Cardiovascular Pathology最新文献_第6页

Descriptive study of the clinical and myocardial status of a population with anatomopathological aortic valve amyloidosis 解剖病理学主动脉瓣淀粉样变性人群临床和心肌状况的描述性研究。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-07-16 DOI: 10.1016/j.carpath.2024.107674

Jean-Baptiste Brette , Magali Colombat , Pauline Fournier , Maxime Moninhas , Bertrand Marcheix , Olivier Lairez , Eve Cariou

{"title":"Descriptive study of the clinical and myocardial status of a population with anatomopathological aortic valve amyloidosis","authors":"Jean-Baptiste Brette , Magali Colombat , Pauline Fournier , Maxime Moninhas , Bertrand Marcheix , Olivier Lairez , Eve Cariou","doi":"10.1016/j.carpath.2024.107674","DOIUrl":"10.1016/j.carpath.2024.107674","url":null,"abstract":"<div><h3>Background</h3><p>Aortic stenosis (AS) and transthyretin (ATTR) cardiac amyloidosis (CA) share the same clinical profiles and cardiac phenotype. Amyloid deposits have been frequently reported in aortic valves of patients with severe AS referred for surgical aortic valve replacement (SAVR). The aim of this study was to determine the clinical and myocardial status of patients with aortic valve amyloidosis after aortic valve surgery.</p></div><div><h3>Methods and results</h3><p>We performed a retrospective descriptive study of 46 patients who underwent SAVR for severe AS with amyloid deposits upon histological analysis. All patients were screened for cardiac involvement. Amyloid deposits typing was successful in 35 (76%) patients and 28 (80%) were ATTR. Two (4%) had positive bone scintigraphy and among the 5 myocardial biopsies performed during surgery, 80% were positive for ATTR deposits.</p></div><div><h3>Conclusion</h3><p>ATTR is the predominant type in the presence of amyloid deposits on the aortic valve after surgery for severe AS but is only rarely accompanied by cardiac uptake on bone scintigraphy. Early stages of myocardial involvement are frequent and myocardial biopsy is more sensitive for detection of mild amyloid deposits than bone scintigraphy</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"73 ","pages":"Article 107674"},"PeriodicalIF":2.3,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S105488072400070X/pdfft?md5=e9397ff43cb58c34cc73809d62be0ecb&pid=1-s2.0-S105488072400070X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141723120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current concepts in the epigenetic regulation of cardiac fibrosis 心脏纤维化表观遗传调控的当前概念。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-07-10 DOI: 10.1016/j.carpath.2024.107673

{"title":"Current concepts in the epigenetic regulation of cardiac fibrosis","authors":"","doi":"10.1016/j.carpath.2024.107673","DOIUrl":"10.1016/j.carpath.2024.107673","url":null,"abstract":"<div><p>Cardiac fibrosis is a significant driver of congestive heart failure, a syndrome that continues to affect a growing patient population globally. Cardiac fibrosis results from a constellation of complex processes at the transcription, receptor, and signaling axes levels. Various mediators and signaling cascades, such as the transformation growth factor-beta pathway, have been implicated in the pathophysiology of cardiac tissue fibrosis. Our understanding of these markers and pathways has improved in recent years as more advanced technologies and assays have been developed, allowing for better delineation of the crosstalk between specific factors. There is mounting evidence suggesting that epigenetic modulation plays a pivotal role in the progression of cardiac fibrosis. Transcriptional regulation of key pro- and antifibrotic pathways can accentuate or blunt the rate and extent of fibrosis at the tissue level. Exosomes, micro-RNAs, and long noncoding RNAs all belong to factors that can impact the epigenetic signature in cardiac fibrosis. Herein, we comprehensively review the latest literature about exosomes, their contents, and cardiac fibrosis. In doing so, we highlight the specific transcriptional factors with pro- or antifibrotic properties. We also assimilate the data supporting these mediators' potential utility as diagnostic or prognostic biomarkers. Finally, we offer insight into where further work can be done to fill existing gaps to translate preclinical findings better and improve clinical outcomes.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"73 ","pages":"Article 107673"},"PeriodicalIF":2.3,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1054880724000693/pdfft?md5=360e02ff4c582ed754af921caf42764d&pid=1-s2.0-S1054880724000693-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141598536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent cardiac tamponade following coronavirus disease 2019 mRNA vaccination: correspondence 2019 年冠状病毒病 mRNA 疫苗接种后复发的心脏填塞：通信。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-06-24 DOI: 10.1016/j.carpath.2024.107672

引用次数: 0

Exploring the role of pericardial miRNAs and exosomes in modulating cardiac fibrosis 探索心包 miRNA 和外泌体在调节心脏纤维化中的作用。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-06-19 DOI: 10.1016/j.carpath.2024.107671

{"title":"Exploring the role of pericardial miRNAs and exosomes in modulating cardiac fibrosis","authors":"","doi":"10.1016/j.carpath.2024.107671","DOIUrl":"10.1016/j.carpath.2024.107671","url":null,"abstract":"<div><p>The potential of the pericardial space as a therapeutic delivery tool for cardiac fibrosis and heart failure (HF) treatment has yet to be elucidated. Recently, miRNAs and exosomes have been discovered to be present in human pericardial fluid (PF). Novel studies have shown characteristic human PF miRNA compositions associated with cardiac diseases and higher miRNA expressions in PF compared to peripheral blood. Five key studies found differentially expressed miRNAs in HF, angina pectoris, aortic stenosis, ventricular tachycardia, and congenital heart diseases with either atrial fibrillation or sinus rhythm. As miRNA-based therapeutics for cardiac fibrosis and HF showed promising results in several <em>in vivo</em> studies for multiple miRNAs, we hypothesize a potential role of miRNA-based therapeutics delivered through the pericardial cavity. This is underlined by the favorable results of the first phase 1b clinical trial in this emerging field. Presenting the first human miRNA antisense drug trial, inhibition of miR-132 by intravenous administration of a novel antisense oligonucleotide, CDR132L, established efficacy in reducing miR-132 in plasma samples in a dose-dependent manner. We screened the literature, provided an overview of the miRNAs and exosomes present in PF, and drew a connection to those miRNAs previously elucidated in cardiac fibrosis and HF. Further, we speculate about clinical implications and potential delivery methods.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"73 ","pages":"Article 107671"},"PeriodicalIF":2.3,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S105488072400067X/pdfft?md5=fd26a5be0c55954fe94eead47f63d87d&pid=1-s2.0-S105488072400067X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141436398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrastructural cardiac pathology: the wide (yet so very small) world of cardiac electron microscopy 心脏超微结构病理学》：心脏电子显微镜的广阔（但又非常小）世界。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-06-14 DOI: 10.1016/j.carpath.2024.107670

{"title":"Ultrastructural cardiac pathology: the wide (yet so very small) world of cardiac electron microscopy","authors":"","doi":"10.1016/j.carpath.2024.107670","DOIUrl":"10.1016/j.carpath.2024.107670","url":null,"abstract":"<div><p>Electron microscopy (EM) was a popular diagnostic tool in the 1970s and early 80s. With the adoption of newer, less expensive techniques, such as immunohistochemistry, the role of EM in diagnostic surgical pathology has dwindled substantially. Nowadays, even in academic centers, EM interpretation is relegated to renal pathologists and the handful of (aging) pathologists with experience using the technique. As such, EM interpretation is truly arcane—understood by few and mysterious to many. Nevertheless, there remain situations in which EM is the best or only ancillary test to ascertain a specific diagnosis. Thus, there remains a critical need for the younger generation of surgical pathologists to learn EM interpretation. Recognizing this need, cardiac EM was made the theme of the Cardiovascular Evening Specialty Conference at the 2023 United States and Canadian Academy of Pathology (USCAP) annual meeting in New Orleans, Louisiana. Each of the speakers contributed their part to this article, the purpose of which is to review EM as it pertains to myocardial tissue and provide illustrative examples of the spectrum of ultrastructural cardiac pathology seen in storage/metabolic diseases, cardiomyopathies, infiltrative disorders, and cardiotoxicities.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"73 ","pages":"Article 107670"},"PeriodicalIF":2.3,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1054880724000668/pdfft?md5=d5028840ce0e0486c8ae7ea9fef6d468&pid=1-s2.0-S1054880724000668-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pathological study on the efficacy of Syk inhibitors in a Candida albicans-induced aortic root vasculitis murine model 关于 Syk 抑制剂在白色念珠菌诱导的小鼠主动脉根部血管炎模型中疗效的病理研究。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-06-11 DOI: 10.1016/j.carpath.2024.107669

Nanae Asakawa , Toshiaki Oharaseki , Yuki Yokouchi , Noriko Miura , Naohito Ohno , Kei Takahashi

{"title":"A pathological study on the efficacy of Syk inhibitors in a Candida albicans-induced aortic root vasculitis murine model","authors":"Nanae Asakawa , Toshiaki Oharaseki , Yuki Yokouchi , Noriko Miura , Naohito Ohno , Kei Takahashi","doi":"10.1016/j.carpath.2024.107669","DOIUrl":"10.1016/j.carpath.2024.107669","url":null,"abstract":"<div><h3>Background</h3><p>The activation of innate immunity may be involved in the development of <em>Candida albicans</em>-induced murine vasculitis, which resembles Kawasaki disease (KD) vasculitis. This study aimed to histologically clarify the time course of the development of vasculitis in this model in detail and to estimate the potential role of spleen tyrosine kinase (Syk) inhibitors in KD vasculitis.</p></div><div><h3>Methods and Results</h3><p>DBA/2 male mice were intraperitoneally injected with a vasculitis-inducing substance and treated with a Syk inhibitor (R788 or GS-9973). Systemic vasculitis, especially in the aortic annulus area, was histologically evaluated. Regarding lesions in the aortic annulus area, some mice in the untreated control group already showed initiation of vasculitis 1 day after the final injection of a vasculitis-inducing substance. The vasculitis expanded over time. Inflammation occurred more frequently at the aortic root than at the coronary artery. The distribution of inflammatory cells was limited to the intima, intima plus adventitia, or all layers. In the Syk inhibitor-treated groups, only one mouse had vasculitis at all observation periods. The severity and area of the vasculitis were reduced by both Syk inhibitors.</p></div><div><h3>Conclusion</h3><p><em>Candida albicans</em>-induced murine vasculitis may occur within 1 day after the injection of a vasculitis-inducing substance. Additionally, Syk inhibitors suppress murine vasculitis.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"72 ","pages":"Article 107669"},"PeriodicalIF":2.3,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A challenging case of eosinophilic myocarditis leading to heart failure and transplantation 嗜酸性粒细胞性心肌炎导致心力衰竭和移植的棘手病例。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-06-11 DOI: 10.1016/j.carpath.2024.107666

Wissam Harmouch , Jared R. Zhang , Joshua M. Peterson , Diana Palacio Uran , Louis Maximilian Buja , Bihong Zhao , Paul J. Boor , Jose Iturrizaga Murrieta , Khaled Chatila , Heather L. Stevenson

{"title":"A challenging case of eosinophilic myocarditis leading to heart failure and transplantation","authors":"Wissam Harmouch , Jared R. Zhang , Joshua M. Peterson , Diana Palacio Uran , Louis Maximilian Buja , Bihong Zhao , Paul J. Boor , Jose Iturrizaga Murrieta , Khaled Chatila , Heather L. Stevenson","doi":"10.1016/j.carpath.2024.107666","DOIUrl":"10.1016/j.carpath.2024.107666","url":null,"abstract":"<div><p>The large spectrum of etiologies, severities, and histologic appearances of eosinophilic myocarditis (EoM) poses challenges to its diagnosis and management. Endomyocardial biopsy is the current gold standard for diagnosis. However, cardiovascular magnetic resonance imaging is becoming more frequently used to diagnose acute myocarditis because of enhanced sensitivity when compared to histopathologic examination, and its less invasive nature. We report a complicated case of EoM in a male in his mid-thirties that led to fulminant cardiogenic shock that required immunosuppressive therapy on day 5 of admission and implantation of a left ventricular assist device (LVAD) on day 30. EoM was diagnosed on histopathologic examination of the resected fragment of the left ventricular myocardium. Nine months after the initial presentation, the patient ultimately required heart transplantation. The explanted heart showed minimal residual interstitial inflammation with evidence of mildly active intimal arteritis and patchy areas of interstitial fibrosis. In this report, we describe our patient's clinical features and correlate them with imaging and histopathologic findings to illustrate the difficulty in diagnosing EoM, particularly in this complicated patient that ultimately required heart transplantation. The diagnosis can be challenging due to the variable histopathologic features, clinical presentation, and utilization of therapeutic medications and devices.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"72 ","pages":"Article 107666"},"PeriodicalIF":2.3,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141316750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular calcification: High incidence sites, distribution, and detection 血管钙化：高发部位、分布和检测。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-06-10 DOI: 10.1016/j.carpath.2024.107667

Zebin Gui , Chen Shao , Yuanzi Zhan , Zhongqun Wang , Lihua Li

{"title":"Vascular calcification: High incidence sites, distribution, and detection","authors":"Zebin Gui , Chen Shao , Yuanzi Zhan , Zhongqun Wang , Lihua Li","doi":"10.1016/j.carpath.2024.107667","DOIUrl":"10.1016/j.carpath.2024.107667","url":null,"abstract":"<div><p>Vascular calcification is an important pathological change in a variety of disease states such as atherosclerosis (AS), diabetes, chronic kidney disease (CKD), hypertension, and is a strong predictor of cardiovascular events. The distribution and location of calcification in different vessels may have different clinical effects and prognosis. Therefore, the study of high-risk sites of vascular calcification will help us to better understand the prevention, diagnosis, and treatment of related diseases, as well as to evaluate the efficacy and prognosis. So far, although there are some studies on the sites with high incidence of vascular calcification, there is a lack of systematic sorting out the distribution and location of vascular calcification in humans. Based on this, relevant databases were searched, literatures were retrieved, analyzed, and summarized, and the locations of high incidence of vascular calcification and their distribution characteristics, the relationship between high incidence of vascular calcification and hemodynamics, and the common detection methods of high incidence of vascular calcification were systematically described, hoping to provide help for clinical and research.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"72 ","pages":"Article 107667"},"PeriodicalIF":2.3,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent cardiac tamponade following coronavirus disease 2019 mRNA vaccination: A case report 2019 年冠状病毒病 mRNA 疫苗接种后复发性心脏填塞：一份病例报告。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-06-10 DOI: 10.1016/j.carpath.2024.107668

引用次数: 0

Clinicopathological features of immunoglobulin G4-related constrictive pericarditis 免疫球蛋白 G4 相关缩窄性心包炎的临床病理特征。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-05-31 DOI: 10.1016/j.carpath.2024.107665

Satomi Kasashima , Yasushi Matsumoto , Atsuhiro Kawashima , Nozomu Kurose , Satoru Ozaki , Hinako Yamamoto , Fuminori Kasashima , Hirofumi Takemura , Hiroko Ikeda

{"title":"Clinicopathological features of immunoglobulin G4-related constrictive pericarditis","authors":"Satomi Kasashima , Yasushi Matsumoto , Atsuhiro Kawashima , Nozomu Kurose , Satoru Ozaki , Hinako Yamamoto , Fuminori Kasashima , Hirofumi Takemura , Hiroko Ikeda","doi":"10.1016/j.carpath.2024.107665","DOIUrl":"10.1016/j.carpath.2024.107665","url":null,"abstract":"<div><h3>Aim</h3><p>Constrictive pericarditis (CP) is characterised by scarring fibrosis and a loss of pericardial elasticity, which causes heart failure. IgG4 (immunoglobulin G4)-related disease (IgG4-RD) is a systemic fibro-inflammatory disease characterised by the infiltration of IgG4-immunopositive plasmacytes and high serum IgG4 levels that frequently shape tumorous lesions. Although pericardial involvement of IgG4-RD is rare, with indications of CP, pericardial effusion and irregular masses, the clinical and pathological features remain unclear. In this study, we examined the relationship between CP and IgG4-RD.</p></div><div><h3>Methods</h3><p>Among 35 thick-walled CP cases (histologically pericardial thickening ≥2 mm), eight cases were aetiology identified. Using the diagnostic criteria for IgG4-RD, 11 cases were classified as IgG4-CP, whereas the remainder were considered true idiopathic CP (16 cases) and the clinical pathological features were evaluated.</p></div><div><h3>Results</h3><p>Compared with the other groups, the IgG4-CP group was more common in men and associated with low-grade fever and massive pericardial effusion with frequent recurrence. Deaths resulting from heart failure occurred in a few cases of the IgG4-CP group, but not in other groups. An increase in C-reactive protein and a high positivity rate of anti-nuclear antibodies frequently occurred in the IgG4-CP group. Histologically, the IgG4-CP group included lymphoid follicle, eosinophil infiltration and few calcifications.</p></div><div><h3>Conclusions</h3><p>Pericardial IgG4-RD occurs not only as nodular lesions, but also as thick-walled CP, and accounts for approximately 40% of thick-walled CP cases of unknown cause. The predominant clinical characteristic was refractory and recurrent pericardial effusion. Recognising IgG4-RD as a cause of CP is important to initiate appropriate therapy.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"72 ","pages":"Article 107665"},"PeriodicalIF":2.3,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0