Turkish neurosurgery最新文献

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Treatment of a Pediatric Recurrent Dissecting Middle Cerebral Artery Aneurysm with a Flow Diverter: A Case Report. 血流分流器治疗儿童复发性脑中动脉瘤1例。
Turkish neurosurgery Pub Date : 2025-01-01 DOI: 10.5137/1019-5149.JTN.46817-24.2
Zejin Li, Yu Feng, Tingbao Zhang, Wenyuan Zhao
{"title":"Treatment of a Pediatric Recurrent Dissecting Middle Cerebral Artery Aneurysm with a Flow Diverter: A Case Report.","authors":"Zejin Li, Yu Feng, Tingbao Zhang, Wenyuan Zhao","doi":"10.5137/1019-5149.JTN.46817-24.2","DOIUrl":"10.5137/1019-5149.JTN.46817-24.2","url":null,"abstract":"<p><p>Intracranial aneurysms are rare in the pediatric population, while fusiform middle cerebral artery (MCA) aneurysms are more common. Although surgical clipping is the generally preferred treatment strategy for aneurysms, occasional recurrence may still occur after successful clipping. As expertise in the use of flow diverters in adults has developed, they have also been applied in the management of aneurysms in children. This study aims to report a case of recurrence of MCA aneurysm after clipping, which was effectively treated using the Tubridge flow diverter. In the event of a recurrently clipped aneurysm, the implementation of a flow diverter treatment may be considered. Furthermore, we investigated the use of dual antiplatelet protocols during the perioperative period in children.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"800-805"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation of Transfontanel Ultrasonography and Brain Magnetic Resonance Imaging Measurements in Neonates with Hydrocephalus. 新生儿脑积水经囟门超声与脑磁共振成像的相关性研究。
Turkish neurosurgery Pub Date : 2025-01-01 DOI: 10.5137/1019-5149.JTN.49103-25.2
Nur Aycan, Harun Arslan, Eyyup Yurekturk, Murat Basaranoglu, Ali Ates, Serap Karaman, Oguz Tuncer, Abdurrahman Aycan
{"title":"Correlation of Transfontanel Ultrasonography and Brain Magnetic Resonance Imaging Measurements in Neonates with Hydrocephalus.","authors":"Nur Aycan, Harun Arslan, Eyyup Yurekturk, Murat Basaranoglu, Ali Ates, Serap Karaman, Oguz Tuncer, Abdurrahman Aycan","doi":"10.5137/1019-5149.JTN.49103-25.2","DOIUrl":"10.5137/1019-5149.JTN.49103-25.2","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate whether transfontanel ultrasonography could serve as a practical and less complex alternative to brain magnetic resonance imaging in infants with hydrocephalus.</p><p><strong>Material and methods: </strong>In this prospective study, 54 infants diagnosed with hydrocephalus underwent both transfontanel ultrasonography and brain magnetic resonance imaging. A neonatologist and a radiologist independently assessed ventricular measurements, including the Evans index, frontooccipital horn ratio, bilateral ventricular index, anterior horn width, thalamooccipital distance, callosal angle, and corpus callosum length.</p><p><strong>Results: </strong>Among the 54 infants, 48 (88.9%) received a ventriculoperitoneal shunt. A strong correlation was found between transfontanel ultrasonography and magnetic resonance imaging for most ventricular measurements: Evans index (r=0.875, p=0.0001), frontooccipital horn ratio (r=0.867, p=0.0001), callosal angle (r=0.868, p=0.0001), bilateral ventricular index (left r=0.937, right r=0.944; p=0.0001 for both), bilateral anterior horn width (left r=0.918, right r=0.908; p=0.0001 for both), and bilateral thalamooccipital distance (left r=0.956, right r=0.919; p=0.0001 for both). The correlation for corpus callosum length was statistically significant but weaker (r=0.386, p=0.004).</p><p><strong>Conclusion: </strong>Our study emphasizes that transfontanel ultrasonography?which achieves better results in experienced hands? should be widespread and an excellent alternative to unnecessary and repeated imaging methods.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"694-700"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145017082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complex Differential Diagnosis Between Cerebral Toxoplasmosis and Primary CNS Lymphoma in Immunocompromised Patients: The Value of Brain Biopsy. 免疫功能低下患者脑弓形虫病和原发性中枢神经系统淋巴瘤的复杂鉴别诊断:脑活检的价值。
Turkish neurosurgery Pub Date : 2025-01-01 DOI: 10.5137/1019-5149.JTN.44943-23.2
Matthieu Landart, Bertrand Mathon
{"title":"Complex Differential Diagnosis Between Cerebral Toxoplasmosis and Primary CNS Lymphoma in Immunocompromised Patients: The Value of Brain Biopsy.","authors":"Matthieu Landart, Bertrand Mathon","doi":"10.5137/1019-5149.JTN.44943-23.2","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.44943-23.2","url":null,"abstract":"<p><p>We report the case of a 24-year-old woman who received immunosuppressive treatment for systemic lupus erythematosus. In her past medical history, she had been treated for disseminated toxoplasmosis (ocular and cardiac). Four months later, she was hospitalized and treated for a presentation suggestive of cerebral toxoplasmosis. The diagnosis of primary central nervous system lymphoma (PCNSL) was finally made using stereotactic brain biopsy; however, the evolution was rapidly fatal within 6 days after admission. We discuss the challenge of differential diagnosis between cerebral toxoplasmosis and PCNSL in immunocompromised patients and the role of brain biopsy in patient management.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"35 3","pages":"518-522"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using Patient-Reported Outcome Measures for Adult Chiari Malformation Type 1. 使用患者报告的成人1型基亚里畸形的结果测量。
Turkish neurosurgery Pub Date : 2025-01-01 DOI: 10.5137/1019-5149.JTN.47107-24.2
Guilherme Lima, Marlon Cesar Souza-Filho, Luiz Oliveira-Junior, Daniel Paiva, Roger Schmidt Brock, Eberval Gadelha Figueiredo
{"title":"Using Patient-Reported Outcome Measures for Adult Chiari Malformation Type 1.","authors":"Guilherme Lima, Marlon Cesar Souza-Filho, Luiz Oliveira-Junior, Daniel Paiva, Roger Schmidt Brock, Eberval Gadelha Figueiredo","doi":"10.5137/1019-5149.JTN.47107-24.2","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.47107-24.2","url":null,"abstract":"<p><strong>Aim: </strong>To validate the Chicago Chiari Outcome Scale (CCOS) as a patient-reported outcome measures (PROMs) tool and identify the cutoffs of CCOS-PROM and EuroQoL-5D-3L score index (EQ-SI) against Gestalt in adults who underwent chiari malformation type 1 (CM1) treatment.</p><p><strong>Material and methods: </strong>This cross-sectional study analyzed the health status of CM1 adults after a 12-month surgery follow-up. An electronic form was sent to groups of CM patients. The self-Gestalt good perception was distributed as a cure or improvement for validation purposes. AUROC was evaluated to verify the ability of each PROM to predict Gestalt outcomes. Ethical approval registry: 64148822.0.0000.5292.</p><p><strong>Results: </strong>The 85 subjects had a mean age of 42.1(±10.6) years and a follow-up of 4.8(±4.1) years. Gestalt outcome was good for 23(27%) patients. The median CCOS-PROM of 74 patients was 11(IQR 4). The median EQ-SI of 84 patients was 0.52(IQR 0.29). CCOS-PROM score of 13 was the optimal cutoff value (sensitivity 82.6%; specificity 78.4%). For EQ-SI, this value was 0.64 (sensitivity 82.6%; specificity 75.4%). The AUROC for CCOS-PROM and EQ-SI were 0.90 and 0.86, respectively.</p><p><strong>Conclusion: </strong>CCOS-PROM is valid for assessing the outcome of CM1 surgery in adults. CCOS-PROM score of 13 and EQ-SI of 0.64 were the best tradeoff values.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"35 3","pages":"503-511"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurosurgical Management and Follow-up of Pediatric Lumbosacral Lipomas: A Single-Center Experience with 28 Patients. 28例儿童腰骶部脂肪瘤的神经外科治疗及随访。
Turkish neurosurgery Pub Date : 2025-01-01 DOI: 10.5137/1019-5149.JTN.46559-24.4
Efecan Cekic, Can Kivrak, Adnan Dagcinar
{"title":"Neurosurgical Management and Follow-up of Pediatric Lumbosacral Lipomas: A Single-Center Experience with 28 Patients.","authors":"Efecan Cekic, Can Kivrak, Adnan Dagcinar","doi":"10.5137/1019-5149.JTN.46559-24.4","DOIUrl":"10.5137/1019-5149.JTN.46559-24.4","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the efficacy of surgical interventions for pediatric lumbosacral lipomas (LSL) by focusing on preoperative symptoms, postoperative outcomes, and long-term prognosis.</p><p><strong>Material and methods: </strong>The medical records and magnetic resonance images (MRI) of 28 pediatric patients (15 boys and 13 girls aged 1?17 years) who underwent LSL resection between 2018 and 2023 were retrospectively reviewed. The study assessed surgical indications, techniques (including using neuromonitoring and the extent of lipoma resection), and postoperative management. The LSLs were classified based on their location and relationship with the spinal cord, which informed the surgical approaches and prognostic predictions. Outcome measures included neurological function, as assessed by the Hoffmann grading system, and complications such as wound dehiscence and cerebrospinal fluid leakage.</p><p><strong>Results: </strong>The dorsal LSLs demonstrated a 62.5% total resection rate with 37.5% symptomatic improvement after surgery. The caudal LSLs demonstrated a lower total resection rate (46.15%), with 30.77% of the patients experiencing symptom worsening. Transitional LSLs demonstrated a 100% positive outcome after total resection. Chaotic LSLs, the most complex LSL, had a postoperative deterioration rate of 40% after subtotal resection. Overall, surgical complications were noted in 17.8% of the patients.</p><p><strong>Conclusion: </strong>Surgical management of symptomatic pediatric patients with LSL yields significant benefits, with a careful balance between radical resection and preservation of neurological function. The type of lipoma significantly influences surgical planning and outcomes. Despite challenges in achieving complete resection in chaotic LSLs, tailored surgical approaches based on preoperative imaging and lipoma classification can optimize patient outcomes.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"609-617"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Initial Treatment Modality on Oncological Outcomes in Children with Ependymoma. 初始治疗方式对室管膜瘤患儿肿瘤预后的影响。
Turkish neurosurgery Pub Date : 2025-01-01 DOI: 10.5137/1019-5149.JTN.46386-24.2
Caglayan Esen, Pantea Bayatfard, Gozde Yazici, Guzide Burca Aydin, Figen Soylemezoglu, Berrin Babaoglu, Tezer Kutluk, Faruk Zorlu
{"title":"The Effect of Initial Treatment Modality on Oncological Outcomes in Children with Ependymoma.","authors":"Caglayan Esen, Pantea Bayatfard, Gozde Yazici, Guzide Burca Aydin, Figen Soylemezoglu, Berrin Babaoglu, Tezer Kutluk, Faruk Zorlu","doi":"10.5137/1019-5149.JTN.46386-24.2","DOIUrl":"10.5137/1019-5149.JTN.46386-24.2","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the oncological outcomes and the prognostic factors for children with ependymoma who receive radiotherapy (RT) ± chemotherapy after surgery.</p><p><strong>Material and methods: </strong>The medical records of 71 children with ependymoma who received RT between 2001 and 2022 were retrospectively evaluated. Survival outcomes and prognostic factors were analyzed using log-rank and cox-regression tests. SPSS v24.0 was utilized for statistical analyses.</p><p><strong>Results: </strong>Gross total resection (GTR) was achieved in 37 (52%) patients. Craniospinal fluid (CSF) seeding was observed in 8 (11%) patients at the time of diagnosis. The median RT dose was 54 Gy (42-60 Gy). The median time from surgery to the first RT was 2.4 months (1-109 months). The median follow-up time was 65.9 months (2.5-242.8 months), and 5-y overall survival, progression-free survival (PFS), and local recurrence-free survival (LRFS) were 74%, 39%, and 46%, respectively. Recurrence was observed in 41 (58%) patients. Among patients who initiated treatment with chemotherapy, 5-y PFS and LRFS were higher in patients who received RT at the time of diagnosis than those who received RT at the progression (23% vs. 0%, p < 0.001 and 39% vs 0%, p < 0.001). In multivariate analysis, increased time from surgery to radiotherapy was found to be a poor prognostic factor for PFS.</p><p><strong>Conclusion: </strong>Young age, less than GTR, large residual tumor volume, initiation of treatment with chemotherapy after surgery, and increased time from surgery to radiotherapy may deteriorate survival. RT should not be delayed until progression, even in young patients receiving chemotherapy.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"35 2","pages":"285-292"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-Surgical Management of Trigonocephalic Patients: An OCT and 3D-CT Based Follow-up Study. 三头症患者的非手术治疗:基于OCT和3D-CT的随访研究。
Turkish neurosurgery Pub Date : 2025-01-01 DOI: 10.5137/1019-5149.JTN.47138-24.2
Elif Basaran Gundogdu, Feriste Yetkin, Mevlüt Ozgur Taskapilioglu
{"title":"Non-Surgical Management of Trigonocephalic Patients: An OCT and 3D-CT Based Follow-up Study.","authors":"Elif Basaran Gundogdu, Feriste Yetkin, Mevlüt Ozgur Taskapilioglu","doi":"10.5137/1019-5149.JTN.47138-24.2","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.47138-24.2","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the cosmetic and visual aspects of trigonocephaly patients who have not received surgical intervention throughout a long-term follow up.</p><p><strong>Material and methods: </strong>Patients with trigonocephaly who did not undergo surgery were evaluated. Using 3D computed tomography images, the frontal (angle of the 2 lines between the bilateral pterion and nasion) and interfrontal angles were measured, and the frontal projections at the first and last examinations were compared. The final appearance was photographed, and detailed eye examinations and optical coherence tomography (OCT) measurements were performed.</p><p><strong>Results: </strong>The study included 6 patients (3 male and 3 female patients). The patient age at diagnosis was between 3 months and 2 years. The mean age at diagnosis was 10.33 months, and the average follow up period was 34 months. The interfrontal angle was not below 118° in any of our patients. We noted that the interfrontal angle increased with an increase in the follow up period. The ophthalmologic examination differed according to the age of the patients. Extraocular motility testing revealed no abnormalities. The anterior segment and fundus examination results were within normal limits. Bilateral OCT images of the optic discs revealed normal retinal nerve fiber layer (RNFL) thickness. No problems were detected in the neurocognitive development of the patients, and no severe cosmetic pathology was observed.</p><p><strong>Conclusion: </strong>Neurocognitive retardation and ophthalmologic problems were not detected in our patients with trigonocephaly who did not undergo surgery. More detailed studies with larger sample sizes are required before changing our approach to the treatment of trigonocephaly.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"35 3","pages":"449-453"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simplifying Transforaminal Endoscopic Lumbar Discectomy (TELD) Through the Guiding Framework of Ten Landmarks. 经椎间孔内窥镜下腰椎间盘切除术(TELD)的十个标志指导框架简化。
Turkish neurosurgery Pub Date : 2025-01-01 DOI: 10.5137/1019-5149.JTN.47234-24.2
Jia-Yuan Liu, Qing Huo, Meng Liu, Xuebin Tang, Haitang Liu, Liang Qiao
{"title":"Simplifying Transforaminal Endoscopic Lumbar Discectomy (TELD) Through the Guiding Framework of Ten Landmarks.","authors":"Jia-Yuan Liu, Qing Huo, Meng Liu, Xuebin Tang, Haitang Liu, Liang Qiao","doi":"10.5137/1019-5149.JTN.47234-24.2","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.47234-24.2","url":null,"abstract":"<p><strong>Aim: </strong>To streamline the transforaminal endoscopic lumbar discectomy (TELD) technique to facilitate a shorter learning curve for novice surgeons by providing a comprehensive guide featuring ten crucial landmarks.</p><p><strong>Material and methods: </strong>In this retrospective study, we reviewed patients diagnosed with lumbar disc herniation who underwent navigational TELD using ten landmarks from September 2021 to October 2022. We compared these patients with those who received conventional TELD from June 2020 to August 2021. A comprehensive account of the TELD surgical procedure, outlining each stage and introducing ten critical landmarks as surgical aids, is presented. Comparative analyses were conducted between the navigational and conventional groups, focusing on operation duration and fluoroscopic exposure.</p><p><strong>Results: </strong>There were no statistically significant differences observed between the navigational and conventional groups with regard to gender, age, and intraoperative VAS (visual analog scale) scores. The operation time and fluoroscopic exposures in the navigational group were notably reduced, measuring 56.33 ± 9.90 minutes and 4.97 ± 1.53, respectively, compared to 71.73 ± 17.80 minutes and 6.44 ± 1.52 in the conventional group (p < 0.05). Both groups exhibited no significant disparity in VAS and ODI (Oswestry disability index) scores. Nevertheless, postoperatively, at both 1 day and 3 months, both groups demonstrated lower VAS and ODI scores in comparison to preoperative values. Notably, the scores at 3 months post-surgery were significantly lower than those recorded at 1 day post-surgery (p < 0.05).</p><p><strong>Conclusion: </strong>The implementation of guiding landmarks significantly streamlines and simplifies the TELD procedure. It substantially decreases operation duration, minimizes fluoroscopy usage, enhances surgical safety, and ensures consistent clinical effectiveness. These landmarks enable novice surgeons to master TELD more easily.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"35 3","pages":"412-421"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Vitro Antitumoral Effect of Tarantula Venom Combined with Temozolomide in Human Glioblastoma Cells. 狼蛛毒液联合替莫唑胺对人胶质母细胞瘤细胞的体外抗肿瘤作用。
Turkish neurosurgery Pub Date : 2025-01-01 DOI: 10.5137/1019-5149.JTN.46498-24.3
Umit Kocaman, Fatih Collu, Berrin Tugrul, Mesut Mete, Emre Cavusoglu, Beyhan Gurcu, Ibrahim Tuglu
{"title":"In Vitro Antitumoral Effect of Tarantula Venom Combined with Temozolomide in Human Glioblastoma Cells.","authors":"Umit Kocaman, Fatih Collu, Berrin Tugrul, Mesut Mete, Emre Cavusoglu, Beyhan Gurcu, Ibrahim Tuglu","doi":"10.5137/1019-5149.JTN.46498-24.3","DOIUrl":"10.5137/1019-5149.JTN.46498-24.3","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the effect of 48-hour (h) administration of Tarantula Logoplex® (TL), a homeopathic medical product containing Tarantula cubensis venom, alone and in combination with temozolomide (TMZ) on T98G glioblastoma cell line with regard to cytotoxicity, cell migration, nitric oxide synthase (NOS) level, and the type of programmed cell death pathway that mediates this cytotoxic effect.</p><p><strong>Material and methods: </strong>Cytotoxic effect was analyzed using the 3-(4,5-dimethylthiazolyl-2)-2.5-diphenyltetrazolium bromide (MTT) method, apoptosis was analyzed by Annexin V-FITC/PI flow cytometry, autophagic cell imaging was performed using the monodansylcadaverine staining method, mitochondrial membrane potential was evaluated using the tetraethylbenzimidazolylcarbocyanine iodide (JC-1) staining method, and cell migration was analyzed using the scratch test. The levels of eNOS, iNOS, and LC3 proteins were evaluated using immunofluorescence (IF) and western blot analyses. Results were compared and statistically evaluated.</p><p><strong>Results: </strong>Annexin V-FITC/PI flow cytometry revealed that the cytotoxicity of the combined administration was high and primarily (37.57%) occurred through apoptosis. According to JC-1 analysis, the apoptotic effect could have originated from mitochondria. Cell migration was lowest at the IC 50 dose of TL. The order of fluorescence intensity from the strongest to the weakest was control > TL > combination > TMZ for eNOS and control TL combination > TMZ for iNOS. Western blotting revealed the highest eNOS and iNOS protein density with TL IC 25 administration and the highest LC3 protein density with TMZ IC 50 administration.</p><p><strong>Conclusion: </strong>Combined administration of TL and TMZ may exert a significant cytotoxic effect on T98G glioblastoma cells, which may occur through apoptosis. TL may play a role in augmenting the effect of conventional therapeutic drugs on glioblastoma.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"35 2","pages":"293-308"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unilateral Vertebroplasty in the Treatment of Osteoporotic Vertebral Compression Fractures: Effects of Cement Amount on Pain, Coronal Balance, and New Compression Fracture Formation. 单侧椎体成形术治疗骨质疏松性椎体压缩性骨折:骨水泥量对疼痛、冠状平衡和新压缩性骨折形成的影响。
Turkish neurosurgery Pub Date : 2025-01-01 DOI: 10.5137/1019-5149.JTN.48236-24.3
Mehmet Meral, Merdan Orunoglu
{"title":"Unilateral Vertebroplasty in the Treatment of Osteoporotic Vertebral Compression Fractures: Effects of Cement Amount on Pain, Coronal Balance, and New Compression Fracture Formation.","authors":"Mehmet Meral, Merdan Orunoglu","doi":"10.5137/1019-5149.JTN.48236-24.3","DOIUrl":"10.5137/1019-5149.JTN.48236-24.3","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the impact of the volume of cement injected during unilateral percutaneous vertebroplasty (PVP) on the occurrence of new fractures, as well as its effect on coronal balance and pain management in patients with osteoporotic vertebral compression fractures (OVCFs).</p><p><strong>Material and methods: </strong>A total of 64 OVCF patients who underwent unilateral PVP were included in this study, and categorized into two groups based on the amount of cement injected during the procedure. The first group comprised 34 patients with an injected cement volume of ?3 ml (37 levels), while the second group comprised the rest with an injected cement volume of > 3 ml (39 levels). Coronal balance changes were evaluated immediately after the procedure and at 6 months post-operatively. The incidence and timing of new fractures following the initial vertebroplasty were also analyzed.</p><p><strong>Results: </strong>No statistically significant difference was found between the two groups regarding improvement in pre- and postoperative Visual Analog Scale scores. Similarly, no significant difference was observed in the Cobb angle measurements between the groups. New fractures developed in 1 patient from the small amount cement augmented group, and in 7 patients from the large amount cement augmented group, revealing a statistically significant difference in the incidence of new fracture formation.</p><p><strong>Conclusion: </strong>A higher volume of cement injection during PVP appears to be a risk factor for the increased incidence of new fractures at other vertebral levels in patients with OVCF and these fractures typically occur within six months following the initial procedure. However, the volume of cement did not significantly affect clinical outcomes such as pain relief, mobility, or the restoration of coronal alignment.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"35 2","pages":"214-221"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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