Vaclav Stejskal , Katerina Vejvalkova , Monika Manethova , Alexander Hudak , Igor Gunka
{"title":"Fibromuscular dysplasia of subclavian artery: A case report and mini-review","authors":"Vaclav Stejskal , Katerina Vejvalkova , Monika Manethova , Alexander Hudak , Igor Gunka","doi":"10.1016/j.carpath.2024.107628","DOIUrl":"10.1016/j.carpath.2024.107628","url":null,"abstract":"<div><p>A case of a 40-year-old male patient with a right subclavian artery aneurysm of fibromuscular dysplasia origin is reported. The patient presented with thoracic outlet-like symptoms and underwent aneurysm resection. Microscopic examination revealed intimal and medial fibroplasia. Additional cases of fibromuscular dysplasia at this rare location are reviewed, indicating a male and right-sided predominance. The most frequent clinicopathological manifestation was an aneurysm, with the histopathological pattern characterized by medial fibroplasia. Treatment modalities included the use of either graft prosthesis or end-to-end anastomosis.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"71 ","pages":"Article 107628"},"PeriodicalIF":3.7,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140058685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multisystem Erdheim-Chester disease presenting with pericardial effusion confirmed by the effusion cytology specimen","authors":"Shishuo Dai , Xueying Su , Wei-ping Liu , Yu Wu","doi":"10.1016/j.carpath.2024.107625","DOIUrl":"10.1016/j.carpath.2024.107625","url":null,"abstract":"<div><p>Erdheim-Chester disease (ECD) is a rare histiocytosis characterized by the foamy CD68+CD1a- histiocytes infiltrating multiple organs and tissues. ECD might be asymptomatic or present with variable manifestations. The diagnosis of ECD requires characteristic radiological findings and pathological features. Herein, we described a 52-year-old female patient who was admitted to our hospital for recurrent pericardial effusion for two months. She has a medical history of papillary thyroid carcinoma (PTC) and underwent a total thyroidectomy two years before admission. The radiological findings suggested a potential diagnosis of ECD. Cytological analysis of the effusion cytology specimen revealed CD68+CD1a<sup>−</sup> histiocytes, confirming the ECD diagnosis. The BRAF V600E mutation was identified in the histiocytes, prompting the administration of vemurafenib, a BRAF inhibitor. After two months of standard-dose vemurafenib treatment, the disease was well controlled with pericardial effusion regression.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"70 ","pages":"Article 107625"},"PeriodicalIF":3.7,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139989405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transthyretin-derived amyloid (ATTR) and sarcoidosis: Does ATTR deposition cause a granulomatous inflammatory response in older adults with sarcoidosis?","authors":"Shojiro Ichimata , Yukiko Hata , Kazuhiro Nomoto , Naoki Nishida","doi":"10.1016/j.carpath.2024.107624","DOIUrl":"10.1016/j.carpath.2024.107624","url":null,"abstract":"<div><p>This study aimed to assess the frequency and association between transthyretin-derived (ATTR) amyloidosis and sarcoidosis in a large autopsy cohort including many cases of sudden cardiac death (SCD). We identified 73 sporadic ATTR amyloidosis cases and 11 sarcoidosis cases, among which we found two cases with concomitant ATTR amyloidosis and sarcoidosis (2.4% of all cases; 2.7% within the sporadic ATTR group). The first case involved a 92-year-old man who experienced SCD. In this patient's heart, we observed ATTR deposition and noncaseating epithelioid granulomas consistent with sarcoidosis. Focally, ATTR deposits and granulomas co-localized, with histiocyte phagocytosis of transthyretin-immunoreactive fragments. However, in most lesions, they were distributed independently. The second case was that of an 86-year-old woman who also experienced SCD. In this patient, we detected ATTR deposition in the heart and lung, while noncaseating epithelioid granulomas were only observed in the lung, liver, kidney, and thyroid. Furthermore, no co-localization of the two lesions was observed. Based on these findings, we concluded that the coexistence of ATTR amyloidosis and sarcoidosis was likely coincidental. Nevertheless, despite the rarity of the combination of these two diseases, it should be recognized as a potential cause of SCD, especially among elderly people.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"70 ","pages":"Article 107624"},"PeriodicalIF":3.7,"publicationDate":"2024-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139982435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jesús Machuca-Aguado , Rosa Rendón-García , Alessia Miraglia , Juan Carlos Téllez-Cantero , Álvaro Gutiérrez-Domingo
{"title":"Rare primary cardiac myxofibrosarcoma in adolescence: Diagnostic challenges and surgical insights.","authors":"Jesús Machuca-Aguado , Rosa Rendón-García , Alessia Miraglia , Juan Carlos Téllez-Cantero , Álvaro Gutiérrez-Domingo","doi":"10.1016/j.carpath.2024.107623","DOIUrl":"10.1016/j.carpath.2024.107623","url":null,"abstract":"<div><p>This article presents a unique case of primary myxofibrosarcoma, an exceptionally rare cardiac neoplasm, in a 16-year-old girl. With fewer than 40 documented cases, this tumor's occurrence in adolescence is particularly uncommon. The patient presented with right-sided paresthesia and subsequent right hemiparesis and dysarthria, along with bilateral pleural effusion. Imaging tests revealed a cerebral ischemic lesion and the presence of a left atrial mass. Initially suspected as a myxoma, the tumor exhibited significant infiltration. Despite prompt excision and cardiac intervention, the patient experienced rapid decompensation and succumbed to heart failure 2 days later. Histopathological analysis revealed an intermediate grade myxofibrosarcoma. This case underscores the diagnostic complexity, emphasizing the need for early identification given the grim prognosis associated with cardiac myxofibrosarcomas, requiring detailed imaging, surgical, and histopathological insights.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"70 ","pages":"Article 107623"},"PeriodicalIF":3.7,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139905082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
James R. Stone , Vidhya Nair , Gregory A. Fishbein , Society for Cardiovascular Pathology Temporal Artery Biopsy Consensus Committee
{"title":"The minimal criteria for active arteritis in a temporal artery biopsy","authors":"James R. Stone , Vidhya Nair , Gregory A. Fishbein , Society for Cardiovascular Pathology Temporal Artery Biopsy Consensus Committee","doi":"10.1016/j.carpath.2024.107622","DOIUrl":"10.1016/j.carpath.2024.107622","url":null,"abstract":"","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"70 ","pages":"Article 107622"},"PeriodicalIF":3.7,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139746176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dilek Taze , Aruna Chakrabarty , Sarah Mackie , Raashid Luqmani , Maria C. Cid , Ann W. Morgan , Kathryn Griffin , the AHEADgca research group
{"title":"Re: Nair et al. Consensus statement on the processing, interpretation and reporting of temporal artery biopsy for arteritis","authors":"Dilek Taze , Aruna Chakrabarty , Sarah Mackie , Raashid Luqmani , Maria C. Cid , Ann W. Morgan , Kathryn Griffin , the AHEADgca research group","doi":"10.1016/j.carpath.2024.107621","DOIUrl":"10.1016/j.carpath.2024.107621","url":null,"abstract":"","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"70 ","pages":"Article 107621"},"PeriodicalIF":3.7,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139746175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luciano Figueiredo Borges , Rafael Souza Pereira Falcão , Sebastião Roberto Taboga , Paulo Sampaio Gutierrez , Jean-Baptiste Michel
{"title":"Are telocytes related to maintenance of vascular homeostasis in normal and pathological aorta?","authors":"Luciano Figueiredo Borges , Rafael Souza Pereira Falcão , Sebastião Roberto Taboga , Paulo Sampaio Gutierrez , Jean-Baptiste Michel","doi":"10.1016/j.carpath.2024.107617","DOIUrl":"10.1016/j.carpath.2024.107617","url":null,"abstract":"<div><p>The telocyte (TC) is a new interstitial cell type described in a wide variety of organs and loose connective tissues around small vessels, but its presence in large arteries remains unexplored. TCs have small cell bodies and remarkably thin, long, moniliform processes called telopods (Tps). Using transmission electron microscopy and immunofluorescence, we identified TCs in normal human thoracic aortas and in those with aneurysm or acute dissection (TAAD). In normal aortas the TCs were distributed throughout the connective tissue of the adventitial layer, in its innermost portion and at the zone of transition with the medial layer, with their long axes oriented parallel to the external elastic lamellae, forming a three-dimensional network, without prevalence in the media layer. In contrast, TAAD TCs were present in the medial layer and in regions of neovascularization. The most important feature of the adventitia of diseased aortas was the presence of numerous contacts between TCs and stem cells, including vascular progenitor cells. Although the biologically functional correlations need to be elucidated, the morphological observations presented here provide strong evidence of the involvement of TCs in maintaining vascular homeostasis in pathological situations of tissue injury.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"70 ","pages":"Article 107617"},"PeriodicalIF":3.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139661729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Commotio cordis: Another cardiac arrest “sine materia”. The 1707 early report and interpretation by Giovanni Maria Lancis","authors":"Daniela Marrone, Cristina Basso, Gaetano Thiene","doi":"10.1016/j.carpath.2024.107606","DOIUrl":"10.1016/j.carpath.2024.107606","url":null,"abstract":"<div><p>Sudden death by commotio cordis is rare. It is the consequence of a blunt trauma of the chest overlying the heart.</p><p>The mechanism is a cardiac arrest by ventricular fibrillation in the absence of grossly or microscopically apparent myocardial injury. It has been reproduced in animals. The first historical case was reported by Giovanni Maria Lancisi in his book \"De Subitaneis Mortibus'' published in 1707. Sudden death occurred in a man receiving a powerful blow under the xiphoid cartilage. Lancisi advanced the hypothesis of acute heart failure by a diastolic stand still (\"death in diastole'').</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"70 ","pages":"Article 107606"},"PeriodicalIF":3.7,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139517647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}