开启血管活力：探索 LIMA 采集技术对内皮健康的影响

IF 2.3 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Pathology Pub Date : 2024-09-30 DOI:10.1016/j.carpath.2024.107699

Serkan Mola , Alp Yıldırım , Nilüfer Onak Kandemir , Gökay Deniz , Enis Burak Gül , Ertekin Utku Ünal

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引用次数: 0

摘要

背景：本研究探讨了不同采集技术对冠状动脉旁路移植术（CABG）中左乳内动脉（LIMA）移植物形态和内皮功能的影响：方法：53 名接受择期冠状动脉旁路移植术的患者根据采集技术随机分为两组：传统剪切组和非剪切组。组织学分析表明，与对照组相比，未剪切组的动脉扩张程度更大，内皮完整性得到保留：结果：与剪切组相比，未剪切组的动脉扩张程度更大，内皮完整性得到了保护。内皮一氧化氮合酶（eNOS）的免疫染色显示，非夹闭组的表达量明显更高，而 COX-2 的染色显示，非夹闭组的表达量更少，这表明内皮功能得到了更好的保护：这些研究结果表明，在采集 LIMA 时保持灌注可改善内皮功能，并有可能提高移植物的长期通畅性。有必要进一步研究以验证这些结果，并优化 CABG 手术的采集技术。

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Unlocking vascular vitality: Exploring the impact of LIMA harvesting technique on endothelial health

Background

This study investigates the impact of different harvesting techniques on the morphology and endothelial function of the left internal mammary artery (LIMA) grafts in coronary artery bypass grafting (CABG).

Methods

Fifty-three patients undergoing elective CABG were randomly assigned to two groups based on the harvesting technique: traditional clipping and nonclipping. Histological analyses revealed that arteries in the nonclipped group exhibited greater dilation and preserved endothelial integrity compared to the control group.

Results

The nonclipped group exhibited greater arterial dilation and preserved endothelial integrity compared to the clipped group. Immunostaining for endothelial nitric oxide synthase (eNOS) showed significantly higher expression in the nonclipped group, conversly COX-2 staining showed fewer expression in the nonclipped group indicating better endothelial function preservation.

Conclusion

These findings suggest that maintaining perfusion during LIMA harvesting may improve endothelial function and potentially enhance graft patency in the long term. Further research is warranted to validate these results and optimize harvesting techniques for CABG procedures.

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来源期刊

Cardiovascular Pathology 医学-病理学

CiteScore

7.50

自引率

2.70%

发文量

审稿时长

18 days

期刊介绍： Cardiovascular Pathology is a bimonthly journal that presents articles on topics covering the entire spectrum of cardiovascular disease. The Journal''s primary objective is to publish papers on disease-oriented morphology and pathogenesis from clinicians and scientists in the cardiovascular field. Subjects covered include cardiovascular biology, prosthetic devices, molecular biology and experimental models of cardiovascular disease.