Jung Eun Seol, Seong Min Hong, Sang Woo Ahn, Jong Uk Kim, Gyeong Je Cho, Woo Jung Jin, So Hee Park, Hyojin Kim
{"title":"A Case of Neutrophil-Rich Anaplastic Large-Cell Lymphoma with Relapse.","authors":"Jung Eun Seol, Seong Min Hong, Sang Woo Ahn, Jong Uk Kim, Gyeong Je Cho, Woo Jung Jin, So Hee Park, Hyojin Kim","doi":"10.5021/ad.21a.028","DOIUrl":"10.5021/ad.21a.028","url":null,"abstract":"<p><p>After anaplastic large-cell lymphoma (ALCL) was first described by Stain in 1985, there have been several histological variants of ALCL reported. There are classified histological subtypes of ALCL, such as lymphohistiocytic, small cell, Hodgkin-like, composite pattern, and other less common variants including neutrophil-rich ALCL. A 63-year-old male patient presented with erythematous exophytic mass on the left lower leg. In the past, his condition had been diagnosed as abdominal primary cutaneous ALCL (pcALCL), which recurred as systemic ALCL (sALCL) in the left bronchus. After treatment, he achieved complete remission. Histopathologic examination showed large-sized pleomorphic, anaplastic mitotic tumor cells, several neutrophils, and a few lymphocytes. Neutrophil-rich ALCL is a rare histological variant of ALCL. It is characterized by the presence of CD30-positive anaplastic tumor cells with numerous neutrophil infiltrations. Neutrophil-rich ALCL responds well to treatment but tends to recur. There were four cases reported to have recurrent neutrophil-rich ALCL. All cases were diagnosed with neutrophil-rich pcALCL prior to recurrence. Three cases had local recurrence, and only one case relapsed as sALCL. Herein, we present the first case of neutrophil-rich ALCL recurring as sALCL twice.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"35 Suppl 1","pages":"S76-S78"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/95/d3/ad-35-S76.PMC10608385.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49687012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joong Ho Kim, Ji An Uh, Jae Ho Lee, Ho Young Kim, Soo Kyung Lee, Myoung Shin Kim, Un Ha Lee
{"title":"A Case of Atypical Granuloma Annulare Presenting As Palmoplantar Pustules.","authors":"Joong Ho Kim, Ji An Uh, Jae Ho Lee, Ho Young Kim, Soo Kyung Lee, Myoung Shin Kim, Un Ha Lee","doi":"10.5021/ad.21.029","DOIUrl":"10.5021/ad.21.029","url":null,"abstract":"Granuloma annulare (GA) is an inflammatory skin disease characterized by ring-shaped, skin-colored to erythematous papules or plaques. GA is clinically classified into localized, generalized, subcutaneous, perforating, and patch types. However, it occasionally shows non-typical patterns such as palmoplantar, blaschkolinear, pustular, and visceral types 1 . Here","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"35 Suppl 1","pages":"S126-S128"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/da/f1/ad-35-S126.PMC10608401.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49687009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gayun Baek, Taehan Koo, Min-Soo Kim, Mihn-Sook Jue
{"title":"Cutaneous Cytomegalovirus Infection Presenting As Recalcitrant Bullous Pemphigoid Lesion.","authors":"Gayun Baek, Taehan Koo, Min-Soo Kim, Mihn-Sook Jue","doi":"10.5021/ad.21.016","DOIUrl":"10.5021/ad.21.016","url":null,"abstract":"<p><p>Cytomegalovirus (CMV) infection is common among immunocompromised hosts; however, its cutaneous manifestation is considered rare in comparison to internal organ involvement. Clinical manifestations of cutaneous CMV infection generally include perioral or perianal ulcerations. On the other hand, autoimmune bullous dermatosis can have bullae and ulcerations similar to those caused by cutaneous CMV infection. Autoimmune bullous dermatosis requires treatment with immunosuppressive agents for relatively long periods, which may cause reduction of immunocompetence. Because of this iatrogenic immunosuppression, patients with autoimmune bullous dermatosis subsequently acquire increased risk for opportunistic infections. However, cases of bullous pemphigoid (BP) complicated by cutaneous CMV infection are rarely reported. Herein, we report the case of an 88-year-old male who had BP and subsequently recalcitrant perianal skin lesions, which were eventually diagnosed as cutaneous CMV infections.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"35 Suppl 1","pages":"S97-S99"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b8/d8/ad-35-S97.PMC10608396.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49687054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dermoscopy for the Diagnosis of Creeping Hair Caused by Ingrowing Hair: A Case Report.","authors":"Lijuan Xu, Xinhai Liu, Wei Zhu, Lingling Zheng","doi":"10.5021/ad.21.036","DOIUrl":"10.5021/ad.21.036","url":null,"abstract":"<p><p>Creeping hair is a rare condition characterized by creeping eruption with a black line at the advancing end, mimicking cutaneous larva migrans. The condition is also referred to as cutaneous pili migrans, migrating hair, and embedded hair. A total of 52 cases have been reported since 1957 and most cases were published in English. Herein, we report a case in which creeping hair occurred in the iliac region and review the literature from 1957 to February 2021. A 35-year-old Chinese female presented with a black moving linear eruption that had migrated from the lower abdomen to the iliac region without causing any symptoms during a 3-year period. Cutaneous examination showed a 6.5-cm-long black linear lesion beneath the skin that was revealed to be a hair shaft. After removal of the hair, the eruption diminished and no recurrence occurred in 3 months of follow-up. The creeping hair that had migrated with its lower end forward was confirmed by observation under dematoscopy and light microscopy. A review of the literature revealed that creeping hair occurs most frequently in young and middle-aged patients and the reported cases are mainly from Asia. The top locations involve the foot. The causative hair includes head hair, beard, pubic hair, body hair, and one case of dog hair. A close-up examination and dermoscopic inspection are helpful for the diagnosis of creeping hair.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"35 Suppl 1","pages":"S112-S116"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/0c/ad-35-S112.PMC10608377.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49687055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sujin Park, Yeongjoo Oh, Howard Chu, Chang Ook Park
{"title":"Development of Demodicosis after Omalizumab Injection.","authors":"Sujin Park, Yeongjoo Oh, Howard Chu, Chang Ook Park","doi":"10.5021/ad.21.027","DOIUrl":"10.5021/ad.21.027","url":null,"abstract":"","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"35 Suppl 1","pages":"S182-S183"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/22/78/ad-35-S182.PMC10608361.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49687056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hae Chan Lee, Yiyoung Kwon, Eun Sil Kim, Soomin Ahn, Yon Ho Choe, Mi Jin Kim
{"title":"Dual Biological Therapy for Ulcerative Colitis with Intractable Pyoderma Gangrenosum.","authors":"Hae Chan Lee, Yiyoung Kwon, Eun Sil Kim, Soomin Ahn, Yon Ho Choe, Mi Jin Kim","doi":"10.5021/ad.21.060","DOIUrl":"10.5021/ad.21.060","url":null,"abstract":"<p><p>Pyoderma gangrenosum is one of the dermatological extra-intestinal manifestations of ulcerative colitis (UC). We report a case of a 26-year-old male patient suffering from relapsed UC with a newly developed pyoderma gangrenosum. His skin and intestinal symptoms were intractable to treatment with steroids, immunosuppressants, or a single biological agent such as infliximab, golimumab, or vedolizumab. For the first time in Korea, we report a successful treatment experience of pyoderma gangrenosum in UC using dual biological agents, vedolizumab and infliximab. We strategically targeted each of the intestinal and skin symptoms, with a specific biological agent based on the drug's mechanism of action.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"35 Suppl 1","pages":"S107-S111"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/d0/ad-35-S107.PMC10608359.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49687058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jee-Woo Kim, Jung-Won Shin, Anna Cho, Chang-Hun Huh
{"title":"Hereditary Leiomyomatosis and Renal Cell Cancer: A Case Report of Pilar Leiomyomatosis with History of Kidney Cancer and Review of the Literature.","authors":"Jee-Woo Kim, Jung-Won Shin, Anna Cho, Chang-Hun Huh","doi":"10.5021/ad.20.287","DOIUrl":"10.5021/ad.20.287","url":null,"abstract":"<p><p>Pilar leiomyoma or piloleiomyoma is a benign neoplasm of the smooth muscle arising from the arrector pili muscle. It manifests as brown to red firm papulonodules with sites of predilection being the face, trunk, and extensor surfaces of the extremities. Histologically, the lesions exhibit ill-defined dermal tumors with interlacing fascicles of spindle cells. Some genodermatoses are characterized by the development of visceral tumors and cutaneous leiomyomatosis such as Reed's syndrome, and hereditary leiomyomatosis and renal cell cancer (HLRCC). A 55-year-old male presented with reddish-brown papules and nodules on the face and upper back, accompanied by sharp episodic pain on the face. He had undergone nephrectomy for renal cancer 9 years ago, and his younger brother had similar cutaneous manifestation. Histopathologic findings were consistent with pilar leiomyoma, showing bundles of smooth muscle tumors in the dermis. Based on the clinical information including clinical features, past medical history, and family history, HLRCC was highly suspected. To confirm the diagnosis, whole exome sequencing was performed using peripheral blood, which revealed a novel point mutation (c.739G>A, p.Glu247Lys) in the fumarate hydratase (<i>FH</i>) gene. We describe a confirmed case of HLRCC, which is a genetic disorder with a potential to cause visceral cancers, which dermatologists might overlook as a benign condition.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"35 Suppl 1","pages":"S14-S18"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/05/95/ad-35-S14.PMC10608374.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49687063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Primary Cutaneous Apocrine Carcinoma and Syringocystadenoma Papilliferum Arising in Nevus Sebaceus: A Case Report and Review of the Literature.","authors":"Jee Woo Kim, Jung Won Shin, Chang-Hun Huh","doi":"10.5021/ad.21.039","DOIUrl":"10.5021/ad.21.039","url":null,"abstract":"<p><p>Nevus sebaceus is a hamartomatous lesion characterized by epidermal, follicular, sebaceus, and apocrine gland abnormalities. Approximately 25% of affected individuals may develop benign or malignant secondary neoplasms within the preceding nevus sebaceus. Primary cutaneous apocrine carcinoma (PCAC) is a rare malignant skin tumor affecting elderly adults in their sixth decade of life. Histologically, PCAC appears as a dermal tumor displaying apocrine differentiation with decapitation secretion and malignant features. Secondary malignancy arising from nevus sebaceus is a rare complication, especially for apocrine carcinoma. To date, approximately 200 cases of PCAC have been reported in the literature, and only a few cases have developed PCAC on the scalp. Very few cases (approximately only 12) of PCACs developing in nevus sebaceus have been reported. Here, we report an extremely rare case of the coexistence of PCAC and syringocystadenoma papilliferum arising within nevus sebaceus of the scalp.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"35 Suppl 1","pages":"S4-S9"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2e/75/ad-35-S4.PMC10608364.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49687071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Consideration for an Unlikely Culprit Drug (Betahistine) Inducing Toxic Epidermal Necrolysis: A Case Report.","authors":"Tetsuharu Ikegami, Shujiro Hayashi, Maki Okamoto, Junko Kanai, Yuki Kaneko, Yuki Saito, Tomoko Kaminaga, Youichiro Hamasaki, Ken Igawa","doi":"10.5021/ad.20.247","DOIUrl":"10.5021/ad.20.247","url":null,"abstract":"which was detached from the dermis on the basal cell side were revealed (A: H&E, ×200). A slight infiltration of inflammatory cells in the upper layer of the dermis was observed (B: H&E, ×200).","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"35 Suppl 1","pages":"S135-S136"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/7b/ad-35-S135.PMC10608363.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49687083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jongwook Kim, Kyung-Nam Bae, Jin-Hwa Son, Kihyuk Shin, Hoon-Soo Kim, Hyun-Chang Ko, Moon-Bum Kim, Byungsoo Kim
{"title":"Unilateral Psoriasis on the Left Leg and Poliomyelitis of the Right Leg: A Case Report and Review of the Etiology.","authors":"Jongwook Kim, Kyung-Nam Bae, Jin-Hwa Son, Kihyuk Shin, Hoon-Soo Kim, Hyun-Chang Ko, Moon-Bum Kim, Byungsoo Kim","doi":"10.5021/ad.21.174","DOIUrl":"10.5021/ad.21.174","url":null,"abstract":"<p><p>Psoriasis is a common immune-mediated, inflammatory skin disease. However, unilateral psoriasis is rare and few cases have been reported. A 59-year-old male with a polio-affected right leg presented with exfoliative skin on the left leg for three months. He had been treated under the diagnosis of contact dermatitis with secondary infection. After the exfoliative skin lesions improved, psoriatic papules were noted, which was ultimately diagnosed as psoriasis and successfully treated with topical steroid and vitamin D agents. We propose that the Koebner phenomenon has acted as the triggering and aggravating factor of unilateral psoriasis in this patient.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"35 Suppl 1","pages":"S93-S96"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/01/47/ad-35-S93.PMC10608392.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49687087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}