Cancer reports最新文献

{"title":"In Lower-Grade Gliomas, the SPARC Family Exacerbates Prognosis by Influencing Immunity, Stemness, and Metabolism.","authors":"Qiaoying Peng, Wenxia Zhou, Ying Chen, Yong Cai","doi":"10.1002/cnr2.70307","DOIUrl":"10.1002/cnr2.70307","url":null,"abstract":"<p><strong>Background: </strong>Involvement of the SPARC stromal protein family in crucial biological regulatory mechanisms is well-documented. But understanding the consequences of imbalanced SPARC protein activity in lower-grade glioma (LGG) is still emerging.</p><p><strong>Aims: </strong>Examining the clinical significance of SPARC proteins, researchers employed RNA-seq data from diverse patient groups to gain insight. A novel SPARCScore was developed via LASSO regression analysis, leveraging data from the PanCanAtlas and MEXPRESS to shed light on the molecular mechanisms involved.</p><p><strong>Methods and results: </strong>Our findings indicate that a majority of SPARC family proteins show atypical expression levels, correlating significantly with adverse outcomes in LGG. Our construction of an SPARCscore, indicative of the SPARC family's presence, revealed a direct correlation between a high SPARCscore and worsened tumor prognosis, irrespective of radiotherapy or chemotherapy treatments. The SPARCScore risk groups showed distinct drivers: PIK3CA predominantly influenced the low-risk category, whereas EGFR was a key factor in the high-risk group. High SPARCScore tumors exhibited a mutation profile similar to glioblastoma, marked by reduced methylation and diverse glioma stem cells (GSC). Conversely, the low SPARCScore tumors were characterized by increased methylation and limited GSC variety. Furthermore, the high-SPARCScore group was notable for its pronounced inflammatory and extracellular matrix signatures, along with activated metabolic pathways. These patterns were closely linked to prognosis.</p><p><strong>Conclusion: </strong>In essence, this research highlights the significance of SPARC proteins in LGG, offering insights into promising avenues for targeted therapy.</p>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 8","pages":"e70307"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12334845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of Survival Prediction Models for Patients With Pineoblastomas Using Deep Learning: A SEER-Based Study.","authors":"Xuanzi Li, Shuai Yang, Yingpeng Peng, Xueqiang You, Shunli Peng, Siyang Wang, Dasong Zha, Shuyuan Zhang, Chuntao Deng","doi":"10.1002/cnr2.70303","DOIUrl":"10.1002/cnr2.70303","url":null,"abstract":"<p><strong>Purpose: </strong>Pineoblastomas (PBs) are rare central nervous system tumors primarily affecting children and adolescents, with limited data on clinical characteristics and survival outcomes. Prognosis prediction models for this disease are lacking. The purpose of this study was to develop deep learning (DL) models for predicting 3-year survival in patients with pineoblastoma.</p><p><strong>Methods: </strong>Patients with pineoblastomas of all ages were identified from the Surveillance, Epidemiology, and End Results (SEER) database (1975-2019). Deep neural networks (DNN) were trained and tested at a ratio of 7:3 in a 5-fold cross-validated fashion. Multivariate CPH models were constructed for comparison. The primary outcomes were 3-year overall survival (OS) and disease-specific survival (DSS). All the variables were included in the analysis. Receiver operating characteristic (ROC) curve analysis and calibration plots were used to evaluate the model performance.</p><p><strong>Results: </strong>A total of 145 patients were included in this study. The area under the curve (AUC) for the DNN models was 0.92, 0.91, and 0.749 for OS and 0.76 for DSS. The DNN models exhibited good calibration: the OS model (slope = 0.94, intercept = 0.07) and DSS model (slope = 0.81, intercept = 0.20).</p><p><strong>Conclusion: </strong>Our DNN models showed a more accurate prediction of survival outcomes in patients with pineoblastoma than the widely used CPH models. These results indicate the potential of DL algorithms to improve outcome prediction in patients with rare tumors.</p>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 8","pages":"e70303"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polish Society's Perspective on the Challenges Related to Childhood Cancer: Analysis of Public Opinion Research in Poland.","authors":"J Pruban, K Maleszewska, J Antoniuk-Majchrzak, M Wujec, M Czerwińska, P Jurowczyk, Ł Zieliński, A Raciborska","doi":"10.1002/cnr2.70297","DOIUrl":"10.1002/cnr2.70297","url":null,"abstract":"<p><strong>Background: </strong>Treatment of children diagnosed with cancer requires coordinated, multimodal therapy that is often resource intensive and can occur over several years. In addition to physical suffering, children diagnosed with cancer experience an emotional burden that also impacts their families and communities. To best support these children and their families, we must understand society's perspective and assess its readiness to take action to improve the situation of children affected by cancer.</p><p><strong>Aims: </strong>The aim of this study was to solicit the attitudes of the Polish community towards childhood cancer. Gaining an understanding of the Polish public's awareness and knowledge regarding childhood cancer will highlight areas for future exploration and education to improve childhood cancer outcomes.</p><p><strong>Methods and results: </strong>This study was conducted in December 2023, as a component of a collaborative research effort (Institute of Mother and Child, SYNO and ABR SESTA). The Computer-Assisted Web Interview via website research technique was used; 1002 respondents from Poland participated, maintaining the structure of Poles according to gender, age, and size of place of residence. Pediatric cancer is an important topic that concerns everyone-young people, as parents or future parents, or older people, as grandparents who often take care of children. Therefore, everyone should have elementary knowledge on this subject. This is admitted by the respondents themselves, with 65% of the total declaring that they would like to know more about childhood cancer. This is emphasized even more by parents-72%. More than half of respondents believe that the availability and quantity of materials on this topic are insufficient, and only 34% admit that in Poland there is talk about childhood cancer. Respondents agree on increasing the coverage of the topic in the media (72%).</p><p><strong>Conclusions: </strong>The perspective of Polish society, faced with the challenges related to childhood cancer, seems to be focused on the need to increase awareness, support families, access to high-quality health care, and promote activities aimed at improving the situation of children with cancer. The analysis of the study determines the need to expand the knowledge of Polish society about childhood cancer.</p>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 8","pages":"e70297"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Skin Cancers Associated With Hydroxyurea: Case Report and Review of Literature.","authors":"Safoura Shakoei, Zahra Nilfroushan","doi":"10.1002/cnr2.70304","DOIUrl":"10.1002/cnr2.70304","url":null,"abstract":"<p><strong>Background: </strong>Hydroxyurea (HU) is an antimetabolite used to treat different myeloproliferative disorders, including chronic myeloid leukemia, polycythemia vera, and essential thrombocytopenia (ET). HU has a significant effect on the treatment of myeloproliferative disease.</p><p><strong>Recent findings: </strong>A 54-year-old woman with a history of ET from 15 years ago presented with multiple erythematous plaques and ulcers on the face and extremities from 2 years ago. She had multiple SCCs, Bowen, and AK on both extremities and face. We reviewed and summarized the literature on the relationship between HU and nonmelanoma skin cancer (NMSC) between 1991 and 2022. Sixty cases (37 men and 23 women) were evaluated. The participants' mean age was 66.73 ± 9.80 years. They received the HU therapy for 9.17 ± 4.29 years. The latency period to the occurrence of symptoms in patients with HU-related skin cancer was 7.33 ± 4.40 years. The HU dose in these patients ranged from 1.21 ± 0.53 g/d. Among NMSCs, SCCs are more frequently associated with the HU treatment, followed by AKs, BCCs, and Bowen.</p><p><strong>Conclusion: </strong>Healthcare providers should be aware of skin cancer risks; patients receiving long-term HU therapy should be screened for early diagnosis and provided with preventive measures and appropriate treatment.</p>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 8","pages":"e70304"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12334849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-Expression of MHC-II and ANXA1: Mediators of PD-1/PD-L1 Therapy Resistance in Breast Cancer","authors":"Hao Wang,&nbsp;Ji-Feng Sun,&nbsp;Chen Wang,&nbsp;Zhan-Sheng Jiang,&nbsp;Zhong-Sheng Tong","doi":"10.1002/cnr2.70291","DOIUrl":"https://doi.org/10.1002/cnr2.70291","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Triple-negative breast cancer (TNBC) presents significant treatment challenges and poor prognosis. While immune checkpoint blockade (ICB) therapy shows promise, patient responses vary widely, highlighting the urgent need for reliable biomarkers to predict efficacy and guide treatment decisions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study aims to investigate the role of Major Histocompatibility Complex class II (MHC-II) expression in breast cancer, specifically focusing on its impact on immune evasion, tumor metastasis, and immunotherapy efficacy. The objective is to emphasize the necessity of targeted research in order to enhance therapeutic strategies for TNBC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We employed Limma for conducting differential expression analysis, clusterProfiler for performing GO and KEGG pathway enrichment analyses, and Mendelian randomization analyses utilizing data from the UK Biobank and GEO data sets. Single-cell sequencing data were analyzed using Scanpy and CellTypist, where UMAP, PCA, and the Leiden algorithm were applied to explore cellular heterogeneity as well as gene expression profiles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We observed significant differential gene expression between MHC-II-high and MHC-II-low hematopoietic stem cells, which has an impact on immune responses and cancer pathways, particularly in TNBC. Mendelian randomization analysis identified key genes associated with breast cancer risk and PD-L1 status. Additionally, ANXA1 was significantly decreased in expression in breast cancer tissues compared to normal tissues and demonstrated increased expression in nonresponders to PD-1/PD-L1 therapies in TNBC patients, suggesting its potential involvement in immunotherapy resistance despite lacking a direct correlation with overall survival rates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The findings of this study highlight the potential role of ANXA1 in mediating resistance to PD-1/PD-L1 therapy in breast cancer, which is associated with MHC-II expression. ANXA1 could serve as both a predictive marker for treatment resistance and a therapeutic target to enhance the efficacy of immunotherapy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 8","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70291","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sonographic Correlations With Histological Grade and Biomarker Profiles in Breast Invasive Ductal Carcinoma","authors":"Golnaz Moradi,&nbsp;Nasrin Ahmadinejad,&nbsp;Diana Zarei,&nbsp;Nahid Sadighi","doi":"10.1002/cnr2.70288","DOIUrl":"https://doi.org/10.1002/cnr2.70288","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Invasive ductal carcinoma (IDC), the most common breast cancer subtype, exhibits significant heterogeneity, limiting traditional prognostic markers. Molecular profiles improve precision, but imaging features may also reflect tumor biology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study evaluates the predictive potential and clinical applicability of ultrasound features for determining tumor grade and molecular profiles in IDC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and Results</h3>\u0000 \u0000 <p>A blinded radiologist retrospectively analyzed 109 IDC cases using the American College of Radiology (ACR) Breast Imaging Reporting and Data System (BI-RADS) classification, evaluating ultrasound features such as lesion shape, margins, orientation, echo pattern, calcifications, vascularity, and lymph node involvement. Tumors were graded histologically (Scarff-Bloom-Richardson system) as low (grades 1 and 2) or high (grade 3). Immunohistochemistry determined estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki-67 status. ER and PR positivity were defined as &gt; 10% nuclear staining, HER2 graded on a 0–3+ scale, and Ki-67 positivity as ≥ 10% staining. Statistical analyses, including logistic and linear regression, examined correlations between ultrasound features and histological/molecular profiles. Among 109 women (mean age 48.4 ± 12.5 years), the mean tumor length and width were 21.83 ± 11.22 mm and 15.3 ± 6.97 mm, respectively. Histopathological grading revealed that grade 2 tumors were predominant (51%), while grade 1 and grade 3 tumors were observed in 25% and 24% of cases, respectively. ER and PR positivity were observed in 76.4% and 67.6% of cases, respectively. High-grade tumors were significantly associated with ER and PR negativity (<i>p</i>-value &lt; 0.05). Ultrasound features associated with high-grade tumors included larger tumor length (<i>p</i>-value = 0.029). ER positive tumors had smaller axillary lymph nodes (<i>p</i>-value &lt; 0.05). Likewise, PR positive tumors exhibited smaller suspicious axillary lymph nodes compared to PR negative cases (<i>p</i>-value = 0.004).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Sonographic features may correlate with histological grades and hormone receptor statuses in breast IDC, suggesting that ultrasound could aid in predictive assessment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 8","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70288","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative Analysis of Novel Ferroptosis-Related Genes Signatures as Prognostic Biomarkers in Ovarian Cancer","authors":"Leilei Cao,&nbsp;Yiqin Ouyang,&nbsp;Wei Lu,&nbsp;Xiao Qi,&nbsp;Zhijie Wang,&nbsp;Jingshuai Wang","doi":"10.1002/cnr2.70284","DOIUrl":"https://doi.org/10.1002/cnr2.70284","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Ferroptosis, an iron-dependent form of cell death, has been implicated in the pathogenesis of several types of cancer. Nevertheless, the exact correlation between ferroptosis-related gene mutations and their influence on ovarian cancer (OV) diagnosis and treatment strategies remains to be fully elucidated. It is crucial to identify the ferroptosis-related gene signature in OV and elucidate the impact of these mutations and their expression on the diagnosis and treatment of OV.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this study, we collected data from the TCGA and GEO databases. We utilized various tools and packages for data analysis, including the cBio Cancer Genomics Portal, Tumor Immune Estimation Resource (TIMER), GSVA package, and WGCNA R packages.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our results showed that ferroptosis subtypes 1 (FS1) and 2 (FS2) exhibited different levels of expression and tumor mutation burden (TMB). FS2 had a higher TMB level and survival rate compared to FS1. Furthermore, our analysis identified three ferroptosis-related genes, including IFNG, KEAP1, and PHKG2, as key biomarkers in prognosis prediction and potential targets for OV cancer therapy. The elevated expression levels of IFNG, KEAP1, and PHKG2 were found to be correlated with a good prognosis. These three genes showed a positive correlation with TMB in OV. We also observed that high TMB was more robustly associated with immune response-related gene expression, including CD28, CD40L, and type I IFN family members. Moreover, high TMB was associated with increased T cell infiltration and exhibited a distinct gene signature, which highlights the potential of IFNG, KEAP1, and PHKG2 as predictive markers for T cell infiltration and the tumor microenvironment status in OV. A significant correlation exists between the expression levels of KEAP1 and PHKG2 and TMB in OV cell lines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In conclusion, our study identified KEAP1, IFNG, and PHKG2 as potential prognostic biomarkers and therapeutic targets in OV. Their expression and mutation burden were correlated with a good prognosis. The association between ferroptosis subtypes, TMB, and survival rates further supports the relevance of these biomarkers. Additionally, the positive correlation between KEAP1, IFNG, and PHKG2 with TMB and immune response-related gene expression highlights their potential as predictive markers for immunotherapy efficacy in OV. The observed association of high TMB with increased T cell infiltra","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 8","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70284","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of PIWI-Interacting RNA in Urologic Carcinoma and Its Clinical Implications","authors":"Jiajia Cai,&nbsp;Shirui Jiang,&nbsp;Dongdong Lu,&nbsp;Ghulam Murtaza,&nbsp;Mingbang Wang,&nbsp;Yuqing Li,&nbsp;Da Shi,&nbsp;Yingrui Li,&nbsp;Hu Fang,&nbsp;Song Wu","doi":"10.1002/cnr2.70272","DOIUrl":"https://doi.org/10.1002/cnr2.70272","url":null,"abstract":"<p>Piwi-interacting RNA (piRNA) represents a class of small non-coding RNA molecules, typically ranging in length from 18 to 35 nucleotides. These molecules are critically involved in the preservation of genomic integrity and the regulation of protein translation processes. Recently, emerging scholarly research indicates that piRNA exhibits tissue-specific expression profiles within a variety of human malignancies, where they intricately regulate key signaling pathways at both the transcriptional and post-transcriptional levels. This review systematically underscores current investigations pertaining to piRNA in urologic carcinoma (UC), elucidating the proposed regulatory mechanisms encompassing N6-methyladenosine (m6A) modification and the silencing of transposable elements. Furthermore, we discuss the detection technology and the application of piRNA in the fields of clinical diagnosis.</p>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 8","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70272","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and Management of Invasive Pleomorphic Lobular Carcinoma of the Breast: A Case Report and Comprehensive Review of Current Literature","authors":"Xiaoyu Sun,&nbsp;Yanze Liu,&nbsp;Mei Wu,&nbsp;Jiaqi Liu","doi":"10.1002/cnr2.70285","DOIUrl":"https://doi.org/10.1002/cnr2.70285","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Invasive pleomorphic lobular carcinoma (IPLC) is a rare and aggressive variant of invasive lobular breast cancer, characterized by its distinct histological features and potential for metastatic spread. This case report aims to highlight the diagnostic challenges of IPLC, particularly regarding its imaging and pathological characteristics, and to review the latest treatment protocols.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 43-year-old female presented with a painless right breast mass that had persisted for 4 months. The breast ultrasound and mammography did not provide an accurate assessment, whereas MRI indicated multiple abnormal signals throughout the right breast, classified as BI-RADS 4c. Surgical intervention and subsequent pathological examination confirmed the diagnosis of multifocal invasive pleomorphic lobular carcinoma with lymph node metastasis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>IPLC presents diagnostic challenges due to its rare and aggressive nature, requiring a high degree of clinical suspicion. This case underscores the importance of comprehensive imaging and pathological assessment for the accurate diagnosis and treatment of IPLC. The standard treatment involves modified radical mastectomy, lymph node dissection, and postoperative chemotherapy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70285","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Site-Specific Mutations on KRAS, NRAS, and BRAF Corelate With the Frequency of ctDNA in Colorectal Cancer","authors":"Fumihiro Yoshimura,&nbsp;Yoichiro Yoshida,&nbsp;Teppei Yamada,&nbsp;Keita Tanaka,&nbsp;Takaomi Hayashi,&nbsp;Hideki Shimaoka,&nbsp;Ryohei Sakamoto,&nbsp;Naoya Aisu,&nbsp;Gumpei Yoshimatsu,&nbsp;Suguru Hasegawa","doi":"10.1002/cnr2.70292","DOIUrl":"https://doi.org/10.1002/cnr2.70292","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Early prediction of metastatic risk after tumor resection for colorectal cancer (CRC) is critical to improve treatment outcomes. Although circulating tumor DNA (ctDNA) is an important biomarker in CRC patients, positivity is variable because cutoff values for each gene have not been clearly established. When examining the mutant allele frequency (MAF) of a gene, the cutoff value is the same for the same gene, even if the mutation sites are different. In this study, we examined the relationship between MAF and the genetic mutation site and factors that influence the prediction of recurrence by ctDNA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study included 422 CRC patients who underwent surgery. ctDNA was sampled from blood samples of 102 CRC patients with <i>KRAS, NRAS</i>, and <i>BRAF</i> mutations and analyzed using the digital polymerase chain reaction system. Preoperative, postoperative day 1, postoperative day 7, and postoperative day 30 MAF were examined for each gene mutation site.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Kruskal–Wallis test revealed significant differences in MAF between mutated codon sites at all MAF assessment times (<i>p</i> &lt; 0.001). The MAF values of <i>KRAS</i> codon 146 at all time points were significantly higher than for the other mutation sites. Steel-Dwass tests revealed <i>KRAS</i> codon 146 had significantly higher MAF values than <i>KRAS</i> codons 12 and 13 on all blood collection dates. Similarly, <i>BRAF</i> codon 600 had significantly higher MAF values than <i>KRAS</i> codon 12 on all blood collection dates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study revealed that MAF values differed significantly depending on the site of mutation, even for the same gene. These results suggest that MAF cutoff values may need to be established for each gene mutation site.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70292","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}