Annals of dermatology最新文献

{"title":"Korean Consensus Criteria for the Severity Classification of Alopecia Areata.","authors":"Yong Hyun Jang, Seung Soo Lee, Do Young Park, Young Lee, Do-Young Kim, Hyunsun Park, Hyun-Tae Shin, Jung Eun Kim, Kihyuk Shin, Ji Hae Lee, Jee Woong Choi, Byung Choel Park, Beom Joon Kim, Soo Hong Seo, Chong Hyun Won, Jin Park, Min Sung Kim, Sang Seok Kim, Bark-Lynn Lew, Chang-Hun Huh, Ohsang Kwon, Yang Won Lee, Moon-Bum Kim","doi":"10.5021/ad.24.058","DOIUrl":"10.5021/ad.24.058","url":null,"abstract":"<p><strong>Background: </strong>A set of criteria for severity classification is essential in alopecia areata (AA). Currently, no guidelines are universally accepted for defining AA severity.</p><p><strong>Objective: </strong>This study aimed to establish a set of consensus criteria for classifying the severity of and identifying treatment refractoriness in AA.</p><p><strong>Methods: </strong>A preliminary draft of the definition for moderate-to-severe AA was crafted based on available evidence, and members of the Korean Hair Research Society (KHRS) subsequently endorsed the recommendation through an online survey.</p><p><strong>Results: </strong>In the first Delphi round, consensus was attained on 15 questions. After refining certain items in the second round, consensus was achieved on 23 out of 26 questions. The KHRS first defined AA severity using the severity of alopecia tool (SALT). SALT ≥50 was defined as severe, 20≤ SALT <50 as moderate, and SALT <20 as mild. Moderate AA was considered severe if it meets one or more of the following criteria: dermatology life quality index >10, presence of accompanying eyebrow or eyelash loss, positive hair loss activity, or treatment-refractory AA.</p><p><strong>Conclusion: </strong>These consensus criteria can help clinicians accurately diagnose AA, provide appropriate treatment, and monitor its progression.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 4","pages":"236-246"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11291096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alopecia Areata and Season of Onset: A Retrospective Study of 492 Cases.","authors":"Sang-Hoon Lee, Seung-Won Jung, Won-Soo Lee","doi":"10.5021/ad.23.032","DOIUrl":"10.5021/ad.23.032","url":null,"abstract":"","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 3","pages":"188-190"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tranexamic Acid Ameliorates Skin Hyperpigmentation by Downregulating Endothelin-1 Expression in Dermal Microvascular Endothelial Cells.","authors":"Lin-Xia Liu, Zhi-Kai Liao, Bing-Qi Dong, Shan Jiang, Tie-Chi Lei","doi":"10.5021/ad.23.108","DOIUrl":"10.5021/ad.23.108","url":null,"abstract":"<p><strong>Background: </strong>Although reports suggest that tranexamic acid (TXA) has clinical benefits for melasma patients by oral, intralesional and topical treatment, the optimal route of TXA therapy and the underlying mechanism involved remain poorly defined.</p><p><strong>Objective: </strong>To compare the skin lightening effect between oral TXA and topical TXA and to dissect the molecular mechanisms using ultraviolet B (UVB)-induced hyperpigmentation mouse model, <i>ex vivo</i> cultured human skin explant, and cultured melanocytes (MCs) and endothelial cells.</p><p><strong>Methods: </strong>Melanin content and cluster of differentiation 31 (CD31)-positive cell numbers were measured in tail skins from UVB-irradiated mice treated by intragastral or topical TXA using immunofluorescent and <i>Fontana-Masson</i> staining. The conditioned medium (CM) was harvested from human umbilical vein endothelial cells treated with or without 3 mM TXA and was used to treat MCs for 48 hours. mRNA and protein levels of tyrosinase and microphthalmia-associated transcription factor were measured using quantitative real-time reverse transcription polymerase chain reaction and western blotting assays. HMB45- and CD31-positive cell numbers as well as melanin content were also examined in <i>ex vivo</i> cultured human skin explants.</p><p><strong>Results: </strong>The hyperpigmented phenotype were significantly mitigated in UVB-irradiated tail skin plus intragastral TXA-treated mice compared with mice treated with UVB only or with UVB plus topical TXA. CD31-positive cell numbers correlated with the anti-melanogenic activity of TXA therapy. The data from cultured cells and skin tissues showed that suppression of endothelin-1 (ET-1) in vascular endothelial cells by TXA reduced melanogenesis and MC proliferation.</p><p><strong>Conclusion: </strong>Oral TXA outperforms topical TXA treatment in skin lightening, which contributes to suppression of ET-1 in dermal microvascular endothelial cells by TXA.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 3","pages":"151-162"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Amount of Daily Water Intake and Use of Moisturizer on Skin Barrier Function in Healthy Female Participants.","authors":"Jung Eun Seol, Gyeong Je Cho, Seung Hee Jang, Sang Woo Ahn, Seong Min Hong, So Hee Park, Hyojin Kim","doi":"10.5021/ad.23.067","DOIUrl":"10.5021/ad.23.067","url":null,"abstract":"<p><strong>Background: </strong>It is well known that adequate water intake and moisturizer application improves skin barrier function.</p><p><strong>Objective: </strong>This study was conducted to analyze the effects of daily water intake and moisturizer application on skin barrier function and the degree of response to barrier recovery.</p><p><strong>Methods: </strong>Participants with daily water intake more than 1 L were classified as high daily water intake group (H) and those with less than 1 L as low daily water intake group (L). Each group was subcategorized into four groups according to intervention method: additional water intake (H1, L1), moisturizer (H2, L2), both (H3, L3), and control (H4, L4). Transepidermal water loss (TEWL) and stratum corneum hydration (SCH) were measured at baseline during the 2nd and 4th week.</p><p><strong>Results: </strong>A total of 43 participants completed the study (H: 22, L: 21). At baseline, there was no significant difference in SCH and TEWL in any on the anatomical sites between the high daily water intake and low daily water intake groups. However, SCHs of left forearm (group H2, <i>p</i>=0.004; group H3, <i>p</i>=0.004), left hand dorsum (group H2, <i>p</i>=0.010; group H3, <i>p</i>=0.026), and left shin (group H2, <i>p</i>=0.016; group H3, <i>p</i>=0.001) in group H2 and H3 were significantly increased in the 4th week as compared to the baseline values.</p><p><strong>Conclusion: </strong>The results suggest that the degree of water intake may be related to improved skin barrier function. However, application of additional moisturizers had more favorable impact on skin hydration as compared to additional water intake.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 3","pages":"145-150"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Bleomycin Intralesional Injection for Treating Digital Mucous Cysts: A Comparative Study of Corticosteroid Intralesional Injection and Surgical Excision.","authors":"Yoon Jae Kim, Hyun Mo Lee, Jun Hyuk Cho, Dai Hyun Kim, Hyo Hyun Ahn, Soo Hong Seo","doi":"10.5021/ad.23.131","DOIUrl":"10.5021/ad.23.131","url":null,"abstract":"<p><strong>Background: </strong>Sclerotherapy has shown superior efficacy among the nonsurgical options for managing digital mucous cysts (DMC). Notably, previous research has indicated that bleomycin offers a more favorable side-effect profile and similar efficacy to conventional sclerosing agents.</p><p><strong>Objective: </strong>This study aimed to assess the efficacy and safety of bleomycin intralesional injection (ILI) for treating DMC through a comparative analysis of corticosteroid ILI and surgical excision.</p><p><strong>Methods: </strong>We retrospectively reviewed electronic medical records and clinical photographs. Telephone interviews were conducted to further investigate long-term treatment efficacy, safety, and overall treatment satisfaction.</p><p><strong>Results: </strong>Ten patients underwent surgical excision, and 13 and 15 patients received bleomycin and corticosteroid ILI, respectively. Both surgical excision and bleomycin ILI demonstrated superior treatment efficacy compared to corticosteroid ILI. No statistically significant difference in the treatment effectiveness between surgical excision and bleomycin ILI was observed. No significant adverse effects were observed. In the survey, the level of satisfaction was the highest for bleomycin ILI, followed by surgical excision and corticosteroid ILI.</p><p><strong>Conclusion: </strong>This study revealed that bleomycin ILI exhibits a treatment efficacy higher than that of corticosteroid ILI and slightly lower than that of surgical excision, without any side effects. Therefore, bleomycin ILI is a safe and effective therapeutic option for the treatment of DMC.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 3","pages":"180-185"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update on Melasma Treatments.","authors":"Ju Young Jo, Su Ji Chae, Hwa Jung Ryu","doi":"10.5021/ad.23.133","DOIUrl":"10.5021/ad.23.133","url":null,"abstract":"<p><p>Melasma is a prevalent hyperpigmentation condition known for its challenging treatment due to its resemblance to photoaged skin disorders. Numerous studies have shed light on the intricate nature of melasma, which often bears similarity to photoaging disorders. Various therapeutic approaches, encompassing topical and systemic treatments, chemical peeling, and laser therapy, have exhibited efficacy in managing melasma in previous research. However, melasma often reoccurs despite successful treatment, primarily due to its inherent photoaged properties. Given that melasma shares features with photoaging disorders, including disruptions in the basement membrane, solar elastosis, angiogenesis, and mast cell infiltration in the dermal layer, a comprehensive treatment strategy is imperative. Such an approach might involve addressing epidermal hyperpigmentation while concurrently restoring dermal components. In this article, we provide a comprehensive review of conventional treatment methods frequently employed in clinical practice, as well as innovative treatments currently under development for melasma management. Additionally, we offer an extensive overview of the pathogenesis of melasma.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 3","pages":"125-134"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical Efinaconazole Combined With Drilling and Grinding for Onychomycosis in Chronic Renal Failure Patients: A Pilot Study.","authors":"So Hee Park, Seung Hee Jang, Sang Woo Ahn, Seong Min Hong, Jung Eun Seol, Hyojin Kim","doi":"10.5021/ad.23.027","DOIUrl":"10.5021/ad.23.027","url":null,"abstract":"","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 3","pages":"186-187"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Perspectives of YAP/TAZ in Human Skin Epidermal and Dermal Aging.","authors":"Jun Young Kim, Taihao Quan","doi":"10.5021/ad.23.156","DOIUrl":"10.5021/ad.23.156","url":null,"abstract":"<p><p>Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are key downstream effectors of the Hippo signaling pathway, which plays a central role in tissue homeostasis, organ development, and regeneration. While the dysregulation of YAP/TAZ has been linked to various human diseases, their involvement in the aging of human skin has only recently begun to manifest. In the skin, the YAP/TAZ effectors emerge as central regulators in maintaining homeostasis of epidermal stem cells and dermal extracellular matrix, and thus intimately linked to skin aging processes. This review underscores recent molecular breakthroughs highlighting how age-related decline of YAP/TAZ activity impacts human epidermal and dermal aging. Gaining insight into the evolving roles of YAP/TAZ in human skin aging presents a promising avenue for the development of innovative therapeutic approaches aimed at enhancing skin health and addressing age-related skin conditions.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 3","pages":"135-144"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survey on Resident Education for Surgical Dermatology in South Korea.","authors":"Seong Jin Jo, Hyun Mo Lee, Nark-Kyoung Rho, Min Sung Kim, Hwa Jung Ryu, Hoon-Soo Kim, Byung Cheol Park, Mi Ryung Roh, Suk Bae Seo, Hyojin Kim, Young-Joon Seo, Kapsok Li, Chang Hun Huh, Ki Hoon Song, Kyle K Seo, Soo Hong Seo","doi":"10.5021/ad.23.130","DOIUrl":"10.5021/ad.23.130","url":null,"abstract":"<p><strong>Background: </strong>With the increasing demand for surgical procedures in dermatology, resident education in surgical dermatology has become important for delivering high-quality treatment. However, it remains unclear if a sufficient number of residency programs with quality standards exist, as there has been little research on this subject in South Korea.</p><p><strong>Objective: </strong>To identify the status of surgical dermatology education among residents and assess dermatologists' perceptions of the subject.</p><p><strong>Methods: </strong>A 35-question survey was developed and distributed to all resident training hospitals and local clinics listed by the Korean Society of Dermatologic Surgery. Only third- and fourth-year residents were included and board-certified specialists from training hospitals and local clinics responded to the surveys.</p><p><strong>Results: </strong>Survey participants included 88 residents and 120 specialists of whom one-quarter of the residents attended regular monthly educational sessions. Most residents (93%) participated in cosmetic procedures, and many performed laser therapy. However, the opportunity for toxin or filler injection was rare, with only 12% of the residents having experience with filler injections. In response, 49% of residents and 32% of specialists said that more cosmetic training was required, whereas 28% of residents and 50% of specialists said that more training for both cosmetic and conventional surgeries was necessary.</p><p><strong>Conclusion: </strong>The survey demonstrated a need for more training programs in surgical dermatology during residency and a perception gap between residents and specialists. Therefore, developing educational residency programs that focus on basic dermatologic surgery principles and their applications in cosmetic procedures is essential.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 3","pages":"172-179"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD4/CD8 Ratio: An Independent Predictor of Herpes Zoster in Patients With Autoimmune Inflammatory Rheumatic Diseases.","authors":"Peng-Cheng Liu, Yi-Lin Peng, Jian-Bin Li, Meng-Na Lv, Shu-Jiao Yu, Rui Wu","doi":"10.5021/ad.23.126","DOIUrl":"10.5021/ad.23.126","url":null,"abstract":"<p><strong>Background: </strong>A higher incidence of herpes zoster (HZ) was found in people with decreased cell-mediated immunity. However, the relationship between cellular immunity and HZ infection in patients with autoimmune inflammatory rheumatic diseases (AIRD) remains elusive.</p><p><strong>Objective: </strong>To investigate the role of CD4/CD8 ratio in patients with AIRD and HZ.</p><p><strong>Methods: </strong>This case-control study compared AIRD patients with and without HZ. We chose 70 AIRD patients with HZ as the experimental group and 140 AIRD patients without HZ as the control group. The clinical and laboratory findings were assessed in each trial participant.</p><p><strong>Results: </strong>The CD4/CD8 ratio (odds ratio [OR], 0.22; 95% confidence interval [CI], 0.10-0.49) was independently associated with the occurrence of HZ after adjusting for various confounders. Nonlinear analysis has unveiled a more profound nonlinear relationship between the CD4/CD8 ratio and the occurrence of HZ in patients with AIRD. The OR of HZ increased with a decreasing CD4/CD8 ratio before the turning point of 2. The adjusted regression coefficient was 0.14 (95% CI, 0.05-0.37, <i>p</i><0.0001) for CD4/CD8 ratio less than 2.</p><p><strong>Conclusion: </strong>The CD4/CD8 ratio was expected to be a very promising quantitative biomarker for predicting the risk of developing HZ in patients with AIRD.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 3","pages":"163-171"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}