JEADV clinical practice最新文献

{"title":"Comprehensive Esthetic Skin Regeneration Strategies: Lifestyle, Minimally Invasive Procedures and Dermocosmetic Integration","authors":"Andrea Belén Rey,&nbsp;Rujipattanakul Thidakarn,&nbsp;May El Samahy","doi":"10.1002/jvc2.70097","DOIUrl":"https://doi.org/10.1002/jvc2.70097","url":null,"abstract":"<p>The skin rejuvenation market is rapidly expanding, driven by demand for effective, minimally invasive solutions. Modern esthetic dermatology embraces a comprehensive approach combining evidence-based lifestyle practices, advanced procedures, and dermocosmetics to deliver personalized, natural-looking outcomes. This review focuses on minimally invasive procedures, which are increasingly favored for their rapid results and minimal recovery time. Key modalities include injectables, energy-based devices, chemical and mechanical treatments, often enhanced through combination protocols. Regenerative technologies show promise in esthetic dermatology, including advanced peptides, exosomes, stem cell-derived vesicles, nano collagen, and fat extracts. Dermatologists must consider patient-specific factors such as skin type and gender, while leveraging emerging tools like AI and social media to improve care and education. Despite growing popularity, more robust clinical evidence is needed to support practice. The future lies in holistic, patient-centered strategies that promote long-term skin wellness.</p>","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"4 S1","pages":"S44-S48"},"PeriodicalIF":0.5,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.70097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Universal Dermatology: Bridging Gaps in Skin Health","authors":"Nokubonga Khoza,&nbsp;Valerie D. Callender,&nbsp;Leihong F. Xiang,&nbsp;Andrew F. Alexis","doi":"10.1002/jvc2.70106","DOIUrl":"https://doi.org/10.1002/jvc2.70106","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 <p>Universal dermatology represents a paradigm shift toward inclusive health that acknowledges and addresses the diverse manifestations of dermatological conditions, recognizing that skin and hair exhibit significant variations across global populations. Pigmentary disorders such as melasma and post-inflammatory hyperpigmentation are more prevalent in individuals with darker skin, while socioeconomic disparities, geographic gaps in specialist availability, and limited health literacy contribute to inequities in care. In this review, innovative solutions are explored, including inclusive classification models, culturally competent education, teledermatology, and AI tools designed to work across skin tones. Advances in noninvasive diagnostics and personalized sunscreen recommendations are also discussed. Community-centered programs and strategic workforce planning in resource-limited settings offer further avenues for change. Inclusive clinical trial design and global research collaborations are essential for the generation of data that is generalizable across diverse populations. Through inclusive educational materials, research, and technological advancements, the delivery of high quality and individualized care across global populations can be achieved.</p>\u0000 </section>\u0000 </div>","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"4 S1","pages":"S26-S35"},"PeriodicalIF":0.5,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.70106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"4P Dermatology: A Shift to a Comprehensive Patient-Centered Model","authors":"Brigitte Dréno,&nbsp;Cristian Navarrete-Dechent,&nbsp;Jorge Ocampo-Candiani,&nbsp;Thierry Passeron,&nbsp;Ketty Peris","doi":"10.1002/jvc2.70090","DOIUrl":"https://doi.org/10.1002/jvc2.70090","url":null,"abstract":"<p>Advances in dermatology are embracing a patient-centered, proactive approach through the ‘4P model’: Personalized, Predictive, Preventive, and Participatory care. This shift aims to improve treatment efficacy and safety as well as patient's quality of life. This review explores the applications of ‘4P medicine’ in dermatology, highlighting key concepts and examples like innovations in onco-dermatology and the skin microbiome. In onco-dermatology, molecular profiling guides targeted treatments, while genetic insights improve risk prediction and prevention. Genetic profiling, such as the identification of <i>BRAF</i> mutations in melanoma, has enabled targeted therapies like BRAF/MEK inhibitors to improve patient outcomes. Predictive technologies, including machine learning, are enabling early detection and risk assessment for both melanoma and non-melanoma skin cancers. Preventive strategies focus on proactive skin care, with public education campaigns and digital tools to increase sun protection behaviors and early detection. Participatory care engages patients in decision making, leading to better adherence and outcomes. This integrated approach optimizes outcomes and reduces the burden of skin cancer. Microbiome research has also transformed dermatology, enabling personalized treatments that target microbial imbalances in conditions such as atopic dermatitis, psoriasis and acne. Predictive dermatology uses microbiome signatures to forecast disease risk and response to treatment, enabling earlier intervention. Preventive strategies aim to maintain a healthy microbiome and prevent disease exacerbations. Participatory dermatology encourages patients to engage in microbiome-focused skin care to optimize outcomes. However, challenges remain in terms of treatment optimization, economic sustainability, ethical considerations and equitable access to care. Addressing these challenges requires innovative solutions, collaborative research, and strategies to ensure the accessibility and cost-effectiveness of dermatologic care.</p>","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"4 S1","pages":"S15-S25"},"PeriodicalIF":0.5,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.70090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Our World Is Changing—Global Epidemiologic and Etiologic Perspectives in Dermatology","authors":"Henry W. Lim,&nbsp;Sergio Schalka,&nbsp;Pascale Guitera,&nbsp;Leihong F. Xiang","doi":"10.1002/jvc2.70091","DOIUrl":"https://doi.org/10.1002/jvc2.70091","url":null,"abstract":"<p>The burden of dermatologic conditions is increasing worldwide and this rise is closely related to the interplay between epidemiologic trends and etiologic influences. The global population is experiencing an unprecedented increase in the proportion of older people. An aging population may be more susceptible to the effects of pollution and lifestyle-induced skin changes due to age-related declines in skin barrier function. Climate change alters the onset and progression of skin conditions through factors such as sunlight exposure, temperature, humidity, and extreme weather. In general, their effects have been associated with an increased incidence of various skin conditions. Environmental pollution, occupational and lifestyle factors not only exacerbate existing skin conditions but also contribute to the development of new dermatologic diseases. Urbanisation leads to increased exposure to pollutants that can induce oxidative stress and inflammatory responses in the skin, contributing to diseases such as atopic dermatitis and psoriasis. Lifestyle factors such as diet, stress, sleep patterns and skin care affect the skin's physiological processes, microbiome and immune response, influencing the onset and progression of various skin conditions. Advances in medical treatments, while improving disease outcomes and prolonging lifespan, are creating new dermatologic challenges that are exacerbated in vulnerable populations. As complexity and prevalence of skin conditions increase due to the intricate interactions of epidemiologic and etiologic factors, dermatologists and healthcare providers must rise to the challenge with understanding and innovation. This special issue will provide a dive deep into transformative strategies and groundbreaking paradigms that are reshaping the future of dermatological practice.</p>","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"4 S1","pages":"S5-S14"},"PeriodicalIF":0.5,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.70091","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatology 3.0: New Technologies Transforming the Management of Skin Conditions","authors":"Jerry Tan,&nbsp;Mark Jean-Aan Koh,&nbsp;Cristian Navarrete-Dechent","doi":"10.1002/jvc2.70089","DOIUrl":"https://doi.org/10.1002/jvc2.70089","url":null,"abstract":"<p>Integration of digital technologies in dermatology is revolutionising patient care by increasing accessibility, accuracy and personalisation. This review explores the impact of emerging digital technologies in dermatology, including teledermatology, artificial intelligence (AI), mobile applications, wearable devices and 3D imaging and printing. Teledermatology, using real-time videoconferencing and store-and-forward imaging, has expanded since the COVID-19 pandemic, improving access to dermatologic care in underserved areas. AI-powered algorithms are being increasingly used, particularly in skin cancer detection, by helping clinicians make faster and more accurate diagnosis and treatment decisions in diverse clinical settings. AI is also improving clinical workflows, increasing automation and reducing documentation burden. Mobile health applications, including AI-based tools, are transforming patient self-management and monitoring. Wearable devices enable continuous monitoring of skin health and environmental factors, providing real-time insights into conditions like atopic dermatitis and melanoma. In addition, advances in 3D imaging and printing technologies are enabling for more precise grafts and early detection of skin cancer, leading to improved clinical outcomes. Despite these advancements, significant challenges remain, including automation bias, the need for standardised validation protocols and equitable access across diverse populations. Successful integration of these technologies into clinical practice will require addressing these issues and ensuring data security, improved digital literacy and clear guidelines for their use. Future research should focus on assessing the real-world effectiveness of these technologies and ensuring their equitable use in diverse geographies and patient populations.</p>","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"4 S1","pages":"S36-S43"},"PeriodicalIF":0.5,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.70089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Media in Dermatology and Skin Health: Challenges and Opportunities","authors":"Andrea Belén Rey,&nbsp;Jerry Tan","doi":"10.1002/jvc2.70096","DOIUrl":"https://doi.org/10.1002/jvc2.70096","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The complex interplay between social media and dermatology represents a significant frontier in contemporary healthcare.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To explore the evolving role of social media in dermatology, its impact on skin conditions, care opportunities, and clinical challenges.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Targeted literature review.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Evidence from recent literature demonstrates how digital platforms are reshaping dermatologic communication, patient experience, and information dissemination. Analysis reveals significant platform-specific engagement patterns, an emerging generational divide between “clinical experts” and “social media experts,” and concerning trends in misinformation proliferation. While digital spaces present documented challenges (including algorithm-amplified misinformation and potential psychological impacts for patients with visible skin conditions), they simultaneously offer valuable engagement opportunities through patient support communities, enhanced education, and information dissemination.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Strategic engagement with social media, guided by evidence-based approaches, represents an important pathway for advancing dermatologic care while addressing digital-specific challenges.</p>\u0000 </section>\u0000 </div>","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"4 S1","pages":"S59-S63"},"PeriodicalIF":0.5,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.70096","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healing in a Greener Future: Sustainable Pathways for Dermatology","authors":"Henry W. Lim","doi":"10.1002/jvc2.70101","DOIUrl":"https://doi.org/10.1002/jvc2.70101","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Sustainable dermatology requires balancing patient outcomes with environmental stewardship and social responsibility.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To examine environmental impacts related to skin health and emerging solutions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Targeted literature review.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This review addresses five key domains: formulation chemistry, packaging lifecycle, clinical operations, healthcare equity, and sustainability verification. We highlight emerging solutions, including biodegradable ingredients, circular packaging systems, energy-efficient practices, and teledermatology platforms that expand access to specialized care. The analysis scrutinizes greenwashing risks and the challenges of transforming established practices toward more sustainable alternatives.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>We advocate for comprehensive lifecycle assessments, dermatology-specific certification standards, clinical waste minimization protocols, inclusive care models, and further research on biodegradation pathways, consumer behavior, and AI-enabled diagnostic tools that can democratize access while reducing the carbon footprint of care delivery.</p>\u0000 </section>\u0000 </div>","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"4 S1","pages":"S64-S67"},"PeriodicalIF":0.5,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.70101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Skin−Brain Dialogue: Advancing Psychodermatology Through Integrated Approaches","authors":"Martin Steinhoff,&nbsp;Brigitte Dréno,&nbsp;Andrea Belén Rey,&nbsp;Morita Akimichi","doi":"10.1002/jvc2.70100","DOIUrl":"https://doi.org/10.1002/jvc2.70100","url":null,"abstract":"<p>The skin−brain link is increasingly recognized as a key subject in the emerging fields of psychodermatology and psychoneuroimmunology. This link represents the complex talk and bidirectional relationship between the skin and the mind, reflecting intricate physiological and psychological connections that directly impact the understanding and treatment of skin diseases. This comprehensive review explores the biological basis of the skin−brain axis, an anatomic and functional connection that explains how psychological factors influence skin health, and how skin conditions, in turn, affect psychological well-being. The review highlights the profound impact of skin conditions beyond their visible manifestations, including social stigma, emotional distress and economic burden. Evidence supports integrative management strategies involving multidisciplinary care, psychotherapeutic interventions, patient education and lifestyle modification. Professional training, public awareness and robust support systems are essential to advance psychodermatologic care and prevention. Promising developments such as psychoneuroimmunologic therapies, telemedicine innovations and interdisciplinary training programs offer significant opportunities to improve outcomes in this evolving field, including the potential for precision medicine-based approaches. This review provides data on promising strategies that can be integrated in dermatologic practice, addressing both the dermatologic and psychological dimensions of skin disorders to optimize patient care and quality of life.</p>","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"4 S1","pages":"S49-S58"},"PeriodicalIF":0.5,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.70100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editor's Picks","authors":"","doi":"10.1002/jvc2.70136","DOIUrl":"https://doi.org/10.1002/jvc2.70136","url":null,"abstract":"<p>Mycosis fungoides (MF), the most common type of cutaneous T cell lymphoma, is uncommon in children. De la Vega et al present the largest series so far of children 0 to 18 years with MF, consisting of 123 retrospectively analyzed cases in Mexico City. The median age at diagnosis was 12 years, and all patients presented with early clinical stages (IA or IB). The hypopigmented type of MF was the most common, followed by classical, hyperpigmented, papular, folliculotropic, and other types. Most cases were treated with phototherapy, with a remission rate of 36%. No cases of disease progression were observed, and relapse occurred in 15% of cases. The overall survival rate after median follow-up of 19 months was 100%.</p>","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"4 4","pages":"707-709"},"PeriodicalIF":0.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.70136","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Classification of Mosaicism","authors":"Andrea Diociaiuti,&nbsp;Teresa Oranges,&nbsp;Eulalia Baselga,&nbsp;May El Hachem","doi":"10.1002/jvc2.70078","DOIUrl":"https://doi.org/10.1002/jvc2.70078","url":null,"abstract":"<p>The term ‘mosaic skin disorders’ encompasses conditions in which the skin is involved by mosaic mutations, including epidermal nevi, vascular nevi, connective tissue nevi and lipomatous nevi, among others. Mosaic skin abnormalities can present under a segmental pattern or as nonsegmental skin lesions. Nonsegmental mosaicism, which is most common, includes individual point lesions, tumours, hamartomatous lesions, or malformations, such as melanocytic nevi, Spitz tumours, and sporadic trichoepitheliomas. In some autosomal dominant genodermatoses with multiple skin lesions, a nonsegmental disseminated mosaicism emerges, often associated with neurological or multi-organ involvement. A patchy skin involvement without midline separation is frequently observed in congenital melanocytic nevi. Segmental mosaicism is less common and presents as asymmetric cutaneous lesions in one or more separate body areas, respecting the body's midline. While the precise mechanisms remain uncertain, these segments possibly reflect clonal expansion of cells during prenatal development. In this article, we provide an overview of the types of mosaicism, discussing their patterns, clinical manifestations, and the varying degrees of severity associated with these conditions.</p>","PeriodicalId":94325,"journal":{"name":"JEADV clinical practice","volume":"4 3","pages":"646-651"},"PeriodicalIF":0.5,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.70078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}