Cardiovascular Pathology最新文献_第6页

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-08-05 DOI: 10.1016/S1054-8807(24)00076-0

引用次数: 0

The uncertain nature of myocarditis classification and the challenging case of eosinophilic myocarditis leading to heart failure and transplantation 心肌炎分类的不确定性以及嗜酸性粒细胞性心肌炎导致心力衰竭和移植的挑战性病例。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-07-27 DOI: 10.1016/j.carpath.2024.107682

Nicholas G. Kounis , Virginia Mplani

引用次数: 0

Decreased smooth muscle cells and fibrous thickening of the tunica media in peripheral pulmonary artery stenosis in Alagille syndrome 阿拉吉尔综合征外周肺动脉狭窄的平滑肌细胞减少和中膜纤维增厚。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-07-26 DOI: 10.1016/j.carpath.2024.107677

Yosuke Ogawa , Amane Yamamoto , Sho Yamazawa , Masako Ikemura , Yasutaka Hirata , Ryo Inuzuka

{"title":"Decreased smooth muscle cells and fibrous thickening of the tunica media in peripheral pulmonary artery stenosis in Alagille syndrome","authors":"Yosuke Ogawa , Amane Yamamoto , Sho Yamazawa , Masako Ikemura , Yasutaka Hirata , Ryo Inuzuka","doi":"10.1016/j.carpath.2024.107677","DOIUrl":"10.1016/j.carpath.2024.107677","url":null,"abstract":"<div><p>Alagille syndrome is caused by mutations in genes involved in NOTCH signaling, specifically <em>JAG1</em> and <em>NOTCH2</em>, and is associated with a high rate of peripheral pulmonary artery stenosis. In this study, we report the case of an infant with Alagille syndrome caused by a <em>JAG1</em> mutation, who succumbed to acute exacerbation of right heart failure due to severe peripheral pulmonary artery stenosis. The autopsy revealed that the peripheral pulmonary arteries were significantly stenosed, exhibiting hypoplasia and thickened vessel walls. Histological examination of the pulmonary artery walls showed a decrease in smooth muscle cells in the tunica media and an increase in collagen and elastic fibers, although the intrapulmonary arteries were intact. These findings are important for understanding the pathogenesis of Alagille syndrome and developing treatment strategies for peripheral pulmonary artery stenosis.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"74 ","pages":"Article 107677"},"PeriodicalIF":2.3,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1054880724000735/pdfft?md5=6579b1f1ca3fc6fcdababe0d7ce5ab6c&pid=1-s2.0-S1054880724000735-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dilated cardiomyopathy due to a novel combination of TTN and BAG3 genetic variants: From acute heart failure to subclinical phenotypes 由 TTN 和 BAG3 基因变异新组合引起的扩张型心肌病：从急性心力衰竭到亚临床表型。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-07-25 DOI: 10.1016/j.carpath.2024.107675

Irene Bottillo , Carla Giordano , Maria Pia Ciccone , Maria Gemma Pignataro , Fiammetta Albi , Gabriella Parisi , Daniela Formicola , Simona Grotta , Federico Ranocchi , Maria Valeria Giuli , Saula Checquolo , Laura Masuelli , Federica Re , Silvia Majore , Giulia d'Amati , Paola Grammatico

{"title":"Dilated cardiomyopathy due to a novel combination of TTN and BAG3 genetic variants: From acute heart failure to subclinical phenotypes","authors":"Irene Bottillo , Carla Giordano , Maria Pia Ciccone , Maria Gemma Pignataro , Fiammetta Albi , Gabriella Parisi , Daniela Formicola , Simona Grotta , Federico Ranocchi , Maria Valeria Giuli , Saula Checquolo , Laura Masuelli , Federica Re , Silvia Majore , Giulia d'Amati , Paola Grammatico","doi":"10.1016/j.carpath.2024.107675","DOIUrl":"10.1016/j.carpath.2024.107675","url":null,"abstract":"<div><p>Dilated cardiomyopathy (DCM) is defined as left ventricular enlargement accompanied by systolic dysfunction not explained by abnormal loading conditions or coronary heart disease. The DCM clinical <em>spectrum</em> is broad, ranging from subclinical to severe presentation with progression to end stage heart failure. To date, different genetic <em>loci</em> have been found to have moderate/definitive evidence for causality in DCM and pathogenic variants in the <em>TTN</em> gene represent the main genetic determinant.</p><p>Here, we describe a family in which the co-occurrence of two genetic hits, one in the <em>TTN</em> and one in the <em>BAG3</em> gene, was associated with heterogeneous clinical presentation ranging from subclinical phenotypes to acute cardiogenic shock mimicking fulminant myocarditis. We hypothesize that at least some specific <em>BAG3</em> genotypes could be related to DCM presenting with acute heart failure and suggest that patients and relatives carrying <em>BAG3</em> pathogenic variants should be addressed to a tertiary-level heart care center.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"73 ","pages":"Article 107675"},"PeriodicalIF":2.3,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1054880724000711/pdfft?md5=36798fb256d6e87a6374f45ee082b089&pid=1-s2.0-S1054880724000711-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141765549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Right atrial cardiac myxoma with malignant transformation to undifferentiated sarcoma: A case report 右心房心脏肌瘤恶变为未分化肉瘤：病例报告。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-07-23 DOI: 10.1016/j.carpath.2024.107676

Ryo Kaimori , Haruto Nishida , Yuzo Oyama , Takahiro Kusaba , Kazuhiro Kawamura , Tsutomu Daa

{"title":"Right atrial cardiac myxoma with malignant transformation to undifferentiated sarcoma: A case report","authors":"Ryo Kaimori , Haruto Nishida , Yuzo Oyama , Takahiro Kusaba , Kazuhiro Kawamura , Tsutomu Daa","doi":"10.1016/j.carpath.2024.107676","DOIUrl":"10.1016/j.carpath.2024.107676","url":null,"abstract":"<div><p>Generally, sarcomas arising from benign soft tissue are rare. Cardiac myxoma (CM) is a benign tumor, and few reports have described its malignant transformation. Herein, we documented a case of an 89-year-old man with prostate cancer and a 5-year history of a right atrium tumor without Carney complex. The tumor was resected surgically and had a myxomatous or gelatinous appearance. Microscopically, the tumor had two components: a sarcomatous area and myxomatous area. In the myxomatous area, typical myxoma cells were demonstrable and were strongly immunoreactive for immunohistochemistry (IHC) of calretinin. In the sarcomatous area, the epithelioid- to spindle-shaped cells with prominent atypia proliferated densely. The IHC profile of cells in the sarcomatous area was different from that of cells in the myxomatous area; MDM2-positive cells were found only in the sarcomatous area. Especially, the Ki-67 index and number of p53-positive cells in the sarcomatous area were higher than those in the myxomatous area. The transition of the two components was seamless. Thus, we made a diagnosis of CM with malignant transformation corresponding to undifferentiated pleomorphic sarcomas. This case suggests that CM may transform into sarcoma, albeit rarely.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"73 ","pages":"Article 107676"},"PeriodicalIF":2.3,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Descriptive study of the clinical and myocardial status of a population with anatomopathological aortic valve amyloidosis 解剖病理学主动脉瓣淀粉样变性人群临床和心肌状况的描述性研究。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-07-16 DOI: 10.1016/j.carpath.2024.107674

Jean-Baptiste Brette , Magali Colombat , Pauline Fournier , Maxime Moninhas , Bertrand Marcheix , Olivier Lairez , Eve Cariou

{"title":"Descriptive study of the clinical and myocardial status of a population with anatomopathological aortic valve amyloidosis","authors":"Jean-Baptiste Brette , Magali Colombat , Pauline Fournier , Maxime Moninhas , Bertrand Marcheix , Olivier Lairez , Eve Cariou","doi":"10.1016/j.carpath.2024.107674","DOIUrl":"10.1016/j.carpath.2024.107674","url":null,"abstract":"<div><h3>Background</h3><p>Aortic stenosis (AS) and transthyretin (ATTR) cardiac amyloidosis (CA) share the same clinical profiles and cardiac phenotype. Amyloid deposits have been frequently reported in aortic valves of patients with severe AS referred for surgical aortic valve replacement (SAVR). The aim of this study was to determine the clinical and myocardial status of patients with aortic valve amyloidosis after aortic valve surgery.</p></div><div><h3>Methods and results</h3><p>We performed a retrospective descriptive study of 46 patients who underwent SAVR for severe AS with amyloid deposits upon histological analysis. All patients were screened for cardiac involvement. Amyloid deposits typing was successful in 35 (76%) patients and 28 (80%) were ATTR. Two (4%) had positive bone scintigraphy and among the 5 myocardial biopsies performed during surgery, 80% were positive for ATTR deposits.</p></div><div><h3>Conclusion</h3><p>ATTR is the predominant type in the presence of amyloid deposits on the aortic valve after surgery for severe AS but is only rarely accompanied by cardiac uptake on bone scintigraphy. Early stages of myocardial involvement are frequent and myocardial biopsy is more sensitive for detection of mild amyloid deposits than bone scintigraphy</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"73 ","pages":"Article 107674"},"PeriodicalIF":2.3,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S105488072400070X/pdfft?md5=e9397ff43cb58c34cc73809d62be0ecb&pid=1-s2.0-S105488072400070X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141723120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current concepts in the epigenetic regulation of cardiac fibrosis 心脏纤维化表观遗传调控的当前概念。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-07-10 DOI: 10.1016/j.carpath.2024.107673

{"title":"Current concepts in the epigenetic regulation of cardiac fibrosis","authors":"","doi":"10.1016/j.carpath.2024.107673","DOIUrl":"10.1016/j.carpath.2024.107673","url":null,"abstract":"<div><p>Cardiac fibrosis is a significant driver of congestive heart failure, a syndrome that continues to affect a growing patient population globally. Cardiac fibrosis results from a constellation of complex processes at the transcription, receptor, and signaling axes levels. Various mediators and signaling cascades, such as the transformation growth factor-beta pathway, have been implicated in the pathophysiology of cardiac tissue fibrosis. Our understanding of these markers and pathways has improved in recent years as more advanced technologies and assays have been developed, allowing for better delineation of the crosstalk between specific factors. There is mounting evidence suggesting that epigenetic modulation plays a pivotal role in the progression of cardiac fibrosis. Transcriptional regulation of key pro- and antifibrotic pathways can accentuate or blunt the rate and extent of fibrosis at the tissue level. Exosomes, micro-RNAs, and long noncoding RNAs all belong to factors that can impact the epigenetic signature in cardiac fibrosis. Herein, we comprehensively review the latest literature about exosomes, their contents, and cardiac fibrosis. In doing so, we highlight the specific transcriptional factors with pro- or antifibrotic properties. We also assimilate the data supporting these mediators' potential utility as diagnostic or prognostic biomarkers. Finally, we offer insight into where further work can be done to fill existing gaps to translate preclinical findings better and improve clinical outcomes.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"73 ","pages":"Article 107673"},"PeriodicalIF":2.3,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1054880724000693/pdfft?md5=360e02ff4c582ed754af921caf42764d&pid=1-s2.0-S1054880724000693-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141598536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent cardiac tamponade following coronavirus disease 2019 mRNA vaccination: correspondence 2019 年冠状病毒病 mRNA 疫苗接种后复发的心脏填塞：通信。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-06-24 DOI: 10.1016/j.carpath.2024.107672

引用次数: 0

Exploring the role of pericardial miRNAs and exosomes in modulating cardiac fibrosis 探索心包 miRNA 和外泌体在调节心脏纤维化中的作用。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-06-19 DOI: 10.1016/j.carpath.2024.107671

{"title":"Exploring the role of pericardial miRNAs and exosomes in modulating cardiac fibrosis","authors":"","doi":"10.1016/j.carpath.2024.107671","DOIUrl":"10.1016/j.carpath.2024.107671","url":null,"abstract":"<div><p>The potential of the pericardial space as a therapeutic delivery tool for cardiac fibrosis and heart failure (HF) treatment has yet to be elucidated. Recently, miRNAs and exosomes have been discovered to be present in human pericardial fluid (PF). Novel studies have shown characteristic human PF miRNA compositions associated with cardiac diseases and higher miRNA expressions in PF compared to peripheral blood. Five key studies found differentially expressed miRNAs in HF, angina pectoris, aortic stenosis, ventricular tachycardia, and congenital heart diseases with either atrial fibrillation or sinus rhythm. As miRNA-based therapeutics for cardiac fibrosis and HF showed promising results in several <em>in vivo</em> studies for multiple miRNAs, we hypothesize a potential role of miRNA-based therapeutics delivered through the pericardial cavity. This is underlined by the favorable results of the first phase 1b clinical trial in this emerging field. Presenting the first human miRNA antisense drug trial, inhibition of miR-132 by intravenous administration of a novel antisense oligonucleotide, CDR132L, established efficacy in reducing miR-132 in plasma samples in a dose-dependent manner. We screened the literature, provided an overview of the miRNAs and exosomes present in PF, and drew a connection to those miRNAs previously elucidated in cardiac fibrosis and HF. Further, we speculate about clinical implications and potential delivery methods.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"73 ","pages":"Article 107671"},"PeriodicalIF":2.3,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S105488072400067X/pdfft?md5=fd26a5be0c55954fe94eead47f63d87d&pid=1-s2.0-S105488072400067X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141436398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrastructural cardiac pathology: the wide (yet so very small) world of cardiac electron microscopy 心脏超微结构病理学》：心脏电子显微镜的广阔（但又非常小）世界。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-06-14 DOI: 10.1016/j.carpath.2024.107670

{"title":"Ultrastructural cardiac pathology: the wide (yet so very small) world of cardiac electron microscopy","authors":"","doi":"10.1016/j.carpath.2024.107670","DOIUrl":"10.1016/j.carpath.2024.107670","url":null,"abstract":"<div><p>Electron microscopy (EM) was a popular diagnostic tool in the 1970s and early 80s. With the adoption of newer, less expensive techniques, such as immunohistochemistry, the role of EM in diagnostic surgical pathology has dwindled substantially. Nowadays, even in academic centers, EM interpretation is relegated to renal pathologists and the handful of (aging) pathologists with experience using the technique. As such, EM interpretation is truly arcane—understood by few and mysterious to many. Nevertheless, there remain situations in which EM is the best or only ancillary test to ascertain a specific diagnosis. Thus, there remains a critical need for the younger generation of surgical pathologists to learn EM interpretation. Recognizing this need, cardiac EM was made the theme of the Cardiovascular Evening Specialty Conference at the 2023 United States and Canadian Academy of Pathology (USCAP) annual meeting in New Orleans, Louisiana. Each of the speakers contributed their part to this article, the purpose of which is to review EM as it pertains to myocardial tissue and provide illustrative examples of the spectrum of ultrastructural cardiac pathology seen in storage/metabolic diseases, cardiomyopathies, infiltrative disorders, and cardiotoxicities.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"73 ","pages":"Article 107670"},"PeriodicalIF":2.3,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1054880724000668/pdfft?md5=d5028840ce0e0486c8ae7ea9fef6d468&pid=1-s2.0-S1054880724000668-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0