Annals of dermatology最新文献

{"title":"Assessment of Serum Zonulin Levels in Individuals Diagnosed With Chronic Spontaneous Urticaria.","authors":"Alkım Ünal, Gözde Ülfer","doi":"10.5021/ad.24.020","DOIUrl":"10.5021/ad.24.020","url":null,"abstract":"<p><strong>Background: </strong>There have been reports indicating a correlation between heightened intestinal permeability and many autoimmune and chronic inflammatory disorders. The involvement of autoimmunity is now recognized as a significant factor in the development of chronic spontaneous urticaria (CSU). Zonulin is an important biomarker that regulates tight junction permeability within cells in the gastrointestinal tract, hence facilitating intestinal permeability.</p><p><strong>Objective: </strong>To evaluate the correlation of CSU with intestinal permeability by measuring the serum levels of zonulin in patients diagnosed with CSU.</p><p><strong>Methods: </strong>The study included 60 patients diagnosed with CSU and 64 age- and sex-matched healthy individuals as controls. Levels of serum zonulin were determined using the ELISA method.</p><p><strong>Results: </strong>Although the serum zonulin value of the patients was higher compared to the controls, the difference did not reach a significant level (24.65±8.49 ng/ml vs. 21.03±7.36 ng/ml, <i>p</i>=0.077). The serum zonulin level had a significant correlation with the urticaria activity score in the CSU group (<i>p</i>=0.013). The results of the current study revealed that serum zonulin values significantly differed between patients with CSU and healthy controls.</p><p><strong>Conclusion: </strong>This study is important in terms of being the first to investigate the serum zonulin levels in CSU. However, there is a need for further studies with larger patient groups.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 4","pages":"231-235"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11291101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term Safety of Dimethyl Fumarate for Psoriasis in Korea.","authors":"Tae Min Kim, Seong Jin Jo","doi":"10.5021/ad.23.054","DOIUrl":"10.5021/ad.23.054","url":null,"abstract":"","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 4","pages":"252-254"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11291097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomaterial Stiffness of Wharton's Jelly-Derived Mesenchymal Stem Cell-Conditioned Medium Modulates Fibroblasts Proliferation and Migration: A Preliminary Study.","authors":"Sangmin Choi, Jaeyun Kim, Soyul Kim, Yoonsung Lee, Man S Kim, Bark-Lynn Lew, Soon-Hyo Kwon","doi":"10.5021/ad.23.048","DOIUrl":"10.5021/ad.23.048","url":null,"abstract":"","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 4","pages":"247-251"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11291095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Having Dual Anti-Wrinkle Effects With Safe and Long-Term Activities.","authors":"Ju Yeop Shin, DongHoon Han, Ki Young Yoon, Do Hyeon Jeong, Yong Il Park","doi":"10.5021/ad.23.136","DOIUrl":"10.5021/ad.23.136","url":null,"abstract":"<p><strong>Background: </strong>Anti-aging products are widely used, but the desire for safe and more efficient anti-aging products continues to increase. Dissolving microneedle patches (MNPs) have provided a more efficient transdermal drug delivery solution. MNP is a promising candidate for developing better anti-aging products.</p><p><strong>Objective: </strong>To develop a more efficient anti-aging MNP product, we fabricated a dual anti-wrinkle microneedle patch (named DA-MNP) using droplet extension (DEN^®) technology and evaluated its skin puncture ability, safety, and efficacy through clinical studies.</p><p><strong>Methods: </strong>A DA-MNP comprising hyaluronic acid (HA) polymer backbone, acetyl octapeptide-3, and L-ascorbic acid 2-glucoside and sodium cyclic lysophosphatidic acid was fabricated using DEN^® technology. Placebo MNPs comprising only HA were also fabricated. Twenty-four healthy subjects were enrolled in this comparative clinical study. The DA-MNP or placebo MNP was separately applied to the left and right eyes of subjects for overnight. Assessments, including wrinkle improvement, trans-epidermal water loss (TEWL), eye lifting and adverse effects were evaluated at each scheduled visit day for 28 days.</p><p><strong>Results: </strong>The DA-MNP showed mechanical strength enough for puncturing the stratum corneum. Compared to placebo MNP group, the DA-MNP treated group showed an effective eye wrinkles improvement and better anti-aging of skin, with reduced TEWL, enhanced skin elasticity and lifting, and no adverse effects.</p><p><strong>Conclusion: </strong>The present study demonstrated that the fabricated DA-MNP exhibited fast acting on deep wrinkles and enhanced anti-aging efficacy, with no skin safety concern. Thus, this DA-MNP may serve as a new transdermal delivery solution for skin wrinkling and aging.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 4","pages":"215-224"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11291098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Korean Consensus Criteria for the Severity Classification of Alopecia Areata.","authors":"Yong Hyun Jang, Seung Soo Lee, Do Young Park, Young Lee, Do-Young Kim, Hyunsun Park, Hyun-Tae Shin, Jung Eun Kim, Kihyuk Shin, Ji Hae Lee, Jee Woong Choi, Byung Choel Park, Beom Joon Kim, Soo Hong Seo, Chong Hyun Won, Jin Park, Min Sung Kim, Sang Seok Kim, Bark-Lynn Lew, Chang-Hun Huh, Ohsang Kwon, Yang Won Lee, Moon-Bum Kim","doi":"10.5021/ad.24.058","DOIUrl":"10.5021/ad.24.058","url":null,"abstract":"<p><strong>Background: </strong>A set of criteria for severity classification is essential in alopecia areata (AA). Currently, no guidelines are universally accepted for defining AA severity.</p><p><strong>Objective: </strong>This study aimed to establish a set of consensus criteria for classifying the severity of and identifying treatment refractoriness in AA.</p><p><strong>Methods: </strong>A preliminary draft of the definition for moderate-to-severe AA was crafted based on available evidence, and members of the Korean Hair Research Society (KHRS) subsequently endorsed the recommendation through an online survey.</p><p><strong>Results: </strong>In the first Delphi round, consensus was attained on 15 questions. After refining certain items in the second round, consensus was achieved on 23 out of 26 questions. The KHRS first defined AA severity using the severity of alopecia tool (SALT). SALT ≥50 was defined as severe, 20≤ SALT <50 as moderate, and SALT <20 as mild. Moderate AA was considered severe if it meets one or more of the following criteria: dermatology life quality index >10, presence of accompanying eyebrow or eyelash loss, positive hair loss activity, or treatment-refractory AA.</p><p><strong>Conclusion: </strong>These consensus criteria can help clinicians accurately diagnose AA, provide appropriate treatment, and monitor its progression.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 4","pages":"236-246"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11291096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alopecia Areata and Season of Onset: A Retrospective Study of 492 Cases.","authors":"Sang-Hoon Lee, Seung-Won Jung, Won-Soo Lee","doi":"10.5021/ad.23.032","DOIUrl":"10.5021/ad.23.032","url":null,"abstract":"","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 3","pages":"188-190"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tranexamic Acid Ameliorates Skin Hyperpigmentation by Downregulating Endothelin-1 Expression in Dermal Microvascular Endothelial Cells.","authors":"Lin-Xia Liu, Zhi-Kai Liao, Bing-Qi Dong, Shan Jiang, Tie-Chi Lei","doi":"10.5021/ad.23.108","DOIUrl":"10.5021/ad.23.108","url":null,"abstract":"<p><strong>Background: </strong>Although reports suggest that tranexamic acid (TXA) has clinical benefits for melasma patients by oral, intralesional and topical treatment, the optimal route of TXA therapy and the underlying mechanism involved remain poorly defined.</p><p><strong>Objective: </strong>To compare the skin lightening effect between oral TXA and topical TXA and to dissect the molecular mechanisms using ultraviolet B (UVB)-induced hyperpigmentation mouse model, <i>ex vivo</i> cultured human skin explant, and cultured melanocytes (MCs) and endothelial cells.</p><p><strong>Methods: </strong>Melanin content and cluster of differentiation 31 (CD31)-positive cell numbers were measured in tail skins from UVB-irradiated mice treated by intragastral or topical TXA using immunofluorescent and <i>Fontana-Masson</i> staining. The conditioned medium (CM) was harvested from human umbilical vein endothelial cells treated with or without 3 mM TXA and was used to treat MCs for 48 hours. mRNA and protein levels of tyrosinase and microphthalmia-associated transcription factor were measured using quantitative real-time reverse transcription polymerase chain reaction and western blotting assays. HMB45- and CD31-positive cell numbers as well as melanin content were also examined in <i>ex vivo</i> cultured human skin explants.</p><p><strong>Results: </strong>The hyperpigmented phenotype were significantly mitigated in UVB-irradiated tail skin plus intragastral TXA-treated mice compared with mice treated with UVB only or with UVB plus topical TXA. CD31-positive cell numbers correlated with the anti-melanogenic activity of TXA therapy. The data from cultured cells and skin tissues showed that suppression of endothelin-1 (ET-1) in vascular endothelial cells by TXA reduced melanogenesis and MC proliferation.</p><p><strong>Conclusion: </strong>Oral TXA outperforms topical TXA treatment in skin lightening, which contributes to suppression of ET-1 in dermal microvascular endothelial cells by TXA.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 3","pages":"151-162"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Amount of Daily Water Intake and Use of Moisturizer on Skin Barrier Function in Healthy Female Participants.","authors":"Jung Eun Seol, Gyeong Je Cho, Seung Hee Jang, Sang Woo Ahn, Seong Min Hong, So Hee Park, Hyojin Kim","doi":"10.5021/ad.23.067","DOIUrl":"10.5021/ad.23.067","url":null,"abstract":"<p><strong>Background: </strong>It is well known that adequate water intake and moisturizer application improves skin barrier function.</p><p><strong>Objective: </strong>This study was conducted to analyze the effects of daily water intake and moisturizer application on skin barrier function and the degree of response to barrier recovery.</p><p><strong>Methods: </strong>Participants with daily water intake more than 1 L were classified as high daily water intake group (H) and those with less than 1 L as low daily water intake group (L). Each group was subcategorized into four groups according to intervention method: additional water intake (H1, L1), moisturizer (H2, L2), both (H3, L3), and control (H4, L4). Transepidermal water loss (TEWL) and stratum corneum hydration (SCH) were measured at baseline during the 2nd and 4th week.</p><p><strong>Results: </strong>A total of 43 participants completed the study (H: 22, L: 21). At baseline, there was no significant difference in SCH and TEWL in any on the anatomical sites between the high daily water intake and low daily water intake groups. However, SCHs of left forearm (group H2, <i>p</i>=0.004; group H3, <i>p</i>=0.004), left hand dorsum (group H2, <i>p</i>=0.010; group H3, <i>p</i>=0.026), and left shin (group H2, <i>p</i>=0.016; group H3, <i>p</i>=0.001) in group H2 and H3 were significantly increased in the 4th week as compared to the baseline values.</p><p><strong>Conclusion: </strong>The results suggest that the degree of water intake may be related to improved skin barrier function. However, application of additional moisturizers had more favorable impact on skin hydration as compared to additional water intake.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 3","pages":"145-150"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Bleomycin Intralesional Injection for Treating Digital Mucous Cysts: A Comparative Study of Corticosteroid Intralesional Injection and Surgical Excision.","authors":"Yoon Jae Kim, Hyun Mo Lee, Jun Hyuk Cho, Dai Hyun Kim, Hyo Hyun Ahn, Soo Hong Seo","doi":"10.5021/ad.23.131","DOIUrl":"10.5021/ad.23.131","url":null,"abstract":"<p><strong>Background: </strong>Sclerotherapy has shown superior efficacy among the nonsurgical options for managing digital mucous cysts (DMC). Notably, previous research has indicated that bleomycin offers a more favorable side-effect profile and similar efficacy to conventional sclerosing agents.</p><p><strong>Objective: </strong>This study aimed to assess the efficacy and safety of bleomycin intralesional injection (ILI) for treating DMC through a comparative analysis of corticosteroid ILI and surgical excision.</p><p><strong>Methods: </strong>We retrospectively reviewed electronic medical records and clinical photographs. Telephone interviews were conducted to further investigate long-term treatment efficacy, safety, and overall treatment satisfaction.</p><p><strong>Results: </strong>Ten patients underwent surgical excision, and 13 and 15 patients received bleomycin and corticosteroid ILI, respectively. Both surgical excision and bleomycin ILI demonstrated superior treatment efficacy compared to corticosteroid ILI. No statistically significant difference in the treatment effectiveness between surgical excision and bleomycin ILI was observed. No significant adverse effects were observed. In the survey, the level of satisfaction was the highest for bleomycin ILI, followed by surgical excision and corticosteroid ILI.</p><p><strong>Conclusion: </strong>This study revealed that bleomycin ILI exhibits a treatment efficacy higher than that of corticosteroid ILI and slightly lower than that of surgical excision, without any side effects. Therefore, bleomycin ILI is a safe and effective therapeutic option for the treatment of DMC.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 3","pages":"180-185"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update on Melasma Treatments.","authors":"Ju Young Jo, Su Ji Chae, Hwa Jung Ryu","doi":"10.5021/ad.23.133","DOIUrl":"10.5021/ad.23.133","url":null,"abstract":"<p><p>Melasma is a prevalent hyperpigmentation condition known for its challenging treatment due to its resemblance to photoaged skin disorders. Numerous studies have shed light on the intricate nature of melasma, which often bears similarity to photoaging disorders. Various therapeutic approaches, encompassing topical and systemic treatments, chemical peeling, and laser therapy, have exhibited efficacy in managing melasma in previous research. However, melasma often reoccurs despite successful treatment, primarily due to its inherent photoaged properties. Given that melasma shares features with photoaging disorders, including disruptions in the basement membrane, solar elastosis, angiogenesis, and mast cell infiltration in the dermal layer, a comprehensive treatment strategy is imperative. Such an approach might involve addressing epidermal hyperpigmentation while concurrently restoring dermal components. In this article, we provide a comprehensive review of conventional treatment methods frequently employed in clinical practice, as well as innovative treatments currently under development for melasma management. Additionally, we offer an extensive overview of the pathogenesis of melasma.</p>","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"36 3","pages":"125-134"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11148313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}