Cardiovascular Pathology最新文献_第7页

A pathological study on the efficacy of Syk inhibitors in a Candida albicans-induced aortic root vasculitis murine model 关于 Syk 抑制剂在白色念珠菌诱导的小鼠主动脉根部血管炎模型中疗效的病理研究。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-06-11 DOI: 10.1016/j.carpath.2024.107669

Nanae Asakawa , Toshiaki Oharaseki , Yuki Yokouchi , Noriko Miura , Naohito Ohno , Kei Takahashi

{"title":"A pathological study on the efficacy of Syk inhibitors in a Candida albicans-induced aortic root vasculitis murine model","authors":"Nanae Asakawa , Toshiaki Oharaseki , Yuki Yokouchi , Noriko Miura , Naohito Ohno , Kei Takahashi","doi":"10.1016/j.carpath.2024.107669","DOIUrl":"10.1016/j.carpath.2024.107669","url":null,"abstract":"<div><h3>Background</h3><p>The activation of innate immunity may be involved in the development of <em>Candida albicans</em>-induced murine vasculitis, which resembles Kawasaki disease (KD) vasculitis. This study aimed to histologically clarify the time course of the development of vasculitis in this model in detail and to estimate the potential role of spleen tyrosine kinase (Syk) inhibitors in KD vasculitis.</p></div><div><h3>Methods and Results</h3><p>DBA/2 male mice were intraperitoneally injected with a vasculitis-inducing substance and treated with a Syk inhibitor (R788 or GS-9973). Systemic vasculitis, especially in the aortic annulus area, was histologically evaluated. Regarding lesions in the aortic annulus area, some mice in the untreated control group already showed initiation of vasculitis 1 day after the final injection of a vasculitis-inducing substance. The vasculitis expanded over time. Inflammation occurred more frequently at the aortic root than at the coronary artery. The distribution of inflammatory cells was limited to the intima, intima plus adventitia, or all layers. In the Syk inhibitor-treated groups, only one mouse had vasculitis at all observation periods. The severity and area of the vasculitis were reduced by both Syk inhibitors.</p></div><div><h3>Conclusion</h3><p><em>Candida albicans</em>-induced murine vasculitis may occur within 1 day after the injection of a vasculitis-inducing substance. Additionally, Syk inhibitors suppress murine vasculitis.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"72 ","pages":"Article 107669"},"PeriodicalIF":2.3,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A challenging case of eosinophilic myocarditis leading to heart failure and transplantation 嗜酸性粒细胞性心肌炎导致心力衰竭和移植的棘手病例。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-06-11 DOI: 10.1016/j.carpath.2024.107666

Wissam Harmouch , Jared R. Zhang , Joshua M. Peterson , Diana Palacio Uran , Louis Maximilian Buja , Bihong Zhao , Paul J. Boor , Jose Iturrizaga Murrieta , Khaled Chatila , Heather L. Stevenson

{"title":"A challenging case of eosinophilic myocarditis leading to heart failure and transplantation","authors":"Wissam Harmouch , Jared R. Zhang , Joshua M. Peterson , Diana Palacio Uran , Louis Maximilian Buja , Bihong Zhao , Paul J. Boor , Jose Iturrizaga Murrieta , Khaled Chatila , Heather L. Stevenson","doi":"10.1016/j.carpath.2024.107666","DOIUrl":"10.1016/j.carpath.2024.107666","url":null,"abstract":"<div><p>The large spectrum of etiologies, severities, and histologic appearances of eosinophilic myocarditis (EoM) poses challenges to its diagnosis and management. Endomyocardial biopsy is the current gold standard for diagnosis. However, cardiovascular magnetic resonance imaging is becoming more frequently used to diagnose acute myocarditis because of enhanced sensitivity when compared to histopathologic examination, and its less invasive nature. We report a complicated case of EoM in a male in his mid-thirties that led to fulminant cardiogenic shock that required immunosuppressive therapy on day 5 of admission and implantation of a left ventricular assist device (LVAD) on day 30. EoM was diagnosed on histopathologic examination of the resected fragment of the left ventricular myocardium. Nine months after the initial presentation, the patient ultimately required heart transplantation. The explanted heart showed minimal residual interstitial inflammation with evidence of mildly active intimal arteritis and patchy areas of interstitial fibrosis. In this report, we describe our patient's clinical features and correlate them with imaging and histopathologic findings to illustrate the difficulty in diagnosing EoM, particularly in this complicated patient that ultimately required heart transplantation. The diagnosis can be challenging due to the variable histopathologic features, clinical presentation, and utilization of therapeutic medications and devices.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"72 ","pages":"Article 107666"},"PeriodicalIF":2.3,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141316750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular calcification: High incidence sites, distribution, and detection 血管钙化：高发部位、分布和检测。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-06-10 DOI: 10.1016/j.carpath.2024.107667

Zebin Gui , Chen Shao , Yuanzi Zhan , Zhongqun Wang , Lihua Li

{"title":"Vascular calcification: High incidence sites, distribution, and detection","authors":"Zebin Gui , Chen Shao , Yuanzi Zhan , Zhongqun Wang , Lihua Li","doi":"10.1016/j.carpath.2024.107667","DOIUrl":"10.1016/j.carpath.2024.107667","url":null,"abstract":"<div><p>Vascular calcification is an important pathological change in a variety of disease states such as atherosclerosis (AS), diabetes, chronic kidney disease (CKD), hypertension, and is a strong predictor of cardiovascular events. The distribution and location of calcification in different vessels may have different clinical effects and prognosis. Therefore, the study of high-risk sites of vascular calcification will help us to better understand the prevention, diagnosis, and treatment of related diseases, as well as to evaluate the efficacy and prognosis. So far, although there are some studies on the sites with high incidence of vascular calcification, there is a lack of systematic sorting out the distribution and location of vascular calcification in humans. Based on this, relevant databases were searched, literatures were retrieved, analyzed, and summarized, and the locations of high incidence of vascular calcification and their distribution characteristics, the relationship between high incidence of vascular calcification and hemodynamics, and the common detection methods of high incidence of vascular calcification were systematically described, hoping to provide help for clinical and research.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"72 ","pages":"Article 107667"},"PeriodicalIF":2.3,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent cardiac tamponade following coronavirus disease 2019 mRNA vaccination: A case report 2019 年冠状病毒病 mRNA 疫苗接种后复发性心脏填塞：一份病例报告。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-06-10 DOI: 10.1016/j.carpath.2024.107668

引用次数: 0

Clinicopathological features of immunoglobulin G4-related constrictive pericarditis 免疫球蛋白 G4 相关缩窄性心包炎的临床病理特征。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-05-31 DOI: 10.1016/j.carpath.2024.107665

Satomi Kasashima , Yasushi Matsumoto , Atsuhiro Kawashima , Nozomu Kurose , Satoru Ozaki , Hinako Yamamoto , Fuminori Kasashima , Hirofumi Takemura , Hiroko Ikeda

{"title":"Clinicopathological features of immunoglobulin G4-related constrictive pericarditis","authors":"Satomi Kasashima , Yasushi Matsumoto , Atsuhiro Kawashima , Nozomu Kurose , Satoru Ozaki , Hinako Yamamoto , Fuminori Kasashima , Hirofumi Takemura , Hiroko Ikeda","doi":"10.1016/j.carpath.2024.107665","DOIUrl":"10.1016/j.carpath.2024.107665","url":null,"abstract":"<div><h3>Aim</h3><p>Constrictive pericarditis (CP) is characterised by scarring fibrosis and a loss of pericardial elasticity, which causes heart failure. IgG4 (immunoglobulin G4)-related disease (IgG4-RD) is a systemic fibro-inflammatory disease characterised by the infiltration of IgG4-immunopositive plasmacytes and high serum IgG4 levels that frequently shape tumorous lesions. Although pericardial involvement of IgG4-RD is rare, with indications of CP, pericardial effusion and irregular masses, the clinical and pathological features remain unclear. In this study, we examined the relationship between CP and IgG4-RD.</p></div><div><h3>Methods</h3><p>Among 35 thick-walled CP cases (histologically pericardial thickening ≥2 mm), eight cases were aetiology identified. Using the diagnostic criteria for IgG4-RD, 11 cases were classified as IgG4-CP, whereas the remainder were considered true idiopathic CP (16 cases) and the clinical pathological features were evaluated.</p></div><div><h3>Results</h3><p>Compared with the other groups, the IgG4-CP group was more common in men and associated with low-grade fever and massive pericardial effusion with frequent recurrence. Deaths resulting from heart failure occurred in a few cases of the IgG4-CP group, but not in other groups. An increase in C-reactive protein and a high positivity rate of anti-nuclear antibodies frequently occurred in the IgG4-CP group. Histologically, the IgG4-CP group included lymphoid follicle, eosinophil infiltration and few calcifications.</p></div><div><h3>Conclusions</h3><p>Pericardial IgG4-RD occurs not only as nodular lesions, but also as thick-walled CP, and accounts for approximately 40% of thick-walled CP cases of unknown cause. The predominant clinical characteristic was refractory and recurrent pericardial effusion. Recognising IgG4-RD as a cause of CP is important to initiate appropriate therapy.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"72 ","pages":"Article 107665"},"PeriodicalIF":2.3,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary diffuse large B-cell lymphoma of the heart: A rare case of heart failure 心脏原发性弥漫大 B 细胞淋巴瘤--一例罕见的心力衰竭病例。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-05-31 DOI: 10.1016/j.carpath.2024.107664

Mariana Martinho , Liliana Brochado , Bárbara Marques Ferreira , Susana Guimarães , Ana Rita Almeida , Hélder Pereira

{"title":"Primary diffuse large B-cell lymphoma of the heart: A rare case of heart failure","authors":"Mariana Martinho , Liliana Brochado , Bárbara Marques Ferreira , Susana Guimarães , Ana Rita Almeida , Hélder Pereira","doi":"10.1016/j.carpath.2024.107664","DOIUrl":"10.1016/j.carpath.2024.107664","url":null,"abstract":"<div><p>A 65-year-old man with previous history of smoking, controlled HIV infection, treated hepatitis B infection, and type III cryoglobulinemia, was admitted due to right heart failure symptoms and significant weight loss. Despite being haemodynamically stable, he had periods of 1:1 conduction atrial flutter and presented with respiratory alkalosis and metabolic acidosis, as well as acute kidney and hepatic dysfunction, elevated D-dimer and cardiac markers. He underwent imaging with chest computed tomography and echocardiogram that confirmed pulmonary embolism and most notably revealed a significant sized cardiac mass causing almost complete obstruction of the right chambers, with no cleavage plane with the myocardial walls and tricuspid valve. Cardiac magnetic resonance was highly suggestive of malignancy. Cardiac surgery for mass excision and endomyocardial biopsy for diagnosis were considered, but the patient died with obstructive shock unresponsive to medical treatment. The autopsy revealed a primary unspecified diffuse large B-cell lymphoma.</p></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"72 ","pages":"Article 107664"},"PeriodicalIF":2.3,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hamartoma of mature cardiac myocytes presenting as a polypoid epicardial tumor in the interatrial groove and with gene fusions by copy number anomalies of chromosome 7 成熟心肌细胞脂肪瘤（Hamartoma of Mature Cardiac Myocytes），表现为位于心房间沟的多形性心外膜肿瘤，并伴有 7 号染色体拷贝数异常的基因融合。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-05-29 DOI: 10.1016/j.carpath.2024.107660

引用次数: 0

Unusual cardiac aneurysms: a surgical pathology experience 不寻常的心脏动脉瘤：手术病理经验。

IF 2.3 4区医学

Cardiovascular Pathology Pub Date : 2024-05-28 DOI: 10.1016/j.carpath.2024.107662

Pradeep Vaideeswar , Pranita Zare , Pranav Bhatia

引用次数: 0

COVER 3: Editorial Board 封面 3：编辑委员会

IF 3.7 4区医学

Cardiovascular Pathology Pub Date : 2024-05-28 DOI: 10.1016/S1054-8807(24)00054-1

引用次数: 0

COVER 4: Table of Contents/Barcode PMS 200 封面 4：目录/条形码 PMS 200

IF 3.7 4区医学

Cardiovascular Pathology Pub Date : 2024-05-28 DOI: 10.1016/S1054-8807(24)00055-3

引用次数: 0