JEADV clinical practice最新文献

{"title":"Combining RNA tape stripping with dermoscopic features for melanoma identification","authors":"Terese von Knorring,&nbsp;Ida M. Heerfordt,&nbsp;Jeppe D. Andersen,&nbsp;Lisbet Rosenkrantz Hølmich,&nbsp;Katrine Karmisholt,&nbsp;Silje H. Omland,&nbsp;Frederikke F. Knudsen,&nbsp;Peter A. Philipsen,&nbsp;Mette Mogensen","doi":"10.1002/jvc2.554","DOIUrl":"https://doi.org/10.1002/jvc2.554","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>A noninvasive, accurate diagnostic method for melanoma is needed to improve early detection and decrease number of excisions. Gene expression as measured by RNA levels uses tape strips to directly assesses genetic markers from skin lesions. Commercial RNA assays show varying diagnostic accuracy in melanoma detection. Combining dermoscopic features with RNA tape strips could reduce unnecessary removal of benign lesions by increasing specificity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To test an RNA-based rule-out test and integrate dermoscopic features with RNA analysis to improve diagnostic accuracy of malignant melanoma (MM). Furthermore, we explore the association between RNA profiles and dermoscopic features.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Seventy patients with pigmented skin lesions suspected of being melanoma were imaged with dermoscopy and tape stripped for RNA analysis before surgical excision. The images were evaluated for seven dermoscopic features, and RNA levels of 11 genes were analyzed. A combined test using both gene expression and dermoscopic features was developed. Associations between RNA profiles and dermoscopic features were explored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Histopathology revealed 19 malignant lesions (17 MM and two basal cell carcinomas) and 51 benign lesions. The combined dermoscopy and RNA test identified all malignant lesions (100% sensitivity) based on <i>PRAME</i> expression, blotch and regression structures and patient age. This combined model increased specificity to 35%, compared to 24% with the original RNA rule-out test, without missing any malignant lesions. Significant differences in RNA profiles were observed for lesions expressing atypical network and regression structures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Combining RNA tape stripping with dermoscopic features can reduce the removal of benign lesions by over one-third while maintaining 100% sensitivity. We found specific RNA profiles to be strongly associated with dermoscopic features, presenting a promising opportunity to integrate molecular and morphological information and provide valuable guidance for dermatologists managing atypical pigmented lesions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"4 1","pages":"128-136"},"PeriodicalIF":0.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.554","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lumbosacral hypertrichosis as a cutaneous manifestation of dysraphism","authors":"Sarah Preis,&nbsp;Tilo Biedermann,&nbsp;Christina Schnopp","doi":"10.1002/jvc2.559","DOIUrl":"https://doi.org/10.1002/jvc2.559","url":null,"abstract":"<p>A 11-year-old girl presented with hypertrichosis in the lumbosacral region, which has been present since birth. Right after birth, the girl underwent surgical intervention for spina bifida with no neurological impairment. On clinical examination, a circumscribed collection of terminal hair is observed on nonpigmented skin in the lumbar spine region (Figure 1a). Skin biopsy was performed, and histologic analysis revealed only a few scattered melanocytes in the basal epidermis and a characteristic dense aggregation of hair follicles (Figure 1b).</p><p>Lumbosacral hypertrichosis, also known as ‘Faun's tail’ after the Italian deity, is a classic sign of dysraphism.<span>¹</span> This generic term describes pathologic conditions related to improper closure of the caudal neuropore and encompasses all conditions associated with spina bifida occulta, traction band or diastematomyelia.<span>^{1, 2}</span> The division between the neuroectoderm and the epithelial ectoderm takes place between the third and fifth week of fetal development, commencing along the posterior midline.<span>²</span> This separation may remain incomplete at various stages, resulting in potential defects in the skin, vertebrae, spinal cord and/or central nervous system, sometimes symptoms may not appear until the child is a toddler or older.<span>³</span> Hence, in cases of lumbosacral hypertrichosis, consideration should be given to an underlying spinal abnormality, prompting subsequent relevant investigations. The most important differential diagnosis is congenital hairy nevus.</p><p>The authors confirm contribution to the paper as follows: <i>Clinical case collection</i>: Sarah Preis. <i>Draft manuscript preparation</i>: Sarah Preis. <i>Manuscript review and proof-reading</i>: Christina Schnopp. All authors reviewed the results and approved the final version of the manuscript.</p><p>The authors declare no conflict of interest.</p><p>The parents/guardians of minor patients have given written informed consent for their child's participation in the study, as well as for the use of their child's deidentified, anonymized, aggregated data and case details (including photographs) for publication. Ethical Approval: not applicable.</p>","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"4 1","pages":"331-332"},"PeriodicalIF":0.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.559","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophilic dermatosis of haematologic malignancy treated with ibrutinib: A case report","authors":"Giulia Greta Dradi,&nbsp;Reyes Gamo Villegas,&nbsp;Fernando Pinedo Moraleda,&nbsp;Jose Luis López Estebaranz","doi":"10.1002/jvc2.410","DOIUrl":"https://doi.org/10.1002/jvc2.410","url":null,"abstract":"<p>Eosinophilic dermatosis of haematologic malignancy is an infrequent skin disorder characterised by severe pruritus and skin lesions resembling arthropod bites. It primarily affects individuals with underlying haematological conditions, most commonly chronic lymphocytic leukaemia (CLL). While it does not correlate with a worse prognosis for the haematological disease itself, it significantly impacts patients' quality of life due to the distressing pruritus and recurring nature. Clinical presentation typically shows erythematous papules resembling arthropod bites, with less frequent occurrences of urticarial plaques or bullous lesions. Histologically, an intense and polymorphous inflammatory infiltrate is found both in the superficial and deep dermis, marked by an abundance of eosinophils and the absence of atypical cells. Treatment of this disease remains uncertain, with corticosteroids often being the only effective therapy. Here, we present the case of an 80-year-old patient with a history of CLL, who experienced a widespread, itchy eruption of papules and plaques over 2 months. Despite various therapeutic attempts, the lesions only responded to high-dose corticosteroids. Following the initiation of ibrutinib at a daily dose of 420 mg, both the skin lesions and pruritus resolved within 3 months. Ibrutinib, a tyrosine kinase inhibitor, is approved as a first-line treatment for CLL. However, its potential as a remedy for refractory eosinophilic dermatosis has not been reported thus far.</p>","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"4 1","pages":"216-219"},"PeriodicalIF":0.0,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.410","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presenting JAK inhibitor safety information to dermatology patients","authors":"Anthony J. Teixeira,&nbsp;Jessica Q. Duong,&nbsp;Shirley P. Parraga,&nbsp;Steven R. Feldman","doi":"10.1002/jvc2.551","DOIUrl":"https://doi.org/10.1002/jvc2.551","url":null,"abstract":"<p>Janus Kinase (JAK) inhibitors are treatment options for dermatologic conditions such as atopic dermatitis, psoriasis, vitiligo, and alopecia areata. Guidance on how to counsel patients on these novel treatments is limited. The purpose of this review is to provide options providers can use to discuss JAK inhibitors with dermatology patients. The PubMed database was searched for terms including “dermatology JAK inhibitor safety” and “presenting information to patients.” Relevant literature was selected for inclusion. Black box warnings were placed on JAK inhibitors after a large, controlled trial in rheumatoid arthritis patients did not prove that tofacitinib was as safe as tumor necrosis factor inhibitors; in clinical trials for dermatologic conditions, JAK inhibitors had low risks of serious adverse events. Patient barriers to comprehending treatment information include conflicting information and limited time for discussion of risks. To address these barriers, suggested approaches have included speaking in simple phrases, providing reliable sources, and offering educational materials appropriate for different cultures. When discussing risks, physicians may use anecdotes and frame risks and side effects in ways that decrease anxiety. JAK inhibitors have uncommon severe side effects and related concerns that may be hard for patients to overcome, even when benefits exceed risks. Standard educational approaches can be complemented by anecdotes and framing to help diminish patients' anxiety.</p>","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"4 1","pages":"12-20"},"PeriodicalIF":0.0,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.551","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creating a dermatologic database for artificial intelligence, a Chilean experience, and advice from ChatGPT","authors":"Leonel Hidalgo,&nbsp;María Paz Salinas,&nbsp;Javiera Sepúlveda,&nbsp;Karina Carrasco,&nbsp;Pamela Romero,&nbsp;Alma Pedro,&nbsp;Soledad Vidaurre,&nbsp;Domingo Mery,&nbsp;Cristian Navarrete-Dechent","doi":"10.1002/jvc2.546","DOIUrl":"https://doi.org/10.1002/jvc2.546","url":null,"abstract":"&lt;p&gt;Since artificial intelligence (AI) has widely shown applications for skin cancer diagnosis, creating comprehensive image datasets is key.&lt;span&gt;&lt;sup&gt;1-4&lt;/sup&gt;&lt;/span&gt; Availability of databases are increasing, with a low representation of higher phototypes, certain ethnic groups, and limited metadata.&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt; Excluding specific populations perpetuates healthcare disparities in the AI era.&lt;span&gt;&lt;sup&gt;6&lt;/sup&gt;&lt;/span&gt; Due to the lack of diverse datasets, external use and validation of AI algorithms is not currently possible in our population. We started a project to create a Chilean AI database: The ‘Trawa’ database ('skin' in Mapuzungun, a native Chilean language). This study aims to describe our current dataset characteristics along with the limitations during its creation.&lt;/p&gt;&lt;p&gt;This was a retrospective study approved by the local Institutional Review Board (IRB). The images were collected from January 2019 to December 2020, from four dermatologists working in a Tertiary Care Academic Hospital. Clinical and dermoscopy images were obtained with variable smartphones. All included lesions are biopsy-proven. Metadata (i.e., age, sex, anatomical location, histopathological details, relevant past medical story, and phototype) was obtained from the electronic medical records. Cases were coded in a specific folder. All data was stored in a Health Insurance Portability and Accountability Act (HIPAA)-compliant web hosting.&lt;/p&gt;&lt;p&gt;During the study period, we collected 860 individual cases consisting of 4435 clinical and dermoscopy images (Figure 1), organized in seven categories: actinic keratosis, basal cell carcinoma, cutaneous squamous cell carcinoma, melanoma, naevus, seborrhoeic keratosis and others (angiomas, warts, etc.) (Table 1), regarding metadata 52.6% were women; the average age was 54 years; 32.8% had photodamage and 70.2% were phototype III. Most cases were located on the head and neck (50.6%); and 26.8% of the diagnosis were malignant.&lt;/p&gt;&lt;p&gt;Finally, we also suggest working with multidisciplinary teams composed of dermatologists and computer science professionals. Creating and improving databases will augment the performance of AI algorithms,&lt;span&gt;&lt;sup&gt;9&lt;/sup&gt;&lt;/span&gt; and for us, this is a necessary step for performing collaborative work with other countries in the region (e.g., Latin America).&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; Potential applications of the current database include algorithm training fine-tuned for local data as well as comparing different algorithms performance on different and diverse databases. The main limitations of our database is its relatively small size. Organising lesions requires a large team and multiple resources. Also, we have included only lesions with histopathology confirmation, biasing the database towards more 'suspicious' lesions. Using noninvasive imaging technologies such as reflectance confocal microscopy could be an alternative to include nonbiopsied benign lesions.&lt;span&gt;&lt;sup&gt;10&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"4 1","pages":"296-298"},"PeriodicalIF":0.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.546","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness of dermoscopy in anogenital warts: A descriptive study of 30 cases","authors":"Marouane Ben Kahla,&nbsp;Lina Bessaad,&nbsp;Nadia Ghariani Fetoui,&nbsp;Maha Lahouel,&nbsp;Sarra Saad,&nbsp;Mohamed Ben Rjab,&nbsp;Jacem Rouatbi,&nbsp;Haifa Mkhinini,&nbsp;Zeineb Nfikha,&nbsp;Dorra Chiba,&nbsp;Cyrine Chelli,&nbsp;Oumayma Ben Rejeb,&nbsp;Badreddine Sriha,&nbsp;Nadia Ben Lasfar,&nbsp;Sana Mokni,&nbsp;Amina Aounallah,&nbsp;Najet Ghriani,&nbsp;Mohamed Denguezli","doi":"10.1002/jvc2.545","DOIUrl":"https://doi.org/10.1002/jvc2.545","url":null,"abstract":"&lt;p&gt;Dermoscopy applications are expanding beyond skin tumours to include various other cutaneous disorders, such as inflammatory and infectious dermatoses. Anogenital warts (AGW) are the most common sexually transmitted infection.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; Our objective is to describe the dermoscopic characteristics of AGW.&lt;/p&gt;&lt;p&gt;We conducted a monocentric prospective study in the dermatology department of Farhat Hached Hospital in Sousse, Tunisia, from 1 January to 31 August 2023. All clinically diagnosed cases of AGW were included. Each patient underwent a clinical examination, a dermoscopy and a biopsy.&lt;/p&gt;&lt;p&gt;Thirty patients were included in the study, with a mean age of 34.24 years (ranging from 3 to 63 years). The male-to-female ratio was 3.28:1. Among the males, 52.17% of warts were located in the penile area and 43.47% in the perianal area. For females, all warts were located in the vulvar area. The papular warts represented 53.33% of the described lesions, condyloma acuminata 40% and Buschke−Lowenstein tumours were observed in two patients (6.66%). The dermoscopic pattern was mosaic-like (Figure 1a). In 53.33% of cases, corresponding clinically to the papular warts. A finger-like pattern (Figure 1b) was seen in 13.33% of cases, a cerebriform pattern in 13.33% of cases and a knob-like pattern (Figure 1c) in 10% of cases. In two female patients aged 18 and 55, the dermoscopy revealed finger-like structures but with separated bases and clinicopathological correlation concluded to vestibular papillomatosis. In a male patient with HIV, dermoscopy showed a cerebriform pattern (Figure 1d) in all warts, and in one wart, it revealed a whitish structureless area, a yellowish keratin area and polymorphous vessels. Malignancy was suspected, and a biopsy guided by dermoscopy confirmed invasive well-differentiated squamous cell carcinoma (SCC). All patients underwent biopsies confirming the diagnosis excepting two female patients with vestibular papillomatosis. However, HPV typing was performed for only five patients due to limited availability. It showed low-risk HPV 6 and 11 in three male patients and negative for two other patients.&lt;/p&gt;&lt;p&gt;AGW are a major risk factor for multiple malignancies, including cancers of the cervix, vagina, vulva, oropharynx, anus, penis and skin.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; AGW are mostly diagnosed with the naked eye, but early-stage diagnosis can be challenging.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; Three principal dermoscopic patterns have been described, though none is specific. Consistent with our findings, the mosaic pattern is the most common. It resembles common warts, with a whitish network surrounding central dotted or glomerular vessels.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; This pattern is associated with papular warts and can coexist with other patterns.&lt;/p&gt;&lt;p&gt;The finger-like and knob-like patterns are more commonly reported with exophytic condyloma acuminata. They are characterized by whitish, finger-like or knob-like papillae with varying ","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"4 1","pages":"293-295"},"PeriodicalIF":0.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.545","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and evaluation of an online training tool to aid in the diagnosis of chronic plaque psoriasis","authors":"Maha Abo-Tabik,&nbsp;Rosa Parisi,&nbsp;Mark Hann,&nbsp;Rod Tucker,&nbsp;Sarah Willis,&nbsp;Darren M. Ashcroft,&nbsp;Christopher E. M. Griffiths,&nbsp;the Global Psoriasis Atlas (GPA)","doi":"10.1002/jvc2.525","DOIUrl":"https://doi.org/10.1002/jvc2.525","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Chronic plaque psoriasis (CPP) is underdiagnosed, undertreated and mistaken for other skin conditions such as eczema, tinea corporis and pityriasis rosea.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To develop and evaluate an online training tool to improve the diagnostic skills of nondermatologists for CPP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study involved: (i) developing an online training tool to improve CPP diagnosis by nondermatologists; and (ii) evaluating the performance of the newly developed training tool by conducting a before-and-after exploratory investigation. Participants included three groups of primary care health professionals: general practitioners (GPs); nurses; and pharmacists. The tool contained written recommendations for the diagnosis of CPP in different skin colours and a medical artist's illustrations of psoriasis to overcome the lack of representative images of the disease in skin of colour and to illustrate the salient features more clearly than clinical photographs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 60 participants completed the study (20 per participant group). The training tool improved participants' diagnostic skills for CPP. The diagnostic ability of GPs was, on average, higher than nurses and pharmacists before and after training. Participants found the training valuable and relevant to CPP diagnosis in primary care settings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings show that a training tool, using medical illustrations, for nondermatologists can be beneficial in terms of recognition of CPP. This may lead to more timely diagnosis and treatment of psoriasis and support relevant and faster referral to specialist dermatology clinics.</p>\u0000 </section>\u0000 </div>","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"4 1","pages":"174-180"},"PeriodicalIF":0.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.525","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Special considerations for hidradenitis suppurativa in skin of colour: A review of literature","authors":"Kaley Prieto,&nbsp;Katie K. Lovell,&nbsp;Steven R. Feldman,&nbsp;Rita O. Pichardo","doi":"10.1002/jvc2.549","DOIUrl":"https://doi.org/10.1002/jvc2.549","url":null,"abstract":"<p>Hidradenitis suppurativa, a chronic inflammatory skin condition, disproportionately affects individuals with skin of colour (SOC), particularly African Americans. Despite the increased prevalence in SOC, racial minorities are underrepresented in HS clinical trials, limiting our understanding of treatment efficacy. The purpose of this narrative review is to discuss the current literature regarding the clinical presentation, comorbidities, and management of HS in SOC individuals. A PubMed search was conducted using the terms Hidradenitis suppurativa, comorbidities, skin of colour, African–American, Hispanic, and quality of life with relevant studies written in English and pertaining to the demographics and clinical trials were included. African American patients with HS tend to experience more severe disease manifestations, higher rates of comorbidities like inflammatory bowel disease and anaemia, increased healthcare utilisation, and a greater likelihood of surgical interventions. While the current literature provides extensive information about African Americans regarding comorbidities and disease prevalence, there is a lack of research on Hispanic and other ethnic groups. For future research, it is important to broaden our focus to include various ethnic groups. Addressing these disparities requires focused interventions, inclusive clinical research initiatives, and healthcare policies tailored to the specific needs of patients with skin of colour.</p>","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"4 1","pages":"7-11"},"PeriodicalIF":0.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.549","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guselkumab for the treatment of pyoderma gangrenosum","authors":"Sera Sarsam,&nbsp;Holly Sexton,&nbsp;Jenny Nicolopoulos,&nbsp;Con Dolianitis","doi":"10.1002/jvc2.547","DOIUrl":"https://doi.org/10.1002/jvc2.547","url":null,"abstract":"<p>Pyoderma gangrenosum (PG) is a complex disease with limited therapeutic options. Here we report the use of higher dose of guselkumab, a monoclonal antibody targeting interleukin (IL-) 23, in the treatment of PG in a medically complex patient. This case contributes additional evidence supporting the potential effectiveness of guselkumab in the treatment of PG and highlights the necessity for larger studies to confirm these findings.</p>","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"4 1","pages":"240-243"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.547","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of alopecia areata on patients' daily lives: A study using social media in France","authors":"S. Barbarot,&nbsp;Z. Reguiai,&nbsp;P. Voillot,&nbsp;J. Malaab,&nbsp;S. Schück,&nbsp;A. Tamzali","doi":"10.1002/jvc2.539","DOIUrl":"https://doi.org/10.1002/jvc2.539","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alopecia areata (AA) significantly affects patients' quality of life, leading them to seek community and support on social media platforms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aims to explore the disease's impact on patients' lives by analyzing their discussions on these platforms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Through a retrospective analysis of French social media posts from January 2011 to October 2022, the study employed algorithm-based methods and machine learning to identify how AA affects patients' quality of life across physical, psychological, social, and financial dimensions. Additionally, qualitative methods (i.e., saturation) were used to detail the main difficulties faced by patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The analysis covered 5075 posts by 4061 patients, primarily from Twitter/X (59.5% of messages) and YouTube (12.9%). It revealed that 81.8% of patients experienced physical impacts, closely linked to psychological issues (66.1%), with many reporting a detrimental cycle of stress and hair loss leading to anxiety and mental fatigue. This cycle adversely affected their self-image and confidence, resulting in social and professional isolation for 52.0% of patients. Financial strain was also significant, with 35.9% discussing the high costs of treatments and aesthetic maintenance. The primary difficulties included managing stress related to AA (32.1% of messages), handling the disease's duration and relapses (14.1%), and coping with damaged self-image and self-esteem issues, such as femininity and societal judgments (11.1%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study highlights the profound and multifaceted impact of AA on patients, who often turn to social media for support. The findings underscore the importance of a holistic approach to managing AA, considering its extensive physical, psychological, social, and financial effects. Integrating insights from social media with traditional healthcare and epidemiological research could offer new directions for improving patient support and treatment strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"3 5","pages":"1735-1744"},"PeriodicalIF":0.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.539","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}