Yeon-Gu Choi, Hyeon Jeong Park, Sunmin Yim, Heun Joo Lee, Young Jun Choi, Won-Serk Kim, Ga-Young Lee
{"title":"Fixed Drug Eruption in a Patient Taking Valacyclovir without Cross-Reactivity to Acyclovir.","authors":"Yeon-Gu Choi, Hyeon Jeong Park, Sunmin Yim, Heun Joo Lee, Young Jun Choi, Won-Serk Kim, Ga-Young Lee","doi":"10.5021/ad.21.074","DOIUrl":"10.5021/ad.21.074","url":null,"abstract":"<p><p>Fixed drug eruption (FDE) is a well-defined hyperpigmented patch that recurs in a fixed location each time a particular drug is taken. Common causative agents of FDE are non-steroidal anti-inflammatory drugs, non-narcotic analgesics, sedatives, anticonvulsants, sulfonamides, and tetracycline. We report a 33-year-old male who presented with a recurrent, localized, brownish-to-erythematous macule and papules on the peri-philtrum area two hours after taking valacyclovir. Three episodes of valacyclovir ingestion for treatment of Herpes simplex virus infection provoked a similar skin rash at the same site. Histopathology results showed vacuolar degeneration in the basal layer of the epidermis, pigmentary incontinence, and perivascular inflammatory cell infiltration in the papillary dermis. Although patch test and skin prick test showed negative responses to acyclovir and valacyclovir, an intradermal test showed a positive reaction only to valacyclovir. The oral provocation test to acyclovir and valacyclovir showed a positive reaction only to valacyclovir. Through drug history, histopathological examination, patch test, intradermal test, and oral provocation test, we established a final diagnosis of FDE due to valacyclovir without cross-reactivity to acyclovir. To find alternative therapeutic drugs, we suggest diagnostic tests with not only the suspected drugs, but also other drugs in the same class.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"35 Suppl 1","pages":"S55-S58"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f4/c5/ad-35-S55.PMC10608398.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49687061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hyeon Jeong Park, Won-Serk Kim, Seung-Wan Chae, Young-Jun Choi
{"title":"Insulin-Derived Cutaneous Amyloidosis: A Possible Complication of Repeated Insulin Injections.","authors":"Hyeon Jeong Park, Won-Serk Kim, Seung-Wan Chae, Young-Jun Choi","doi":"10.5021/ad.20.207","DOIUrl":"10.5021/ad.20.207","url":null,"abstract":"<p><p>Primary localized cutaneous amyloidosis (PLCA) is characterized by extracellular deposition of pathological fibril aggregation of proteins in the skin without systemic involvement. Macular amyloidosis, lichen (papular) amyloidosis, and nodular amyloidosis are three different subtypes of PLCA. Although the pathological mechanism of PLCA has not yet been clarified, it is assumed that a nucleus formation of amyloid fibril is formed due to repeated external stimulation, such as subcutaneous injection, which often poses diagnostic challenges. Herein, we present a 54-year-old Korean male patient with cutaneous localized amyloidosis which occurred after repeated local insulin injections, and discuss the relationship between insulin therapy in patients with diabetes mellitus and dermal amyloid deposition.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"35 Suppl 1","pages":"S71-S75"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ee/b6/ad-35-S71.PMC10608354.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49687065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jang Hwan Jung, Sun Mun Jeong, Do Ik Kwon, Seol Hwa Seong, Joon Hee Kim, Jong Bin Park, Kee Suck Suh, Min Soo Jang
{"title":"Successful Treatment of Recalcitrant Palmoplantar Pustulosis with Guselkumab.","authors":"Jang Hwan Jung, Sun Mun Jeong, Do Ik Kwon, Seol Hwa Seong, Joon Hee Kim, Jong Bin Park, Kee Suck Suh, Min Soo Jang","doi":"10.5021/ad.21b.064","DOIUrl":"10.5021/ad.21b.064","url":null,"abstract":"Palmoplantar","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"35 Suppl 1","pages":"S165-S167"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/98/83/ad-35-S165.PMC10608383.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49687081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Young Sun Suh, Eui Chang Jung, Yun Sun Moon, Seung-Geun Lee, Hyun-Ok Kim
{"title":"A Case of Palisaded Neutrophilic and Granulomatous Dermatitis Associated with an Initial Presentation in Ankylosing Spondylitis.","authors":"Young Sun Suh, Eui Chang Jung, Yun Sun Moon, Seung-Geun Lee, Hyun-Ok Kim","doi":"10.5021/ad.21.063","DOIUrl":"10.5021/ad.21.063","url":null,"abstract":"<p><p>Palisaded neutrophilic and granulomatous dermatitis (PNGD) is an inflammatory dermatosis associated with systemic immune-mediated diseases such as rheumatoid arthritis, systemic sclerosis, lupus erythematosus, and ulcerative colitis. Histologically, serial development of leukocytoclastic vasculitis is shown from an early stage, which can progress to palisading granuloma in the fully developed stage and to fibrosis in the final stage. A 32-year-old man presented with ankylosing spondylitis showing multiple erythematous papules on his fingers, elbows, knees, and left auricle. Histologic examination from his skin lesion revealed a perforating palisading granuloma with leukocytoclastic vasculitis, which was consistent with PNGD. Therefore, this study reported a case of PNGD accompanied by ankylosing spondylitis as an initial presentation.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"35 Suppl 1","pages":"S34-S37"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/17/11/ad-35-S34.PMC10608376.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49686948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hye Won Hwang, Seon Bok Lee, Jeonghyun Shin, Gwang Seong Choi, Ji Won Byun
{"title":"A Case of Perineal Hemangioma, External Genitalia Malformations, Lipomyelomeningocele, Vesicorenal Abnormalities, Imperforate Anus, and Skin Tag (PELVIS) Syndrome with Extensive Perineal Infantile Hemangioma.","authors":"Hye Won Hwang, Seon Bok Lee, Jeonghyun Shin, Gwang Seong Choi, Ji Won Byun","doi":"10.5021/ad.21.183","DOIUrl":"10.5021/ad.21.183","url":null,"abstract":"<p><p>PELVIS syndrome describes the constellation of perineal hemangioma, external genitalia malformations, lipomyelomeningocele, vesicorenal abnormalities, imperforate anus, and skin tag. A 2-month-old girl presented with infantile hemangioma on her perineum and genitalia with imperforate anus, rectovaginal fistula and perineal skin tag at birth. Under the impression of PELVIS syndrome, consequential spinal sonography was conducted and revealed an intrasacral meningocele without clinical neurologic deficit. The anorectal malformation was surgically corrected, she was taking oral propranolol for the cutaneous lesion, and she showed improvement and no complications.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"35 Suppl 1","pages":"S88-S92"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/34/38/ad-35-S88.PMC10608397.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49686949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jung Eun Yim, Hyeong Mok Kwon, Hye Ri Kim, Dong Hoon Shin, Jong Soo Choi, Joon Hyuk Choi, Young Kyung Bae
{"title":"Superficial CD34-Positive Fibroblastic Tumor: Two Case Reports.","authors":"Jung Eun Yim, Hyeong Mok Kwon, Hye Ri Kim, Dong Hoon Shin, Jong Soo Choi, Joon Hyuk Choi, Young Kyung Bae","doi":"10.5021/ad.20.328","DOIUrl":"10.5021/ad.20.328","url":null,"abstract":"<p><p>Superficial CD34-positive fibroblastic tumor (SCPFT) is a recently described disease entity characterized by marked nuclear pleomorphism, low mitotic count, and diffuse CD34 positivity. It is a rare, distinctive, low-grade fibroblastic neoplasm. To date, only 44 cases have been reported in the English-language literature. Herein, we report two cases of SCPFT involving a 48-year-old male and a 22-year-old male with superficial tumors on the right and left thighs, respectively. Excision was performed in both cases. Histologically, both tumors showed spindle-to-epithelioid cells arranged in fascicular or sheet-like patterns. Most cells displayed granular or eosinophilic glassy cytoplasm, marked nuclear pleomorphism, and a low mitotic rate. On immunohistochemical staining, tumor cells were diffusely positive for CD34 and negative for S100 protein, smooth muscle actin, and desmin. After wide excision, neither patient experienced recurrence or metastasis after 16 months and 11 months of clinical follow-up, respectively. To the best of our knowledge, these are the first two cases of SCPFT reported in Korea. We believe these case reports would contribute to the clinicopathological understanding of SCPFT and assist clinicians in differentiating this tumor from other superficial soft tissue neoplasms.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"35 Suppl 1","pages":"S25-S29"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a8/bf/ad-35-S25.PMC10608372.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49687082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}