Turkish neurosurgery最新文献

{"title":"Coexistence of Chiari 1 Malformation and Marsh 3b Celiac Disease.","authors":"Tamer Tamdogan, Gokhan Aydin, Sevim Ondul, Esma Cinar, Ahmet Cumhur Dulger","doi":"10.5137/1019-5149.JTN.49761-25.3","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.49761-25.3","url":null,"abstract":"<p><strong>Abstract: </strong>This case report presents the first simultaneous occurrence of Chiari malformation type 1 and celiac disease in a 27-year-old male patient. To the best of our knowledge, there are no previously published cases in the literature. This rare association suggests that nutrient malabsorption caused by celiac disease may exacerbate the symptomatic severity of Chiari malformation. We recommend screening for celiac disease in patients diagnosed with Chiari malformation who present with anaemia, vitamin deficiency or unexplained gastrointestinal complaints. Conversely, in the presence of atypical neurological symptoms in celiac disease, craniocervical magnetic resonance imaging should be performed and a multidisciplinary approach strategy should be considered in treatment.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 5","pages":"771-774"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149121026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracranial Neuroenteric Cyst in the Cerebellopontine Angle with Calcified Cyst Wall: A Rare Case Report.","authors":"Xiaozhou Zuo, YiHang Ma, Jun Yang, Chunfa Qian, Yong Liu, Yihao Zhu","doi":"10.5137/1019-5149.JTN.49701-25.2","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.49701-25.2","url":null,"abstract":"<p><strong>Abstract: </strong>Neuroenteric cysts (NCs) are rare benign lesions believed to originate from ectopic endodermal tissue. They are lined by gastrointestinal or respiratory epithelium capable of secreting mucin. Although most frequently located within the spinal canal, intracranial NCs are exceedingly rare and typically occur ventral to the brainstem. We report a case of a young female patient with an NC located in the cerebellopontine angle-an atypical site-exhibiting uncommon imaging features. Radiological evaluation revealed cystic contents with signal intensities similar to cerebrospinal fluid, a partially calcified cyst wall, and mild contrast enhancement. Extensive calcification resulted in firm adhesion to adjacent neurovascular structures. Surgical resection was performed, preserving a small calcified plaque that was tightly adherent to critical surrounding tissues. This case underscores the importance of including NCs in the differential diagnosis of intracranial cystic lesions, particularly when cyst wall calcification is present. Calcification can significantly influence surgical planning and increase the risk of adhesion to neurovascular structures, necessitating cautious dissection.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 5","pages":"766-770"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149121096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stereotactic Radiosurgery-Induced Peritumoral Edema in Asymptomatic Convexity, Parasagittal, and Parafalcine Meningiomas.","authors":"Osman Burak Can, Mete Ruksen, Burcu Durmak Isman, Mehmet Orbay Askeroglu, Seray Zorlu, Alper Yuksel, Dilsat Camli, Ali Akay","doi":"10.5137/1019-5149.JTN.49153-25.2","DOIUrl":"10.5137/1019-5149.JTN.49153-25.2","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the incidence and identify the risk factors of stereotactic radiosurgery (SRS)-induced peritumoral edema (PTE) in the asymptomatic convexity, parasagittal, and parafalcine meningiomas without pre-existing PTE.</p><p><strong>Material and methods: </strong>We retrospectively analyzed 52 patients with asymptomatic convexity, parasagittal, or parafalcine meningiomas without pre-existing PTE who underwent single-fraction Gamma Knife radiosurgery between 2019 and 2024. The median tumor volume and the maximum tumor diameter were 3.3 cc (range: 0.31–10.2 cc) and 2.0 cm (range: 0.98–3.1 cm), respectively. The median margin dose was 12 Gy (range: 11 Gy–13 Gy). The median radiological and clinical follow-up durations were 21 months (range: 6–65 months) and 26 months (range: 12–66 months), respectively.</p><p><strong>Results: </strong>SRS-induced PTE occurred in 5.8% of patients (n=3), exclusively in elderly individuals (≥65 years) with parasagittal or parafalcine meningiomas. No cases were observed in convexity meningiomas (0/24). Multivariable analysis revealed a trend toward statistical significance for the association between age and SRS-induced PTE (p=0.074). In the overall cohort, the incidence of SRS-induced PTE was significantly higher in elderly patients compared to younger patients (< 65 years) (3/14 vs. 0/38, p=0.016), and this difference remained significant within the parasagittal/parafalcine subgroup (3/7 vs. 0/21, p=0.011).</p><p><strong>Conclusion: </strong>SRS appears to be a safe treatment modality in terms of PTE risk in patients aged below 65 years with asymptomatic convexity, parasagittal, or parafalcine meningiomas without pre-existing PTE. In contrast, elderly patients with parasagittal or parafalcine meningiomas may be more susceptible to SRS-induced PTE, thereby warranting a more cautious approach to SRS in this subgroup. Additional studies involving larger cohorts are warranted to validate these findings.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"136-144"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SPECT/CT in the Assessment of Postoperative Spine: A Comprehensive Literature Review.","authors":"Aydın Sinan Apaydin, Mehmet Denizhan Yurtluk, Mounica Paturu, Brittany Grace Futch, Khoi D Than, Muhammad Abd-El-Barr","doi":"10.5137/1019-5149.JTN.48508-25.3","DOIUrl":"10.5137/1019-5149.JTN.48508-25.3","url":null,"abstract":"<p><p>Back pain is a widespread and debilitating condition that significantly impairs quality of life, often eroding patients' sense of autonomy and independence, and contributes to global disability rates. The initial management of back pain generally follows a conservative approach, encompassing physical therapy, pharmacological interventions, and lifestyle modifications aimed at alleviating symptoms and restoring functionality. Spine surgery, while frequently beneficial in addressing underlying structural issues, carries certain inherent risks. Among the most challenging outcomes of spine surgery is the persistence or recurrence of pain, a condition commonly referred to as failed back surgery syndrome (FBSS). The effective management of FBSS requires a comprehensive and meticulous approach. When conservative measures for FBSS fail to yield satisfactory results, revision surgery can be considered. The role of advanced imaging techniques is critical in these cases. Standard imaging modalities each involve unique advantages and limitations, and a multimodal approach is therefore important to achieve a comprehensive and accurate evaluation of the patient's condition. In recent years, single-photon emission computed tomography combined with computed tomography (SPECT/CT) has gained recognition as a valuable tool in the postoperative assessment of spine surgery patients. SPECT/CT has demonstrated superior efficacy in detecting specific complications, such as pseudoarthrosis, hardware failure, and screw loosening. By integrating metabolic activity data from the spine and surrounding bony structures with the three-dimensional reconstruction capabilities of CT, SPECT/CT enhances diagnostic accuracy and informs more precise treatment decisions. This review aims to synthesize the current body of literature on the application of SPECT/CT in the postoperative evaluation of spine surgery patients, while also providing a comparative overview of other imaging modalities within this context. Our objective is to underscore the pivotal role that advanced imaging techniques play in improving patient outcomes after spine surgery, reducing the incidence of FBSS, and shortening its duration.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"108-118"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracranial Mature Bone Formation: Report of Three Uncommon Cases and a Proposed Pathogenetic Mechanism.","authors":"Ersin Haciyakupoglu, Evren Yuvruk, Ayca Ersan Danyeli, Dervis Mansuri Yilmaz, Sebahattin Haciyakupoglu","doi":"10.5137/1019-5149.JTN.47293-24.4","DOIUrl":"10.5137/1019-5149.JTN.47293-24.4","url":null,"abstract":"<p><p>The formation of histologically mature bone within the intracranial compartment is an exceptionally rare phenomenon. Although intracranial calcifications are frequently encountered in clinical practice, true ossification culminating in the development of mature bone tissue remains poorly characterized. Herein, we report three cases of female patients presenting with intra- and extra-axial cranial masses, all histologically confirmed to comprise mature bone. We describe the associated radiologic features, surgical challenges, and histopathological findings. Furthermore, we propose a novel pathogenetic hypothesis implicating the intraoperative dispersion of bone dust as a potential etiologic factor in iatrogenic ossification. Our findings highlight the importance of surgical vigilance and meticulous intraoperative technique to mitigate this rare but avoidable complication.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"327-331"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147358375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergent Endovascular Parent Artery Occlusion for Type III Carotid Blowout Syndrome After Charged Particle Therapy for Recurrent Maxillary Carcinoma: A Case Report and Literature Review.","authors":"Daisuke Wajima, Sho Takata, Tomoya Kamide, Kouichi Misaki, Koji Sato, Mitsutoshi Nakada, Takumi Taniguchi","doi":"10.5137/1019-5149.JTN.48274-24.3","DOIUrl":"10.5137/1019-5149.JTN.48274-24.3","url":null,"abstract":"<p><p>Carotid blowout syndrome (CBS) refers to involvement of the carotid artery by malignant processes of the head and neck with compromise of vessel integrity and rupture. Carotid hemorrhage (CBS type III) is fatal, particularly when it occurs outside hospital settings. Bleeding can occur through the skin or mucosa and may cause airway compromise. It is associated with high mortality and morbidity. A 55-year-old woman presented to the emergency room with shock state, bleeding from the oral and nasal cavity. The patient had previously experienced recurrent maxillary carcinoma treated with radiation therapy 9 years prior. Digital subtraction angiography revealed active extravasation from the cavernous portion of the left internal carotid artery. Emergent parent artery occlusion was performed by coil embolization, including the extravasation site; complete hemostasis was achieved. Endovascular parent artery occlusion (PAO) is the preferred management method; covered stents are an option for managing patients who are not candidates for PAO. In our case, additional left superficial and middle cerebral artery anastomoses were needed on the day after PAO for preventing hemodynamic cerebral infarction. Since type III CBS can be fatal, early recognition of CBS predictors by multidisciplinary teams is crucial for preventing fatal bleeding.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"332-336"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147358333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Takayasu Arteritis Complicated with Vertebral Artery Dissection Aneurysm Treated Endovascularly: Report of One Case.","authors":"Han Wang, Liping Cheng, Jiao Cheng, Zuyao Song, Chao Li, Jing Ye","doi":"10.5137/1019-5149.JTN.48672-25.3","DOIUrl":"10.5137/1019-5149.JTN.48672-25.3","url":null,"abstract":"<p><p>Takayasu arteritis (TA) is a chronic granulomatous large-vessel vasculitis that primarily affects the aorta and its major branches, such as the subclavian, carotid, and renal arteries. Pathologically, it is characterized by transmural infiltration of lymphocytes and macrophages with granulomatous inflammation, leading to intimal fibrosis and thickening, destruction of medial elastic fibers, and subsequent luminal stenosis or occlusion. Aneurysmal dilation may occur in some cases. We here report a case of TA complicated by a vertebral artery dissecting aneurysm. Our patient was a 47-year-old male who had previously undergone surgical interventions at our institution for a common iliac artery aneurysm and splenic artery aneurysm 6 years and 2 years prior to the present admission, respectively. Most recently, the patient was presented with right shoulder pain and was subsequently diagnosed with a right vertebral artery dissecting aneurysm, for which endovascular intervention was performed. This case underscores the critical importance of long-term clinical surveillance in patients with TA, along with the necessity for aggressive treatment of aneurysms that are identified to have a high risk of rupture.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 3","pages":"467-470"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148145820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferulic Acid Increases Temozolomide Sensitivity in Glioblastoma Cells, Causing DNA Damage and Inhibiting Cell Proliferation.","authors":"Halil Ulutabanca, Zuhal Hamurcu, Serhat Albayrak, Ahsen Guler, Venhar Cinar, Nursultan Nurdinov","doi":"10.5137/1019-5149.JTN.49811-25.3","DOIUrl":"10.5137/1019-5149.JTN.49811-25.3","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the antitumor effects of ferulic acid (FA) on glioblastoma multiforme (GBM) cells both alone and in combination with temozolomide (TMZ), and also to determine the potential of this synergy for treatment processes.</p><p><strong>Material and methods: </strong>Human glioblastoma U87-MG cells were used in this study. To evaluate the potential constructive interaction between temozolomide (TMZ) and ferulic acid (FA), a sequential treatment protocol was applied in which cells were first treated with TMZ (20, 40, and 80 μM) for 48 hours, followed by FA (1000 μM and 1500 μM) for an additional 24 hours. Cell viability was assessed using the MTS assay, clonogenic capacity was evaluated by the clonogenic assay, and nuclear morphological changes were examined by Hoechst 33258 staining. The expression levels of Cyclin D1 and PARP were also analyzed to explore the molecular mechanisms underlying the treatment effects.</p><p><strong>Results: </strong>FA treatment reduced cell viability and increased DNA damage in U87-MG cells. It suppressed the expression of Cyclin D1 and PARP. Furthermore, the combination of FA and TMZ almost completely inhibited cell proliferation and colony formation and significantly increased DNA damage.</p><p><strong>Conclusion: </strong>Although FA has demonstrated antitumor activity at high concentrations, this may limit its clinical applicability. However, its ability to enhance the effects of TMZ suggests that FA could be used as a supportive treatment strategy in GBM therapy.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 3","pages":"377-384"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148145744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Group 1 Metabotropic Glutamate Receptors Expression After Lacosamide Treatment in a Kainic Acid-Induced Temporal Lobe Epilepsy Model.","authors":"Firat Narin, Tural Rehimli, Sahin Hanalioglu, Zarifa Yusifli, Hidir Ozer, Ibrahim Basar, Alaeddin Acar, Mustafa Berker, Burcak Bilginer","doi":"10.5137/1019-5149.JTN.50380-26.3","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.50380-26.3","url":null,"abstract":"<p><strong>Abstract: </strong>AIM: To investigate the effects of lacosamide (LCM), an antiepileptic agent, on group 1 metabotropic glutamate receptors (mGluR1 and mGluR5) expression in a temporal lobe epilepsy (TLE) model. MATERIAL and METHODS: Thirty-two rats were divided into 4 groups: (1) only burr hole without intrahippocampal injection, (2) burr hole and stereotaxic intrahippocampal saline injection, (3) burr hole, stereotaxic intrahippocampal kainic acid injection and 2 weeks of intraperitoneal saline treatment, and (4) burr hole, stereotaxic intrahippocampal KA injection and 50mg/kg intraperitoneal LCM treatment for 2 weeks. RESULTS: No hippocampal sclerosis was detected in group 2 but sclerosis was observed in Groups 3 and 4. Despite increase in mGluR1 and mGluR5 expressions on the side of kainic acid injection, no significant effect of LCM was found on mGluR1 or mGluR5 expression. In the experimental rat model of TLE with intrahippocampal kainic acid injection in the present study, LCM was found to have no effect on mGluR expression in Group 1. CONCLUSION: The antiepileptic effect of LCM does not seem to be mediated through group I metabotropic glutamate receptors. Since the efficacy of mGluR1 and mGluR5 antagonists as monotherapy in drug-resistant TLE remains uncertain, these findings suggest that lacosamide may act through alternative mechanisms, which require further investigation.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"36 5","pages":"734-743"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149121099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Affordable Excellence: A Meta-Analysis on the Efficacy of Topical Tranexamic Acid in Reducing Blood Loss in Thoracolumbar Spinal Surgery.","authors":"Jyun-Yuan Huang, Tzu-Ning Chen, Hao-Kuang Wang, Kang Lu, Jui-Sheng Chen, Tsung-Jen Hsieh, Yu-Ying Wu, Min-Jung Lee, Po-Yuan Chen","doi":"10.5137/1019-5149.JTN.48875-25.2","DOIUrl":"10.5137/1019-5149.JTN.48875-25.2","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the efficacy and safety of topical tranexamic acid (tTXA) in thoracolumbar fusion surgery.</p><p><strong>Material and methods: </strong>A systematic review was conducted per PRISMA guidelines. Studies from January 1970 to August 2024 were retrieved from PubMed, Cochrane, EMBASE, Medline, and Google Scholar. Randomized controlled trials, non-RCTs, and cohort studies comparing tTXA with placebo or standard care in thoracolumbar surgery were included.</p><p><strong>Results: </strong>Eleven studies with 986 patients met the criteria. tTXA significantly reduced intraoperative blood loss (MD: -25.85 mL, p = 0.002), postoperative drain output (MD: -84.82 mL, p < 0.00001), transfusion rates (OR: 0.33, p = 0.0004), and hospital stay (MD: -0.67 days, p < 0.00001). It also increased postoperative hemoglobin (MD: 0.39 g/dL, p < 0.00001) but slightly prolonged operative time (MD: 3.73 minutes, p < 0.00001). No significant difference was found in complication rates (p = 0.36).</p><p><strong>Conclusion: </strong>tTXA is effective in reducing blood loss and transfusion needs in thoracolumbar surgery, with minimal risk. Slightly increased operative time is clinically acceptable.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"218-228"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147358330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}