JEADV clinical practice最新文献

{"title":"A reply to “Letter to the editor in response to the article ‘To assess the attitudes of Irish patients attending a pigmented lesion clinic and healthcare staff employed in an academic hospital to biobanking, a quantitative study’”","authors":"Stephanie Bowe,&nbsp;Claire Quigley,&nbsp;Liana Victory,&nbsp;Eoin Storan","doi":"10.1002/jvc2.558","DOIUrl":"https://doi.org/10.1002/jvc2.558","url":null,"abstract":"<p>Stephanie Bowe conceived and designed the analysis, collected the data, contributed data or analysis tools, performed the analysis, wrote the paper. Claire Quigley collected data at pigmented lesion clinics via paper forms. Liana Victory collected data at pigmented lesion clinics via paper forms. Eoin Storan supervised the project and edited the final paper.</p><p>The authors declare no conflict of interest.</p><p>All subjects gave their informed consent for inclusion before they participated in the study. The study was conducted in accordance with the Declaration of Helsinki, and the protocol was approved by the MMUH and Mater Private Hospital Dublin Institutional Review Board at a meeting in October 2022, with the project reference number: 1/378/2322.</p>","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"3 5","pages":"1716-1717"},"PeriodicalIF":0.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.558","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor in response to the article “To assess the attitudes of Irish patients attending a pigmented lesion clinic and healthcare staff employed in an academic hospital to biobanking, a quantitative study”","authors":"Claudine Howard-James,&nbsp;Claire Quigley,&nbsp;Caoimhe Dalton,&nbsp;Anne-Marie Tobin","doi":"10.1002/jvc2.557","DOIUrl":"https://doi.org/10.1002/jvc2.557","url":null,"abstract":"&lt;p&gt;We read with great interest the recent article by Bowe et al. on the attitudes of Irish patients to biobanking. It is heartening to learn that the majority of patients, healthcare workers and members of the public in Ireland are willing to donate biospecimens for medical research purposes.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; Biobanks are vital to the progression of medical research, and can be defined as structured collections of biological samples and associated data stored for the purposes of present and future research.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; One of the most recognised is the UK Biobank, a database containing genetic, lifestyle and health information from half a million UK participants. Recent UK Biobank data shows malignant melanoma is the fourth most common prevalent malignant cancer and the second most common incident malignant cancer in the 40–49 years age group.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;This willingness of patients to participate in biobanking is not always reflected in the literature. In a literature search conducted on PubMed using the terms ‘biobank’ or ‘biobanking,’ ‘attitudes’ and ‘public’; 337 abstracts were identified. These were reviewed for suitability by the authors and 62 deemed appropriate for inclusion as they contained content specific to public attitudes towards biobanking. Overall, the literature reveals a lack of knowledge of biobanking amongst the general public but a generally positive public opinion on the subject.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; A further literature search was conducted with a melanoma-specific focus on PubMed using the terms ‘biobank’ or ‘biobanking,’ ‘melanoma’ and ‘public.’ This search identified 55 abstracts, which were reviewed for suitability by the authors. There were no papers identified with content specific to public attitudes towards biobanking in melanoma, while there were 32 papers which analysed UK Biobank data for cancer research including in melanoma. We also looked at social media. Targeted searches were performed on TikTok, Facebook, Instagram and Twitter/X using the terms or hashtags ‘biobank’ and ‘biobanking’. The top 10 results on each site were analysed to identify content creator demographics, number of views and/or followers of the page, the type of content and associated hashtags or themes, as outlined in Table 1. On TikTok, the most common demographic of content creator was healthcare professionals, while on the other platforms the most common demographic was research organisations. The reach on TikTok was found to be greater than other platforms, with a mean of 20,100 views per post (range 300–96,000) and an average follower count of 4816. This compares to a mean follower count of 3497 on Instagram, 4340 on Facebook and 4688 on Twitter/X. The type of content across all platforms was predominantly educational, followed by advertising. The most common themes across all platforms were genomics and cancer research. Across all platforms, none of the top posts mentioned biobanking in the","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"3 5","pages":"1713-1715"},"PeriodicalIF":0.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.557","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of alopecia areata on patients' daily lives: A study using social media in France","authors":"S. Barbarot,&nbsp;Z. Reguiai,&nbsp;P. Voillot,&nbsp;J. Malaab,&nbsp;S. Schück,&nbsp;A. Tamzali","doi":"10.1002/jvc2.539","DOIUrl":"https://doi.org/10.1002/jvc2.539","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alopecia areata (AA) significantly affects patients' quality of life, leading them to seek community and support on social media platforms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aims to explore the disease's impact on patients' lives by analyzing their discussions on these platforms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Through a retrospective analysis of French social media posts from January 2011 to October 2022, the study employed algorithm-based methods and machine learning to identify how AA affects patients' quality of life across physical, psychological, social, and financial dimensions. Additionally, qualitative methods (i.e., saturation) were used to detail the main difficulties faced by patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The analysis covered 5075 posts by 4061 patients, primarily from Twitter/X (59.5% of messages) and YouTube (12.9%). It revealed that 81.8% of patients experienced physical impacts, closely linked to psychological issues (66.1%), with many reporting a detrimental cycle of stress and hair loss leading to anxiety and mental fatigue. This cycle adversely affected their self-image and confidence, resulting in social and professional isolation for 52.0% of patients. Financial strain was also significant, with 35.9% discussing the high costs of treatments and aesthetic maintenance. The primary difficulties included managing stress related to AA (32.1% of messages), handling the disease's duration and relapses (14.1%), and coping with damaged self-image and self-esteem issues, such as femininity and societal judgments (11.1%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study highlights the profound and multifaceted impact of AA on patients, who often turn to social media for support. The findings underscore the importance of a holistic approach to managing AA, considering its extensive physical, psychological, social, and financial effects. Integrating insights from social media with traditional healthcare and epidemiological research could offer new directions for improving patient support and treatment strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"3 5","pages":"1735-1744"},"PeriodicalIF":0.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.539","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV-negative HHV8-positive multicentric Castleman's disease coexistent with atypical Kaposi's sarcoma","authors":"Anna Scattone,&nbsp;Giacomo Loseto,&nbsp;Biagina Gisella Mennuni,&nbsp;Valentina Mastrandrea,&nbsp;Rosalba Buquicchio,&nbsp;Caterina Foti,&nbsp;Francesco Alfredo Zito,&nbsp;Raffaele Filotico","doi":"10.1002/jvc2.460","DOIUrl":"https://doi.org/10.1002/jvc2.460","url":null,"abstract":"<p>The co-occurence of multicentric Castleman's disease (MCD) and Kaposi's sarcoma (KS) represents a rare clinical entity, mostly observed in individuals infected with the human immunodeficiency virus (HIV). Human herpesvirus 8 (HHV-8) is attributed a crucial etiological role in both conditions. This study presents the case of a 75-year-old woman who manifested an angiomatous lesion on the right thigh and erythematous firm plaques on the trunk and limbs, accompanied by asthenia, weight loss, and recurrent febrile episodes. Serological markers for HIV yielded negative results. Contrast-enhanced computed tomography (CT) and fluorine-18 fluorodeoxyglucose positron emission tomography (18 F FDG PET/CT) revealed multiple enlarged and intensely hypermetabolic lymph nodes in the supraclavicular, cervical, thoracic, and abdominopelvic regions. Subsequent excisional biopsy and immunohistochemical analysis confirmed the diagnosis of HIV-negative HHV8-positive MCD coexisting with KS.</p>","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"3 5","pages":"1606-1610"},"PeriodicalIF":0.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.460","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol for high-intensity focused ultrasound (HIFU) treatment of cutaneous neurofibromas","authors":"Mimmi Tang,&nbsp;Katrine Elisabeth Karmisholt,&nbsp;Martin Gillstedt,&nbsp;Jaishri O. Blakeley,&nbsp;Joshua Roberts,&nbsp;Jørgen Serup,&nbsp;Torsten Bove,&nbsp;Sirkku Peltonen","doi":"10.1002/jvc2.543","DOIUrl":"https://doi.org/10.1002/jvc2.543","url":null,"abstract":"&lt;p&gt;High-intensity focused ultrasound (HIFU) is widely used for various applications including treatment of cancers of the thyroid,&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; prostate,&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; pancreas&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; and bone metastases&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; as well as targeting deep brain nuclei to treat tremor.&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt; HIFU systems for these treatments operate at frequencies of 0.5–3 MHz. Ultrasound is also used for aesthetic applications, such as body contouring, at frequencies of 4–12 MHz.&lt;/p&gt;&lt;p&gt;The 20 MHz HIFU device used in this study is developed for selective destructive treatments of very small targets in the epidermis and the dermis while sparing the surroundings.&lt;span&gt;&lt;sup&gt;6&lt;/sup&gt;&lt;/span&gt; Each dose produces a combination of mechanical disruption and local heating to approximately 60–65°C at the focal point of the focused ultrasound beam emitted from a concave transducer. The primary effect is cell necrosis. This 20 MHz HIFU has previously been documented useful in actinic keratoses basal cell carcinoma, Kaposi sarcoma and superficial vascular lesions.&lt;span&gt;&lt;sup&gt;7-9&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;The present study reports on efforts to optimise the dose of HIFU applied to cutaneous neurofibroma (cNF) in patients with Neurofibromatosis Type 1 (NF1). This is a second phase extension of an original study of the tolerability and safety of HIFU.&lt;span&gt;&lt;sup&gt;10&lt;/sup&gt;&lt;/span&gt; The two studies are referred to as Phase A and Phase B, respectively. There are no currently approved therapies for NF1-associated cNFs. These skin tumours can count in the hundreds or thousands for a given individual. Due to their associated symptoms of itching, pain and disfigurement, cNF represents a major unmet need.&lt;/p&gt;&lt;p&gt;The study was a 6-month prospective open-label study conducted at the Department of Dermatology and Venereology, University of Gothenburg, Gothenburg, Sweden. The study was registered on www.clinicaltrials.gov under number NCT05119582. The original study included 20 participants across two centres, Bispebjerg Hospital in Copenhagen, Denmark and University of Gothenburg.&lt;span&gt;&lt;sup&gt;10&lt;/sup&gt;&lt;/span&gt; Seven patients from the original cohort were recruited for an additional dosimetry study.&lt;/p&gt;&lt;p&gt;Written informed consent with permission to use anonymized data and photos was obtained on study start in February 2023. All patients had clinically or otherwise verified NF1. cNFs were categorised into flat, sessile and globular types.&lt;/p&gt;&lt;p&gt;Tumours were numbered, and the locations of the included tumours were drawn on a plastic registration sheet to identify the treatment sites at follow-up visits. Tumours were documented by conventional 2D clinical photos at baseline, 1 week, 3 months and 6 months after treatment. A total of four to nine cNFs per patient were treated. An additional two cNFs were included as control tumours. Data were collected in case report forms on the Research Electronic Data Capture (RedCap) platform.&lt;/p&gt;&lt;p&gt;Each selected cNF rec","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"3 5","pages":"1723-1729"},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.543","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of interleukins in dermatology: Exploring the immune mechanisms in skin diseases","authors":"Alvaro Prados-Carmona,&nbsp;Francisco J. Navarro-Triviño,&nbsp;Ricardo Ruiz-Villaverde,&nbsp;Alfredo Corell","doi":"10.1002/jvc2.537","DOIUrl":"https://doi.org/10.1002/jvc2.537","url":null,"abstract":"<p>Interleukins are central in the modulation of immune responses. This narrative review aims to summarize the growing evidence on their significance as key drivers of numerous cutaneous diseases with a special focus in some of the more prevalent chronic inflammatory dermatologic diseases such as psoriasis, atopic dermatitis, allergic contact dermatitis, urticaria, and hidradenitis suppurativa. Additionally, we discuss their relevance in the recent developments in targeted therapies that have significantly transformed the management of these skin conditions. To this end, we have conducted a comprehensive search through the Cochrane Library and Database of Systematic Reviews and the MEDLINE search engine, and we have summarized the available clinical evidence considering up to 466 records including meta-analyses, systematic reviews, reviews and clinical trials. Ultimately, this review intents to foster both dermatologist and non-dermatologist physicians' understanding of the immunology behind the clinical manifestations of some of the most common inflammatory skin diseases and engage with the novel therapeutic approaches by providing accessible insights into the implications of interleukin pathways dysregulation.</p>","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"3 5","pages":"1381-1398"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.537","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment switching and associated economic outcomes in patients with plaque psoriasis treated with biologics: A retrospective analysis of German claims data 2016−2021","authors":"Andreas Pinter,&nbsp;Ahmed M. Soliman,&nbsp;Karina C. Manz,&nbsp;Valeria Weber,&nbsp;Paul Ludwig,&nbsp;Anja Mocek,&nbsp;Ariane Höer,&nbsp;Mark G. Lebwohl","doi":"10.1002/jvc2.512","DOIUrl":"https://doi.org/10.1002/jvc2.512","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Biologics are therapeutic options for the management of moderate−severe plaque psoriasis. Some patients need to switch biologic treatment to achieve satisfactory outcomes, which might have a considerable economic impact.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>We assessed the characteristics and switch rates of patients with plaque psoriasis initiating biologic treatment and compared healthcare resource utilization (HCRU) and associated costs for switching and non-switching.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study was a retrospective claims-based analysis comprising a 182-day baseline period to identify patient characteristics and a 365-day follow-up to assess switch rates, HCRU and associated costs. Data covering claims activity from 2016 to 2021 in a representative sample of four million individuals with statutory insurance in Germany was used.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified 2565 patients with psoriasis initiating biologic treatment with anti-IL-17 (<i>n</i> = 1037), anti-IL-23 (<i>n</i> = 704), anti-TNF-α (<i>n</i> = 583) and anti-IL-12/23 (<i>n</i> = 241) agents. A total of 9.2% of patients switched therapy to another biologic during follow-up, ranging from 4.9% (secukinumab) to 16.5% (etanercept). The probability of treatment switching was significantly lower in patients treated with risankizumab (<i>p</i> &lt; 0.05) than in patients treated with other biologics except guselkumab (<i>p</i> = 0.14). HCRU and associated costs during the follow-up were generally higher with a therapy switch (all-cause: 32,263 ± 15,381€) than without (25,041 ± 12,090€). This applied to direct costs (outpatient services, hospitalization, drug treatment) and indirect costs (sickness benefits). Drug treatment accounted for the largest share of costs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Treatment switching is frequent in patients with moderate−severe plaque psoriasis initiating biologic therapy and is associated with increased HCRU and associated costs. As the probability that a switch occurs within 365 days after treatment initiation widely differs between biologic agents, further research is warranted to determine the underlying reasons for switching to help establish clinically and economically sound therapy sequences.</p>\u0000 </section>\u0000 </div>","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"3 5","pages":"1537-1547"},"PeriodicalIF":0.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.512","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The global epidemiology of vitiligo: A systematic review and meta-analysis of the incidence and prevalence","authors":"Morten Bahrt Haulrig,&nbsp;Rownaq Al-Sofi,&nbsp;Subisan Baskaran,&nbsp;Mie Siewertsen Bergmann,&nbsp;Marianne Løvendorf,&nbsp;Beatrice Dyring-Andersen,&nbsp;Lone Skov,&nbsp;Nikolai Loft","doi":"10.1002/jvc2.526","DOIUrl":"https://doi.org/10.1002/jvc2.526","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 <p>Vitiligo is described with a prevalence of 0.5%−1%. Recent studies suggest an increasing prevalence, but there is a scarcity of studies that have systematically evaluated the global incidence and prevalence. We examined the incidence and the global, regional, and country-specific prevalence of vitiligo in the general population (PROSPERO: CRD42021261643). We systematically searched PubMed, EMBASE, and Web of Science. Each study was categorised in subgroups. The overall analysis comprised all studies, except for studies only examining children and adolescents. Pooled proportions were calculated with the DerSimonian-Laird method for random-effects models with 95% confidence intervals (CI). Of the 7,838 identified studies, 171 were eligible for analysis (participants <i>n</i> = 572,334,973). The overall incidence was 1.59 per 10,000 person-years (95% CI: 0.70−2.83). The overall prevalence was 0.40% (95% CI: 0.37−0.44); no difference was observed between females (0.50%, 95% CI: 0.36−0.66) and males (0.49%, 95% CI: 0.35−0.65). West Asia showed the highest prevalence (0.77%, 95% CI: 0.44−1.10) and East Asia the lowest (0.12%, 95% CI: 0.10−0.14). The highest country-specific prevalence was reported in Jordan (1.34%, 95% CI: 0.12−3.87) and the lowest in Sweden (0.19%, 95% CI: 0.08−0.34). Children and adolescents showed a lower prevalence (0.27%, 95% CI: 0.24−0.31) compared to adults (0.70%, 95% CI: 0.59−0.81). Questionnaire-based studies showed a higher prevalence (0.73%, 95% CI: 0.52−0.98) compared to examination-based studies (0.59%, 95% CI: 0.46−0.73) and register-based studies (0.13%, 95% CI: 0.10−0.17). The prevalence in examination-based studies increased from 0.40% (95% CI: 0.17−0.73) between 1943 and 1979 to 0.89% (95% CI: 0.68−1.13) between 2020 and 2023. Questionnaire-based studies also showed an increasing prevalence, while in register-based studies, the prevalence was continuously low. This study shows the global impact of vitiligo and how subgroup analyses influence the prevalence. The overall prevalence of vitiligo is lower than previously assumed; females and males are equally affected, and vitiligo is more common in adults.</p>\u0000 </section>\u0000 </div>","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"3 5","pages":"1410-1419"},"PeriodicalIF":0.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.526","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clinical trial on the efficacy of mesotherapy with dutasteride for frontal fibrosing alopecia","authors":"Patrizia Elva Aguilar-Calderón,&nbsp;Sonia Sofia Ocampo-Garza,&nbsp;Maira Herz-Ruelas,&nbsp;Jorge Ocampo-Candiani,&nbsp;Adrian Cuellar-Barboza,&nbsp;Emmanuel Sánchez-Meza,&nbsp;Andrea Guerra-Garza,&nbsp;Minerva Gómez-Flores","doi":"10.1002/jvc2.518","DOIUrl":"https://doi.org/10.1002/jvc2.518","url":null,"abstract":"&lt;p&gt;Frontal fibrosing alopecia (FFA) is a lymphocytic cicatricial alopecia characterised by a progressive alopecic band, that affects the hairline, typically in the frontal region of the scalp, responsible for around 40% of all cicatricial alopecias.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; It predominantly affects post-menopausal women aged 55–70 years.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; Different treatments have been proposed, though oral dutasteride is considered the most effective therapeutic option.&lt;/p&gt;&lt;p&gt;However, adverse effects (AE) such as libido alterations, depression, and teratogenicity, warrant consideration. Consequently, intralesional dutasteride has emerged as an alternative without systemic AE.&lt;/p&gt;&lt;p&gt;We performed a clinical trial involving 16 adult women with FFA, diagnosed according to IFFACG criteria.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; This study was approved by our Institutional Review Board (code DE22-00002) and adheres to the Code of Ethics of the World Medical Association, following the Declaration of Helsinki.&lt;/p&gt;&lt;p&gt;After meticulous antiseptic procedures,1 mL of local anaesthesia of 2% lidocaine solution was applied (ring block). Subsequently, multiple 0.1 mL injections of 0.01% dutasteride were administered 1 cm apart into the frontal scalp region using 30 G × 4 mm needles to 1 mL. This monthly procedure was repeated for a total of four sessions.&lt;/p&gt;&lt;p&gt;Statistical analysis was performed with SPSS v. 22.0 (IBM Corp.). Wilcoxon test was conducted to compare density, vellus hair, terminal hair, vellus/terminal hair ratio, thickness and Dermatology Life Quality Index (DLQI) between Visit 1 (V1) and Visit 5 (V5). A &lt;i&gt;p&lt;/i&gt;-value &lt; 0.05 was significant.&lt;/p&gt;&lt;p&gt;Trichoscopic findings indicated significant improvements in hair density and vellus hair count between V1 and V5, as detailed in Table 1. Additionally, there was a notable improvement in perifollicular erythema and scaling, enhancing overall patient satisfaction.&lt;/p&gt;&lt;p&gt;Hair density, hair thickness, vellus hairs and vellus/terminal hair ratio (VTHR) were evaluated using Fotofinder Trichoscale (Bad Birnbach). General characteristics are summarised in Table 1.&lt;/p&gt;&lt;p&gt;GPA showed important improvement in 9 (56.3%) with a Kappa index of 0.81. There was a decrease in perifollicular erythema and perifollicular scale between V1 and V5 (&lt;i&gt;p&lt;/i&gt; = 0.020) and (&lt;i&gt;p&lt;/i&gt; = 0.01), respectively (Table 1).&lt;/p&gt;&lt;p&gt;Regarding the comparison of trichoscopic findings, patients had a density of 71.43 in V1 versus 95.58 hairs/cm&lt;sup&gt;2&lt;/sup&gt; in V5 (&lt;i&gt;p&lt;/i&gt; = 0.036). They presented 12.50 vellus hairs in V1 compared with 29.63 in V5, respectively (&lt;i&gt;p&lt;/i&gt; = 0.008). The VTHR was 0.253 in V1 versus 0.548 in V5 (&lt;i&gt;p&lt;/i&gt; = 0.016) (Figure 1). Concerning the DLQI, patients had a mean score of 3.43 ± 2.58 at V1 compared with 1.56 ± 1.26 at V5 (&lt;i&gt;p&lt;/i&gt; = 0.004).&lt;/p&gt;&lt;p&gt;Our findings suggest significant improvements in hair density and patient satisfaction. This aligns with previous studies that have highlighted the potential of dutasteride","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"3 5","pages":"1694-1697"},"PeriodicalIF":0.0,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.518","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trichoscopy of tinea capitis caused by Microsporum audouinii","authors":"Oscar Ariel Bautista,&nbsp;Vanessa Castro,&nbsp;Carolina Rodriguez,&nbsp;Eduardo Mastrangelo Marinho Falcão,&nbsp;Regina Casz Schechtman,&nbsp;Luna Azulay-Abulafia","doi":"10.1002/jvc2.530","DOIUrl":"https://doi.org/10.1002/jvc2.530","url":null,"abstract":"&lt;p&gt;&lt;i&gt;Tinea capitis&lt;/i&gt; (TC), primarily affecting children aged 3–7, has globally increased in prevalence, and &lt;i&gt;Microsporum canis, a&lt;/i&gt; zoophilic fungi, and &lt;i&gt;Trichophyton tonsurans, an&lt;/i&gt; anthropophilic fungi, have become the major aetiologic agents.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; In the 21st century, reports indicate an increase in the number of cases of anthropophilic transmission due to migrations, urbanization, changes in lifestyle and socioeconomic levels.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;i&gt;Microsporum audouinii&lt;/i&gt;, an anthropophilic fungi endemic to Africa, causes milder inflammatory and chronic TC with late detection due to the lack of subjective symptoms, in comparison with &lt;i&gt;M. canis&lt;/i&gt; infections which are more severe and accompanied by erythema.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;In 2017, the first two cases of TC caused by &lt;i&gt;M. audouinii&lt;/i&gt; in South America were reported in Brazil, involving two siblings without a history of prior travel, indicating possible autochthonous transmission.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;Mycological examination is considered the gold standard diagnostic method of TC.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; However, trichoscopy can be useful for making a correct and early diagnosis before culture results are available.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; Trichoscopy exhibits higher sensitivity (94% vs. 49.1%) and specificity (83%) compared to direct KOH testing in diagnosing TC.&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;An observational, descriptive cross-sectional study was conducted at Instituto de Dermatologia Professor Rubem David Azulay of the Santa Casa da Misericórdia do Rio de Janeiro. We describe the trichoscopic findings of nine children, eight males and one female, aged between 3 and 14 years, average age 7 years, diagnosed with TC caused by &lt;i&gt;M. audouinii&lt;/i&gt; from 2019 to 2023. Fluorescence with Wood lamp was performed identifying bluish-green fluorescence in all of them (Figure 1). Data were extracted from the patients' medical records to analyze clinical and sociodemographic characteristics. Statistical analysis involved calculating absolute frequencies (&lt;i&gt;n&lt;/i&gt;) and relative frequencies (percentages).&lt;/p&gt;&lt;p&gt;The diagnosis of TC caused by &lt;i&gt;M. audouinii&lt;/i&gt; was confirmed by direct KOH testing and culture. KOH testing showed ectothrix parasitism in all samples, while culture on Sabouraud agar displayed colonies of &lt;i&gt;Microsporum&lt;/i&gt; spp. Slide cultures on potato dextrose agar were assessed under light microscopy using lactophenol cotton blue identifying species-specific structures. Growth pattern on boiled rice confirmed the identification. Trichoscopy performed without immersion liquid showed specific TC signs in at least two hairs per analyzed field, assessed by two independent dermatologists. Patients with recent antifungal medication use or inflammatory TC were excluded.&lt;/p&gt;&lt;p&gt;The characteristic trichoscopic findings evaluated for TC observed in the patients were as follows (&lt;i&gt;n&lt;/i&gt; = 9): Morse code-like hairs in seven (78%","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"3 5","pages":"1698-1700"},"PeriodicalIF":0.0,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.530","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}