Cardiovascular Pathology最新文献_第5页

Ruptured pulmonary artery aneurysm with prior dissection and persistent ductus arteriosus: Autopsy case report 肺动脉动脉瘤破裂并伴有动脉夹层和持续性动脉导管未闭：尸检病例报告。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-08-10 DOI: 10.1016/j.carpath.2024.107684

Patcharanun Chulamanee , Pornpatsorn Siriwattanaskul , Vijarn Vachirawongsakorn , Sakda Sathirareuangchai

引用次数: 0

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-08-05 DOI: 10.1016/j.carpath.2024.107683

Ashot Avagimyan , Nana Pogosova , Lev Kakturskiy , Mohammad Sheibani , Abhiram Challa , Eugenia Kogan , Federica Fogacci , Liudmila Mikhaleva , Rositsa Vandysheva , Marianna Yakubovskaya , Andrea Faggiano , Stefano Carugo , Olga Urazova , Behnaz Jahanbin , Ekaterina Lesovaya , Srujana Polana , Kirill Kirsanov , Yasar Sattar , Artem Trofimenko , Tatiana Demura , Nizal Sarrafzadegan

{"title":"Doxorubicin-related cardiotoxicity: review of fundamental pathways of cardiovascular system injury","authors":"Ashot Avagimyan , Nana Pogosova , Lev Kakturskiy , Mohammad Sheibani , Abhiram Challa , Eugenia Kogan , Federica Fogacci , Liudmila Mikhaleva , Rositsa Vandysheva , Marianna Yakubovskaya , Andrea Faggiano , Stefano Carugo , Olga Urazova , Behnaz Jahanbin , Ekaterina Lesovaya , Srujana Polana , Kirill Kirsanov , Yasar Sattar , Artem Trofimenko , Tatiana Demura , Nizal Sarrafzadegan","doi":"10.1016/j.carpath.2024.107683","DOIUrl":"10.1016/j.carpath.2024.107683","url":null,"abstract":"<div><p>Over the years, advancements in the field of oncology have made remarkable strides in enhancing the efficacy of medical care for patients with cancer. These modernizations have resulted in prolonged survival and improved the quality of life for these patients. However, this progress has also been accompanied by escalation in mortality rates associated with anthracycline chemotherapy.</p><p>Anthracyclines, which are known for their potent antitumor properties, are notorious for their substantial cardiotoxic potential. Remarkably, even after 6 decades of research, a conclusive solution to protect the cardiovascular system against doxorubicin-induced damage has not yet been established. A comprehensive understanding of the pathophysiological processes driving cardiotoxicity combined with targeted research is crucial for developing innovative cardioprotective strategies.</p><p>This review seeks to explain the mechanisms responsible for structural and functional alterations in doxorubicin-induced cardiomyopathy.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"73 ","pages":"Article 107683"},"PeriodicalIF":2.3,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVER 4: Table of Contents/Barcode PMS 200 封面 4：目录/条形码 PMS 200

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-08-05 DOI: 10.1016/S1054-8807(24)00077-2

引用次数: 0

COVER 3: Editorial Board 封面 3：编辑委员会

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-08-05 DOI: 10.1016/S1054-8807(24)00076-0

引用次数: 0

The uncertain nature of myocarditis classification and the challenging case of eosinophilic myocarditis leading to heart failure and transplantation 心肌炎分类的不确定性以及嗜酸性粒细胞性心肌炎导致心力衰竭和移植的挑战性病例。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-07-27 DOI: 10.1016/j.carpath.2024.107682

Nicholas G. Kounis , Virginia Mplani

引用次数: 0

Decreased smooth muscle cells and fibrous thickening of the tunica media in peripheral pulmonary artery stenosis in Alagille syndrome 阿拉吉尔综合征外周肺动脉狭窄的平滑肌细胞减少和中膜纤维增厚。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-07-26 DOI: 10.1016/j.carpath.2024.107677

Yosuke Ogawa , Amane Yamamoto , Sho Yamazawa , Masako Ikemura , Yasutaka Hirata , Ryo Inuzuka

{"title":"Decreased smooth muscle cells and fibrous thickening of the tunica media in peripheral pulmonary artery stenosis in Alagille syndrome","authors":"Yosuke Ogawa , Amane Yamamoto , Sho Yamazawa , Masako Ikemura , Yasutaka Hirata , Ryo Inuzuka","doi":"10.1016/j.carpath.2024.107677","DOIUrl":"10.1016/j.carpath.2024.107677","url":null,"abstract":"<div><p>Alagille syndrome is caused by mutations in genes involved in NOTCH signaling, specifically <em>JAG1</em> and <em>NOTCH2</em>, and is associated with a high rate of peripheral pulmonary artery stenosis. In this study, we report the case of an infant with Alagille syndrome caused by a <em>JAG1</em> mutation, who succumbed to acute exacerbation of right heart failure due to severe peripheral pulmonary artery stenosis. The autopsy revealed that the peripheral pulmonary arteries were significantly stenosed, exhibiting hypoplasia and thickened vessel walls. Histological examination of the pulmonary artery walls showed a decrease in smooth muscle cells in the tunica media and an increase in collagen and elastic fibers, although the intrapulmonary arteries were intact. These findings are important for understanding the pathogenesis of Alagille syndrome and developing treatment strategies for peripheral pulmonary artery stenosis.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"74 ","pages":"Article 107677"},"PeriodicalIF":2.3,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1054880724000735/pdfft?md5=6579b1f1ca3fc6fcdababe0d7ce5ab6c&pid=1-s2.0-S1054880724000735-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dilated cardiomyopathy due to a novel combination of TTN and BAG3 genetic variants: From acute heart failure to subclinical phenotypes 由 TTN 和 BAG3 基因变异新组合引起的扩张型心肌病：从急性心力衰竭到亚临床表型。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-07-25 DOI: 10.1016/j.carpath.2024.107675

Irene Bottillo , Carla Giordano , Maria Pia Ciccone , Maria Gemma Pignataro , Fiammetta Albi , Gabriella Parisi , Daniela Formicola , Simona Grotta , Federico Ranocchi , Maria Valeria Giuli , Saula Checquolo , Laura Masuelli , Federica Re , Silvia Majore , Giulia d'Amati , Paola Grammatico

{"title":"Dilated cardiomyopathy due to a novel combination of TTN and BAG3 genetic variants: From acute heart failure to subclinical phenotypes","authors":"Irene Bottillo , Carla Giordano , Maria Pia Ciccone , Maria Gemma Pignataro , Fiammetta Albi , Gabriella Parisi , Daniela Formicola , Simona Grotta , Federico Ranocchi , Maria Valeria Giuli , Saula Checquolo , Laura Masuelli , Federica Re , Silvia Majore , Giulia d'Amati , Paola Grammatico","doi":"10.1016/j.carpath.2024.107675","DOIUrl":"10.1016/j.carpath.2024.107675","url":null,"abstract":"<div><p>Dilated cardiomyopathy (DCM) is defined as left ventricular enlargement accompanied by systolic dysfunction not explained by abnormal loading conditions or coronary heart disease. The DCM clinical <em>spectrum</em> is broad, ranging from subclinical to severe presentation with progression to end stage heart failure. To date, different genetic <em>loci</em> have been found to have moderate/definitive evidence for causality in DCM and pathogenic variants in the <em>TTN</em> gene represent the main genetic determinant.</p><p>Here, we describe a family in which the co-occurrence of two genetic hits, one in the <em>TTN</em> and one in the <em>BAG3</em> gene, was associated with heterogeneous clinical presentation ranging from subclinical phenotypes to acute cardiogenic shock mimicking fulminant myocarditis. We hypothesize that at least some specific <em>BAG3</em> genotypes could be related to DCM presenting with acute heart failure and suggest that patients and relatives carrying <em>BAG3</em> pathogenic variants should be addressed to a tertiary-level heart care center.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"73 ","pages":"Article 107675"},"PeriodicalIF":2.3,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1054880724000711/pdfft?md5=36798fb256d6e87a6374f45ee082b089&pid=1-s2.0-S1054880724000711-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141765549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Right atrial cardiac myxoma with malignant transformation to undifferentiated sarcoma: A case report 右心房心脏肌瘤恶变为未分化肉瘤：病例报告。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-07-23 DOI: 10.1016/j.carpath.2024.107676

Ryo Kaimori , Haruto Nishida , Yuzo Oyama , Takahiro Kusaba , Kazuhiro Kawamura , Tsutomu Daa

{"title":"Right atrial cardiac myxoma with malignant transformation to undifferentiated sarcoma: A case report","authors":"Ryo Kaimori , Haruto Nishida , Yuzo Oyama , Takahiro Kusaba , Kazuhiro Kawamura , Tsutomu Daa","doi":"10.1016/j.carpath.2024.107676","DOIUrl":"10.1016/j.carpath.2024.107676","url":null,"abstract":"<div><p>Generally, sarcomas arising from benign soft tissue are rare. Cardiac myxoma (CM) is a benign tumor, and few reports have described its malignant transformation. Herein, we documented a case of an 89-year-old man with prostate cancer and a 5-year history of a right atrium tumor without Carney complex. The tumor was resected surgically and had a myxomatous or gelatinous appearance. Microscopically, the tumor had two components: a sarcomatous area and myxomatous area. In the myxomatous area, typical myxoma cells were demonstrable and were strongly immunoreactive for immunohistochemistry (IHC) of calretinin. In the sarcomatous area, the epithelioid- to spindle-shaped cells with prominent atypia proliferated densely. The IHC profile of cells in the sarcomatous area was different from that of cells in the myxomatous area; MDM2-positive cells were found only in the sarcomatous area. Especially, the Ki-67 index and number of p53-positive cells in the sarcomatous area were higher than those in the myxomatous area. The transition of the two components was seamless. Thus, we made a diagnosis of CM with malignant transformation corresponding to undifferentiated pleomorphic sarcomas. This case suggests that CM may transform into sarcoma, albeit rarely.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"73 ","pages":"Article 107676"},"PeriodicalIF":2.3,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Descriptive study of the clinical and myocardial status of a population with anatomopathological aortic valve amyloidosis 解剖病理学主动脉瓣淀粉样变性人群临床和心肌状况的描述性研究。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-07-16 DOI: 10.1016/j.carpath.2024.107674

Jean-Baptiste Brette , Magali Colombat , Pauline Fournier , Maxime Moninhas , Bertrand Marcheix , Olivier Lairez , Eve Cariou

{"title":"Descriptive study of the clinical and myocardial status of a population with anatomopathological aortic valve amyloidosis","authors":"Jean-Baptiste Brette , Magali Colombat , Pauline Fournier , Maxime Moninhas , Bertrand Marcheix , Olivier Lairez , Eve Cariou","doi":"10.1016/j.carpath.2024.107674","DOIUrl":"10.1016/j.carpath.2024.107674","url":null,"abstract":"<div><h3>Background</h3><p>Aortic stenosis (AS) and transthyretin (ATTR) cardiac amyloidosis (CA) share the same clinical profiles and cardiac phenotype. Amyloid deposits have been frequently reported in aortic valves of patients with severe AS referred for surgical aortic valve replacement (SAVR). The aim of this study was to determine the clinical and myocardial status of patients with aortic valve amyloidosis after aortic valve surgery.</p></div><div><h3>Methods and results</h3><p>We performed a retrospective descriptive study of 46 patients who underwent SAVR for severe AS with amyloid deposits upon histological analysis. All patients were screened for cardiac involvement. Amyloid deposits typing was successful in 35 (76%) patients and 28 (80%) were ATTR. Two (4%) had positive bone scintigraphy and among the 5 myocardial biopsies performed during surgery, 80% were positive for ATTR deposits.</p></div><div><h3>Conclusion</h3><p>ATTR is the predominant type in the presence of amyloid deposits on the aortic valve after surgery for severe AS but is only rarely accompanied by cardiac uptake on bone scintigraphy. Early stages of myocardial involvement are frequent and myocardial biopsy is more sensitive for detection of mild amyloid deposits than bone scintigraphy</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"73 ","pages":"Article 107674"},"PeriodicalIF":2.3,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S105488072400070X/pdfft?md5=e9397ff43cb58c34cc73809d62be0ecb&pid=1-s2.0-S105488072400070X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141723120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current concepts in the epigenetic regulation of cardiac fibrosis 心脏纤维化表观遗传调控的当前概念。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-07-10 DOI: 10.1016/j.carpath.2024.107673

{"title":"Current concepts in the epigenetic regulation of cardiac fibrosis","authors":"","doi":"10.1016/j.carpath.2024.107673","DOIUrl":"10.1016/j.carpath.2024.107673","url":null,"abstract":"<div><p>Cardiac fibrosis is a significant driver of congestive heart failure, a syndrome that continues to affect a growing patient population globally. Cardiac fibrosis results from a constellation of complex processes at the transcription, receptor, and signaling axes levels. Various mediators and signaling cascades, such as the transformation growth factor-beta pathway, have been implicated in the pathophysiology of cardiac tissue fibrosis. Our understanding of these markers and pathways has improved in recent years as more advanced technologies and assays have been developed, allowing for better delineation of the crosstalk between specific factors. There is mounting evidence suggesting that epigenetic modulation plays a pivotal role in the progression of cardiac fibrosis. Transcriptional regulation of key pro- and antifibrotic pathways can accentuate or blunt the rate and extent of fibrosis at the tissue level. Exosomes, micro-RNAs, and long noncoding RNAs all belong to factors that can impact the epigenetic signature in cardiac fibrosis. Herein, we comprehensively review the latest literature about exosomes, their contents, and cardiac fibrosis. In doing so, we highlight the specific transcriptional factors with pro- or antifibrotic properties. We also assimilate the data supporting these mediators' potential utility as diagnostic or prognostic biomarkers. Finally, we offer insight into where further work can be done to fill existing gaps to translate preclinical findings better and improve clinical outcomes.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"73 ","pages":"Article 107673"},"PeriodicalIF":2.3,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1054880724000693/pdfft?md5=360e02ff4c582ed754af921caf42764d&pid=1-s2.0-S1054880724000693-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141598536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0