising uses, the current body of literature relies predominantly on in vitro evidence, with limited knowledge regarding in vivo validation, metabolism, and bioavailability. This review synthesizes findings from the past decade on the <i>Premna serratifolia</i> group (<i>P. serratifolia, P. odorata</i>, and <i>P. tomentosa</i>), focusing on their bioactive compounds and mechanisms of in vitro anticancer activity. The compounds identified-such as flavonoids, terpenoids, and steroids-exhibit diverse actions, including cell cycle arrest, apoptosis induction, inhibition of metastasis, oxidative stress modulation, and autophagy. Key compounds like quercetin, kaempferol, and stigmasterol demonstrate multi-targeted actions, effectively regulating pathways such as PI3K/AKT and NF-κB while selectively targeting cancer cells. These findings underscore chemopreventive potential from <i>P. serratifolia</i> group and their ability to complement conventional cancer therapies, potentially reducing side effects and overcoming drug resistance. Furthermore, the review validates the ethnomedicinal use of <i>Premna</i> species and bridges traditional knowledge with modern oncology. However, the absence of comprehensive in vivo and clinical data warrants further research to fully harness these compounds' potential. This study highlights <i>P. serratifolia, P. odorata</i>, and <i>P. tomentosa</i> as promising sources for novel plant-derived anticancer agents, offering opportunities for future drug discovery.</p>","PeriodicalId":9479,"journal":{"name":"Cancer Management and Research","volume":"17 ","pages":"1029-1045"},"PeriodicalIF":2.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Study of Part-Solid Lung Adenocarcinoma with Lymph Node Metastasis: Clinical, Pathological, and Radiological Perspectives.","authors":"Ziya Zhao, Hui Gan, Bin-Jie Fu, Wangjia Li, Fajin Lv, Zhigang Chu","doi":"10.2147/CMAR.S520781","DOIUrl":"10.2147/CMAR.S520781","url":null,"abstract":"<p><strong>Purpose: </strong>Compared to solid lung adenocarcinomas (LUADs), part-solid LUADs rarely exhibit lymph node metastasis (LNM) and generally have a favorable prognosis. This study aims to comprehensively investigate the clinical, pathological, and CT characteristics of part-solid LUADs with LNM.</p><p><strong>Patients and methods: </strong>This study collected 70 pathologically confirmed part-solid LUADs at two centers, including 35 cases with LNM and 35 matched cases without LNM based on size, CT pattern, and pathological subtype. Their clinical, pathological, and CT features were comprehensively analyzed and compared to identify the characteristics of part-solid LUADs associated with a high risk of LNM.</p><p><strong>Results: </strong>Among the 3,457 IACs manifested as part-solid lesions, a total of 35 (1.01%) cases were found to be associated with LNMs. Clinically, patients with and without LNM were similar. Pathologically, lesions exhibiting predominant micropapillary/solid pattern (11.4% vs 0.0%), and containing micropapillary (48.6% vs 25.7%) or any high-grade histological pattern were all more common in part-solid LUADs with LNM than in those without (each P < 0.05). Radiologically, solid components located at the tumor margins or distributed in a scattered manner (odds ratio [OR] = 4.048, P = 0.038) and consolidation-to-tumor ratio (CTR) > 57.2% (area) (OR = 45.649, P = 0.041) were independent predictors of LNM, with an area under the curve of this model being 0.881, sensitivity of 97%, and specificity of 77.1% (P < 0.001).</p><p><strong>Conclusion: </strong>LNM in part-solid LUADs is more prevalent in IACs with high-grade patterns, particularly the micropapillary pattern, with these lesions presenting as part-solid lesions that often have a larger CTR or distinct distribution of solid components.</p>","PeriodicalId":9479,"journal":{"name":"Cancer Management and Research","volume":"17 ","pages":"1015-1027"},"PeriodicalIF":2.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Naples Prognostic Score Exerts a Significant Impact on the Prognosis of Patients Diagnosed with External Auditory Canal Carcinoma After Surgery.","authors":"Xue-Lian Xu, Hao Cheng, Xin-Meng Wu, Jin-Hong Xu","doi":"10.2147/CMAR.S527496","DOIUrl":"10.2147/CMAR.S527496","url":null,"abstract":"<p><strong>Background: </strong>External auditory canal carcinoma (EACC) is a rare malignant tumor. This study aimed to investigate the influence of the comprehensive index of nutrition- Naples prognostic score (NPS) on the prognosis of EACC patients with surgical resection.</p><p><strong>Methods: </strong>A total of 73 EACC patients with surgical resection were selected from two tertiary medical institutions, and were diagnosed between Sep 2008 and Aug 2019. The univariate and multivariate Cox regression analyses were used to identify the independent prognostic factors for disease-free survival (DFS) and overall survival (OS) for postoperative EACC patients. The prognosis for postoperative EACC patients with varying NPS were displayed by Kaplan-Meier plots.</p><p><strong>Results: </strong>The 3- and 5-year survival rate for EACC patients with surgical resection were 72.6%, 32.9% for DFS, and 76.7%, 52.1% for OS, respectively. The multivariate Cox regression analysis revealed that advanced Pittsburgh stage, perineural invasion, vascular invasion, and higher NPS were identified as independent prognostic factors for DFS. Additionally, advanced Pittsburgh stage, vascular invasion, an ACCI score of 6 or higher, and higher NPS were found to be independent predictors for OS.</p><p><strong>Conclusion: </strong>NPS serves as a crucial predictor of postoperative outcomes in patients with EACC, with higher levels indicating poorer disease-free and overall survival. Additionally, factors such as Pittsburgh stage, perineural and vascular invasion, and ACCI are also significant prognostic indicators.</p>","PeriodicalId":9479,"journal":{"name":"Cancer Management and Research","volume":"17 ","pages":"985-996"},"PeriodicalIF":2.5,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}