Cardiovascular Pathology最新文献

{"title":"BAG3 in cardiovascular diseases","authors":"Nicola De Maio , Margot De Marco","doi":"10.1016/j.carpath.2024.107687","DOIUrl":"10.1016/j.carpath.2024.107687","url":null,"abstract":"","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"74 ","pages":"Article 107687"},"PeriodicalIF":2.3,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute pericardial postischemic inflammatory responses: Characterization using a preclinical porcine model","authors":"Ali Fatehi Hassanabad ,&nbsp;Jeannine Turnbull ,&nbsp;Cheryl Hall ,&nbsp;Friederike I. Schoettler ,&nbsp;Mortaza Fatehi Hassanabad ,&nbsp;Eleanor Love ,&nbsp;Emilie de Chantal ,&nbsp;Jameson A. Dundas ,&nbsp;Carmina A. Isidoro ,&nbsp;Sun Kim ,&nbsp;Rosalie Morrish ,&nbsp;Barb McLellan ,&nbsp;Anna N. Zarzycki ,&nbsp;Guoqi Teng ,&nbsp;Darrell D. Belke ,&nbsp;Bryan Har ,&nbsp;Paul W.M. Fedak ,&nbsp;Justin F. Deniset","doi":"10.1016/j.carpath.2024.107686","DOIUrl":"10.1016/j.carpath.2024.107686","url":null,"abstract":"<div><h3>Background</h3><p>Pericardial fluid (PF) contains cells, proteins, and inflammatory mediators, such as cytokines, chemokines, growth factors, and matrix metalloproteinases. To date, we lack an adequate understanding of the inflammatory response that acute injury elicits in the pericardial space.</p></div><div><h3>Objective</h3><p>To characterize the inflammatory profile in the pericardial space acutely after ischemia/reperfusion.</p></div><div><h3>Methods</h3><p>Pigs were used to establish a percutaneous ischemia/reperfusion injury model. PF was removed from pigs at different time points postanesthesia or postischemia/reperfusion. Flow cytometry was used to characterize the immune cell composition of PF, while multiplex analysis was performed on the acellular portion of PF to determine the concentration of inflammatory mediators. There was a minimum of 3 pigs per group.</p></div><div><h3>Results</h3><p>While native PF mainly comprises macrophages, we show that neutrophils are the predominant inflammatory cell type in the pericardial space after injury. The combination of acute ischemia/reperfusion (IR) and repeatedly accessing the pericardial space significantly increases the concentration of interleukin-1 beta (IL-1β) and interleukin-1 receptor antagonist (IL-1ra). IR significantly increases the pericardial concentration of TGFβ1 but not TGFβ2. We observed that repeated manipulation of the pericardial space can also drive a robust pro-inflammatory response, resulting in a significant increase in immune cells and the accumulation of potent inflammatory mediators in the pericardial space.</p></div><div><h3>Conclusion</h3><p>In the present study, we show that both IR and surgical manipulation can drive robust inflammatory processes in the pericardial space, consisting of an increase in inflammatory cytokines and alteration in the number and composition of immune cells.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"73 ","pages":"Article 107686"},"PeriodicalIF":2.3,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1054880724000826/pdfft?md5=2e63ee4dedad7d40c1c66d153a3fdba5&pid=1-s2.0-S1054880724000826-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous leiomyomatosis in the inferior vena cava and right atrium with pulmonary benign metastasizing leiomyoma secondary to a pelvic arteriovenous fistula: A case report and literature review","authors":"Tingting Zheng ,&nbsp;Chunyan Huang ,&nbsp;Qin Xia ,&nbsp;Wencong He ,&nbsp;Yufei Liu ,&nbsp;Hong Ye","doi":"10.1016/j.carpath.2024.107685","DOIUrl":"10.1016/j.carpath.2024.107685","url":null,"abstract":"<div><h3>Background</h3><p>To report the diagnosis and treatment of a rare disease of intravenous leiomyomatosis (IVL) originating from the uterus, growing in the inferior vena cava (IVC) and extending into the right atrium (RA) associated with a pelvic arteriovenous fistula (AVF). This is the first reported case of IVL in the IVC and RA with pulmonary benign metastasizing leiomyoma (PBML) secondary to a pelvic AVF despite the use of GnRH agonists in a nonmenopausal woman.</p></div><div><h3>Case presentation</h3><p>The patient was a 50-year-old premenopausal woman with a history of surgical resection for and antiestrogen conservative drug for pulmonary benign metastasizing leiomyoma (PBML) 5 years. The patient nevertheless developed IVL in the IVC, internal iliac vein and RA accompanied by AVF. Vaginal ultrasound combined with echocardiography and computerized tomographic venography imaging assists in the diagnosis of IVL combined with AVF, with histopathology and immunohistochemistry ultimately confirming the diagnosis. The patient ultimately was performed with a combination of hysterectomy, bilateral adnexectomy, and resection of tumors in the IVC and RA without cardiopulmonary bypass and sternotomy.</p></div><div><h3>Conclusion</h3><p>BML may be difficult to control with incomplete removal of the uterus and ovaries even with the use of antiestrogenic medications, and medically induced AVF resulting from fibroid surgery may accelerate this process and the development of IVL.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"73 ","pages":"Article 107685"},"PeriodicalIF":2.3,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141981698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ruptured pulmonary artery aneurysm with prior dissection and persistent ductus arteriosus: Autopsy case report","authors":"Patcharanun Chulamanee ,&nbsp;Pornpatsorn Siriwattanaskul ,&nbsp;Vijarn Vachirawongsakorn ,&nbsp;Sakda Sathirareuangchai","doi":"10.1016/j.carpath.2024.107684","DOIUrl":"10.1016/j.carpath.2024.107684","url":null,"abstract":"<div><p>Cardiac tamponade from ruptured intrathoracic organs can lead to sudden cardiac death. In rare circumstances, the pulmonary artery can be the source of hemopericardium. We describe a case of a 62-year-old woman with no significant past medical history, who presented with sudden unexpected death. A forensic autopsy revealed 500 ml of hemopericardium. Further dissection demonstrated a saccular aneurysm in the pulmonary artery trunk, along with the evidence of prior dissection, i.e., neointimal layer. Persistent ductus arteriosus (PDA) was also present. Pulmonary artery aneurysms (PAA) are rare and often associated with congenital heart disease (CHD). PDA is the most common CHD related to PAA. Secondary pulmonary hypertension makes the pulmonary artery vulnerable to medial degeneration and increases the risk of dissection and rupture. Careful inspection of the great vessels and congenital anomalies are essential in the forensic autopsies for sudden death investigation.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"73 ","pages":"Article 107684"},"PeriodicalIF":2.3,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doxorubicin-related cardiotoxicity: review of fundamental pathways of cardiovascular system injury","authors":"Ashot Avagimyan ,&nbsp;Nana Pogosova ,&nbsp;Lev Kakturskiy ,&nbsp;Mohammad Sheibani ,&nbsp;Abhiram Challa ,&nbsp;Eugenia Kogan ,&nbsp;Federica Fogacci ,&nbsp;Liudmila Mikhaleva ,&nbsp;Rositsa Vandysheva ,&nbsp;Marianna Yakubovskaya ,&nbsp;Andrea Faggiano ,&nbsp;Stefano Carugo ,&nbsp;Olga Urazova ,&nbsp;Behnaz Jahanbin ,&nbsp;Ekaterina Lesovaya ,&nbsp;Srujana Polana ,&nbsp;Kirill Kirsanov ,&nbsp;Yasar Sattar ,&nbsp;Artem Trofimenko ,&nbsp;Tatiana Demura ,&nbsp;Nizal Sarrafzadegan","doi":"10.1016/j.carpath.2024.107683","DOIUrl":"10.1016/j.carpath.2024.107683","url":null,"abstract":"<div><p>Over the years, advancements in the field of oncology have made remarkable strides in enhancing the efficacy of medical care for patients with cancer. These modernizations have resulted in prolonged survival and improved the quality of life for these patients. However, this progress has also been accompanied by escalation in mortality rates associated with anthracycline chemotherapy.</p><p>Anthracyclines, which are known for their potent antitumor properties, are notorious for their substantial cardiotoxic potential. Remarkably, even after 6 decades of research, a conclusive solution to protect the cardiovascular system against doxorubicin-induced damage has not yet been established. A comprehensive understanding of the pathophysiological processes driving cardiotoxicity combined with targeted research is crucial for developing innovative cardioprotective strategies.</p><p>This review seeks to explain the mechanisms responsible for structural and functional alterations in doxorubicin-induced cardiomyopathy.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"73 ","pages":"Article 107683"},"PeriodicalIF":2.3,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVER 4: Table of Contents/Barcode PMS 200","authors":"","doi":"10.1016/S1054-8807(24)00077-2","DOIUrl":"10.1016/S1054-8807(24)00077-2","url":null,"abstract":"","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"72 ","pages":"Article 107681"},"PeriodicalIF":2.3,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1054880724000772/pdfft?md5=499f1371f7f22e8a777133cdc7b0981a&pid=1-s2.0-S1054880724000772-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141960216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVER 3: Editorial Board","authors":"","doi":"10.1016/S1054-8807(24)00076-0","DOIUrl":"10.1016/S1054-8807(24)00076-0","url":null,"abstract":"","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"72 ","pages":"Article 107680"},"PeriodicalIF":2.3,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1054880724000760/pdfft?md5=64fc02b4068be73b36066013c0e0a722&pid=1-s2.0-S1054880724000760-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141952189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The uncertain nature of myocarditis classification and the challenging case of eosinophilic myocarditis leading to heart failure and transplantation","authors":"Nicholas G. Kounis ,&nbsp;Virginia Mplani","doi":"10.1016/j.carpath.2024.107682","DOIUrl":"10.1016/j.carpath.2024.107682","url":null,"abstract":"","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"73 ","pages":"Article 107682"},"PeriodicalIF":2.3,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased smooth muscle cells and fibrous thickening of the tunica media in peripheral pulmonary artery stenosis in Alagille syndrome","authors":"Yosuke Ogawa ,&nbsp;Amane Yamamoto ,&nbsp;Sho Yamazawa ,&nbsp;Masako Ikemura ,&nbsp;Yasutaka Hirata ,&nbsp;Ryo Inuzuka","doi":"10.1016/j.carpath.2024.107677","DOIUrl":"10.1016/j.carpath.2024.107677","url":null,"abstract":"<div><p>Alagille syndrome is caused by mutations in genes involved in NOTCH signaling, specifically <em>JAG1</em> and <em>NOTCH2</em>, and is associated with a high rate of peripheral pulmonary artery stenosis. In this study, we report the case of an infant with Alagille syndrome caused by a <em>JAG1</em> mutation, who succumbed to acute exacerbation of right heart failure due to severe peripheral pulmonary artery stenosis. The autopsy revealed that the peripheral pulmonary arteries were significantly stenosed, exhibiting hypoplasia and thickened vessel walls. Histological examination of the pulmonary artery walls showed a decrease in smooth muscle cells in the tunica media and an increase in collagen and elastic fibers, although the intrapulmonary arteries were intact. These findings are important for understanding the pathogenesis of Alagille syndrome and developing treatment strategies for peripheral pulmonary artery stenosis.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"74 ","pages":"Article 107677"},"PeriodicalIF":2.3,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1054880724000735/pdfft?md5=6579b1f1ca3fc6fcdababe0d7ce5ab6c&pid=1-s2.0-S1054880724000735-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dilated cardiomyopathy due to a novel combination of TTN and BAG3 genetic variants: From acute heart failure to subclinical phenotypes","authors":"Irene Bottillo ,&nbsp;Carla Giordano ,&nbsp;Maria Pia Ciccone ,&nbsp;Maria Gemma Pignataro ,&nbsp;Fiammetta Albi ,&nbsp;Gabriella Parisi ,&nbsp;Daniela Formicola ,&nbsp;Simona Grotta ,&nbsp;Federico Ranocchi ,&nbsp;Maria Valeria Giuli ,&nbsp;Saula Checquolo ,&nbsp;Laura Masuelli ,&nbsp;Federica Re ,&nbsp;Silvia Majore ,&nbsp;Giulia d'Amati ,&nbsp;Paola Grammatico","doi":"10.1016/j.carpath.2024.107675","DOIUrl":"10.1016/j.carpath.2024.107675","url":null,"abstract":"<div><p>Dilated cardiomyopathy (DCM) is defined as left ventricular enlargement accompanied by systolic dysfunction not explained by abnormal loading conditions or coronary heart disease. The DCM clinical <em>spectrum</em> is broad, ranging from subclinical to severe presentation with progression to end stage heart failure. To date, different genetic <em>loci</em> have been found to have moderate/definitive evidence for causality in DCM and pathogenic variants in the <em>TTN</em> gene represent the main genetic determinant.</p><p>Here, we describe a family in which the co-occurrence of two genetic hits, one in the <em>TTN</em> and one in the <em>BAG3</em> gene, was associated with heterogeneous clinical presentation ranging from subclinical phenotypes to acute cardiogenic shock mimicking fulminant myocarditis. We hypothesize that at least some specific <em>BAG3</em> genotypes could be related to DCM presenting with acute heart failure and suggest that patients and relatives carrying <em>BAG3</em> pathogenic variants should be addressed to a tertiary-level heart care center.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"73 ","pages":"Article 107675"},"PeriodicalIF":2.3,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1054880724000711/pdfft?md5=36798fb256d6e87a6374f45ee082b089&pid=1-s2.0-S1054880724000711-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141765549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}